Nanoplatforms for mRNA Therapeutics

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

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Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

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Principles of nanoparticle design for overcoming biological barriers to drug delivery

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Recent advances with liposomes as pharmaceutical carriers

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Liposomal drug delivery systems: From concept to clinical applications

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mRNA vaccines — a new era in vaccinology

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PLGA-based nanoparticles: An overview of biomedical applications

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<i>LMO2</i> -Associated Clonal T Cell Proliferation in Two Patients after Gene Therapy for SCID-X1

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Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

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Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis

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Friedreich's Ataxia: Autosomal Recessive Disease Caused by an Intronic GAA Triplet Repeat Expansion

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Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA

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mRNA-based therapeutics--developing a new class of drugs

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Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR–Cas gene editing

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Toxicity of cationic lipids and cationic polymers in gene delivery

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Control of adaptive immunity by the innate immune system

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Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability

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Adenovirus-Associated Virus Vector–Mediated Gene Transfer in Hemophilia B

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Delivery materials for siRNA therapeutics

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Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy

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Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape

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Endosomal escape pathways for delivery of biologicals

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Graphene and graphene oxide: biofunctionalization and applications in biotechnology

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The basic principles of chimeric antigen receptor (CAR) design

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Graphene-based nanomaterials for drug delivery and tissue engineering

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IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses

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Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo

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Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms

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Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences

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Zika Virus

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Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery

Kowalski, P. S., Rudra, A., Miao, L., & Anderson, D. G. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2019.02.012 · Cited by 1,127 · see citing works

Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes

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Nanomedicine(s) under the Microscope

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Polyethylenimine-based non-viral gene delivery systems

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Cationic liposome-mediated RNA transfection.

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Modified mRNA vaccines protect against zika virus infection

Richner, J. M., Himansu, S., Dowd, K. A., Butler, S. L., Salazar, V., Fox, J. M., Julander, J. G., Tang, W. W., Shresta, S., Pierson, T. C., et al. (2017) · Cell · doi:10.1016/j.cell.2017.02.017 · Cited by 909 · see citing works

Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA

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Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination

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Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo

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A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates

Sabnis, S., Kumarasinghe, E. S., Salerno, T., Mihai, C., Ketova, T., Senn, J. J., Lynn, A., Bulychev, A., McFadyen, I., Chan, J., et al. (2018) · Molecular Therapy · doi:10.1016/j.ymthe.2018.03.010 · Cited by 820 · see citing works

Biodegradable microspheres for protein delivery

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Nanoparticle delivery of Cas9 ribonucleoprotein and donor DNA in vivo induces homology-directed DNA repair

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Expression of therapeutic proteins after delivery of chemically modified mRNA in mice

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Delivery of mRNA vaccines with heterocyclic lipids increases anti-tumor efficacy by STING-mediated immune cell activation

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Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy

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Lipid–polymer hybrid nanoparticles as a new generation therapeutic delivery platform: A review

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The role of helper lipids in lipid nanoparticles (LNPs) designed for oligonucleotide delivery

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Efficient RNA drug delivery using red blood cell extracellular vesicles

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Advances in the delivery of RNA therapeutics: from concept to clinical reality

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Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction

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Preclinical and clinical demonstration of immunogenicity by mRNA vaccines against H10N8 and H7N9 influenza viruses

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Ionizable Lipid Nanoparticle-Mediated mRNA Delivery for Human CAR T Cell Engineering

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Mechanism of oligonucleotide release from cationic liposomes.

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Deficiency of Pulmonary Surfactant Protein B in Congenital Alveolar Proteinosis

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Modification of antigen-encoding RNA increases stability, translational efficacy, and T-cell stimulatory capacity of dendritic cells

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Developing mRNA-vaccine technologies

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On the mechanism whereby cationic lipids promote intracellular delivery of polynucleic acids

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Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA

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Opportunities and Challenges in the Delivery of mRNA-Based Vaccines

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Cationic lipid saturation influences intracellular delivery of encapsulated nucleic acids

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Autologous dendritic cells transfected with prostate-specific antigen RNA stimulate CTL responses against metastatic prostate tumors

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Non‐Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co‐Delivery of Cas9 mRNA and sgRNA

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VEGF-C-driven lymphatic drainage enables immunosurveillance of brain tumours

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Genetic programming of macrophages to perform anti-tumor functions using targeted mRNA nanocarriers

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Exosome mimetics: a novel class of drug delivery systems

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Sequence-engineered mRNA without chemical nucleoside modifications enables an effective protein therapy in large animals

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Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles

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DNA transfection mediated by cationic liposomes containing lipopolylysine: characterization and mechanism of action

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CAR T-cell Therapy: A New Era in Cancer Immunotherapy

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Induction of virus‐specific cytotoxic T lymphocytes <i>in vivo</i> by liposome‐entrapped mRNA

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Potentiation of Cationic Liposome-Mediated Gene Delivery by Polycations

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Protective efficacy of in vitro synthesized, specific mRNA vaccines against influenza A virus infection

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mRNA vaccines against H10N8 and H7N9 influenza viruses of pandemic potential are immunogenic and well tolerated in healthy adults in phase 1 randomized clinical trials

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Brief update on endocytosis of nanomedicines

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Rapid development of a DNA vaccine for Zika virus

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Epigenetic mechanisms in neurogenesis

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Direct Injection of Protamine-protected mRNA: Results of a Phase 1/2 Vaccination Trial in Metastatic Melanoma Patients

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Fast and Efficient CRISPR/Cas9 Genome Editing In Vivo Enabled by Bioreducible Lipid and Messenger RNA Nanoparticles

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Polyplexes from Poly(aspartamide) Bearing 1,2-Diaminoethane Side Chains Induce pH-Selective, Endosomal Membrane Destabilization with Amplified Transfection and Negligible Cytotoxicity

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Gene Transfer with Synthetic Cationic Amphiphiles: Prospects for Gene Therapy

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Improving mRNA-Based Therapeutic Gene Delivery by Expression-Augmenting 3′ UTRs Identified by Cellular Library Screening

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SiRNA delivery with exosome nanoparticles

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Influenza and the challenge for immunology

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In Vivo Gene Delivery by Nonviral Vectors: Overcoming Hurdles?

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Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge

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Untitled work

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