The DOI matches its Crossref record; 244 of the 244 references it cites were found in a registry or an index.
MicroRNA delivery through nanoparticles
Open accessAbstract
MicroRNAs (miRNAs) are attracting a growing interest in the scientific community due to their central role in the etiology of major diseases. On the other hand, nanoparticle carriers offer unprecedented opportunities for cell specific controlled delivery of miRNAs for therapeutic purposes. This review critically discusses the use of nanoparticles for the delivery of miRNA-based therapeutics in the treatment of cancer and neurodegenerative disorders and for tissue regeneration. A fresh perspective is presented on the design and characterization of nanocarriers to accelerate translation from basic research to clinical application of miRNA-nanoparticles. Main challenges in the engineering of miRNA-loaded nanoparticles are discussed, and key application examples are highlighted to underline their therapeutic potential for effective and personalized medicine.
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Cites
2 retracted
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“To overcome these barriers, miRNA-loaded nanoparticles (NPs) have been proposed [21–23], by virtue of NPs ability to shield the loaded agent from the external environment, thereby reducing inactivation or degradation, and enhancing circulation time and targeted accumulation [24].”
BackgroundUnderstanding the tumor immune microenvironment (TIME) for effective therapy
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Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
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Cited by
Liang, Y., Xu, X., Li, X., Xiong, J., Li, B., Duan, L., Wang, D., & Xia, J. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c10458 · Cited by 391
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Gajos-Michniewicz, A., & Czyz, M. (2024) · Genes & Diseases · doi:10.1016/j.gendis.2023.02.050 · Cited by 89
Xia, W., Li, M., Jiang, X., Huang, X., Gu, S., Ye, J., Zhu, L., Hou, M., & Zan, T. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01348-2 · Cited by 72
Mafi, A., Rahmati, A., Babaei Aghdam, Z., Salami, R., Salami, M., Vakili, O., & Aghadavod, E. (2022) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-022-00354-4 · Cited by 56
Metadata
- Authors
- Lee, S. W. L., Paoletti, C., Campisi, M., Osaki, T., Adriani, G., Kamm, R. D., Mattu, C., & Chiono, V.
- Venue
- Journal of Controlled Release
- Publisher
- Elsevier BV
- Published
- 2019-11
- Volume
- 313
- Pages
- 80-95
- ISSN
- 0168-3659 (ISSN-L)
- OpenAlex
- W2980389467
- Cited by
- 437
- References
- 244
- FWCI
- 11.74
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Lee, S. W. L., Paoletti, C., Campisi, M., Osaki, T., Adriani, G., Kamm, R. D., Mattu, C., & Chiono, V. (2019). MicroRNA delivery through nanoparticles. Journal of Controlled Release. https://doi.org/10.1016/j.jconrel.2019.10.007
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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