Cited by 347Drug Solubulity and Delivery SystemsNanoparticle-Based Drug DeliveryAdvancements in Transdermal Drug Delivery

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Drug nanocrystals: in vivo performances.

Gao, Lei, Liu, Guiyang, Ma, Jianli, Wang, Xiaoqing, Zhou, Liang, Li, Xiang·2012·Journal of Controlled Release

DOI 10.1016/j.jconrel.2012.03.013

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Abstract

Over the past few decades, there has been a considerable research interest in drug nanocrystal system as a pharmaceutical approach for poorly soluble drugs. At the beginning lots of works have been done to study various technologies associated with production of drug nanocrystals and their in vitro physical and chemical properties, such as morphology, formulation composition, stabilities, crystalline structure and enhanced solubility and dissolution velocity. Recently, in vivo behaviors of the nanocrystals have been generally studied in animals (including human), and the results proved that drug nanocrystals could be used as a versatile formulation to alter and improve the pharmacokinetic, pharmacodynamic and targeting properties of poorly soluble drugs. In this paper, in vivo performances of drug nanocrystals exhibited in animals in different administration route were reviewed, and the advantages of drug nanocrystals in the aspect of safety, pharmacodynamics, pharmacokinetics and targeting delivery were discussed in detail.

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Authors: Gao, L., Liu, G., Ma, J., Wang, X., Zhou, L., & Li, X.
Affiliations: First Affiliated Hospital of Chinese PLA General Hospital (CN)
Corresponding author: Gao, Lei
Liu, Guiyang
ORCID: Gao, Lei
Liu, Guiyang
Ma, Jianli
Wang, Xiaoqing
Zhou, Liang
Li, Xiang
Venue: Journal of Controlled Release
Publisher: Elsevier BV
Published: 2012-06
Volume: 160
Issue: 3
Pages: 418-430
ISSN: 0168-3659 (ISSN-L)
DOI: 10.1016/j.jconrel.2012.03.013
OpenAlex: W2041317416
Cited by: 347
References: 159
Citations by year: 2026: 13 · 2025: 20 · 2024: 20 · 2023: 23 · 2022: 31 · 2021: 29 · 2020: 36 · 2019: 26 · 2018: 27 · 2017: 28 · 2016: 36 · 2015: 18 · 2014: 19 · 2013: 19 · 2012: 2
FWCI: 2.30
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Journal of Controlled Release (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
Keywords: drug nanocrystals, poorly water-soluble drugs, pharmacokinetics, pharmacodynamics, targeted drug delivery, in vivo performance, route of administration, dissolution enhancement
MeSH terms: Animals, Drug Administration Routes, Pharmaceutical Preparations, Humans, Pharmacokinetics, Drug Delivery Systems, Nanoparticles

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Drug nanocrystals: in vivo performances.

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