Predicting drug release kinetics from nanocarriers inside dialysis bags
Abstract
Dialysis methods are frequently used to determine the in vitro drug release kinetics of nanoparticle drug delivery systems. However, the need for the released drug to diffuse through the dialysis membrane delays its appearance in the sampling compartment. Thus, the apparent drug release data outside the dialysis bag typically does not match the desired release kinetics inside the bag adjacent to the nanocarriers. To address this issue, here we describe a simple approach to determine the actual drug release kinetics from nano drug carriers inside the dialysis bag from the experimental data measured from the sampling compartment. First, a calibration experiment is carried out to determine the diffusion barrier properties of the dialysis membranes. The apparent drug release profile of the nanocarrier is then determined using the dialysis method, and a mathematical model is applied to determine the actual drug release kinetics from the experimental data. The model was tested on DOXIL® (doxorubicin liposomes), and an excellent agreement was found between the predicted and measured drug concentration inside the dialysis membranes. By taking the barrier effects of dialysis membranes into consideration, our model independent of drug carrier not only enables the proper interpretation of the data from dialysis studies but also helps to evaluate the dialysis methodology applied to in vitro drug release assays.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Results of drug release from nanocarriers should always be compared with those from a reference solution of the drug alone to determine the diffusion barrier properties of the dialysis membrane.
“Thus, results of drug release from nanocarriers should always be compared with those coming from a reference solution of the drug alone [121], to determine the diffusion barrier properties of the dialysis membrane.”
From Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions (2021) · cites this paper as [121]
Cites
On the use of the Weibull function for the discernment of drug release mechanisms
Papadopoulou, V., Kosmidis, K., Vlachou, M., & Macheras, P. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2005.10.044 · Cited by 882 · see citing works
Drug release from microdisperse systems: a critical review
Washington, C. (1990) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(90)90280-h · Cited by 315 · see citing works
Modi, S., & Anderson, B. D. (2013) · Molecular Pharmaceutics · doi:10.1021/mp400154a · Cited by 314 · see citing works
Release Kinetics Study of Poorly Water-Soluble Drugs from Nanoparticles: Are We Doing It Right?
Abouelmagd, S. A., Sun, B., Chang, A. C., Ku, Y. J., & Yeo, Y. (2015) · Molecular Pharmaceutics · doi:10.1021/mp500817h · Cited by 259 · see citing works
Drug release from nanomedicines: selection of appropriate encapsulation and release methodology
Wallace, S. J., Li, J., Nation, R. L., & Boyd, B. J. (2012) · Drug Delivery and Translational Research · doi:10.1007/s13346-012-0064-4 · Cited by 218 · see citing works
Shen, J., & Burgess, D. J. (2013) · Drug Delivery and Translational Research · doi:10.1007/s13346-013-0129-z · Cited by 200 · see citing works
Drug release from submicronized o/w emulsion: a new in vitro kinetic evaluation model
Levy, M. Y., & Benita, S. (1990) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(90)90381-d · Cited by 193 · see citing works
Is dialysis a reliable method for studying drug release from nanoparticulate systems?—A case study
Zambito, Y., Pedreschi, E., & Di Colo, G. (2012) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2012.05.020 · Cited by 136 · see citing works
A two-stage reverse dialysis in vitro dissolution testing method for passive targeted liposomes
Xu, X., Khan, M. A., & Burgess, D. J. (2012) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2012.01.030 · Cited by 106 · see citing works
Solomon, D., Gupta, N., Mulla, N. S., Shukla, S. K., Guerrero, Y. A., & Gupta, V. (2017) · The AAPS Journal · doi:10.1208/s12248-017-0142-0 · Cited by 104 · see citing works
Washington, C. (1989) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(89)90062-8 · Cited by 95 · see citing works
Moreno‐Bautista, G., & Tam, K. C. (2011) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2011.07.032 · Cited by 90 · see citing works
Fugit, K. D., & Anderson, B. D. (2014) · Molecular Pharmaceutics · doi:10.1021/mp400765n · Cited by 40 · see citing works
Development of a Flow-Through USP-4 Apparatus Drug Release Assay to Evaluate Doxorubicin Liposomes
Yuan, W., Kuai, R., Dai, Z., Yuan, Y., Zheng, N., Jiang, W., Noble, C. O., Hayes, M. E., Szoka, F. C., & Schwendeman, A. A. (2016) · The AAPS Journal · doi:10.1208/s12248-016-9958-2 · Cited by 39 · see citing works
Santos-Magalhães, N. S., Fessi, H., Puisieux, F., Benita, S., & Seiller, M. (1995) · Journal of Microencapsulation · doi:10.3109/02652049509015290 · Cited by 36 · see citing works
General method for the quantification of drug loading and release kinetics of nanocarriers
Schwarzl, R., Du, F., Haag, R., & Netz, R. R. (2016) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2016.12.015 · Cited by 33 · see citing works
Nanoparticles as Drug Carriers: Current Issues with in Vitro Testing
Boushehri, M. A. S., & Lamprecht, A. (2015) · Nanomedicine · doi:10.2217/nnm.15.154 · Cited by 24 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Ghezzi, M., Pescina, S., Padula, C., Santi, P., Del Favero, E., Cantù, L., & Nicoli, S. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.02.031 · Cited by 1,135 · see citing works
Analytical characterization of liposomes and other lipid nanoparticles for drug delivery
Fan, Y., Marioli, M., & Zhang, K. (2020) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2020.113642 · Cited by 400 · see citing works
Weng, J., Tong, H. H. Y., & Chow, S. F. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12080732 · Cited by 304 · see citing works
Ortiz, A. C., Yáñez, O., Salas‐Huenuleo, E., & Morales, J. O. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13040531 · Cited by 126 · see citing works
Giordani, S., Marassi, V., Zattoni, A., Roda, B., & Reschiglian, P. (2023) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2023.115751 · Cited by 132 · see citing works
Javed, S., Mangla, B., Almoshari, Y., Sultan, M. H., & Ahsan, W. (2022) · Nanotechnology Reviews · doi:10.1515/ntrev-2022-0109 · Cited by 119 · see citing works
Truong, T. H., Alcantara, K. P., Bulatao, B. P. I., Sorasitthiyanukarn, F. N., Muangnoi, C., Nalinratana, N., Vajragupta, O., Rojsitthisak, P., & Rojsitthisak, P. (2022) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2022.119401 · Cited by 91 · see citing works
Quality by Design Approach in Liposomal Formulations: Robust Product Development
Alshaer, W., Nsairat, H., Lafi, Z. M., Hourani, O. M., Al-Kadash, A., Esawi, E., & Alkilany, A. M. (2022) · Molecules · doi:10.3390/molecules28010010 · Cited by 90 · see citing works
Gómez-Lázaro, L., Martín‐Sabroso, C., Aparicio-Blanco, J., & Torres‐Suárez, A. I. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16010103 · Cited by 88 · see citing works
Siavashy, S., Soltani, M., Ghorbani‐Bidkorbeh, F., Fallah, N., Farnam, G., Mortazavi, S. A., Shirazi, F. H., Tehrani, M. H. H., & Hamedi, M. H. (2021) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2021.118027 · Cited by 76 · see citing works
Meirinho, S., Rodrigues, M., Santos, A. O., Falcão, A. C., & Alves, G. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14071487 · Cited by 54 · see citing works
Drug-Delivery Silver Nanoparticles: A New Perspective for Phenindione as an Anticoagulant
Nikolova, S., Milusheva, M., Gledacheva, V., Feizi‐Dehnayebi, M., Kaynarova, L., Georgieva, D., Delchev, V. B., Stefanova, I. D., Tumbarski, Y. D., Mihaylova, R., et al. (2023) · Biomedicines · doi:10.3390/biomedicines11082201 · Cited by 54 · see citing works
Procopio, A., Lagreca, E., Jamaledin, R., Manna, S. L., Corrado, B., Natale, C. D., & Onesto, V. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14040872 · Cited by 52 · see citing works
Gallic acid loaded self-nano emulsifying hydrogel-based drug delivery system against onychomycosis
Khan, M. S., Fatima, M., Wahab, S., Khalid, M., & Kesharwani, P. (2024) · Nanomedicine · doi:10.1080/17435889.2024.2386923 · Cited by 52 · see citing works
Ndung’u, J., Gathirwa, J. W., Sauli, E., & Hulda, S. S. (2022) · Molecules · doi:10.3390/molecules27144430 · Cited by 51 · see citing works
An expanding horizon of complex injectable products: development and regulatory considerations
Panchal, K., Katke, S., Dash, S. K., Gaur, A., Shinde, A., Saha, N., Mehra, N. K., & Chaurasiya, A. (2022) · Drug Delivery and Translational Research · doi:10.1007/s13346-022-01223-5 · Cited by 51 · see citing works
Zhao, L., Ling, L., Lu, J., Jiang, F., Sun, J., Zhang, Z., Huang, Y., Liu, X., Zhu, Y., Fu, X., et al. (2022) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10460 · Cited by 48 · see citing works
Darabi, F., Saidijam, M., Nouri, F., Mahjub, R., & Soleimani, M. (2022) · BioMed Research International · doi:10.1155/2022/6253978 · Cited by 47 · see citing works
Chan, H. W., Chow, S., Zhang, X., Kwok, P. C. L., & Chow, S. F. (2023) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2023.07.002 · Cited by 45 · see citing works
Jiang, G., Jia, H., Qiu, J., Mo, Z., Wen, Y., Zhang, Y., Wen, Y., Xie, Q., Ban, J., Lu, Z., et al. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s272750 · Cited by 46 · see citing works
Influence of lipid matrix composition on biopharmaceutical properties of lipid nanoparticles
Keck, C. M., Specht, D., & Brüßler, J. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.08.016 · Cited by 43 · see citing works
Chen, M., Cui, Y., Hao, W., Fan, Y., Zhang, J., Liu, Q., Jiang, M., Yang, Y., Wang, Y., & Gao, C. (2021) · Drug Delivery · doi:10.1080/10717544.2021.1992038 · Cited by 43 · see citing works
Wang, Y., Otte, A., Park, H., & Park, K. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.11.021 · Cited by 39 · see citing works
Hu, C., Wang, J., Gao, X., Xia, J., Li, W., Song, P., Zhang, W., Ge, F., & Zhu, L. (2024) · ACS Nano · doi:10.1021/acsnano.4c01120 · Cited by 37 · see citing works
Li, L., Tan, L., Zhang, Q. Y., Cheng, Y., Liu, Y., Li, R., & Hou, S. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1168408 · Cited by 36 · see citing works
Role of Nanotechnology and Their Perspectives in the Treatment of Kidney Diseases
Merlin, J. P. J., & Li, X. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2021.817974 · Cited by 35 · see citing works
Mast, M.-P., Modh, H., Knoll, J., Fecioru, E., & Wacker, M. G. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13122007 · Cited by 34 · see citing works
Song, Y., Ismail, M., Shan, Q., Zhao, J., Zhu, Y., Zhang, L., Du, Y., & Ling, L. (2021) · Nanoscale · doi:10.1039/d1nr05518f · Cited by 34 · see citing works
Jackson, N., Ortiz, A. C., Jerez, A., Morales, J. O., & Arriagada, F. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15061590 · Cited by 31 · see citing works
Polymer-based nanocarriers for biomedical and environmental applications
Idris, D. S., Roy, A., Pandit, S., Alghamdi, S. A., Almehmadi, M. M., Alsaiari, A. A., Abdulaziz, O., Alsharif, A., Khandaker, M. U., & Faruque, M. R. I. (2023) · e-Polymers · doi:10.1515/epoly-2023-0049 · Cited by 31 · see citing works
Todorova, M. M., Milusheva, M., Kaynarova, L., Georgieva, D., Delchev, V. B., Simeonova, S., Pilicheva, B., & Nikolova, S. (2023) · Biomedicines · doi:10.3390/biomedicines11061593 · Cited by 29 · see citing works
Wang, B., Qiu, D., Gu, Y., Zhu, S., Shi, R., Luo, J. T., Qi, S., Wang, Y., Jiang, B., & Jin, Y. (2024) · Journal of Bioresources and Bioproducts · doi:10.1016/j.jobab.2024.10.002 · Cited by 28 · see citing works
Dasineh, S., Akbarian, M., Ebrahimi, H. A., & Behbudi, G. (2021) · Applied Nanoscience · doi:10.1007/s13204-021-01744-4 · Cited by 28 · see citing works
San, H. H. M., Alcantara, K. P., Bulatao, B. P. I., Chaichompoo, W., Nalinratana, N., Suksamrarn, A., Vajragupta, O., Rojsitthisak, P., & Rojsitthisak, P. (2022) · Polymers · doi:10.3390/polym14091835 · Cited by 28 · see citing works
Wang, Z., Liu, L., Yin, W., Liu, Z., Shi, L., & Tang, M. (2021) · AAPS PharmSciTech · doi:10.1208/s12249-021-01927-w · Cited by 27 · see citing works
Deol, P. K., Kaur, I. P., Dhiman, R., Kaur, H., Sharma, G., Rishi, P., & Ghosh, D. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.123974 · Cited by 26 · see citing works
Rajesh, S., Zhai, J., Drummond, C. J., & Tran, N. L. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14102175 · Cited by 25 · see citing works
Wang, J., Huang, Z., Zhang, C., Ni, Y., Li, B., Wang, Y., & Wu, J. (2025) · Journal of drug targeting · doi:10.1080/1061186x.2025.2484773 · Cited by 24 · see citing works
Sabbagh, F. (2025) · ACS Applied Bio Materials · doi:10.1021/acsabm.5c00257 · Cited by 24 · see citing works
Maliyakkal, N., Beeran, A. A., & Udupa, N. (2021) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2021.07.001 · Cited by 24 · see citing works
Synergistic Activity of Anticancer Polyphenols Embedded in Amphiphilic Dendrimer Nanoparticles
Ben-Zichri, S., Meltzer, M., Lacham‐Hartman, S., Kolusheva, S., Hadad, U., Papo, N., & Jelinek, R. (2022) · ACS Applied Polymer Materials · doi:10.1021/acsapm.2c01316 · Cited by 24 · see citing works
Polymeric Micelles for Pulmonary Drug Delivery: A Comprehensive Review
Teama, M. T., Abdelmalak, N. S., Naguib, M. J., & Ahmed, S. (2025) · BioNanoScience · doi:10.1007/s12668-025-02105-z · Cited by 23 · see citing works
Liu, X., Du, J., Xie, Z., Wang, L., Liu, X., Hou, Z., Wang, X., & Tang, R. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.07.047 · Cited by 23 · see citing works
RetractedHosseini, S. M., Farmany, A., Alikhani, M. Y., Taheri, M., Asl, S. S., Alamian, S., & Arabestani, M. R. (2022) · Frontiers in Chemistry · doi:10.3389/fchem.2022.890252 · Cited by 22 · see citing works
Dynamic carboxymethyl chitosan-based nano-prodrugs precisely mediate robust synergistic chemotherapy
Wang, Z., Wang, D., Liu, X., Wu, H., Liu, Y., Ge, Y., Yan, G., & Tang, R. (2022) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2022.119671 · Cited by 22 · see citing works
Layer-by-layer coated calcium carbonate nanoparticles for targeting breast cancer cells
Bastos, F. R., da Costa, D. S., Reis, R. L., Alves, N. M., Pashkuleva, I., & Costa, R. R. (2023) · Biomaterials Advances · doi:10.1016/j.bioadv.2023.213563 · Cited by 22 · see citing works
Chemmalar, S., Razak, I. S. A., Abdullah, C. A. C., Razak, N. A. A., Yusof, L. M., Ajat, M., Gowthaman, N. S. K., & Bakar, M. Z. A. (2021) · Nanomaterials · doi:10.3390/nano11081988 · Cited by 23 · see citing works
Rozas, R., Ortiz, A. C., Peñaloza, S., Lizama, S., Flores, M. E., Morales, J. O., & Arriagada, F. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17060694 · Cited by 20 · see citing works
Marine polysaccharides, proteins, lipids, and silica for drug delivery systems: A review
Galasso, C., Ruocco, N., Mutalipassi, M., Barra, L., Costa, V., Giommi, C., Dinoi, A., Genovese, M., Pica, D., Romano, C., et al. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.127145 · Cited by 21 · see citing works
Radwan, I. T., El-sherbiny, I. M., & Metwally, N. H. (2024) · Scientific Reports · doi:10.1038/s41598-024-63149-x · Cited by 21 · see citing works
Synthesis, properties and application of pesticides encapsulated hydrogels
Han, D., Meng, F., Li, J., Liu, H., Cao, J., Song, X., Chen, H., & Xu, W. (2024) · European Polymer Journal · doi:10.1016/j.eurpolymj.2024.113196 · Cited by 19 · see citing works
Development of poly(lactide-co-glycolide) microparticles for sustained delivery of meloxicam
Pei, Y., Wang, J., Khaliq, N. U., Meng, F., Oucherif, K. A., Xue, J., Horava, S. D., Cox, A. L., Richard, C. A., Swinney, M. R., et al. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.12.019 · Cited by 17 · see citing works
The Increased Release Kinetics of Quercetin from Superparamagnetic Nanocarriers in Dialysis
Mandić, L., Matković, M., Baranović, G., & Šegota, S. (2023) · Antioxidants · doi:10.3390/antiox12030732 · Cited by 17 · see citing works
Creţu, C., Nicola, R., Marinescu, S., Picioruş, E.-M., Suba, M., Duda-Seiman, C., Len, A., Illés, L., Horváth, Z. E., & Putz, A.-M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241813887 · Cited by 17 · see citing works
Sahu, N., Alam, P., Ali, A., Kumar, N., Tyagi, R., Madan, S., Walia, R., & Saxena, S. (2024) · Gels · doi:10.3390/gels10020119 · Cited by 17 · see citing works
Shikonin-loaded PLGA nanoparticles: A promising strategy for psoriasis treatment
Fu, J., You, L., Sun, D., Zhang, L., Zhao, J., & Li, P. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e31909 · Cited by 17 · see citing works
Zhao, Z., Zhao, D., Su, L., Ding, M., Zhang, M., He, H., & Li, C. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.136811 · Cited by 16 · see citing works
Zhang, L., Duan, C., Feng, S., Zhao, B., Li, H., Zhang, X., Zhou, Y., & Qin, Z. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117670 · Cited by 16 · see citing works
Yang, B., Zhang, M., Qiao, W., Zhao, J., Chen, J., Yang, K., Hu, J., Hou, J., & Chen, L. (2022) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2022.107697 · Cited by 17 · see citing works
Xia, X., Zhang, J., Adu‐Frimpong, M., Li, X., Shen, X., He, Q. H., Rong, W., Ji, H., Toreniyazov, E., Xu, X., et al. (2022) · Pharmaceutical Development and Technology · doi:10.1080/10837450.2022.2122506 · Cited by 16 · see citing works
Reliable Kinetics for Drug Delivery with a Microfluidic Device Integrated with the Dialysis Bag
Esmaeili, J., Barati, A., Salehi, E., & Ai, J. (2023) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.2c00846 · Cited by 16 · see citing works
Mandić, L., Sadžak, A., Erceg, I., Baranović, G., & Šegota, S. (2021) · Antioxidants · doi:10.3390/antiox10081212 · Cited by 16 · see citing works
Fard, G. H., Moinipoor, Z., Anastasova, S., Iqbal, H. M. N., Dwek, M. V., Getting, S. J., & Keshavarz, T. (2022) · Carbohydrate Polymer Technologies and Applications · doi:10.1016/j.carpta.2022.100250 · Cited by 16 · see citing works
Cai, W., Geng, C., Jiang, L., Sun, J., Chen, B., Zhou, Y., Yang, B.-F., & Lu, H. (2020) · Pharmaceutical Development and Technology · doi:10.1080/10837450.2020.1727920 · Cited by 16 · see citing works
Zhu, L., Xu, W., Zhang, W., Wu, M.-C., Li, W., Ge, F., Tao, Y., & Song, P. (2021) · Nanotechnology · doi:10.1088/1361-6528/abee49 · Cited by 15 · see citing works
Partheniadis, I., Zarafidou, E., Litinas, Κ. E., & Nikolakakis, I. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12060571 · Cited by 15 · see citing works
Zhang, J., Yang, W., Zhu, Y., Li, Z., Yin, Z., Zhang, Y., Gao, W., Zhang, X., Wu, Z., & Gao, L. (2025) · Acta Biomaterialia · doi:10.1016/j.actbio.2025.01.019 · Cited by 14 · see citing works
Pavaloiu, R., Sha’at, F., Hlevca, C., Sha’at, M., Savoiu, G., & Osman, S. (2021) · Analele Universităţii "Ovidius" Constanţa. Seria Chimie/"Ovidius" University Annals of Chemistry · doi:10.2478/auoc-2021-0020 · Cited by 14 · see citing works
Xiu, Y., Luo, H., Xu, Q., Li, W., Wu, J., Sun, R., Sun, D., Yan, K., Liu, H., & Wang, Q. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.141556 · Cited by 14 · see citing works
Raîche-Marcoux, G., Loiseau, A., Maranda, C., Poliquin, A., & Boisselier, É. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232416191 · Cited by 14 · see citing works
Aziz, A. Y. R., Mahfufah, U., Syahirah, N. A., Habibie, H., Asri, R. M., Yulianty, R., Kastian, R. F., Sari, Y. W., Chabib, L., Hamzah, H., et al. (2023) · Drug Delivery and Translational Research · doi:10.1007/s13346-023-01483-9 · Cited by 13 · see citing works
Abla, K. K., Alamoudi, M. K., Soliman, G. A., Abdel-Kader, M. S., Aldawsari, M. F., & Mehanna, M. M. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s500487 · Cited by 13 · see citing works
Monoolein-based nanoparticles containing indinavir: a taste-masked drug delivery system
Bianchin, M. D., Prebianca, G., Immich, M. F., Teixeira, M. L., Colombo, M., Koester, L., de Araújo, B. V., Poletto, F. S., & Külkamp‐Guerreiro, I. C. (2020) · Drug Development and Industrial Pharmacy · doi:10.1080/03639045.2020.1862167 · Cited by 13 · see citing works
Kim, C. H., Lee, S. K., Choi, J. Y., Lyu, M. J., Jung, H. M., Goo, Y. T., Kang, M. J., & Choi, Y. W. (2023) · Pharmaceuticals · doi:10.3390/ph16030349 · Cited by 12 · see citing works
Sohail, M., Pirzada, T., Guenther, R. H., Barbieri, E., Sit, T. L., Menegatti, S., Crook, N., Opperman, C., & Khan, S. A. (2023) · ACS Sustainable Chemistry & Engineering · doi:10.1021/acssuschemeng.3c02428 · Cited by 12 · see citing works
Rout, S., Satapathy, B. S., Sahoo, R. N., & Pattnaik, S. (2024) · Nanotechnology · doi:10.1088/1361-6528/ad64e0 · Cited by 12 · see citing works
Fabrication of salicylic acid nanosphere for long-term induced immunity performance
Feng, C., Tian, X., Wang, X., Cui, M., Xu, C., Wang, W., & Wang, W. (2020) · RSC Advances · doi:10.1039/d0ra01161d · Cited by 12 · see citing works
Ağardan, N. B. M., & Tort, S. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.104749 · Cited by 12 · see citing works
Rana, S. J., Zafar, S., Shahzad, A., Basit, M. A., Mudassir, J., Akhlaq, M., Chohan, T. A., & Arshad, M. S. (2023) · AAPS PharmSciTech · doi:10.1208/s12249-023-02700-x · Cited by 11 · see citing works
In situ forming gels as subcutaneous delivery systems of curcumin and piperine
Pula, W., Pepe, A., Ferrara, F., Bondi, A., Mariani, P., Ortore, M. G., Pecorelli, A., Ivarsson, J., Valacchi, G., & Esposito, E. (2025) · Scientific Reports · doi:10.1038/s41598-025-87750-w · Cited by 11 · see citing works
Maarof, N. N. N., Abdulmalek, E., Fakurazi, S., & Rahman, M. B. A. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14061230 · Cited by 11 · see citing works
Wang, Y., Fens, M. H. A. M., van Kronenburg, N. C. H., Shi, Y., Lammers, T., Heger, M., van Nostrum, C. F., & Hennink, W. E. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.07.044 · Cited by 11 · see citing works
Spatiotemporal Theranostic Nanoprobes Dynamically Monitor Targeted Tumor Therapy
Fang, W. P., Song, B., Han, L., Tao, J., Li, Y., Tang, R., & Yan, G. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202306174 · Cited by 11 · see citing works
Eskandani, M., Mohabbat, A., Karimiyan, A., Dadashi, H., Adibkia, K., Sanaat, Z., & Vandghanooni, S. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.105278 · Cited by 11 · see citing works
Production of lipophilic nanogels by spontaneous emulsification
Ding, S., Mustafa, B., Anton, N., Serra, C. A., Chan‐Seng, D., & Vandamme, T. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119481 · Cited by 11 · see citing works
Singh, N., Shaikh, A. M., Gupta, P., Kovács, B., Abuzinadah, M. F., Ahmad, A., Goel, R., Singh, S., & Narayan, C. V. (2024) · Pharmaceuticals · doi:10.3390/ph17020213 · Cited by 10 · see citing works
Flores-Cruz, R. D., Espinoza-Guillén, A., Reséndiz-Acevedo, K., Mendoza-Rodríguez, V., López‐Casillas, F., Jiménez‐Sánchez, A., Méndez, F. J., & Ruíz-Azuara, L. (2024) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2024.112623 · Cited by 10 · see citing works
Ajayi, T. O., Poka, M., & Witika, B. A. (2024) · Scientific Reports · doi:10.1038/s41598-024-83408-1 · Cited by 10 · see citing works
Li, Y., Zang, X., Song, J., Xie, Y., & Chen, X. (2022) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2022.103520 · Cited by 9 · see citing works
Biopredictive tools for the development of injectable drug products
Nova, M. V., Gan, K., & Wacker, M. G. (2022) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2022.2081682 · Cited by 10 · see citing works
Das, S., Chakrabarty, S., Kundu, M., Nandi, S., Bera, D., Basu, T., Das, S., & Dey, A. (2024) · Polymer · doi:10.1016/j.polymer.2024.127712 · Cited by 8 · see citing works
Juang, V., Gan, J., Xia, Z., Wang, Y., & Schwendeman, A. A. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.124854 · Cited by 8 · see citing works
Ma, J., Gong, B., Hu, W., Liu, J., Wang, Y., Wang, Z., Yang, X., Wang, X., Yang, H., & Yan, G. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202418295 · Cited by 8 · see citing works
Peroxidase modification-driven silymarin liposomes for the treatment of liver fibrosis
Wu, J., Liu, X., Wen, L., Liang, C., Sun, Z., Liu, X., Wang, S., & Li, X. (2025) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2025.102851 · Cited by 8 · see citing works
In vitro drug release profiling of Sirolimus polymeric microparticles coated long-acting stents
Jadhav, S. A., Raval, A., Jariwala, A., Engineer, C., Tailor, J., & Patravale, V. B. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.124572 · Cited by 8 · see citing works
Pradhan, A., Mishra, S., Basu, S. M., Surolia, A., Giri, J., Srivastava, R., & Panda, D. (2021) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2021.111702 · Cited by 8 · see citing works
Garner, J., Skidmore, S., Hadar, J., Park, H., Park, K., Qin, B., & Wang, Y. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.08.052 · Cited by 8 · see citing works
Vidal-Diniz, A. T., Guimarães, H. N., Garcia, G. M., Braga, É. M., Richard, S., Grabe‐Guimarães, A., & Mosqueira, V. C. F. (2022) · Polymers · doi:10.3390/polym14245503 · Cited by 8 · see citing works
Abla, K. K., Torossian, T., Ammar, J., Karam, M., Fawaz, M., Debian, R., Mehanna, M. M., Daou, A., & Mhanna, R. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.148548 · Cited by 7 · see citing works
Santos, J. F., de Azevedo, R. S., Prudêncio, M., Marques, F., Gal, Y. L., Lorcy, D., & Fernandes, C. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15031030 · Cited by 7 · see citing works
- Authors
- Yu, M., Yuan, W., Li, D., Schwendeman, A., & Schwendeman, S. P.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Schwendeman, Anna
- Schwendeman, Steven P.
- Venue
- Journal of Controlled Release
- Publisher
- Elsevier BV
- Published
- 2019-12
- Volume
- 315
- Pages
- 23-30
- ISSN
- 0168-3659 (ISSN-L)
- OpenAlex
- W2981215046
- Cited by
- 232
- References
- 17
- Citations by year
- 2026: 48 · 2025: 49 · 2024: 40 · 2023: 33 · 2022: 33 · 2021: 19 · 2020: 9 · 2019: 1
- FWCI
- 4.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Controlled Release (publishedVersion)
- PubMed (publishedVersion)
- Funders
- United States-Israel Binational Science Foundation
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Keywords
- drug release kinetics, dialysis, nanocarriers, mathematical modeling of drug release, liposomal doxorubicin, pegylated liposomal doxorubicin, nanoparticle drug delivery
- MeSH terms
- Dialysis, Diffusion, Doxorubicin, Drug Carriers, Membranes, Artificial, Models, Theoretical, Polyethylene Glycols, Drug Delivery Systems, Nanoparticles, Drug Liberation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
