The DOI matches its Crossref record; 76 of the 76 references it cites were found in a registry or an index.
Review of hair follicle dermal cells
Open accessAbstract
Hair follicle stem cells in the epithelial bulge are responsible for the continual regeneration of the hair follicle during cycling. The bulge cells reside in a niche composed of dermal cells. The dermal compartment of the hair follicle consists of the dermal papilla and dermal sheath. Interactions between hair follicle epithelial and dermal cells are necessary for hair follicle morphogenesis during development and in hair reconstitution assays. Dermal papilla and dermal sheath cells express specific markers and possess distinctive morphology and behavior in culture. These cells can induce hair follicle differentiation in epithelial cells and are required in hair reconstitution assays either in the form of intact tissue, dissociated freshly prepared cells or cultured cells. This review will focus on hair follicle dermal cells since most therapeutic efforts to date have concentrated on this aspect of the hair follicle, with the idea that enriching hair-inductive dermal cell populations and expanding their number by culture while maintaining their properties, will establish an efficient hair reconstitution assay that could eventually have therapeutic implications.
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“Bulge stem cells are the origin of sebaceous glands, epidermal basal layer, and hair follicle formation, and they play an important role in the maintenance of the basic structure of the skin.”
From Morphological characteristics and notes of the skin in preclinical toxicity assessment (2023) · cites this paper as [33]
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“Dogs differ from these categories, although hair loss associated with hair cycle arrest is seen33, 36, 37.”
From Morphological characteristics and notes of the skin in preclinical toxicity assessment (2023) · cites this paper as [33]
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Cites
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Self-citationIto, M., Liu, Y., Yang, Z., Nguyen, J., Liang, F., Morris, R. J., & Cotsarelis, G. (2005) · Nature Medicine · doi:10.1038/nm1328 · Cited by 1,317
Self-citationCapturing and profiling adult hair follicle stem cells
Morris, R. J., Liu, Y., Marles, L., Yang, Z., Trempus, C., Li, S., Lin, J. S., Sawicki, J. A., & Cotsarelis, G. (2004) · Nature Biotechnology · doi:10.1038/nbt950 · Cited by 1,283
Self-citationWNT Signals Are Required for the Initiation of Hair Follicle Development
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Molecular Mechanisms Regulating Hair Follicle Development
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Sonic hedgehog signaling is essential for hair development
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A dermal niche for multipotent adult skin-derived precursor cells
Fernandes, K. J. L., McKenzie, I. A., Mill, P., Smith, K. M., Akhavan, M., Barnabé‐Heider, F., Biernaskie, J. A., Junek, A., Kobayashi, N., Toma, J. G., et al. (2004) · Nature Cell Biology · doi:10.1038/ncb1181 · Cited by 733
Induction of hair growth by implantation of cultured dermal papilla cells
Jahoda, C. A. B., Horne, K. A., & OLIVER, R. F. (1984) · Nature · doi:10.1038/311560a0 · Cited by 637
Molecular principles of hair follicle induction and morphogenesis
Schmidt‐Ullrich, R., & Paus, R. (2005) · BioEssays · doi:10.1002/bies.20184 · Cited by 557
Epithelial Stem Cells: A Folliculocentric View
Cotsarelis, G. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700376 · Cited by 554
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Items 401–418 of 418
The Muscarinic Acetylcholine Receptor in Dermal Papilla Cells Regulates Hair Growth
Yuen, G. K.-W., Leung, K. W., Lai, Q. W. S., Guo, M. S., Gao, X., Ho, J. Y. M., Chu, H. Y., & Tsim, K. W. K. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27041671 · Cited by 1
Hu, Y., Hu, K., Liang, J., Zhang, X., Li, H., Wu, J., & Huang, Q. (2026) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(26)61091-6
Kwack, M. H., Jung, M., & Sung, Y. K. (2026) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-026-00792-7
Garcı́a-Delgado, N., Lapeyre, A., & Ayats, J. (2026) · Cosmetics · doi:10.3390/cosmetics13030120
Luo, H., Wang, S., Wang, H., Geng, X., Xu, Q., Ye, L., Yang, L., Xiang, W., Wang, J., Li, C., et al. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.152552
Kang, D., Yoo, H., Lim, H., Kang, M. S., Kim, D.-Y., Kim, N., Kim, S., & Pak, P. J. (2026) · Applied Biological Chemistry · doi:10.1186/s13765-026-01102-4
Chi, W.-Y., Cruz, C. J. G., & Yang, C. Y. (2026) · Dermatologica Sinica · doi:10.4103/ds.ds-d-26-00021
Self-citationAn updated landscape of female pattern hair loss
ALVAREZ, C., Raynaud, E., Pavlovic, M., Thibaut, S., Michel, L., & Reygagne, P. (2026) · JAAD reviews. · doi:10.1016/j.jdrv.2026.06.011
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Siegfried, L. G., Zhou, L., Wang, J., Campbell, A., Hahn, J. M., Blackstone, B. N., Boyce, S. T., Supp, D. M., Powell, H. M., Andl, T., et al. (2026) · Acta Biomaterialia · doi:10.1016/j.actbio.2026.07.041 · Cited by 1
Hair Follicle Stem Cells: Emerging Physiology and Therapeutic Applications
Yang, S., Chen, Q., Li, H., & Yang, G. (2026) · Stem Cell Reviews and Reports · doi:10.1007/s12015-026-11199-1
Kim, H. S., Lee, E., Cho, D. Y., Um, M. Y., Ahn, J., & Jung, C. H. (2026) · Food Science and Biotechnology · doi:10.1007/s10068-026-02280-z
Seo, J., & Yun, J. (2026) · Frontiers in Veterinary Science · doi:10.3389/fvets.2026.1907027
Yuen, G. K.-W., Li, Y., Dong, T. T.-X., & Tsim, K. W. K. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27198781
Tsang, M. (2015) · Scholarship@Western (Western University)
Metadata
- Authors
- Yang, C.-C., & Cotsarelis, G.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Cotsarelis, George
- Venue
- Journal of Dermatological Science
- Publisher
- Elsevier BV
- Published
- 2010-01
- Volume
- 57
- Issue
- 1
- Pages
- 2-11
- ISSN
- 0923-1811 (ISSN-L)
- PMC
- PMC2818774
- OpenAlex
- W2150518449
- Cited by
- 418
- References
- 76
- Citations by year
- 2026: 17 · 2025: 22 · 2024: 23 · 2023: 36 · 2022: 33 · 2021: 31 · 2020: 40 · 2019: 29 · 2018: 32 · 2017: 25 · 2016: 26 · 2015: 21 · 2014: 24 · 2013: 15 · 2012: 26
- FWCI
- 2.28
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Dermatological Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Science Council
- National Cheng Kung University
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR055309, R01AR046837)
- Topics
- Health Sciences › Medicine › Dermatology › Hair Growth and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Health Sciences › Dentistry › General Dentistry › dental development and anomalies
- Keywords
- dermal papilla, dermal sheath, hair follicle stem cells, hair follicle regeneration, hair follicle morphogenesis, cell expansion
- MeSH terms
- AC133 Antigen, Actins, Alkaline Phosphatase, Animals, Glycoproteins, Humans, Models, Biological, Muscle, Smooth, Peptides, Regeneration, Serine Endopeptidases, Skin, Signal Transduction, Antigens, CD, Hair Follicle, Bone Morphogenetic Proteins, Wnt Proteins, Versicans
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