Cited by 36Hidradenitis Suppurativa and TreatmentsGut microbiota and healthDermatology and Skin Diseases

A microbiome study to explore the gut-skin axis in hidradenitis suppurativa

Open access
Lam, Suk Yee, Radjabzadeh, Djawad, Eppinga, Hester, Nossent, Yoena Roos Anna, van der Zee, Hessel Hindrik, Kraaij, Robert, Konstantinov, Sergey Rumenov, Fuhler, Gwenny Manel +3 more·2021·Journal of Dermatological Science

Integrity signals

Registry

Crossref · 10.1016/j.jdermsci.2020.12.008

Cites

10 of 10 references verified0 citation errors · 0 not checkable

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  • Postbiotics can help the immune system learn to distinguish between innocuous and hazardous chemicals (immunological tolerance), preventing inappropriate immune responses to innocuous antigens and allergens by instructing the immune system and encouraging the growth of regulatory immune cells.

    “Postbiotics can help the immune system learn to distinguish between innocuous and hazardous chemicals, a process known as immunological tolerance. Postbiotics aid in preventing inappropriate immune responses to innocuous antigens and allergens by instructing the immune system and encouraging the growth of regulatory immune cells.”
  • Some postbiotics, such as bacteriocins and organic acids, have antibacterial capabilities that can impede the development and spread of dangerous pathogenic microorganisms in the digestive tract, reducing harmful microbes and protecting against infections.

    “Some postbiotics, such as bacteriocins and organic acids, have antibacterial capabilities that can impede the development and spread of dangerous pathogenic microorganisms in the digestive tract.”
  • SCFAs might boost the production of anti-inflammatory cytokines like interleukin-10 (IL-10) and encourage the formation of regulatory T cells (Tregs), resulting in a more normal immune response, which decreases inflammation and protects against autoimmune diseases.

    “SCFAs, for instance, might boost the production of anti-inflammatory cytokines like interleukin-10 (IL-10) and encourage the formation of regulatory T cells (Tregs). This results in a more normal immune response, which in turn decreases inflammation and protects against autoimmune diseases.”
  • Many postbiotics, including short-chain fatty acids (SCFAs) and peptidoglycans, have anti-inflammatory effects by regulating the activity of inflammatory immune cells and reducing the production of inflammatory cytokines, which is critical for protecting against chronic inflammation and keeping the gut in good working order.

    “Many postbiotics, including short-chain fatty acids (SCFAs) and peptidoglycans, have anti-inflammatory effects. They can regulate the activity of inflammatory immune cells and reduce the production of inflammatory cytokines. This anti-inflammatory impact is critical for protecting against chronic inflammation and keeping the gut in good working order.”
  • Postbiotics like short-chain fatty acids (SCFAs) and exopolysaccharides (EPS) can provide food for beneficial bacteria such as Lactobacilli and Bifidobacteria, boosting their development and activity, increasing their dominance, diversity and stability of the microbiome.

    “Postbiotics like short-chain fatty acids (SCFAs) and exopolysaccharides (EPS) can provide food for beneficial bacteria.In the gut, such as Lactobacilli and Bifidobacterial.”

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Authors
Lam, S. Y., Radjabzadeh, D., Eppinga, H., Nossent, Y. R. A., van der Zee, H. H., Kraaij, R., Konstantinov, S. R., Fuhler, G. M., Prens, E. P., Thio, H. B., & Peppelenbosch, M. P.
Affiliations
Erasmus MC (NL)
Corresponding author
Peppelenbosch, Maikel Petrus
Venue
Journal of Dermatological Science
Publisher
Elsevier BV
Published
2021-03
Volume
101
Issue
3
Pages
218-220
ISSN
0923-1811 (ISSN-L)
OpenAlex
W3120051316
Cited by
36
References
10
Citations by year
2026: 1 · 2025: 8 · 2024: 6 · 2023: 11 · 2022: 7 · 2021: 3
FWCI
5.97
Type
journal article
Language
en
Open access
Locations
  • Journal of Dermatological Science (publishedVersion)
  • PubMed (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (publishedVersion, cc-by-nc-nd)
  • EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, cc-by-nc-nd)
Topics
  • Health Sciences › Medicine › Dermatology › Hidradenitis Suppurativa and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
Keywords
hidradenitis suppurativa, gut-skin axis, gut microbiota, fecal microbiota, dysbiosis, hair follicle inflammation, bacterial metabolites, inflammatory skin diseases
MeSH terms
Gastrointestinal Microbiome, Adult, Feces, Female, Humans, Male, Middle Aged, Skin, Case-Control Studies, Hidradenitis Suppurativa, Young Adult, Healthy Volunteers, Dysbiosis

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