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Mesenchymal stem versus stromal cells: International Society for Cell & Gene Therapy (ISCT®) Mesenchymal Stromal Cell committee position statement on nomenclature
Abstract
The International Society for Cell & Gene Therapy (ISCT®) Mesenchymal Stromal Cell (ISCT MSC) committee offers a position statement to clarify the nomenclature of mesenchymal stromal cells (MSCs). The ISCT MSC committee continues to support the use of the acronym "MSCs" but recommends this be (i) supplemented by tissue-source origin of the cells, which would highlight tissue-specific properties; (ii) intended as MSCs unless rigorous evidence for stemness exists that can be supported by both in vitro and in vivo data; and (iii) associated with robust matrix of functional assays to demonstrate MSC properties, which are not generically defined but informed by the intended therapeutic mode of actions.
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“MSCs demonstrate multifaceted advantages, including immunomodulatory properties, anti-fibrotic effects (via hepatic stellate cell inhibition and ECM remodeling), promotion of hepatocyte regeneration, and mitigation of oxidative stress.”
From Mechanisms, efficacy, and future perspectives of cellular-based therapies for liver fibrosis/cirrhosis: focusing on mesenchymal stromal cells (2025) · cites this paper as [27]
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Metadata
- Authors
- Viswanathan, S., Shi, Y., Galipeau, J., Krampera, M., Leblanc, K., Martin, I., Nolta, J., Phinney, D. G., & Sensebe, L.
- Affiliations
- University Health Network (CA)
- Chinese Academy of Sciences (CN)
- University of Wisconsin–Madison (US)
- University of Verona (IT)
- Karolinska Institutet (SE)
- University of California Davis Medical Center (US)
- Scripps Research Institute (US)
- Corresponding author
- Viswanathan, S.
- Shi, Y.
- Venue
- Cytotherapy
- Publisher
- Elsevier BV
- Published
- 2019-10
- Volume
- 21
- Issue
- 10
- Pages
- 1019-1024
- ISSN
- 1465-3249 (ISSN-L)
- OpenAlex
- W2973068260
- Cited by
- 839
- References
- 61
- Citations by year
- 2026: 109 · 2025: 127 · 2024: 124 · 2023: 128 · 2022: 137 · 2021: 136 · 2020: 75 · 2019: 2
- FWCI
- 48.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cytotherapy (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Keywords
- mesenchymal stem cells, stemness, functional assays, cell therapy
- MeSH terms
- Cell Differentiation, Humans, Terminology as Topic, Societies, Medical, Genetic Therapy, Stromal Cells, Cell Culture Techniques, Internationality, Mesenchymal Stem Cells, Cell- and Tissue-Based Therapy
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