Cited by 77Probiotics and Fermented FoodsGut microbiota and healthReproductive tract infections research

Lactobacillus paracasei 24 Attenuates Lipid Accumulation in High-Fat Diet-Induced Obese Mice by Regulating the Gut Microbiota

Liu, Zhijing, Zhou, Xuan, Wang, Wan, Gu, Liya, Hu, Chuanbing, Sun, Hong, Xu, Cong, Hou, Juncai +1 more·2022·Journal of Agricultural and Food Chemistry

Abstract

Obesity has become a worldwide public health problem. Lactic acid bacteria have attracted extensive attention for alleviating obesity and fat accumulation. This study aimed to evaluate the alleviating effects of Lactobacillus paracasei 24 (LP24) on lipid accumulation in an obese mouse model induced by a high-fat diet (HFD). The results showed that LP24 treatment significantly reduced body weight and fat deposition in HFD mice, improved blood lipid levels and liver steatosis, reduced liver oxidative stress injury and the inflammatory response, and regulated fat metabolism-related factors. Moreover, LP24 regulated the abundance and diversity of the gut microbiota, reduced the abundance of Firmicutes and the ratio of Firmicutes / Bacteroidetes (F/B), and increased the abundance of Akkermansia . In summary, LP24 regulates lipid metabolism by activating the expression level of related genes and regulating the gut microbiota through the gut-liver axis to attenuate the development of obesity. This study provides a theoretical basis for probiotics to regulate gut microbiota to reduce lipid accumulation.

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Crossref · 10.1021/acs.jafc.1c07884

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Authors
Liu, Z., Zhou, X., Wang, W., Gu, L., Hu, C., Sun, H., Xu, C., Hou, J., & Jiang, Z.
Affiliations
Northeast Agricultural University (CN)
Corresponding author
  • Hou, Juncai
  • Jiang, Zhanmei
Venue
Journal of Agricultural and Food Chemistry
Published
2022-04-04
Volume
70
Issue
15
Pages
4631-4643
ISSN
  • 0021-8561 (ISSN-L)
  • 1520-5118
OpenAlex
W4224297345
Cited by
77
References
56
Citations by year
2026: 10 · 2025: 18 · 2024: 20 · 2023: 13 · 2022: 15 · 2017: 1
FWCI
8.78
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Agricultural and Food Chemistry (publishedVersion)
  • PubMed (publishedVersion)
Funders
Natural Science Foundation of Heilongjiang Province (ZD2021C007)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
Keywords
probiotics, obesity, high-fat diet, lipid accumulation, gut microbiota, gut-liver axis, hepatic steatosis, liver oxidative stress, inflammation, Akkermansia, Firmicutes/Bacteroidetes ratio, fat metabolism, serum lipids
MeSH terms
Gastrointestinal Microbiome, Lacticaseibacillus paracasei, Animals, Mice, Inbred C57BL, Mice, Obese, Obesity, Lipid Metabolism, Mice, Diet, High-Fat

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