A microbiome study to explore the gut-skin axis in hidradenitis suppurativa
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Postbiotics can help the immune system learn to distinguish between innocuous and hazardous chemicals (immunological tolerance), preventing inappropriate immune responses to innocuous antigens and allergens by instructing the immune system and encouraging the growth of regulatory immune cells.
“Postbiotics can help the immune system learn to distinguish between innocuous and hazardous chemicals, a process known as immunological tolerance. Postbiotics aid in preventing inappropriate immune responses to innocuous antigens and allergens by instructing the immune system and encouraging the growth of regulatory immune cells.”
From Unveiling the therapeutic symphony of probiotics, prebiotics, and postbiotics in gut-immune harmony (2024) · cites this paper as [40]
Some postbiotics, such as bacteriocins and organic acids, have antibacterial capabilities that can impede the development and spread of dangerous pathogenic microorganisms in the digestive tract, reducing harmful microbes and protecting against infections.
“Some postbiotics, such as bacteriocins and organic acids, have antibacterial capabilities that can impede the development and spread of dangerous pathogenic microorganisms in the digestive tract.”
From Unveiling the therapeutic symphony of probiotics, prebiotics, and postbiotics in gut-immune harmony (2024) · cites this paper as [40]
SCFAs might boost the production of anti-inflammatory cytokines like interleukin-10 (IL-10) and encourage the formation of regulatory T cells (Tregs), resulting in a more normal immune response, which decreases inflammation and protects against autoimmune diseases.
“SCFAs, for instance, might boost the production of anti-inflammatory cytokines like interleukin-10 (IL-10) and encourage the formation of regulatory T cells (Tregs). This results in a more normal immune response, which in turn decreases inflammation and protects against autoimmune diseases.”
From Unveiling the therapeutic symphony of probiotics, prebiotics, and postbiotics in gut-immune harmony (2024) · cites this paper as [40]
Many postbiotics, including short-chain fatty acids (SCFAs) and peptidoglycans, have anti-inflammatory effects by regulating the activity of inflammatory immune cells and reducing the production of inflammatory cytokines, which is critical for protecting against chronic inflammation and keeping the gut in good working order.
“Many postbiotics, including short-chain fatty acids (SCFAs) and peptidoglycans, have anti-inflammatory effects. They can regulate the activity of inflammatory immune cells and reduce the production of inflammatory cytokines. This anti-inflammatory impact is critical for protecting against chronic inflammation and keeping the gut in good working order.”
From Unveiling the therapeutic symphony of probiotics, prebiotics, and postbiotics in gut-immune harmony (2024) · cites this paper as [40]
Postbiotics like short-chain fatty acids (SCFAs) and exopolysaccharides (EPS) can provide food for beneficial bacteria such as Lactobacilli and Bifidobacteria, boosting their development and activity, increasing their dominance, diversity and stability of the microbiome.
“Postbiotics like short-chain fatty acids (SCFAs) and exopolysaccharides (EPS) can provide food for beneficial bacteria.In the gut, such as Lactobacilli and Bifidobacterial.”
From Unveiling the therapeutic symphony of probiotics, prebiotics, and postbiotics in gut-immune harmony (2024) · cites this paper as [40]
Probiotics have been investigated for their ability to alleviate irritable bowel syndrome (IBS) symptoms, and certain probiotic strains like Bifidobacterium infantis and Lactobacillus plantarum can reduce inflammation and restore gut barrier function in IBS patients.
“Bloating, stomach discomfort, and constipation are all signs of irritable bowel syndrome (IBS), and probiotics have been investigated for their ability to alleviate these conditions. Inflammation can be reduced and gut barrier function can be restored in IBS patients by taking certain probiotic strains like Bifidobacterium infantis and Lactobacillus plantarum.”
From Unveiling the therapeutic symphony of probiotics, prebiotics, and postbiotics in gut-immune harmony (2024) · cites this paper as [40]
Both probiotics and postbiotics have demonstrated positive results in the treatment of inflammatory bowel disease (IBD), and disease severity and remission rates in people with ulcerative colitis and Crohn's disease have been linked to the use of certain probiotics, such as Saccharomyces boulardii and Bifidobacterium breve.
“Both probiotics and postbiotics have demonstrated positive results in the treatment of inflammatory bowel disease (IBD). Disease severity and remission rates in people with ulcerative colitis and Crohn’s disease have been linked to the use of certain probiotics, such as Saccharomyces boulardii and Bifidobacterium breve.”
From Unveiling the therapeutic symphony of probiotics, prebiotics, and postbiotics in gut-immune harmony (2024) · cites this paper as [40]
Evidence is mounting that probiotics and prebiotics may be useful in controlling autoimmune illnesses including rheumatoid arthritis and multiple sclerosis by altering the composition of the gut flora, affecting immunological dysregulation and potentially reducing autoimmune reactions.
“Evidence is mounting that probiotics and prebiotics may be useful in controlling autoimmune illnesses including rheumatoid arthritis and multiple sclerosis by altering the composition of the gut flora. These bioactive compounds affect immunological dysregulation and might reduce autoimmune reactions.”
From Unveiling the therapeutic symphony of probiotics, prebiotics, and postbiotics in gut-immune harmony (2024) · cites this paper as [40]
Probiotics and prebiotics improve glucose metabolism and decrease inflammation in diabetes patients by altering the makeup and function of the gut microbiota.
“Glycemic management and insulin sensitivity in people with type 2 diabetes have been studied as a possible benefit of probiotics and prebiotics. These bioactive compounds improve glucose metabolism and decrease inflammation in diabetes patients by altering the makeup and function of the gut microbiota.”
From Unveiling the therapeutic symphony of probiotics, prebiotics, and postbiotics in gut-immune harmony (2024) · cites this paper as [40]
Weight loss and enhancement of metabolic indicators in obese people have been linked to the use of probiotics such as Lactobacillus rhamnosus and Bifidobacterium lactis.
“Weight loss and enhancement of metabolic indicators in obese people have also been linked to the use of probiotics such as Lactobacillus rhamnosus and Bifidobacterium lactis.”
From Unveiling the therapeutic symphony of probiotics, prebiotics, and postbiotics in gut-immune harmony (2024) · cites this paper as [40]
The anti-inflammatory effects of postbiotics, especially short-chain fatty acids, are important in the regulation of inflammatory bowel disease (IBD) symptoms.
“The anti-inflammatory effects of postbiotics, especially short-chain fatty acids, are important in the regulation of inflammatory bowel disease (IBD) symptoms.”
From Unveiling the therapeutic symphony of probiotics, prebiotics, and postbiotics in gut-immune harmony (2024) · cites this paper as [40]
Probiotics and prebiotics can mitigate allergy diseases including eczema and rhinitis by regulating the balance between Th1 and Th2 immune responses.
“It has been investigated whether or not probiotics and prebiotics can mitigate allergy diseases including eczema and rhinitis. They are essential in the regulation of the balance between Th1 and Th2 immune responses, which are responsible for the development of allergic disorders.”
From Unveiling the therapeutic symphony of probiotics, prebiotics, and postbiotics in gut-immune harmony (2024) · cites this paper as [40]
Probiotics have been shown to alleviate symptoms and enhance gut health in irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and infectious diarrhea by restoring the natural balance of gut bacteria, decreasing inflammation, and strengthening the gut barrier.
“Irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and infectious diarrhea are all gastrointestinal conditions for which probiotics have been the subject of substantial research. They have been shown to alleviate symptoms and enhance gut health by restoring the natural balance of gut bacteria, decreasing inflammation, and strengthening the gut barrier.”
From Unveiling the therapeutic symphony of probiotics, prebiotics, and postbiotics in gut-immune harmony (2024) · cites this paper as [40]
Probiotics have potential for allergy prevention and management, especially in young children, by modulating immunological responses and fostering immune tolerance.
“There has been research on the potential of probiotics for allergy prevention and management, especially in young children. Inhibiting allergy reactions by modulating immunological responses and fostering immune tolerance may be one of their effects.”
From Unveiling the therapeutic symphony of probiotics, prebiotics, and postbiotics in gut-immune harmony (2024) · cites this paper as [40]
Probiotics and prebiotics have potential immunomodulatory effects including increased immune cell activity, increased synthesis of anti-inflammatory cytokines, and strengthened immunological responses, and may aid in immune system development and decrease the likelihood of infection.
“The potential immunomodulatory effects of probiotics and prebiotics have been studied. Increased immune cell activity, increased synthesis of anti-inflammatory cytokines, and strengthened immunological responses are all possible results of their use. Therefore, they may aid in immune system development and decrease the likelihood of infection.”
From Unveiling the therapeutic symphony of probiotics, prebiotics, and postbiotics in gut-immune harmony (2024) · cites this paper as [40]
Probiotics and prebiotics are being studied for their potential to improve mental health issues like depression, anxiety, and stress by creating neuroactive chemicals that affect mood and emotional well-being and hence modify the gut-brain axis.
“Probiotics and prebiotics are being studied for their potential to improve mental health issues like depression, anxiety, and stress. They may create neuroactive chemicals that affect mood and emotional well-being, and hence modify the gut-brain axis.”
From Unveiling the therapeutic symphony of probiotics, prebiotics, and postbiotics in gut-immune harmony (2024) · cites this paper as [40]
Probiotics show promise in preventing and treating vaginal infections including bacterial vaginosis and yeast infections by reestablishing the natural balance of bacteria there.
“Vaginal infections including bacterial vaginosis and yeast infections are common among women, and probiotics have shown promise in preventing and treating these conditions. Probiotics can keep your vagina healthy and cut down on the frequency of infections by reestablishing the natural balance of bacteria there.”
From Unveiling the therapeutic symphony of probiotics, prebiotics, and postbiotics in gut-immune harmony (2024) · cites this paper as [40]
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- Authors
- Lam, S. Y., Radjabzadeh, D., Eppinga, H., Nossent, Y. R. A., van der Zee, H. H., Kraaij, R., Konstantinov, S. R., Fuhler, G. M., Prens, E. P., Thio, H. B., & Peppelenbosch, M. P.
- Affiliations
- Erasmus MC (NL)
- Corresponding author
- Peppelenbosch, Maikel Petrus
- ORCID
- Venue
- Journal of Dermatological Science
- Publisher
- Elsevier BV
- Published
- 2021-03
- Volume
- 101
- Issue
- 3
- Pages
- 218-220
- ISSN
- 0923-1811 (ISSN-L)
- OpenAlex
- W3120051316
- Cited by
- 36
- References
- 10
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 6 · 2023: 11 · 2022: 7 · 2021: 3
- FWCI
- 5.97
- Type
- journal article
- Language
- en
- Open access
- green
- pure.eur.nl
- Licence
- Locations
- Journal of Dermatological Science (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion, cc-by-nc-nd)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Dermatology › Hidradenitis Suppurativa and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- hidradenitis suppurativa, gut-skin axis, gut microbiota, fecal microbiota, dysbiosis, hair follicle inflammation, bacterial metabolites, inflammatory skin diseases
- MeSH terms
- Gastrointestinal Microbiome, Adult, Feces, Female, Humans, Male, Middle Aged, Skin, Case-Control Studies, Hidradenitis Suppurativa, Young Adult, Healthy Volunteers, Dysbiosis
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