Lactobacillus paracasei 24 Attenuates Lipid Accumulation in High-Fat Diet-Induced Obese Mice by Regulating the Gut Microbiota
Abstract
Obesity has become a worldwide public health problem. Lactic acid bacteria have attracted extensive attention for alleviating obesity and fat accumulation. This study aimed to evaluate the alleviating effects of Lactobacillus paracasei 24 (LP24) on lipid accumulation in an obese mouse model induced by a high-fat diet (HFD). The results showed that LP24 treatment significantly reduced body weight and fat deposition in HFD mice, improved blood lipid levels and liver steatosis, reduced liver oxidative stress injury and the inflammatory response, and regulated fat metabolism-related factors. Moreover, LP24 regulated the abundance and diversity of the gut microbiota, reduced the abundance of Firmicutes and the ratio of Firmicutes / Bacteroidetes (F/B), and increased the abundance of Akkermansia . In summary, LP24 regulates lipid metabolism by activating the expression level of related genes and regulating the gut microbiota through the gut-liver axis to attenuate the development of obesity. This study provides a theoretical basis for probiotics to regulate gut microbiota to reduce lipid accumulation.
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A growing body of evidence strongly supports the possibility of targeting the gastrointestinal microbiome to prevent and treat dyslipidemia.
“A growing body of evidence strongly supports the possibility of targeting the gastrointestinal microbiome to prevent and treat dyslipidemia (Zhang et al., 2020; Lv et al., 2021; Liu et al., 2022).”
From Lactiplantibacillus plantarum N4 ameliorates lipid metabolism and gut microbiota structure in high fat diet-fed rats (2024) · cites this paper as Liu et al., 2022
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- Authors
- Liu, Z., Zhou, X., Wang, W., Gu, L., Hu, C., Sun, H., Xu, C., Hou, J., & Jiang, Z.
- Affiliations
- Northeast Agricultural University (CN)
- Corresponding author
- Hou, Juncai
- Jiang, Zhanmei
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2022-04-04
- Volume
- 70
- Issue
- 15
- Pages
- 4631-4643
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W4224297345
- Cited by
- 77
- References
- 56
- Citations by year
- 2026: 10 · 2025: 18 · 2024: 20 · 2023: 13 · 2022: 15 · 2017: 1
- FWCI
- 8.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Agricultural and Food Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Natural Science Foundation of Heilongjiang Province (ZD2021C007)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Keywords
- probiotics, obesity, high-fat diet, lipid accumulation, gut microbiota, gut-liver axis, hepatic steatosis, liver oxidative stress, inflammation, Akkermansia, Firmicutes/Bacteroidetes ratio, fat metabolism, serum lipids
- MeSH terms
- Gastrointestinal Microbiome, Lacticaseibacillus paracasei, Animals, Mice, Inbred C57BL, Mice, Obese, Obesity, Lipid Metabolism, Mice, Diet, High-Fat
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