pH-responsive drug delivery systems as intelligent carriers for targeted drug therapy: Brief history, properties, synthesis, mechanism and application

Nano based drug delivery systems: recent developments and future prospects

Patra, J. K., Das, G., Fraceto, L. F., Campos, E. V. R., Rodríguez-Torres, M. D. P., Acosta‐Torres, L. S., Diaz-Torres, L. A., Grillo, R., Swamy, M. K., Sharma, S., et al. (2018) · Journal of Nanobiotechnology · doi:10.1186/s12951-018-0392-8 · Cited by 7,085

Stimuli-responsive nanocarriers for drug delivery

Mura, S., Nicolas, J., & Couvreur, P. (2013) · Nature Materials · doi:10.1038/nmat3776 · Cited by 6,289

Hydrogel: Preparation, characterization, and applications: A review

Ahmed, E. M. (2015) · Journal of Advanced Research · doi:10.1016/j.jare.2013.07.006 · Cited by 5,800

The Warburg Effect: How Does it Benefit Cancer Cells?

Liberti, M. V., & Locasale, J. W. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2015.12.001 · Cited by 5,150

A New Class of Polymers: Starburst-Dendritic Macromolecules

Tomalia, D. A., Baker, H., Dewald, J., Hall, M., Kallos, G. J., Martin, S., Roeck, J., Ryder, J., & Smith, P. B. (1985) · Polymer Journal · doi:10.1295/polymj.17.117 · Cited by 3,908

Disease control priorities in developing countries

(2006) · Choice Reviews Online · doi:10.5860/choice.44-0343 · Cited by 3,636

Degradable controlled-release polymers and polymeric nanoparticles: mechanisms of controlling drug release

Kamaly, N., Yameen, B., Wu, J., & Farokhzad, O. C. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00346 · Cited by 3,070

Thermo- and pH-responsive polymers in drug delivery☆

SCHMALJOHANN, D. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.09.020 · Cited by 3,023

Biomedical applications of hydrogels: A review of patents and commercial products

Caló, E., & Khutoryanskiy, V. V. (2015) · European Polymer Journal · doi:10.1016/j.eurpolymj.2014.11.024 · Cited by 2,634

Chitosan-based hydrogels for controlled, localized drug delivery

Bhattarai, N., Gunn, J., & Zhang, M. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.07.019 · Cited by 2,495

Current updated review on preparation of polymeric nanoparticles for drug delivery and biomedical applications

Bhardwaj, H., & Jangde, R. (2023) · Next Nanotechnology · doi:10.1016/j.nxnano.2023.100013 · Cited by 179

Applications of the ROS-Responsive Thioketal Linker for the Production of Smart Nanomedicines

Rinaldi, A., Caraffi, R., Grazioli, M. V., Oddone, N., Giardino, L., Tosi, G., Vandelli, M. A., Calzà, L., Ruozi, B., & Duskey, J. T. (2022) · Polymers · doi:10.3390/polym14040687 · Cited by 171

Recent Advances in the Additive Manufacturing of Stimuli‐Responsive Soft Polymers

Tariq, A., Arif, Z. U., Khalid, M. Y., Hossain, M., Rasool, P. I., Umer, R., & Ramakrishna, S. (2023) · Advanced Engineering Materials · doi:10.1002/adem.202301074 · Cited by 151

pH-responsive membranes: Mechanisms, fabrications, and applications

Al-Shaeli, M. N. Z., Benkhaya, S., Al-Juboori, R. A., Koyuncu, İ., & Vatanpour, V. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.173865 · Cited by 109

Current Principles, Challenges, and New Metrics in pH-Responsive Drug Delivery Systems for Systemic Cancer Therapy

Verkhovskii, R. A., Aa, I., Ленгерт, Е. В., Tulyakova, K. A., Shilyagina, N. Y., & Ermakov, A. V. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15051566 · Cited by 103

Lipid-Based Nanotechnology: Liposome

Jiang, Y., Li, W., Wang, Z., & Lu, J. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics16010034 · Cited by 102

Rational design and combinatorial chemistry of ionizable lipids for RNA delivery

Xu, Y., Golubovic, A., Xu, S., Pan, A., & Li, B. (2023) · Journal of Materials Chemistry B · doi:10.1039/d3tb00649b · Cited by 87

pH stimuli-responsive hydrogels from non-cellulosic biopolymers for drug delivery.

Vegad, U., Patel, M., Khunt, D., Zupančič, O., Chauhan, S., & Paudel, A. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1270364 · Cited by 85

Exploring the potential of pH-sensitive polymers in targeted drug delivery

Gomte, S. S., Agnihotri, T. G., Khopade, S., & Jain, A. (2023) · Journal of Biomaterials Science Polymer Edition · doi:10.1080/09205063.2023.2279792 · Cited by 77

Glycopolymer-Based Materials: Synthesis, Properties, and Biosensing Applications

Thalji, M. R., Ibrahim, A. A., Chong, K. F., Soldatov, A. V., & Ali, G. A. M. (2022) · Topics in Current Chemistry · doi:10.1007/s41061-022-00395-5 · Cited by 73

Lipid-based nano-carriers for the delivery of anti-obesity natural compounds: advances in targeted delivery and precision therapeutics

Uti, D. E., Alum, E. U., Atangwho, I. J., Ugwu, O. P.-C., Egbung, G. E., & Aja, P. M. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03412-z · Cited by 104

pH-Dependent Drug Delivery Systems for Ulcerative Colitis Treatment

Gvozdeva, Y., & Staynova, R. A. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17020226 · Cited by 67

Soft and Flexible Bioelectronic Micro‐Systems for Electronically Controlled Drug Delivery

Mariello, M., Eş, İ., & Proctor, C. M. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202302969 · Cited by 70

Electrospun multi‐chamber core–shell nanofibers and their controlled release behaviors: A review

Liu, Y., Chen, X., Lin, X., Yan, J., Yu, D., Liu, P., & Yang, H. (2024) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1954 · Cited by 62

Emerging frontiers in drug delivery with special focus on novel techniques for targeted therapies

Yu, L., Liu, S., Jia, S., & Xu, F. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115049 · Cited by 59

Therapeutic applications and potential biological barriers of nano-delivery systems in common gastrointestinal disorders: a comprehensive review

Zheng, G., Zhang, B., Yu, H., Song, Z., Xu, X., Zheng, Z., Zhao, K., Zhao, J. H., & Zhao, Y. (2025) · Advanced Composites and Hybrid Materials · doi:10.1007/s42114-025-01292-3 · Cited by 66

pH-Responsive and Mucoadhesive Nanoparticles for Enhanced Oral Insulin Delivery: The Effect of Hyaluronic Acid with Different Molecular Weights

Wang, S., Meng, S., Zhou, X., Gao, Z., & Piao, M. G. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15030820 · Cited by 50

Beyond Skin Deep: Phospholipid-Based Nanovesicles as Game-Changers in Transdermal Drug Delivery

Akl, M. A., Eldeen, M. A., & Kassem, A. M. (2024) · AAPS PharmSciTech · doi:10.1208/s12249-024-02896-6 · Cited by 50

Unlocking the biological response of smart Stimuli-Responsive hydrogels and their application in biological systems

Kumi, M., Ejeromedoghene, O., Sudane, W. D., & Zhang, Z. (2024) · European Polymer Journal · doi:10.1016/j.eurpolymj.2024.112906 · Cited by 52

Cellulose derivatives and natural gums as gelling agents for preparation of emulgel-based dosage forms: A brief review

Estabragh, M. A. R., Bami, M. S., Dehghannoudeh, G., Noudeh, Y. D., & Moghimipour, E. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.124538 · Cited by 45

Deciphering the Power of Resveratrol in Mitophagy: From Molecular Mechanisms to Therapeutic Applications

Liu, H., Song, Y., Wang, H., Zhou, Y., Xu, M., & Xian, J. (2025) · Phytotherapy Research · doi:10.1002/ptr.8433 · Cited by 37

Introduction to Stimuli-Responsive Materials and Their Biomedical Applications

Khizar, S., Zine, N., Errachid, A., & Elaı̈ssari, A. (2023) · ACS symposium series · doi:10.1021/bk-2023-1436.ch001 · Cited by 35

Recent Advances in Smart Polymeric Micelles for Targeted Drug Delivery

Othman, R. S., Zarei, S., Haghighat, H. R., Taromi, A. A., & Khonakdar, H. A. (2025) · Polymers for Advanced Technologies · doi:10.1002/pat.70180 · Cited by 39

PLA-HA/Fe3O4 magnetic nanoparticles loaded with curcumin: physicochemical characterization and toxicity evaluation in HCT116 colorectal cancer cells

Bourang, S., Asadian, S., Noruzpour, M., Mansuryar, A., Azizi, S., Ebrahimi, H. A., & Hooshyar, V. A. (2024) · Discover Applied Sciences · doi:10.1007/s42452-024-05858-6 · Cited by 30

Smart Bioorthogonal Nanozymes: From Rational Design to Appropriate Bioapplications

Zhang, B., Zhu, J., Ren, J., & Qu, X. (2024) · Advanced Materials · doi:10.1002/adma.202405318 · Cited by 29

Synthesis, characterization, and acute toxicity of pH-responsive Salvia spinosa mucilage-co-acrylic acid hydrogel: A smart excipient for drug release applications

Ali, A., Hussain, M. A., Haseeb, M. T., Tulain, U. R., Farid-ul-Haq, M., Tabassum, T., Muhammad, G., Hussain, S. Z., Hussaın, I., & Erum, A. (2022) · Reactive and Functional Polymers · doi:10.1016/j.reactfunctpolym.2022.105466 · Cited by 29

Recent advances in stimuli-responsive polymeric carriers for controllable CRISPR/Cas9 gene editing system delivery

Ma, P., Wang, Q., Luo, X., Mao, L., Wang, Z., Ye, E., Loh, X. J., Li, Z., & Wu, Y. (2023) · Biomaterials Science · doi:10.1039/d3bm00529a · Cited by 27

Aerosol assisted synthesis of a pH responsive curcumin anticancer drug nanocarrier using chitosan and alginate natural polymers

Asadi, S., Madrakian, T., Ahmadi, M., Aguirre, M. Á., Afkhami, A., Uroomiye, S. S., Ghaffari, F., & Ranjbar, A. (2023) · Scientific Reports · doi:10.1038/s41598-023-46904-4 · Cited by 26

Alginate/hyaluronic acid/gelatin ternary blended films as pH-sensitive drug carriers: In vitro ampicillin release and kinetic studies

Aycan, D. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.134111 · Cited by 25

Cation–π Interaction-Enhanced Self-Healing Injectable Hydrogels for Gastric Perforation Repair

He, C., Bi, S., Liu, R., Zhao, H., Chen, C., Zhao, X., Gu, J., & Yan, B. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c01944 · Cited by 26

Intelligent Drug Delivery: Pioneering Stimuli-Responsive Systems to Revolutionize Disease Management- An In-depth Exploration

Kallepalli, S. B., Garg, U., Jain, N., Nagpal, R., Malhotra, S., Tiwari, T., Kaul, S., & Nagaich, U. (2024) · Current Drug Delivery · doi:10.2174/0115672018278641231221051359 · Cited by 24

Tailored synthesis of pH-responsive biodegradable microcapsules incorporating gelatin, alginate, and hyaluronic acid for effective-controlled release

Do, U. T., Nguyen, Q. T., Kim, J., Luu, Q. S., Park, Y., Song, M., Yang, S., Choi, J., Yun, S., Kang, D., et al. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.132178 · Cited by 22

Engineering biomaterials by inkjet printing of hydrogels with functional particulates

Cheng, C., Williamson, E. J., Chiu, G. T. ‐., & Han, B. (2024) · Med-X · doi:10.1007/s44258-024-00024-4 · Cited by 23

Recent advances in drug delivery applications of aqueous two-phase systems

Baghbanbashi, M., Shiran, H. S., Kakkar, A. K., Pazuki, G., & Ristroph, K. D. (2024) · PNAS Nexus · doi:10.1093/pnasnexus/pgae255 · Cited by 19

Different applications of temperature responsive nanogels as a new drug delivery system mini review

Sam, R., Kermani, M. D., Ohadi, M., Salarpour, S., & Dehghannoudeh, G. (2023) · Pharmaceutical Development and Technology · doi:10.1080/10837450.2023.2209796 · Cited by 17

Nanomedicine for phage therapy: Encapsulation strategies for enhanced antimicrobial efficacy

Dorta-Gorrín, A., Salgueiriño, V., & García-Hevia, L. (2026) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2025.107660 · Cited by 16

Development of Drug-Loaded PCL@MOF Film Enclosed in a Photo Polymeric Container for Sustained Release

Shukla, S., Joshi, N., Kadian, S., & Narayan, R. J. (2024) · ACS Applied Bio Materials · doi:10.1021/acsabm.4c00564 · Cited by 15

Tumor Targeting and pH-Sensitive Inclusion Complex Based on HP-β-CD as a Potential Carrier for Paclitaxel: Fabrication, Molecular Docking, and Characterization

Li, Z., Zhao, W. G., Liang, N., Yan, P., & Sun, S. (2022) · Biomacromolecules · doi:10.1021/acs.biomac.2c01023 · Cited by 13

Intrinsically Disordered Synthetic Polymers in Biomedical Applications

Yüce, E., Domb, A. J., Kasem, H., Uversky, V. N., & Coskuner‐Weber, O. (2023) · Polymers · doi:10.3390/polym15102406 · Cited by 13

Review and Future Perspectives of Stimuli-Responsive Bridged Polysilsesquioxanes in Controlled Release Applications

Zhang, X., Zhang, H., Liu, X., Wang, J., Li, S., & Gao, P. (2024) · Polymers · doi:10.3390/polym16223163 · Cited by 13

Research Progress of Antioxidant Nanomaterials for Acute Pancreatitis

Zheng, X., Zhao, J., Wang, S., & Hu, L. (2022) · Molecules · doi:10.3390/molecules27217238 · Cited by 13

Facile synthesis of fluorescent mesoporous nanocarriers with pH-sensitive controlled release of naturally derived dieckol

Son, M. J., Kim, T., & Lee, S. (2022) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2022.130535 · Cited by 12

Preparation and biological evaluation of novel 5-Fluorouracil and Carmofur loaded polyethylene glycol / rosin ester nanocarriers as potential anticancer agents and ceramidase inhibitors

Kalındemirtaş, F. D., Birman, H., Karakuş, S., Kilislioğlu, A., & Kuruca, S. E. (2022) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2022.103456 · Cited by 11

Curcumin for inflammatory bowel disease therapy: advances in mechanisms, clinical applications, and drug delivery

Zhang, Z., Ding, C., Xu, H., Guo, F., Li, Y., Zhang, D., & Wang, R. (2025) · Archives of Pharmacal Research · doi:10.1007/s12272-025-01569-7 · Cited by 13

Advancing drug delivery systems through biomedical engineering: Innovations and future directions

Afrose, N., Chakraborty, R., Bhowmick, P., & Bhowmick, M. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-30146-9.00001-0 · Cited by 10

Synergizing effects of chemodynamic therapy and chemotherapy against breast cancer by oxaliplatin-loaded polydopamine/BSA@copper ferrite

Alamer, N., Meshkini, A., Khoshtabiat, L., & Behnamsani, A. (2022) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2022.103391 · Cited by 10

Diversely substituted poly(N-vinyl amide) derivatives towards non-toxic, stealth and pH-responsive lipid nanocapsules

Toussaint, F., Lepeltier, É., Franconi, F., Pautu, V., Jérôme, C., Passirani, C., & Debuigne, A. (2024) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2024.113788 · Cited by 9

AIE luminogen labeled polymeric micelles for biological imaging and chemotherapy

Liang, N., Xu, Y., Zhao, W. G., Liu, Z., Li, G., & Sun, S. (2024) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2024.113792 · Cited by 9

Agarose as a tunable platform for oral drug delivery: Controlled release of a highly soluble drug, theophylline, within a sequentially-changing-pH medium

Marras-Marquez, T., Peña, J., & Veiga-Ochoa, M. D. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.105521 · Cited by 9

Stimuli-responsive nanogels in wound care: A comprehensive review

Das, T., Das, M., Sultana, S., & Swain, R. (2025) · Next Nanotechnology · doi:10.1016/j.nxnano.2025.100260 · Cited by 9

Cargo-Dependent Targeted Cellular Uptake Using Quaternized Starch as a Carrier

Blitsman, Y., Benafsha, C., Yarza, N., Zorea, J., Goldbart, R., Traitel, T., Elkabets, M., & Kost, J. (2023) · Nanomaterials · doi:10.3390/nano13131988 · Cited by 9

Absorption enhancer approach for protein delivery by various routes of administration: a rapid review

Salehi, T., Estabragh, M. A. R., Salarpour, S., Ohadi, M., & Dehghannoudeh, G. (2023) · Journal of drug targeting · doi:10.1080/1061186x.2023.2271680 · Cited by 7

Enhancing the Acidity of Polymers for Improved Stabilization of Amorphous Solid Dispersions: Protonation of Weakly Basic Compounds

Kelsall, K. N., Schubiner, R. O., Schenck, L., Frank, D. S., & Matzger, A. J. (2024) · ACS Applied Polymer Materials · doi:10.1021/acsapm.3c02882 · Cited by 7

Coactive chemoradiotherapy using polysaccharides- and synthetic polymers-based hydrogels for cancer treatment: A review

Dolati, M., Vandghanooni, S., Veisi, K., & Jaymand, M. (2024) · Carbohydrate Polymer Technologies and Applications · doi:10.1016/j.carpta.2024.100463 · Cited by 7

API Salt Solubility: Unresolved Problems and Innovative Solutions Beyond Conventional Approaches

Verma, A., Patil, R., Kumar, D. K., & Agrawal, A. K. (2025) · Crystal Growth & Design · doi:10.1021/acs.cgd.5c01374 · Cited by 6

The Biophysics of Nanocellulose Packaging: Linking Nanoscale Structure to Food Preservation and Safety

Riaz, T., Zeng, X., Ye, X., Yu, T., Xia, Z., Khan, M. M., Ahmad, T., Kalsoom, A., Rauf, M. A., Ashraf, M. A., et al. (2025) · Food Biophysics · doi:10.1007/s11483-025-10082-9 · Cited by 6

Block-copolymer-armed star polyampholyte with pH- and temperature-tunable supramolecular nanostructures for enhanced dye adsorption

Mohammadzadeh, F., Haddadi‐Asl, V., & Salami‐Kalajahi, M. (2024) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2024.133288 · Cited by 6

Intelligent Nanomaterials Design for Osteoarthritis Managements

Chen, Z., Zheng, X., Mu, Z., Lu, W., Zhang, H., & Yan, J. (2025) · Small Methods · doi:10.1002/smtd.202402263 · Cited by 6

Drug Delivery Strategies for the Lower GI Tract: A Review

Munter, B. D., Brebels, J., & Mignon, A. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202501540 · Cited by 7

Solvent-exchange-based in situ forming implants: advances and challenges as long-lasting formulations

Lozza, I., Fraguas‐Sánchez, A. I., Martín‐Sabroso, C., & Torres‐Suárez, A. I. (2025) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2025.2565422 · Cited by 5

Biopolymeric micro and nanoscale colloidal delivery systems for controlled drug release in pharmaceutical sector

Odocheanu, R., Călinoiu, L. F., Martău, G. A., & Vodnar, D. C. (2026) · Bioresource Technology · doi:10.1016/j.biortech.2026.134626 · Cited by 5

NATURALLY OCCURRING SWELLABLE POLYSACCHARIDES-BASED STIMULI-RESPONSIVE SMART TABLETS – A NEW WINDOW OF OPPORTUNITY

Hussain, M. A., & Haseeb, M. T. (2024) · Cellulose Chemistry and Technology · doi:10.35812/cellulosechemtechnol.2024.58.24 · Cited by 5

Co-axial electrosprayed RAD001-loaded polycaprolactone/polyvinyl alcohol core–shell particles for treating pediatric brain tumours

Louis, L., Simonassi-Paiva, B., McAfee, M., & Nugent, M. (2024) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2024.114376 · Cited by 5

Commercially available and recently approved hydrogels for clinical applications

Ovatlarnporn, C., & Basit, A. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-16168-1.00020-9 · Cited by 5

Graphene Oxide and Iron Sulfide Nanoparticle–Enhanced Chitosan/PVA Hydrogel for pH‐Responsive Cefadroxil Monohydrate Delivery System

Arshad, T., Hassan, S., Imran, Z., Afzal, S., Aminullah, S., & Mazhar, D. (2025) · Starch - Stärke · doi:10.1002/star.70055 · Cited by 4

Application and progress of smart hydrogels in regulating oxidative stress and improving the immune microenvironment in osteoarthritis

Wang, W., Jiang, J., Yu, H., & Sun, Y. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.167273 · Cited by 4

Leveraging Recent Advances in Self‐Assembled Polysaccharide‐Based Delivery Systems in Therapeutics: A Review of Key Properties and Strategies

Karmakar, P. D., & Pal, A. (2025) · Polymer Engineering and Science · doi:10.1002/pen.70120 · Cited by 4

Hyaluronic Acid Microgels as Sequential Drug Delivery Systems

Maier, M. A., Pieper, M. I., & Pich, A. (2025) · ACS Applied Bio Materials · doi:10.1021/acsabm.5c01272 · Cited by 4

Recent Advances in Stimuli-Responsive Iron Oxide Nanoparticles for Glioma Theranostics: Progress and Perspective

Li, Z., Peng, Y., Wang, Q., Zhou, H., & Fu, X. (2026) · ACS Nano Medicine · doi:10.1021/acsnanomed.5c00190 · Cited by 5

Targeted Delivery of Anticancer Therapeutics with Polymers by Harnessing Tumor Microenvironment Acidity

Shi, J., Ma, B., Zhang, Y., Yong, H., Li, Z., Sigen, A., Huang, X., & Zhou, D. (2023) · Chemistry of Materials · doi:10.1021/acs.chemmater.3c01151 · Cited by 4

Constant-pH MD Simulations of LipidsPreprint

Trollmann, M. F. W., Rossetti, P., & Böckmann, R. A. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.06.627182 · Cited by 4

An overview on developing the formulation to keep away the food impact on absorption

Magar, G. B., Laddha, U. D., Gaikwad, S. S., Wani, S. V., Dashputre, N. L., & Kakad, S. P. (2025) · Next Nanotechnology · doi:10.1016/j.nxnano.2025.100186 · Cited by 3

Liposomal Nanosystems Versus Hydrogels in the Prevention and Treatment of Metabolic Diseases

Eremia, M. C., Pavaloiu, R., Sha’at, F., Miu, D. M., Savoiu, G., & Raiciu, A. D. (2025) · Gels · doi:10.3390/gels11110917 · Cited by 3

Directional Liquid Transport Enabled pH‐Responsive Hierarchical Composite for Enhanced Wound Healing

Wang, B., Zhu, L., Lang, Y., Zhang, S., Chen, F., & Chang, M. (2026) · Advanced Healthcare Materials · doi:10.1002/adhm.202505497 · Cited by 3

Quantum dots incorporated hydrogels for biomedical applications: a review

Selvaraj, S., Subbarayan, R., & Chauhan, A. (2026) · Green Chemistry Letters and Reviews · doi:10.1080/17518253.2026.2670153 · Cited by 3

A Comprehensive Review on Transformative Role of Polymer in Advancing Pharmaceutical Drug Delivery System

Bole, S. S., Kothawade, S. N., Wagh, V. S., & Pande, V. V. (2024) · Current Applied Polymer Science · doi:10.2174/0124522716311647240613050008 · Cited by 3

Nanoparticles for the Delivery of Drugs to Specific Targets: An Update

Arif, I., Mohi-ud-din, N., Raza, S. N., Mir, R. H., & Khan, N. A. (2025) · Current Nanoscience · doi:10.2174/0115734137354461250312091944 · Cited by 2

Sustainable Nano-Hydroxyapatite from Eggshell Waste for pH-Responsive Doxycycline Delivery: In Situ Loading, Biphasic Release Kinetics, and Enhanced Antibacterial Activity against Pathogens

Mobarak, M. B., Hossain, M. S., Tabassum, S., Uddin, M. N., Hossain, M. S., Tanvir, N. I., Chowdhury, F., & Ahmed, S. (2026) · ACS Sustainable Resource Management · doi:10.1021/acssusresmgt.5c00575 · Cited by 2

Self‐Healing and pH‐Robust Hydrogels Enabled by Synergistic Supramolecular Interactions for Injectable Gastrointestinal Wound Repair

Xiang, L., Liu, L., Zhang, S., Zhang, Y., Zhao, Z., Chen, J., Zhang, J., Hu, J., Chen, Y., & Zeng, H. (2026) · Small · doi:10.1002/smll.202514672 · Cited by 2

Gastrointestinal tract environment and its implications on oral drug delivery

Patole, V., Deshkar, S. S., Baheti, R., & Giram, P. S. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-13774-7.00001-3 · Cited by 1

Zinc oxide nanoparticles reinforced drinkable hydrogels with antioxidative, antibacterial and gut microbiota regulation capacity for effective treatment of inflammatory bowel disease

Ding, B., Qu, W., Zou, Y., Liu, X., Liu, K., Tian, W., Ding, Z., Zhang, R., Liu, H., Yuan, Y., et al. (2026) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2026.140150 · Cited by 1

Changes in Functional Activity of Platelets under the Influence of Submicron Particles Based on Mesoporous Silica and pH-Sensitive Polymers

Иванов, А. Н., Kuznetsov, А. О., Loiko, D. D., Vlasicheva, Y. N., Ленгерт, Е. В., & Ermakov, A. V. (2024) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-025-06308-y · Cited by 1

Wrapping of Drug Assembly with Silica Layer and Confinement through Reversible Linkage with Copper(II) for Glutathione-responsive Nanocapsule

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pH-responsive nanocarriers for drug delivery

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