The DOI matches its Crossref record; 205 of the 205 references it cites were found in a registry or an index.
Insight into nanoparticle cellular uptake and intracellular targeting
Open accessAbstract
Collaborative efforts from the fields of biology, materials science, and engineering are leading to exciting progress in the development of nanomedicines. Since the targets of many therapeutic agents are localized in subcellular compartments, modulation of nanoparticle-cell interactions for an efficient cellular uptake through the plasma membrane, and the development of nanomedicines for precise delivery to subcellular compartments remain formidable challenges. The cellular internalization routes have a determining effect on the post-internalization fate and intracellular localization of nanoparticles. This review highlights the cellular uptake routes most relevant to the field of non-targeted nanomedicine, and presents an account of ligand targeted nanoparticles for receptor mediated cellular internalization as a strategy for modulating the cellular uptake of nanoparticles. Ligand targeted nanoparticles have been the main impetus behind the progress of nanomedicines towards the clinic. This strategy has even resulted in a remarkable development towards effective oral delivery of nanomedicines that can overcome the intestinal epithelial cellular barrier. A detailed overview of the recent developments towards subcellular targeting that is emerging as a platform for the next generation organelle specific nanomedicines is also provided. Each section of the review includes prospect, potential, and concrete expectations from the field of targeted nanomedicines and strategies to meet those expectations.
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Self-citationCellular uptake of nanoparticles: Journey inside the cell
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Self-citationInsight into Cellular Uptake and Intracellular Trafficking of Nanoparticles
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Chitosan Nanoparticles at the Biological Interface: Implications for Drug Delivery
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Metadata
- Authors
- Yameen, B., Choi, W. I., Vilos, C., Swami, A., Shi, J., & Farokhzad, O. C.
- Venue
- Journal of Controlled Release
- Publisher
- Elsevier BV
- Published
- 2014-09
- Volume
- 190
- Pages
- 485-499
- ISSN
- 0168-3659 (ISSN-L)
- OpenAlex
- W2087824631
- Cited by
- 787
- References
- 205
- FWCI
- 17.02
- Type
- journal article
- Language
- en
- Open access
- green
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- Yameen, B., Choi, W. I., Vilos, C., Swami, A., Shi, J., & Farokhzad, O. C. (2014). Insight into nanoparticle cellular uptake and intracellular targeting. Journal of Controlled Release. https://doi.org/10.1016/j.jconrel.2014.06.038
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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