Cited by 200RNA Interference and Gene DeliveryNanoparticle-Based Drug DeliveryAdvanced Drug Delivery Systems

Progress in the development of lipopolyplexes as efficient non-viral gene delivery systems

Rezaee, Mehdi, Oskuee, Reza Kazemi, Nassirli, Hooriyeh, Malaekeh-Nikouei, Bizhan·2016·Journal of Controlled Release

Abstract

Efficient gene therapy is mainly dependent on the gene transfer capability of gene delivery vectors. Non-viral vectors have become the research interest of many researchers because these vectors are safer than viral vectors. Acquiring the advantages of both polyplexes and lipoplexes, the lipopolyplex (LPP) is a ternary nanocomplex composed of cationic liposome, polycation, and nucleic acid. Considering the polycationic component, ternary complexes (LPPs) are divided into cationic polymer-based LPPs and cationic peptide-based LPPs. Considering the capability of rational design, LPP is an interesting field of research to design a more potent nucleic acid carrier. With the promising transfection activity and safety observed in the LPPs, many researchers have formulated various types of lipids and polycations to achieve an efficient and safe carrier for gene therapy. Here we provide a review on the designed LPPs for efficient delivery of different nucleic acids such as plasmid DNA, siRNA, shRNA, and DNA vaccines.

Integrity signals

Registry

Crossref · 10.1016/j.jconrel.2016.06.023

Cites

126 of 126 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • LPPs have higher stability, low cytotoxicity, cell delivery and endosomal escape efficiency.

    “LPPs have higher stability, low cytotoxicity, cell delivery and endosomal escape efficiency.327–329”

    From Advances in COVID-19 mRNA vaccine development (2022) · cites this paper as [327]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Rezaee, M., Oskuee, R. K., Nassirli, H., & Malaekeh-Nikouei, B.
Affiliations
Mashhad University of Medical Sciences (IR)
Venue
Journal of Controlled Release
Publisher
Elsevier BV
Published
2016-08
Volume
236
Pages
1-14
ISSN
0168-3659 (ISSN-L)
OpenAlex
W2421622109
Cited by
200
References
126
Citations by year
2026: 8 · 2025: 11 · 2024: 17 · 2023: 21 · 2022: 23 · 2021: 22 · 2020: 23 · 2019: 21 · 2018: 28 · 2017: 24 · 2016: 2
FWCI
2.26
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Controlled Release (publishedVersion)
  • PubMed (publishedVersion)
Funders
Mashhad University of Medical Sciences (931108)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords
lipopolyplexes, non-viral gene delivery, cationic liposomes, cationic polymers, cationic peptides, gene therapy vectors, plasmid DNA delivery, siRNA delivery, shRNA delivery, DNA vaccine, transfection efficiency
MeSH terms
Animals, Chemistry, Pharmaceutical, Humans, Lipids, Liposomes, Nucleic Acids, Peptides, Polymers, Transfection, Genetic Therapy, Gene Transfer Techniques, Nanoparticles

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review