Cited by 843Mesenchymal stem cell researchHematopoietic Stem Cell TransplantationPluripotent Stem Cells Research

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Mesenchymal stem versus stromal cells: International Society for Cell & Gene Therapy (ISCT®) Mesenchymal Stromal Cell committee position statement on nomenclature

Viswanathan, S., Shi, Y., Galipeau, J., Krampera, M., Leblanc, K., Martin, I., Nolta, J., Phinney, D.G., Sensebe, L.·2019·Cytotherapy

DOI 10.1016/j.jcyt.2019.08.002

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Abstract

The International Society for Cell & Gene Therapy (ISCT®) Mesenchymal Stromal Cell (ISCT MSC) committee offers a position statement to clarify the nomenclature of mesenchymal stromal cells (MSCs). The ISCT MSC committee continues to support the use of the acronym "MSCs" but recommends this be (i) supplemented by tissue-source origin of the cells, which would highlight tissue-specific properties; (ii) intended as MSCs unless rigorous evidence for stemness exists that can be supported by both in vitro and in vivo data; and (iii) associated with robust matrix of functional assays to demonstrate MSC properties, which are not generically defined but informed by the intended therapeutic mode of actions.

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Authors: Viswanathan, S., Shi, Y., Galipeau, J., Krampera, M., Leblanc, K., Martin, I., Nolta, J., Phinney, D. G., & Sensebe, L.
Affiliations: University Health Network (CA)
Chinese Academy of Sciences (CN)
University of Wisconsin–Madison (US)
University of Verona (IT)
Karolinska Institutet (SE)
University of California Davis Medical Center (US)
Scripps Research Institute (US)
Corresponding author: Viswanathan, S.
Shi, Y.
ORCID: Viswanathan, S.
Shi, Y.
Galipeau, J.
Krampera, M.
Nolta, J.
Phinney, D.G.
Venue: Cytotherapy
Publisher: Elsevier BV
Published: 2019-10
Volume: 21
Issue: 10
Pages: 1019-1024
ISSN: 1465-3249 (ISSN-L)
DOI: 10.1016/j.jcyt.2019.08.002
OpenAlex: W2973068260
Cited by: 839
References: 61
Citations by year: 2026: 109 · 2025: 127 · 2024: 124 · 2023: 128 · 2022: 137 · 2021: 136 · 2020: 75 · 2019: 2
FWCI: 48.06
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Cytotherapy (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
Keywords: mesenchymal stem cells, stemness, functional assays, cell therapy
MeSH terms: Cell Differentiation, Humans, Terminology as Topic, Societies, Medical, Genetic Therapy, Stromal Cells, Cell Culture Techniques, Internationality, Mesenchymal Stem Cells, Cell- and Tissue-Based Therapy

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Mesenchymal stem versus stromal cells: International Society for Cell & Gene Therapy (ISCT®) Mesenchymal Stromal Cell committee position statement on nomenclature

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