Progress in the development of lipopolyplexes as efficient non-viral gene delivery systems
Abstract
Efficient gene therapy is mainly dependent on the gene transfer capability of gene delivery vectors. Non-viral vectors have become the research interest of many researchers because these vectors are safer than viral vectors. Acquiring the advantages of both polyplexes and lipoplexes, the lipopolyplex (LPP) is a ternary nanocomplex composed of cationic liposome, polycation, and nucleic acid. Considering the polycationic component, ternary complexes (LPPs) are divided into cationic polymer-based LPPs and cationic peptide-based LPPs. Considering the capability of rational design, LPP is an interesting field of research to design a more potent nucleic acid carrier. With the promising transfection activity and safety observed in the LPPs, many researchers have formulated various types of lipids and polycations to achieve an efficient and safe carrier for gene therapy. Here we provide a review on the designed LPPs for efficient delivery of different nucleic acids such as plasmid DNA, siRNA, shRNA, and DNA vaccines.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
LPPs have higher stability, low cytotoxicity, cell delivery and endosomal escape efficiency.
“LPPs have higher stability, low cytotoxicity, cell delivery and endosomal escape efficiency.327–329”
From Advances in COVID-19 mRNA vaccine development (2022) · cites this paper as [327]
Cites
Non-viral vectors for gene-based therapy
Yin, H., Kanasty, R. L., Eltoukhy, A. A., Vegas, A. J., Dorkin, J. R., & Anderson, D. G. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3763 · Cited by 3,123 · see citing works
Liou, J., Diao, C.-C., Lin, J., Chen, Y., & Yang, C. (2014) · Nanoscale Research Letters · doi:10.1186/1556-276x-9-1 · Cited by 2,069 · see citing works
Polyethylenimine-based non-viral gene delivery systems
Lungwitz, U., Breunig, M., Blunk, T., & Göpferich, A. M. (2005) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2004.11.011 · Cited by 985 · see citing works
Gene Therapy Death Prompts Review of Adenovirus Vector
Marshall, E. (1999) · Science · doi:10.1126/science.286.5448.2244 · Cited by 918 · see citing works
Dendrimer toxicity: Let's meet the challenge
Jain, K., Kesharwani, P., Gupta, U. D., & Jain, N. K. (2010) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2010.04.027 · Cited by 711 · see citing works
Towards safe, non-viral therapeutic gene expression in humans
Glover, D., Lipps, H., & Jans, D. (2005) · Nature reviews genetics · doi:10.1038/nrg1577 · Cited by 622 · see citing works
Zhou, X., & Huang, L. (1994) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(94)90066-3 · Cited by 499 · see citing works
Potentiation of Cationic Liposome-Mediated Gene Delivery by Polycations
Gao, X., & Huang, L. (1996) · Biochemistry · doi:10.1021/bi952436a · Cited by 461 · see citing works
Lee, R. J., & Huang, L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.14.8481 · Cited by 400 · see citing works
Martin, M. E., & Rice, K. G. (2007) · The AAPS Journal · doi:10.1208/aapsj0901003 · Cited by 321 · see citing works
Hong, K., Zheng, W., Baker, A., & Papahadjopoulos, D. (1997) · FEBS Letters · doi:10.1016/s0014-5793(96)01397-x · Cited by 317 · see citing works
Viral gene therapy strategies: from basic science to clinical application
Young, L. S., Searle, P. F., Onion, D., & Mautner, V. (2005) · The Journal of Pathology · doi:10.1002/path.1896 · Cited by 316 · see citing works
Discrimination Between Intracellular Uptake and Surface Adhesion of Bacterial Pathogens
Isberg, R. R. (1991) · Science · doi:10.1126/science.1674624 · Cited by 300 · see citing works
Su, X., Fricke, J., Kavanagh, D. G., & Irvine, D. J. (2011) · Molecular Pharmaceutics · doi:10.1021/mp100390w · Cited by 287 · see citing works
Integrin-ligarid interactions: a year in review
Haas, T. A., & Plow, E. F. (1994) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(94)90091-4 · Cited by 285 · see citing works
Polyethylene Glycol-Conjugated Copolymers for Plasmid DNA Delivery
Lee, M., & Kim, S. W. (2005) · Pharmaceutical Research · doi:10.1007/s11095-004-9003-5 · Cited by 277 · see citing works
Wang, T., Upponi, J. R., & Torchilin, V. P. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2011.07.013 · Cited by 267 · see citing works
A polymer library approach to suicide gene therapy for cancer
Anderson, D. G., Peng, W., Akinc, A., Hossain, N., Kohn, A., Padera, R. F., Langer, R., & Sawicki, J. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407218101 · Cited by 258 · see citing works
Pasqualini, R., Koivunen, E., & Ruoslahti, E. I. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.130.5.1189 · Cited by 235 · see citing works
Perche, F., Benvegnu, T. J., Berchel, M., Lebegue, L., Pichon, C., Jaffrès, P., & Midoux, P. (2011) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2010.12.010 · Cited by 219 · see citing works
A sight on the current nanoparticle-based gene delivery vectors
Dizaj, S. M., Jafari, S., & Khosroushahi, A. Y. (2014) · Nanoscale Research Letters · doi:10.1186/1556-276x-9-252 · Cited by 213 · see citing works
The Role of the Helper Lipid on the DNA Transfection Efficiency of Lipopolyplex Formulations
Du, Z., Munye, M. M., Tagalakis, A. D., Manunta, M., & Hart, S. L. (2014) · Scientific Reports · doi:10.1038/srep07107 · Cited by 200 · see citing works
Liposome–polyethylenimine complexes for enhanced DNA and siRNA delivery
Schäfer, J., Höbel, S., Bakowsky, U., & Aigner, A. M. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.05.043 · Cited by 196 · see citing works
Huang, X., Schwind, S., Yu, B., Santhanam, R., Wang, H., Hoellerbauer, P., Mims, A. S., Klisovic, R. B., Walker, A. R., Chan, K. K., et al. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-3191 · Cited by 193 · see citing works
Octaarginine- and Octalysine-modified Nanoparticles Have Different Modes of Endosomal Escape
El‐Sayed, A., Khalil, I. A., Kogure, K., Futaki, S., & Harashima, H. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709387200 · Cited by 191 · see citing works
Lipid-Mediated Enhancement of Transfection by a Nonviral Integrin-Targeting Vector
Hart, S. L., Arancibia-Cárcamo, C. V., Wolfert, M. A., Mailhos, C., O’Reilly, N., Ali, R. R., Coutelle, C. C., George, A. J. T., Harbottle, R. P., Knight, A. M., et al. (1998) · Human Gene Therapy · doi:10.1089/hum.1998.9.4-575 · Cited by 176 · see citing works
Novel polyethylenimine-derived nanoparticles forin vivogene delivery
Patnaik, S., & Gupta, K. C. (2012) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2013.744964 · Cited by 162 · see citing works
Mockey, M., Bourseau, E., Voshavar, C., Chaudhuri, A., Lafosse, S., Cam, É. L., Quesniaux, V. F. J., Ryffel, B., Pichon, C., & Midoux, P. (2007) · Cancer Gene Therapy · doi:10.1038/sj.cgt.7701072 · Cited by 161 · see citing works
Gene Transfer into Mammalian Cells Using Histone-Condensed Plasmid DNA
Fritz, J. D., Herweijer, H., Zhang, G., & Wolff, J. A. (1996) · Human Gene Therapy · doi:10.1089/hum.1996.7.12-1395 · Cited by 161 · see citing works
Seeking the Cause of Induced Leukemias in X-SCID Trial
Kaiser, J. (2003) · Science · doi:10.1126/science.299.5606.495 · Cited by 144 · see citing works
Gene delivery and expression mediated by an integrin-binding peptide.
Hart, S. L., Harbottle, R. P., Cooper, R., Miller, A. D., Williamson, R. E., & Coutelle, C. C. (1995) · PubMed · Cited by 142 · see citing works
Toward Gene Therapy for Cystic Fibrosis Using a Lentivirus Pseudotyped With Sendai Virus Envelopes
Mitomo, K., Uta Griesenbach, D., Inoue, M., Somerton, L., Meng, C., Akiba, E., Tabata, T., Ueda, Y., Frankel, G. M., Farley, R., et al. (2010) · Molecular Therapy · doi:10.1038/mt.2010.13 · Cited by 135 · see citing works
Growth-factor gene therapy for neurodegenerative disorders
Tuszynski, M. H. (2002) · The Lancet Neurology · doi:10.1016/s1474-4422(02)00006-6 · Cited by 125 · see citing works
Gene Therapy for Infectious Diseases
Bunnell, B. A., & Morgan, R. A. (1998) · Clinical Microbiology Reviews · doi:10.1128/cmr.11.1.42 · Cited by 123 · see citing works
Liposome encapsulated polyethylenimine/ODN polyplexes for brain targeting
Ko, Y. T., Bhattacharya, R., & Bickel, U. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2008.10.013 · Cited by 119 · see citing works
DEWOLF, H., Snel, C. J., Verbaan, F. J., Schiffelers, R. M., Hennink, W. E., & Storm, G. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2006.10.029 · Cited by 113 · see citing works
Billiet, L., Gomez, J., Berchel, M., Jaffrès, P., Gall, T. L., Montier, T., Bertrand, E., Cheradame, H., Guégan, P., Mével, M., et al. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2011.12.027 · Cited by 105 · see citing works
Pyridylhydrazone-based PEGylation for pH-reversible lipopolyplex shielding
Nie, Y., Günther, M., Gu, Z., & Wagner, E. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.09.032 · Cited by 104 · see citing works
Vitiello, L., Chonn, A., Wasserman, J. D., Duff, C., & Worton, R. G. (1996) · PubMed · Cited by 104 · see citing works
Schwartz, B., Ivanov, M. A., Pitard, B., Escriou, V., Rangara, R., Byk, G., Wils, P., Crouzet, J., & Scherman, D. (1999) · Gene Therapy · doi:10.1038/sj.gt.3300795 · Cited by 101 · see citing works
Gene Therapy Progress and Prospects: cancer gene therapy using tumour suppressor genes
McNeish, I. A., Bell, S. J. D., & Lemoine, N. R. (2004) · Gene Therapy · doi:10.1038/sj.gt.3302238 · Cited by 100 · see citing works
Lee, C.-H., Ni, Y., Chen, C., Chou, C.-K., & Chang, F. (2003) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(03)00027-0 · Cited by 90 · see citing works
Integrin-mediated transfection with peptides containing arginine-glycine-aspartic acid domains
Hart, S. L., Collins, L., Gustafsson, K. T., & Fabre, J. W. (1997) · Gene Therapy · doi:10.1038/sj.gt.3300513 · Cited by 90 · see citing works
Zhou, X. Y., Laroche, F., Lamers, G. E. M., Torraca, V., Voskamp, P., Lu, T., Chu, F., Spaink, H. P., Abrahams, J. P., & Liu, Z. (2012) · Nano Research · doi:10.1007/s12274-012-0254-x · Cited by 86 · see citing works
Ramezani, M., Khoshhamdam, M., Dehshahri, A., & Malaekeh‐Nikouei, B. (2009) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2009.03.018 · Cited by 83 · see citing works
Self-citationCationic Polymer Based Nanocarriers for Delivery of Therapeutic Nucleic Acids
Nimesh, S., Gupta, N., & Chandra, R. (2011) · Journal of Biomedical Nanotechnology · doi:10.1166/jbn.2011.1313 · Cited by 82 · see citing works
An integrin-targeted non-viral vector for pulmonary gene therapy
Jenkins, G. R., Herrick, S. E., Meng, Q.-H., Kinnon, C., Laurent, G. J., McAnulty, R. J., & Hart, S. L. (2000) · Gene Therapy · doi:10.1038/sj.gt.3301095 · Cited by 82 · see citing works
Li, L., Song, P., Wang, X., He, B., Li, J., Lai, Xu, & Gu, Z. (2012) · International Journal of Nanomedicine · doi:10.2147/ijn.s33923 · Cited by 79 · see citing works
Tagawa, T., Manvell, M. C., Brown, N., Keller, M., Pérouzel, É., Murray, K. D., Harbottle, R. P., Tecle, M., Booy, F. P., Brahimi-Horn, M. C., et al. (2002) · Gene Therapy · doi:10.1038/sj.gt.3301686 · Cited by 78 · see citing works
Multifunctional nanocomplexes for gene transfer and gene therapy
Hart, S. (2010) · Cell Biology and Toxicology · doi:10.1007/s10565-009-9141-y · Cited by 77 · see citing works
Serum-resistant lipopolyplexes for gene delivery to liver tumour cells
Garcia, L. G., Buñuales, M., Düzgüneş, N., & de Ilarduya, C. T. (2007) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2007.01.005 · Cited by 77 · see citing works
Ewe, A., Schaper, A., Barnert, S., Schubert, R., Temme, A., Bakowsky, U., & Aigner, A. M. (2014) · Acta Biomaterialia · doi:10.1016/j.actbio.2014.02.037 · Cited by 75 · see citing works
Co-polymer of histidine and lysine markedly enhances transfection efficiency of liposomes
Chen, Q.-R., Zhang, L.-Q., Stass, S. A., & Mixson, A. J. (2000) · Gene Therapy · doi:10.1038/sj.gt.3301294 · Cited by 74 · see citing works
Hagstrom, J. E., Sebestyén, M. G., Budker, V. G., Ludtke, J. J., Fritz, J. D., & Wolff, J. A. (1996) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(96)00106-x · Cited by 73 · see citing works
A Receptor-targeted Nanocomplex Vector System Optimized for Respiratory Gene Transfer
Tagalakis, A. D., McAnulty, R. J., Devaney, J., Bottoms, S. E., Wong, J. B., Elbs, M., Writer, M. J., Hailes, H. C., Tabor, A. B., O’Callaghan, C., et al. (2008) · Molecular Therapy · doi:10.1038/mt.2008.38 · Cited by 66 · see citing works
Colin, M., Harbottle, R. P., Knight, A., Kornprobst, M., Cooper, R., Miller, A. D., Trugnan, G., Capeau, J., Coutelle, C. C., & Brahimi-Horn, M. C. (1998) · Gene Therapy · doi:10.1038/sj.gt.3300760 · Cited by 65 · see citing works
Peptides in DNA delivery: current insights and future directions
Mann, A., Thakur, G., Shukla, V., & Ganguli, M. (2008) · Drug Discovery Today · doi:10.1016/j.drudis.2007.11.008 · Cited by 63 · see citing works
Selective gene delivery in dendritic cells with mannosylated and histidylated lipopolyplexes
Perche, F., Gosset, D., Mével, M., Miramon, M., Yaouanc, J., Pichon, C., Benvegnu, T. J., Jaffrès, P., & Midoux, P. (2010) · Journal of drug targeting · doi:10.3109/1061186x.2010.504262 · Cited by 61 · see citing works
Grosse, S. M., Tagalakis, A. D., Mustapa, M. F. M., Elbs, M., Meng, Q., Mohammadi, A., Tabor, A. B., Hailes, H. C., & Hart, S. L. (2010) · The FASEB Journal · doi:10.1096/fj.09-144220 · Cited by 59 · see citing works
Synergism in gene delivery by small PEIs and three different nonviral vectors
Lampela, P., Soininen, P., Urtti, A. O., Männistö, P. T., & Raasmaja, A. (2003) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2003.10.004 · Cited by 57 · see citing works
Pelisek, J., Gaedtke, L., DeRouchey, J. E., Walker, G. F., Nikol, S., & Wagner, E. (2005) · The Journal of Gene Medicine · doi:10.1002/jgm.836 · Cited by 57 · see citing works
Writer, M. J., Marshall, B. J., Pilkington‐Miksa, M. A., Barker, S. E., Jacobsen, M. C., Kritz, A., Bell, P. C., Lester, D. H., Tabor, A. B., Hailes, H. C., et al. (2004) · Journal of drug targeting · doi:10.1080/10611860410001724459 · Cited by 55 · see citing works
Factors Determining the Superior Performance of Lipid/DNA/Protammine Nanoparticles over Lipoplexes
Caracciolo, G., Pozzi, D., Capriotti, A. L., Marianecci, C., Carafa, M., Marchini, C., Montani, M., Amici, A. R. D., Amenitsch, H. W., Digman, M. A., et al. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm200237p · Cited by 53 · see citing works
Integrin-targeted nanocomplexes for tumour specific delivery and therapy by systemic administration
Tagalakis, A. D., Grosse, S. M., Meng, Q., Mustapa, M. F. M., Kwok, A., Salehi, S. E., Tabor, A. B., Hailes, H. C., & Hart, S. L. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.10.037 · Cited by 52 · see citing works
Gonçalves, C., Berchel, M., Gosselin, M.-P., Malard, V., Cheradame, H., Jaffrès, P., Guégan, P., Pichon, C., & Midoux, P. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.11.005 · Cited by 51 · see citing works
Different synergistic roles of small polyethylenimine and Dosper in gene delivery
Lampela, P., Elomaa, M. A., Ruponen, M., Urtti, A. O., Männistö, P. T., & Raasmaja, A. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(02)00489-3 · Cited by 49 · see citing works
Enhanced Transfection Efficiency and Reduced Cytotoxicity of Novel Lipid–Polymer Hybrid Nanoplexes
Jain, S., Kumar, S., Agrawal, A. K., Thanki, K., & Banerjee, U. C. (2013) · Molecular Pharmaceutics · doi:10.1021/mp400036w · Cited by 47 · see citing works
Namiki, Y., Takahashi, T., & Ohno, T. (1998) · Gene Therapy · doi:10.1038/sj.gt.3300577 · Cited by 46 · see citing works
Gene therapy Progress and Prospects: Gene therapy for the hemophilias
Walsh, C. (2003) · Gene Therapy · doi:10.1038/sj.gt.3302024 · Cited by 45 · see citing works
Non-viral eNOS gene delivery and transfection with stents for the treatment of restenosis
Brito, L. A., Chandrasekhar, S., Little, S. R., & Amiji, M. M. (2010) · BioMedical Engineering OnLine · doi:10.1186/1475-925x-9-56 · Cited by 44 · see citing works
Lipid-coated polyplexes for targeted gene delivery to ovarian carcinoma cells
Mastrobattista, E., Kapel, R. H., Eggenhuisen, M. H., Roholl, P. J. M., Crommelin, D. J. A., Hennink, W. E., & Storm, G. (2001) · Cancer Gene Therapy · doi:10.1038/sj.cgt.7700311 · Cited by 44 · see citing works
Tailoring minimalist self-assembling peptides for localized viral vector gene delivery
Rodriguez, A. L., Wang, T., Bruggeman, K. F., Li, R., Williams, R. J., Parish, C. L., & Nisbet, D. R. (2015) · Nano Research · doi:10.1007/s12274-015-0946-0 · Cited by 43 · see citing works
Mustapa, M. F. M., Grosse, S. M., Kudsiova, L., Elbs, M., Raiber, E., Wong, J. B., Brain, A. P. R., Armer, H. E. J., Warley, A., Epple, M., et al. (2009) · Bioconjugate Chemistry · doi:10.1021/bc800450r · Cited by 40 · see citing works
Munye, M. M., Ravi, J., Tagalakis, A. D., McCarthy, D., Ryadnov, M. G., & Hart, S. L. (2015) · Scientific Reports · doi:10.1038/srep09292 · Cited by 39 · see citing works
Chen, J., Xu, X., Yang, S., Yang, J., Zhuo, R., & Zhang, X. (2012) · Macromolecular Bioscience · doi:10.1002/mabi.201200283 · Cited by 38 · see citing works
Lipid peptide nanocomplexes for gene delivery and magnetic resonance imaging in the brain
Writer, M. J., Kyrtatos, P. G., Bienemann, A. S., Pugh, J., Lowe, A., Villegas-Llerena, C., Kenny, G. D., White, E. A., Gill, S., McLeod, C. W., et al. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.07.002 · Cited by 35 · see citing works
Brito, L., Little, S. R., Langer, R., & Amiji, M. M. (2008) · Biomacromolecules · doi:10.1021/bm7011373 · Cited by 34 · see citing works
Welser, K., Campbell, F., Kudsiova, L., Mohammadi, A., Dawson, N. L., Hart, S. L., Barlow, D. J., Hailes, H. C., Lawrence, M. J., & Tabor, A. B. (2012) · Molecular Pharmaceutics · doi:10.1021/mp300187t · Cited by 33 · see citing works
Ko, Y. T., & Bickel, U. (2012) · AAPS PharmSciTech · doi:10.1208/s12249-012-9757-8 · Cited by 33 · see citing works
Brito, L. A., Chandrasekhar, S., Little, S. R., & Amiji, M. M. (2009) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.32488 · Cited by 32 · see citing works
Double Charge Inversion in Polyethylenimine-Decorated Liposomes
Sabín, J., Vázquez-Vázquez, C., Prieto, G., Bordi, F., & Sarmiento, F. (2012) · Langmuir · doi:10.1021/la3019259 · Cited by 32 · see citing works
Hybrid vector including polyethylenimine and cationic lipid, DOTMA, for gene delivery
Matsumoto, M., Reiko, K., Kurosaki, T., Nakagawa, H., Ichikawa, N., Hamamoto, T., To, H., Kitahara, T., & Sasaki, H. (2008) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2008.07.010 · Cited by 30 · see citing works
Jenkins, G. R., Meng, Q.-H., Hodges, R. J., Lee, L. K., Bottoms, S. E., Laurent, G. J., Willis, D., Shamlou, P. A., McAnulty, R. J., & Hart, S. L. (2003) · Gene Therapy · doi:10.1038/sj.gt.3301963 · Cited by 27 · see citing works
The role of PEI structure and size in the PEI/liposome-mediated synergism of gene transfection
Hanzlíková, M., Soininen, P., Lampela, P., Männistö, P. T., & Raasmaja, A. (2008) · Plasmid · doi:10.1016/j.plasmid.2008.08.003 · Cited by 27 · see citing works
Efficient serum-resistant lipopolyplexes targeted to the folate receptor
Urbiola, K., Garcia, L. G., Zalba, S., Garrido, M. J., & de Ilarduya, C. T. (2012) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2012.10.012 · Cited by 26 · see citing works
Chitosan enhanced gene delivery of cationic liposome via non-covalent conjugation
Wang, B., Zhang, S., Cui, S., Yang, B., Zhao, Y., Chen, H., Hao, X., Shen, Q., & Zhou, J. (2011) · Biotechnology Letters · doi:10.1007/s10529-011-0748-8 · Cited by 26 · see citing works
Irvine, S. A., Meng, Q., Afzal, F., Ho, J., Wong, J. B., Hailes, H. C., Tabor, A. B., McEwan, J. R., & Hart, S. L. (2008) · Molecular Therapy · doi:10.1038/sj.mt.6300381 · Cited by 25 · see citing works
Acid cleavable PEG-lipids for applications in a ternary gene delivery vector
Wong, J. B., Grosse, S. M., Tabor, A. B., Hart, S. L., & Hailes, H. C. (2008) · Molecular BioSystems · doi:10.1039/b719782a · Cited by 25 · see citing works
Kenny, G., Villegas-Llerena, C., Tagalakis, A., Campbell, F., Welser, K., Botta, M., Tabor, A., Hailes, H., Lythgoe, M., & Hart, S. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.06.042 · Cited by 24 · see citing works
Ma, K., Shen, H., Shen, S., Men, X., Mao, C., Qiu, L., & Jin, Y. (2011) · The Journal of Gene Medicine · doi:10.1002/jgm.1569 · Cited by 23 · see citing works
Vaysse, L., & Arveiler, B. (2000) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(00)00007-6 · Cited by 23 · see citing works
Meng, Q.-H., Irvine, S. A., Tagalakis, A. D., McAnulty, R. J., McEwan, J. R., & Hart, S. L. (2013) · Gene Therapy · doi:10.1038/gt.2013.20 · Cited by 22 · see citing works
Writer, M. J., Hurley, C. A., Sarkar, S., Copeman, D. M., Wong, J. B., Odlyha, M., Lawrence, M. J., Tabor, A. B., McAnulty, R. J., Shamlou, P. A., et al. (2006) · Journal of Liposome Research · doi:10.1080/08982100600992500 · Cited by 22 · see citing works
Foglieni, C., Bragonzi, A., Cortese, M., Cantú, L., Boletta, A., Chiossone, I., Soria, M. R., & Monaco, L. (2000) · Gene Therapy · doi:10.1038/sj.gt.3301092 · Cited by 22 · see citing works
Hurley, C. A., Wong, J. B., Ho, J., Writer, M. J., Irvine, S. A., Lawrence, M. J., Hart, S. L., Tabor, A. B., & Hailes, H. C. (2008) · Organic & Biomolecular Chemistry · doi:10.1039/b719702k · Cited by 20 · see citing works
Perche, F., Lambert, O., Berchel, M., Jaffrès, P., Pichon, C., & Midoux, P. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2011.04.009 · Cited by 20 · see citing works
Kurosaki, T., Reiko, K., Matsumoto, M., Kodama, Y., Hamamoto, T., To, H., Niidome, T., Takayama, K., Kitahara, T., & Sasaki, H. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.02.005 · Cited by 20 · see citing works
Anderson, W. F. (1994) · Human Gene Therapy · doi:10.1089/hum.1994.5.2-149 · Cited by 20 · see citing works
Type and composition of surfactants mediating gene transfection of polyethylenimine-coated liposomes
Opanasopt, P., Paecharoenchai, Rojanarata, T., Ngawhirunpat, & Ruktanonchai (2011) · International Journal of Nanomedicine · doi:10.2147/ijn.s18647 · Cited by 19 · see citing works
Ewe, A., & Aigner, A. M. (2014) · European Journal of Lipid Science and Technology · doi:10.1002/ejlt.201300404 · Cited by 19 · see citing works
Meng, Q., Jamal, W., Hart, S. L., & McEwan, J. R. (2006) · Human Gene Therapy · doi:10.1089/hum.2006.17.717 · Cited by 17 · see citing works
Adsorption of plasmid DNA onto lipid/polymer particle assemblies
Troutier, A., Thévenot, J., Delair, T., & Ladavière, C. (2009) · Soft Matter · doi:10.1039/b911260j · Cited by 16 · see citing works
Malaekeh‐Nikouei, B., Malaekeh-Nikouei, M., Oskuee, R. K., & Ramezani, M. (2009) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2009.02.001 · Cited by 16 · see citing works
Self-citationOskuee, R. K., Dosti, F., Gholami, L., & Malaekeh‐Nikouei, B. (2015) · Materials Science and Engineering C · doi:10.1016/j.msec.2015.01.016 · Cited by 16 · see citing works
Self-citationPilkington‐Miksa, M. A., Writer, M. J., Sarkar, S., Meng, Q., Barker, S. E., Shamlou, P. A., Hailes, H. C., Hart, S. L., & Tabor, A. B. (2007) · Bioconjugate Chemistry · doi:10.1021/bc0700943 · Cited by 15 · see citing works
Jiang, Y., Korolev, N., Eom, K. D., Tam, J. P., & Nordenskiöld, L. (2011) · Biomacromolecules · doi:10.1021/bm201359r · Cited by 15 · see citing works
Lipopolyplex Ternary Delivery Systems Incorporating C14 Glycerol-Based Lipids
Kudsiova, L., Fridrich, B., Ho, J., Mustapa, M. F. M., Campbell, F., Welser, K., Epple, M., Ng, T., Barlow, D. J., Tabor, A. B., et al. (2011) · Molecular Pharmaceutics · doi:10.1021/mp2001796 · Cited by 15 · see citing works
A Covalently Stabilized Lipid−Polycation−DNA (sLPD) Vector for Antisense Oligonucleotide Delivery
Yang, X., Peng, Y., Yu, B., Yu, J., Zhou, C., Mao, Y., Lee, L. J., & Lee, R. J. (2011) · Molecular Pharmaceutics · doi:10.1021/mp100272k · Cited by 15 · see citing works
Pilkington‐Miksa, M. A., Sarkar, S., Writer, M. J., Barker, S. E., Shamlou, P. A., Hart, S. L., Hailes, H. C., & Tabor, A. B. (2008) · European Journal of Organic Chemistry · doi:10.1002/ejoc.200701188 · Cited by 14 · see citing works
THE TRANSFECTION OF JURKAT T-LEUKEMIC CELLS BY USE OF PH-SENSITIVE IMMUNOLIPOSOMES
Turner, C. T., Weir, N., Catterall, C. F., BAKER, T. S., Carrington, B., & Jones, M. N. (2002) · Journal of Liposome Research · doi:10.1081/lpr-120016197 · Cited by 14 · see citing works
Gaedtke, L., Pelisek, J., Lipinski, K. S., Wrighton, C. J., & Wagner, E. (2006) · Molecular Pharmaceutics · doi:10.1021/mp0600586 · Cited by 13 · see citing works
Golda, A., Pelisek, J., Klocke, R., Engelmann, M. G., Rolland, P., Mekkaoui, C., & Nikol, S. (2007) · Journal of Vascular Research · doi:10.1159/000101449 · Cited by 13 · see citing works
Penacho, N., Rosa, M., Lindman, B., Miguel, M. G., Simões, S., & de Lima, M. C. P. (2009) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2009.10.034 · Cited by 12 · see citing works
Cationic liposomes-polyallylamine-plasmid nanocomplexes for gene delivery
Oskuee, R. K., Mohtashami, E., Golami, L., & Malaekeh‐Nikouei, B. (2013) · Journal of Experimental Nanoscience · doi:10.1080/17458080.2013.771245 · Cited by 12 · see citing works
Self-citationMahmoudi, A., Oskuee, R. K., Ramezani, M., & Malaekeh‐Nikouei, B. (2014) · Current Drug Delivery · doi:10.2174/1567201811666140616160237 · Cited by 12 · see citing works
Self-citationLiposomes and lipopolymeric carriers for gene delivery
de Ilarduya, C. T., Garcia, L. G., & Düzgüneş, N. (2010) · Journal of Microencapsulation · doi:10.3109/02652048.2010.501396 · Cited by 11 · see citing works
Penacho, N., Simões, S., & de Lima, M. C. P. (2009) · Molecular Membrane Biology · doi:10.1080/09687680902766716 · Cited by 10 · see citing works
Tailoring minimalist self-assembling peptides for localized viral vector aene deliverv
alexandra, Rodríguez, Ting-Yi, Wang, ., Kiara, Bruggeman, Rui, R., Li, Richard, Williams, et al. (2016) · 纳米研究:英文版 · Cited by 9 · see citing works
Down‐regulated lysosomal processing improved pegylated lipopolyplex‐mediated gene transfection
Bai, J., Liu, Y., Sun, W., Chen, J., Miller, A. D., & Xu, Y. (2013) · The Journal of Gene Medicine · doi:10.1002/jgm.2707 · Cited by 8 · see citing works
Gene transfer in skeletal muscle by systemic injection of DODAC lipopolyplexes
Pampinella, F., Pozzobon, M., Gamba, P., McLachlan, I., Cantini, M., Vitiello, L., & Zanetti, E. (2000) · Neurological Sciences · doi:10.1007/s100720070011 · Cited by 7 · see citing works
In vitro studies of polyethyleneimine coated miRNA microspheres as anticancer agents
Irena, R., Wu, N., Xu, H., Gedanken, A., & Lin, X. (2016) · Nano Research · doi:10.1007/s12274-016-1055-4 · Cited by 7 · see citing works
Oskuee, R. K., Zakeri, V., Gholami, L., & Malaekeh‐Nikouei, B. (2015) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 6 · see citing works
Self-citationRamezani, M., Malaekeh‐Nikouei, B., Malekzadeh, S., Baghayeripour, M. R., & Malaekeh-Nikouei, M. (2012) · Current Nanoscience · doi:10.2174/157341312802884535 · Cited by 4 · see citing works
Self-citationMotaharinia, J., Ramezani, M., Malaekeh-Nikouei, M., & Malaekeh‐Nikouei, B. (2011) · Current Nanoscience · doi:10.2174/157341311796196808 · Cited by 3 · see citing works
Self-citationRamezani, M., Malaekeh‐Nikouei, B., Khakshoor, T., & Malaekeh-Nikouei, M. (2011) · DOAJ (DOAJ: Directory of Open Access Journals) · doi:10.22038/ijbms.2011.4968 · Cited by 2 · see citing works
Self-citationBrito, L., Chandrasekhar, S., Little, S. R., & Amiji, M. M. (2008) · TechConnect Briefs · Cited by 1 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Advances in COVID-19 mRNA vaccine development
Fang, E., Liu, X., Li, M., Zhang, Z., Song, L., Zhu, B., Wu, X., Liu, J., Zhao, D., & Li, Y. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00950-y · Cited by 601 · see citing works
DNA Vaccines—How Far From Clinical Use?
Hobernik, D., & Bros, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113605 · Cited by 457 · see citing works
“Cationic lipids are generally very suitable for transfection as they preferably interact with the anionic cell membrane thus facilitating uptake of the transfection complex into the cell [173].”
BackgroundRNA Drugs and RNA Targets for Small Molecules: Principles, Progress, and Challenges
Yu, A., Choi, Y. H., & Tu, M. (2020) · Pharmacological Reviews · doi:10.1124/pr.120.019554 · Cited by 405 · see citing works
“, 2006), lipidation of the polyethylenimine-RNApolyplex offers lipopolyplex (LPP), which may retain the benefits of both materials while reducing the toxicity of polyplex (Rezaee et al., 2016).”
BackgroundPolymeric Delivery of Therapeutic Nucleic Acids
Kumar, R., Chalarca, C. F. S., Bockman, M. R., Bruggen, C. V., Grimme, C. J., Dalal, R. J., Hanson, M. G., Hexum, J. K., & Reineke, T. M. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00997 · Cited by 370 · see citing works
RNA interference-based therapy and its delivery systems
Chen, X., Mangala, L. S., Rodriguez‐Aguayo, C., Kong, X., Lopez‐Berestein, G., & Sood, A. K. (2017) · Cancer and Metastasis Reviews · doi:10.1007/s10555-017-9717-6 · Cited by 333 · see citing works
Chitosan-based Colloidal Polyelectrolyte Complexes for Drug Delivery: A Review
Wu, D., Zhu, L., Li, Y., Zhang, X., Xu, S., Yang, G., & Delair, T. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.116126 · Cited by 289 · see citing works
Non-viral Delivery of Nucleic Acids: Insight Into Mechanisms of Overcoming Intracellular Barriers
Durymanov, M. O., & Reineke, J. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00971 · Cited by 258 · see citing works
Trenkenschuh, E., & Frieß, W. (2021) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2021.05.024 · Cited by 234 · see citing works
Liposome-Based Drug Delivery Systems in Cancer Immunotherapy
Gu, Z., Silva, C. G. D., van der Maaden, K., OSSENDORP, F. A., & Cruz, L. J. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12111054 · Cited by 177 · see citing works
“, mild flu-like symptoms and liver toxicity and related autoimmune pathologies) [107].”
BackgroundA review on cationic lipids with different linkers for gene delivery
Zhi, D., Bai, Y., Yang, J., Cui, S., Zhao, Y., Chen, H., & Zhang, S. (2017) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2017.12.006 · Cited by 163 · see citing works
Henry, N., Clouet, J., Bideau, J. L., Visage, C. L., & Guicheux, J. (2017) · Biotechnology Advances · doi:10.1016/j.biotechadv.2017.11.009 · Cited by 141 · see citing works
Van der Jeught, K., De Koker, S., Bialkowski, L., Heirman, C., Tjok Joe, P., Perche, F., Maenhout, S., Bevers, S., Broos, K., Deswarte, K., et al. (2018) · ACS Nano · doi:10.1021/acsnano.8b00966 · Cited by 139 · see citing works
Nanoplatforms for mRNA Therapeutics
Meng, C., Chen, Z., Li, G., Welte, T., & Shen, H. (2021) · Advanced Therapeutics · doi:10.1002/adtp.202000099 · Cited by 130 · see citing works
Endocytosis and Organelle Targeting of Nanomedicines in Cancer Therapy
Wang, X., Qiu, Y., Wang, M., Zhang, C.-H., Zhang, T., Zhou, H., Zhao, W., Zhao, W., Xia, G., & Shao, R. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s274289 · Cited by 126 · see citing works
“Diolylphosphatidylcholine (DOPC) is a conventional composition of liposome with a neutral charge, which is widely used in gene delivery.(37,45) NMs composed of DOPC are also Figure 2 Molecular structures and process related to clathrin-mediated endocytosis.”
BackgroundTseu, G. Y. W., & Kamaruzaman, K. A. (2023) · Molecules · doi:10.3390/molecules28031498 · Cited by 121 · see citing works
“There have been several approaches, such as attaching biocompatible polymers, cleavable polymers that are cleaved to their subunits in the cytosol and endosome, using less cationic polymers (resulting in lower cytotoxicity) that are compensated with more cationic liposome, hydrophobic modifications, and conjugation of…”
BackgroundInfluentialEngineered Nanodelivery Systems to Improve DNA Vaccine Technologies
Lim, M., Badruddoza, A. Z. M., Firdous, J., Azad, M. A., Mannan, A., Al-Hilal, T. A., Cho, C., & Islam, M. A. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12010030 · Cited by 114 · see citing works
“The lipopolyplex design provides the synergistic benefits of both polymer and liposomal materials, offering higher transfection efficiency and lower cytotoxicity than other platforms implementing only one or the other [82,83].”
BackgroundA perspective on oligonucleotide therapy: Approaches to patient customization
Thakur, S., Sinhari, A., Jain, P., & Jadhav, H. R. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1006304 · Cited by 114 · see citing works
“Due to their high specificity, biocompatibility and versatility, lipopolyplexes are being developed for different therapeutic needs (Rezaee et al., 2016; Jerzykiewicz and Czogalla, 2021).”
BackgroundmRNA-Based Cancer Vaccines: A Therapeutic Strategy for the Treatment of Melanoma Patients
Bidram, M., Zhao, Y., Shebardina, N. G., Baldin, A. V., Bazhin, A. V., Ganjalikhany, M. R., Zamyatnin, A. A., & Ganjalıkhani-Hakemi, M. (2021) · Vaccines · doi:10.3390/vaccines9101060 · Cited by 106 · see citing works
Review of structural design guiding the development of lipid nanoparticles for nucleic acid delivery
Cárdenas, M., Campbell, R. A., Arteta, M. Y., Lawrence, M. J., & Sebastiani, F. (2023) · Current Opinion in Colloid & Interface Science · doi:10.1016/j.cocis.2023.101705 · Cited by 101 · see citing works
Dong, Y., Chen, Y., Zhu, D., Shi, K., Ma, C., Zhang, W., Rocchi, P., Jiang, L., & Liu, X. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.04.003 · Cited by 94 · see citing works
Therapeutic Potentials of BDNF/TrkB in Breast Cancer; Current Status and Perspectives
Tajbakhsh, A., Mokhtari‐Zaer, A., Rezaee, M., Afzaljavan, F., Rivandi, M., Hassanian, S. M., Ferns, G. A., Pasdar, A., & Avan, A. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25943 · Cited by 93 · see citing works
“Several approaches have been developed for targeting of BDNF/TkrB pathway such as TKr inhibitors and RNA interference [Rezaee et al., 2016].”
MethodSelf-citationA molecular view on the escape of lipoplexed DNA from the endosome
Bruininks, B. M. H., Souza, P. C. T., Ingólfsson, H. I., & Marrink, . J. (2020) · eLife · doi:10.7554/elife.52012 · Cited by 89 · see citing works
“The major downside to many of these non-viral based methods, is that their transfection rates in vivo are rather low (Tros de Ilarduya et al., 2010; Rezaee et al., 2016; Nayerossadat et al., 2012).”
BackgroundDeliver the promise: RNAs as a new class of molecular entities for therapy and vaccination
Yu, A., & Tu, M. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107967 · Cited by 88 · see citing works
“Lipids are also used to coat polyplexes to offer lipopolyplexes to improve the stability RNAs and reduce the use and toxicity of polymers (Rezaee et al., 2016).”
BackgroundncRNAs in Therapeutics: Challenges and Limitations in Nucleic Acid-Based Drug Delivery
Hueso, M., Mallén, A., Suñé-Pou, M., Aran, J. M., Suñé-Negre, J. M., & Navarro, E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111596 · Cited by 86 · see citing works
Synthetic Approaches for Nucleic Acid Delivery: Choosing the Right Carriers
Ni, R., Feng, R., & Chau, Y. (2019) · Life · doi:10.3390/life9030059 · Cited by 80 · see citing works
Advances in nanotechnology-based strategies for the treatments of amyotrophic lateral sclerosis
Wang, G., Rayner, S. L., Chung, R. S., Shi, B., & Liang, X. J. (2020) · Materials Today Bio · doi:10.1016/j.mtbio.2020.100055 · Cited by 81 · see citing works
“The immunogenicity and safety of these carriers is a major obstacle that hinders their further clinical application [159].”
BackgroundNanoparticles as Adjuvants and Nanodelivery Systems for mRNA-Based Vaccines
Alfagih, I. M., Aldosari, B. N., AlQuadeib, B. T., Almurshedi, A. S., & Alfagih, M. M. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics13010045 · Cited by 79 · see citing works
Sargazi, S., Arshad, R., Ghamari, R., Rahdar, A., Bakhshi, A., Fathi‐karkan, S., Ajalli, N., Bilal, M., & Diez-Pascual, A. M. (2022) · Cell Biology International · doi:10.1002/cbin.11841 · Cited by 77 · see citing works
“polymers with noncovalent bonds to escape the endosome (Rezaee et al., 2016) (Figure 8).”
BackgroundAdvances in the polymeric delivery of nucleic acid vaccines
Chen, G., Zhao, B., Ruiz, E. F., & Zhang, F. (2022) · Theranostics · doi:10.7150/thno.70853 · Cited by 75 · see citing works
“The lipopolyplex combined the advantages of both polymer and lipid systems [88].”
BackgroundSabín, J., Alatorre‐Meda, M., Miñones, J., Domínguez-Arca, V., & Prieto, G. (2021) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2021.112219 · Cited by 74 · see citing works
“Ever since, multiple in vivo and in vitro studies using different types of PEI have shown a relatively high efficiency in gene expression compared with other polymer vectors [5,6].”
Nucleic Acid-Based Approaches for Tumor Therapy
Hager, S., Fittler, F. J., Wagner, E., & Bros, M. (2020) · Cells · doi:10.3390/cells9092061 · Cited by 74 · see citing works
“Cationic lipids complex negatively charged nucleic acids by electrostatic interactions, and by interaction with the negatively charged cell membrane confer internalization of lipoplexes [160].”
BackgroundNanomaterials for mRNA ‐based therapeutics: Challenges and opportunities
Li, D., Liu, Q., Yang, M., Xu, H., Zhu, M., Zhang, Y., Xu, J., Tian, C., Yao, J., Wang, L., et al. (2023) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10492 · Cited by 71 · see citing works
Two-Photon Near-Infrared AIE Luminogens as Multifunctional Gene Carriers for Cancer Theranostics
Tang, F., Liu, J., Wu, C., Liang, Y., Lu, Z., Ding, A., & Xu, M. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c02600 · Cited by 71 · see citing works
Recent advances in mRNA vaccine delivery
Tan, L., & Sun, X. (2018) · Nano Research · doi:10.1007/s12274-018-2091-z · Cited by 70 · see citing works
“They combine the advantages of both lipoplexes (high stability, low cytotoxicity, acceptable cellular uptake) and polyplexes (homogenous and small particle size, endosomal escape, high transfection activity) [97], and they can perfectly protect mRNA from degradation.”
BackgroundAssembly strategy of liposome and polymer systems for siRNA delivery
Song, H., Hart, S. L., & Du, Z. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.120033 · Cited by 67 · see citing works
“16 Based on the above two formulations, a variety of LPR have been reported [56],”
BackgroundSerum Nuclease Susceptibility of mRNA Cargo in Condensed Polyplexes
Yen, A., Cheng, Y., Sylvestre, M., Gustafson, H. H., Puri, S., & Pun, S. H. (2018) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.8b00134 · Cited by 67 · see citing works
Molecular nanoparticle-based gene delivery systems
Blanco, J. L. J., Benito, J. M., Mellet, C. O., & Fernández, J. M. G. (2017) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2017.03.012 · Cited by 63 · see citing works
Cell based therapeutics in type 1 diabetes mellitus.
Zamboni, F., & Collins, M. (2017) · International journal of pharmaceutics · doi:10.1016/j.ijpharm.2017.02.063 · Cited by 49 · see citing works
mRNA therapies: Pioneering a new era in rare genetic disease treatment
Shen, G., Liu, J., Yang, H., Xie, N., & Yang, Y. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.03.056 · Cited by 61 · see citing works
Organic/Inorganic Self‐Assembled Hybrid Nano‐Architectures for Cancer Therapy Applications
Yang, C., Lin, Z., Chen, J., Xu, Z., Gu, J., Law, W., Yang, J. H. C., & Chen, C. (2021) · Macromolecular Bioscience · doi:10.1002/mabi.202100349 · Cited by 60 · see citing works
Jiang, H., Li, Z., Tian, G., Pan, R., Xu, C.-M., Zhang, B., & Wu, J. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s188971 · Cited by 58 · see citing works
“Moreover, LPs ,200 nm can improve accumulation in solid tumors, due to the enhanced permeability and retention (EPR) effect, which contributes to enhanced antitumor efficacy and reduced systemic toxicity.(25,26) On the basis of these properties, we selected LPs as nanocarriers to improve therapeutic effects against tu…”
BackgroundLipid-Based Vectors for Therapeutic mRNA-Based Anti-Cancer Vaccines
Guevara, M. L., Persano, S., & Persano, F. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190619150221 · Cited by 56 · see citing works
Neutral Lipopolyplexes for In Vivo Delivery of Conventional and Replicative RNA Vaccine
Perche, F., Clemençon, R., Schulze, K., Ebensen, T., Guzmán, C. A., & Pichon, C. (2019) · Molecular Therapy - Nucleic Acids · doi:10.1016/j.omtn.2019.07.014 · Cited by 55 · see citing works
Recent advances in targeted delivery of non-coding RNA-based therapeutics for atherosclerosis
Li, X., Qi, H., Cui, W., Wang, Z., Fu, X., Li, T., Ma, H., Yang, Y., & Yu, T. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.07.018 · Cited by 51 · see citing works
Lipid nanoparticles for RNA delivery: Self-assembling vs driven-assembling strategies
Nele, V., Campani, V., Moosavian, S. A., & Rosa, G. D. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2024.115291 · Cited by 53 · see citing works
Navigating the landscape of RNA delivery systems in cardiovascular disease therapeutics
Gil-Cabrerizo, P., Simón‐Yarza, T., Garbayo, E., & Blanco‐Prieto, M. J. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2024.115302 · Cited by 51 · see citing works
Mesenchymal stem cell-derived microvesicles mediate BMP2 gene delivery and enhance bone regeneration
Liang, Z., Luo, Y. G., & Lv, Y. (2020) · Journal of Materials Chemistry B · doi:10.1039/d0tb00422g · Cited by 51 · see citing works
The potential for targeted rewriting of epigenetic marks in COPD as a new therapeutic approach
Wu, D., Song, J., Bartel, S., Krauss‐Etschmann, S., Rots, M. G., & Hylkema, M. N. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.08.007 · Cited by 49 · see citing works
“cationic polymers) or be absorbed to the surface of the “shell” (liposomes), forming lipopolyplexes (Rezaee et al., 2016).”
BackgroundBuilding Blocks to Design Liposomal Delivery Systems
Juszkiewicz, K., Sikorski, A. F., & Czogalla, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249559 · Cited by 48 · see citing works
Sukocheva, O. A., Liu, J., Евгеньевна, Н. М., Beeraka, N. M., Aleksandrova, Y. R., Manogaran, P., Grigorevskikh, E., Chubarev, V. N., & Fan, R. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.05.012 · Cited by 46 · see citing works
Inoh, Y., Nagai, M., Matsushita, K., Nakanishi, M., & Furuno, T. (2017) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2017.03.023 · Cited by 45 · see citing works
Zhang, Q.-Y., Ho, P. Y., Tu, M., Jilek, J. L., Chen, Q., Zeng, S., & Yu, A.-M. (2018) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2018.06.026 · Cited by 45 · see citing works
“Therefore, lipidation of polyplexes may reduce the toxicity of polyplexes while retaining the benefits of both carriers (Rezaee et al., 2016).”
Utilizing the Organizational Power of DNA Scaffolds for New Nanophotonic Applications
Bui, H., Dı́az, S. A., Fontana, J. P., Chiriboga, M., Veneziano, R., & Medintz, I. L. (2019) · Advanced Optical Materials · doi:10.1002/adom.201900562 · Cited by 43 · see citing works
Francis, J. E., Skakic, I., Dekiwadia, C. D., Shukla, R., Taki, A. C., Walduck, A. K., & Smooker, P. M. (2020) · Vaccines · doi:10.3390/vaccines8030551 · Cited by 41 · see citing works
“Lipid nanoparticles are biocompatible nanocarriers which have been widely developed for the delivery of therapeutics and vaccine antigens due to their excellent safety profile and capacity to carry both lipophilic and hydrophilic payloads [10].”
BackgroundTajbakhsh, A., Pasdar, A., Rezaee, M., Fazeli, M., Soleimanpour, S., Hassanian, S. M., FarshchiyanYazdi, Z., Rad, T. Y., Ferns, G. A., & Avan, A. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.26277 · Cited by 40 · see citing works
Self-citationJilek, J. L., Zhang, Q.-Y., Tu, M., Ho, P. Y., Duan, Z., Qiu, J., & Yu, A. (2019) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2019.01.007 · Cited by 39 · see citing works
“Among lipid-based delivery systems, LPPs convey the favorable properties of both liposomes and polyplexes.(28,29,53) Our recent studies have demonstrated that IPEI is able to deliver biologic RNAs to livers to achieve target gene knockdown,(20) as well as tumor tissues to control disease.”
BackgroundJia, X., Bai, X., Yang, X., Wang, L., Lu, Y., Zhu, L., Zhao, Y., Cheng, W., Shu, M., Mei, Q., et al. (2022) · Metabolism · doi:10.1016/j.metabol.2022.155274 · Cited by 39 · see citing works
Gupta, R., Salave, S., Rana, D., Karunakaran, B., Butreddy, A., Benival, D. M., & Kommineni, N. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15051435 · Cited by 39 · see citing works
“Lipopolyplex is a ternary nanocomplex composed of a cationic liposome, polycation, and nucleic acid [72].”
BackgroundGenetic Modification of the Lung Directed Toward Treatment of Human Disease
Sondhi, D., Stiles, K. M., De, B. P., & Crystal, R. G. (2017) · Human Gene Therapy · doi:10.1089/hum.2016.152 · Cited by 36 · see citing works
Mashal, M., Attia, N., Soto‐Sánchez, C., Martı́nez, G., Fernández, E., Puras, G., & Pedraz, J. L. (2018) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2018.09.038 · Cited by 36 · see citing works
Chen, W., Deng, W., Xu, X., Zhao, X., Vo, J. N., Anwer, A. G., Williams, T. C., Cui, H., & Goldys, E. M. (2018) · Journal of Materials Chemistry B · doi:10.1039/c8tb00994e · Cited by 35 · see citing works
Scaffold-Mediated Gene Delivery for Osteochondral Repair
Madry, H., Venkatesan, J. K., Carballo-Pedrares, N., Rey‐Rico, A., & Cucchiarini, M. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12100930 · Cited by 35 · see citing works
“Gene transfer via nonviral vectors (transfection) is the incorporation of the DNA plasmid (pDNA) either alone or complexed with cationic or ionizable lipids (lipoplexes), cationic polymers (polyplexes), or a combination of both (lipopolyplexes) [35] into the target cell population [36] (Table 1).”
BackgroundRegulating the Obesity-Related Tumor Microenvironment to Improve Cancer Immunotherapy
Fang, H., Wu, Y. D., Chen, L., Cao, Z., Deng, Z., Zhao, R., Zhang, L., Yang, Y., Liu, Z., & Chen, Q. (2023) · ACS Nano · doi:10.1021/acsnano.2c11159 · Cited by 34 · see citing works
Zhang, L., & Wang, Y. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112075 · Cited by 34 · see citing works
Recent advances in gene delivery nanoplatforms based on spherical nucleic acids
Valatabar, N., Oroojalian, F., Kazemzadeh, M., Mokhtarzadeh, A. A., Safaralizadeh, R., & Sahebkar, A. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02648-5 · Cited by 33 · see citing works
Khan, F. A., Akhtar, S., Almohazey, D., Alomari, M., & Almofty, S. A. (2018) · International Journal of Biomaterials · doi:10.1155/2018/8479439 · Cited by 33 · see citing works
Toxicological exploration of peptide-based cationic liposomes in siRNA delivery
Zhu, Y., Meng, Y., Zhao, Y., Zhu, J., Xu, H., Zhang, E. X., Shi, L., Du, L., Liu, G., Zhang, C., et al. (2019) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2019.03.052 · Cited by 32 · see citing works
Alinejad-Mofrad, E., Malaekeh‐Nikouei, B., Gholami, L., Mousavi, S., Sadeghnia, H. R., Mohajeri, M., Darroudi, M., & Oskuee, R. K. (2019) · Human & Experimental Toxicology · doi:10.1177/0960327119846924 · Cited by 33 · see citing works
Self-citationCao, M., Gao, Zhan, M., Qiu, Piao, Zhou, Z., & Shen, Y. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20205074 · Cited by 33 · see citing works
Paris, J. L., de la Torre, P., Cabañas, M. V., Manzano, M., Flores, A. I., & Vallet‐Regí, M. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.11.006 · Cited by 32 · see citing works
“However, most of these approaches have relied on viral vectors as transfection agents, which present several safety concerns regarding their clinical application [8,15,16].”
BackgroundBerger, M., Lechanteur, A., Évrard, B., & Piel, G. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.120851 · Cited by 32 · see citing works
Supe, S., Upadhya, A., Tripathi, S. D., Dighe, V. D., & Singh, K. (2023) · Drug Delivery and Translational Research · doi:10.1007/s13346-022-01281-9 · Cited by 29 · see citing works
“The favorable effects of both polymers and lipids may be enhanced when combined while reducing the toxic effects [37].”
BackgroundBiomaterial-Guided Gene Delivery for Musculoskeletal Tissue Repair
Madrigal, J. L., Stilhano, R. S., & Silva, E. A. (2017) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2016.0462 · Cited by 28 · see citing works
Simion, V., Henriet, E., Jurić, V., Aquino, R., Loussouarn, C., Laurent, Y., Martı́n, F., Midoux, P., Garcion, E., Pichon, C., et al. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.08.028 · Cited by 27 · see citing works
Peptide-Assisted Nucleic Acid Delivery Systems on the Rise
Tarvirdipour, S., Skowicki, M., Schoenenberger, C., & Palivan, C. G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22169092 · Cited by 29 · see citing works
Cholesterol inhibits entotic cell-in-cell formation and actomyosin contraction
Ruan, B., Zhang, B., Chen, A., Yuan, L., Liang, J., Wang, M., Zhang, Z., Fan, J., Yu, X., Zhang, X., et al. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.11.197 · Cited by 28 · see citing works
“Therefore, liposomes were usually used as an ideal vector for transfection and tool for plasma membrane research [19,20].”
BackgroundMethodpH-Sensitive Polymers as Dynamic Mediators of Barriers to Nucleic Acid Delivery
Peeler, D. J., Sellers, D. L., & Pun, S. H. (2018) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.8b00695 · Cited by 27 · see citing works
Hasan, M., Hama, S., & Kogure, K. (2019) · Scientific Reports · doi:10.1038/s41598-019-40904-z · Cited by 27 · see citing works
Polyethyleneimine-Based Lipopolyplexes as Carriers in Anticancer Gene Therapies
Jerzykiewicz, J., & Czogalla, A. (2021) · Materials · doi:10.3390/ma15010179 · Cited by 27 · see citing works
“Exposure of polyethyleneimine helps to circumvent some limitations of lipid carriers, namely short circulation times (especially considering lipoplexes), simultaneously increasing endosomal release due to its increased efficiency as a proton sponge [86,95].”
BackgroundImmunoprotein-Mediated siRNA Delivery
Bäumer, N., Berdel, W. E., & Bäumer, S. (2017) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.6b01039 · Cited by 27 · see citing works
Collapse of DNA in packaging and cellular transport
Thomas, T., & Thomas, T. (2017) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2017.12.076 · Cited by 26 · see citing works
Lipid‐Peptide‐mRNA Nanoparticles Augment Radioiodine Uptake in Anaplastic Thyroid Cancer
Li, Q., Zhang, L., Lang, J., Tan, Z., Feng, Q., Zhu, F., Liu, G., Ying, Z., Yu, X., Feng, H., et al. (2022) · Advanced Science · doi:10.1002/advs.202204334 · Cited by 25 · see citing works
A comprehensive review on histone-mediated transfection for gene therapy
Han, H., Yang, J., Chen, W., Li, Q., Yang, Y., & Li, Q. (2018) · Biotechnology Advances · doi:10.1016/j.biotechadv.2018.11.009 · Cited by 25 · see citing works
Aydin, Ö. F., Kanarya, D., Yilmaz, U., & Tunç, C. Ü. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2010-6_7 · Cited by 25 · see citing works
Togashi, R., Tanaka, H., Nakamura, S., Yokota, H., Tange, K., Nakai, Y., Yoshioka, H., Harashima, H., & Akita, H. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.04.022 · Cited by 25 · see citing works
Li, Q., Hu, Z., Liang, Y., Xu, C., Hong, Y., & Liu, X. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.03.059 · Cited by 24 · see citing works
Barrios-Gumiel, A., Sánchez‐Nieves, J., Pędziwiatr‐Werbicka, E., Abashkin, V., Shcharbina, N., Shcharbin, D., Glińska, S., Ciepluch, K., Kuc‐Ciepluch, D., Lach, D., et al. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.118867 · Cited by 24 · see citing works
Adjei, I. M., Jordan, J. C., Tu, N., Trinh, T. L., Kandell, W. M., Wei, S., & Sharma, B. (2019) · Journal of Interdisciplinary Nanomedicine · doi:10.1002/jin2.63 · Cited by 24 · see citing works
“However, little is known about the NP characteristics required for their uptake by NK cells (Rezaee et al., 2016).”
BackgroundAdvances in targeted delivery of mRNA into immune cells for enhanced cancer therapy
Huang, L., Huang, Z., Zhang, Y., Lin, C., Zhao, Z., Li, R., Saw, P. E., & Xu, X. (2024) · Theranostics · doi:10.7150/thno.93745 · Cited by 23 · see citing works
“Hybrid lipid-shell-polymer core mRNA nanoparticles (LPRs) may be valuable alternatives to lipid-based mRNA nanocomplexes (LRs), as they combine improved stability and reduced cytotoxicity [87].”
BackgroundThe Progress and Evolving Trends in Nucleic-Acid-Based Therapies
Liu, Y., Wang, C., Fu, X., & Ren, M. (2025) · Biomolecules · doi:10.3390/biom15030376 · Cited by 23 · see citing works
“Lipid complexes and lipid polycomplexes (LPPs) offer enhanced encapsulation and protection for aptamer RNA, while microbial LPP nanoplatforms are designed to specifically target dendritic cells, thereby activating T cell immune responses [174].”
Research progress on non-protein-targeted drugs for cancer therapy
Zhang, Y., Lu, L., Song, F., Zou, X., Liu, Y., Zheng, X., Qian, J., Gu, C., Huang, P. C., & Yang, Y. (2023) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-023-02635-y · Cited by 21 · see citing works
DNA vaccines as promising immuno-therapeutics against cancer: a new insight
Shariati, A., Khezrpour, A., Shariati, F. S., Afkhami, H., Yarahmadi, A., Alavimanesh, S., Kamrani, S., Modarressi, M. H., & Khani, P. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1498431 · Cited by 21 · see citing works
Thornalley, K. A., Laurini, E., Pricl, S., & Smith, D. K. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201803298 · Cited by 20 · see citing works
Hede, E., Christiansen, C., Heegaard, C. W., Moos, T., & Burkhart, A. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.14982 · Cited by 19 · see citing works
“In addition to that, the gene therapy vector should be able to induce cellular uptake of the genetic material in the target cell, followed by the release of the genetic material within the cell (Rezaee et al. 2016; Jayant et al. 2016), a process often referred to as endosomal escape.”
BackgroundXie, W., Gao, Q., Wang, D., Wang, W., Yuan, J., Guo, Z., Yan, H., Wang, X., Sun, X., & Zhao, L. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s148520 · Cited by 20 · see citing works
Bofinger, R., Thin, M. Z., Mitchell, N. J., Patrick, P. S., Stowe, C., Gomez‐Ramirez, A., Hailes, H. C., Kalber, T. L., & Tabor, A. B. (2018) · Journal of Peptide Science · doi:10.1002/psc.3131 · Cited by 19 · see citing works
Burkhart, A., Andresen, T. L., Aigner, A. M., Thomsen, L. B., & Moos, T. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2501-5 · Cited by 18 · see citing works
“They, therefore, still holds the potential to supplant viral vectors in the future [47, 49].”
BackgroundInfluentialSoleimani, A., Mirzavi, F., Nikoofal‐Sahlabadi, S., Nikpoor, A. R., Taghizadeh, B., Barati, M., Soukhtanloo, M., & Jaafari, M. R. (2022) · Scientific Reports · doi:10.1038/s41598-022-14392-7 · Cited by 17 · see citing works
Husteden, C., Barrera, Y. A. B., Tegtmeyer, S., Borges, J., Giselbrecht, J., Menzel, M., Langner, A., Mano, J. F., Schmelzer, C. E. H., Wölk, C., et al. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202201978 · Cited by 17 · see citing works
Difatty Acyl-Conjugated Linear and Cyclic Peptides for siRNA Delivery
Do, H., Sharma, M., El‐Sayed, N. S., Mahdipoor, P., Bousoik, E., Parang, K., & Aliabadi, H. M. (2017) · ACS Omega · doi:10.1021/acsomega.7b00741 · Cited by 17 · see citing works
- Authors
- Rezaee, M., Oskuee, R. K., Nassirli, H., & Malaekeh-Nikouei, B.
- Affiliations
- Mashhad University of Medical Sciences (IR)
- Venue
- Journal of Controlled Release
- Publisher
- Elsevier BV
- Published
- 2016-08
- Volume
- 236
- Pages
- 1-14
- ISSN
- 0168-3659 (ISSN-L)
- OpenAlex
- W2421622109
- Cited by
- 200
- References
- 126
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 17 · 2023: 21 · 2022: 23 · 2021: 22 · 2020: 23 · 2019: 21 · 2018: 28 · 2017: 24 · 2016: 2
- FWCI
- 2.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Controlled Release (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Mashhad University of Medical Sciences (931108)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- lipopolyplexes, non-viral gene delivery, cationic liposomes, cationic polymers, cationic peptides, gene therapy vectors, plasmid DNA delivery, siRNA delivery, shRNA delivery, DNA vaccine, transfection efficiency
- MeSH terms
- Animals, Chemistry, Pharmaceutical, Humans, Lipids, Liposomes, Nucleic Acids, Peptides, Polymers, Transfection, Genetic Therapy, Gene Transfer Techniques, Nanoparticles
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review