The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Synthesis and characterization of ZIF-8 nanoparticles for controlled release of 6-mercaptopurine drug
Open accessAbstract
Zeolitic imidazolate framework (ZIF-8) has been synthesized at room temperature in aqueous medium. Their suitability as potential drug carrier for delivery of an anti-leukemia drug, 6-mercaptopurine (6-MP) is examined. 6-MP was loaded in situ into the ZIF-8 nanoparticles during synthesis. Both ZIF-8 and 6-MP@ZIF-8 have been characterized using various characterization tools. The structural integrity and phase purity of 6-MP@ZIF-8 nanoparticles was obtained through X-ray diffraction pattern and was comparable to that of sodalite type ZIF-8. FESEM micrographs of pure ZIF-8 showed hexagonal nanocrystals with well-developed facets and uniform particle size distribution of around 80–100 nm. Encapsulation of 6-MP into ZIF-8 resulted into a nearly two fold increase of size while preserving the well-developed facets and hexagonal morphology. The encapsulation of 6-MP was confirmed by UV-Visible and FTIR spectroscopy studies. Furthermore, the release kinetics of 6-MP drug from 6-MP@ZIF-8 has been investigated in phosphate buffer saline 37 °C at two different pH values 7.4 and 5.0. The 6-MP@ZIF-8 exhibited much faster release of drug in acidic pH as compared with release in pH 7.4 owing to the decomposition of ZIF-8 structure, thus, indicating the potential of ZIF-8 to be used as a carrier for controlled delivery of 6-MP against cancerous cells.
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Cites
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Cited by
Zhang, Y., Jia, Y., Li, M., & Hou, L. (2018) · Scientific Reports · doi:10.1038/s41598-018-28015-7 · Cited by 334
Cai, M., Yao, Y., Yin, D., Zhu, R., Fu, T., Kong, J., Wang, K., Liu, J., Yao, A., Ruan, Y., et al. (2023) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2023.04.126 · Cited by 45
Rahmani, A., Maleki, A., Jafari, R., Rezaeejam, H., & Nadri, S. (2025) · Journal of Materials Chemistry B · doi:10.1039/d5tb00789e · Cited by 10
Metadata
- Authors
- Kaur, H., Mohanta, G. C., Gupta, V., Kukkar, D., & Tyagi, S.
- Venue
- Journal of Drug Delivery Science and Technology
- Publisher
- Elsevier BV
- Published
- 2017-10
- Volume
- 41
- Pages
- 106-112
- ISSN
- 1773-2247 (ISSN-L)
- OpenAlex
- W2724117952
- Cited by
- 434
- References
- 31
- FWCI
- 6.09
- Type
- journal article
- Language
- en
- Open access
- green
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- Kaur, H., Mohanta, G. C., Gupta, V., Kukkar, D., & Tyagi, S. (2017). Synthesis and characterization of ZIF-8 nanoparticles for controlled release of 6-mercaptopurine drug. Journal of Drug Delivery Science and Technology. https://doi.org/10.1016/j.jddst.2017.07.004
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