Novel nano-encapsulated probiotic agents: Encapsulate materials, delivery, and encapsulation systems
Abstract
Gut microbes are closely associated with most human health. When ingested orally, probiotics can effectively regulate the composition and quantity of human intestinal microorganisms, which is beneficial to human health. However, probiotics will be affected by the harsh environment of the digestive tract during the in vivo transportation process, and ensuring the viability of probiotics is a great challenge. Probiotic encapsulating technology provides an effective solution to this problem. The introduction of extreme temperatures, large probiotic microcapsule sizes and the difficulty in controlling probiotic microcapsule particle sizes mean that traditional microcapsule encapsulation methods have some limitations. From traditional microcapsule technology to the bulk encapsulation of probiotics with nanofibers and nanoparticles to the recent ability to wear nano "armor" for a single probiotic through biofilm, biological membrane and nanocoating. Emerging probiotic nanoagents provides a new conceptual and development direction for the field of probiotic encapsulation. In this review, we presented the characteristics of encapsulated probiotic carrier materials and digestive tract transport systems, we focused on the encapsulation systems of probiotic nanoagents, we analyzed the shortcomings and advantages of the current agent encapsulation systems, and we stated the developmental direction and challenges for these agents for the future.
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Low mucoadhesive capability and insufficient intestinal retention of probiotics greatly hamper their intestinal colonization.
“In addition, the low mucoadhesive capability and insufficient intestinal retention of probiotics greatly hamper their intestinal colonization.733”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [733]
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Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases
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Zhang, Q., Yang, Y., Chen, Y., Ban, S., Gu, S., Li, F., Xue, M., Sun, J., Li, X., & Tie, S. (2025) · Food Chemistry · doi:10.1016/j.foodchem.2024.141691 · Cited by 11 · see citing works
Tao, W., Yu, Y., Tan, D., Huang, X., Huang, J., Lin, C., & Yu, R. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1603442 · Cited by 9 · see citing works
- Authors
- Xu, C., Ban, Q., Wang, W., Hou, J., & Jiang, Z.
- Affiliations
- Northeast Agricultural University (CN)
- Corresponding author
- Hou, Juncai
- Jiang, Zhanmei
- Venue
- Journal of Controlled Release
- Publisher
- Elsevier BV
- Published
- 2022-09
- Volume
- 349
- Pages
- 184-205
- ISSN
- 0168-3659 (ISSN-L)
- OpenAlex
- W4284883841
- Cited by
- 225
- References
- 158
- Citations by year
- 2026: 54 · 2025: 68 · 2024: 63 · 2023: 33 · 2022: 7
- FWCI
- 3.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Controlled Release (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Natural Science Foundation of Heilongjiang Province (ZD2021C007)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Microencapsulation and Drying Processes
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- probiotics, probiotic encapsulation, nanoencapsulation, encapsulation systems, probiotic viability, gastrointestinal transit, nanofibers, nanoparticles, nanostructured coatings, biofilm, gut microbiota
- MeSH terms
- Capsules, Excipients, Humans, Probiotics, Nanofibers
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