The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
Impact of lipid nanoparticle size on mRNA vaccine immunogenicity
Open accessAbstract
Lipid nanoparticles (LNP) are effective delivery vehicles for messenger RNA (mRNA) and have shown promise for vaccine applications. Yet there are no published reports detailing how LNP biophysical properties can impact vaccine performance. In our hands, a retrospective analysis of mRNA LNP vaccine in vivo studies revealed a relationship between LNP particle size and immunogenicity in mice using LNPs of various compositions. To further investigate this, we designed a series of studies to systematically change LNP particle size without altering lipid composition and evaluated biophysical properties and immunogenicity of the resulting LNPs. While small diameter LNPs were substantially less immunogenic in mice, all particle sizes tested yielded a robust immune response in non-human primates (NHP).
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Cited by
Chemistry of Lipid Nanoparticles for RNA Delivery
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mRNA lipid nanoparticle formulation, characterization and evaluation
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Metadata
- Authors
- Hassett, K. J., Higgins, J., Woods, A., Levy, B., Xia, Y., Hsiao, C. J., Acosta, E., Almarsson, Ö., Moore, M. J., & Brito, L. A.
- Venue
- Journal of Controlled Release
- Publisher
- Elsevier BV
- Published
- 2021-07
- Volume
- 335
- Pages
- 237-246
- ISSN
- 0168-3659 (ISSN-L)
- OpenAlex
- W3160196662
- Cited by
- 367
- References
- 68
- FWCI
- 14.76
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Hassett, K. J., Higgins, J., Woods, A., Levy, B., Xia, Y., Hsiao, C. J., Acosta, E., Almarsson, Ö., Moore, M. J., & Brito, L. A. (2021). Impact of lipid nanoparticle size on mRNA vaccine immunogenicity. Journal of Controlled Release. https://doi.org/10.1016/j.jconrel.2021.05.021
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