Gut microbiota dysbiosis in a cohort of patients with psoriasis
Abstract
BACKGROUND: There is increasing evidence of the key role that the gut microbiota plays in inflammatory diseases. OBJECTIVES: To identify differences in the faecal microbial composition of patients with psoriasis compared with healthy individuals in order to unravel the microbiota profiling in this autoimmune disease. METHODS: 16S rRNA gene sequencing and bioinformatic analyses were performed with the total DNA extracted from the faecal microbiota of 19 patients with psoriasis and 20 healthy individuals from the same geographic location. RESULTS: Gut microbiota composition of patients with psoriasis displayed a lower diversity and different relative abundance of certain bacterial taxa compared with healthy individuals. CONCLUSIONS: The gut microbiota profile of patients with psoriasis displayed a clear dysbiosis that can be targeted for microbiome-based therapeutic approaches. What's already known about this topic? Psoriasis is a chronic inflammatory immune-mediated skin disease, the aetiology of which remains unclear. The human microbiota is a complex microbial community that inhabits our body and has been related with the maintenance of a healthy status. Several studies have focused on the skin microbiome and its connection with psoriasis although less attention has been focused on the potential role of the gut microbiota in psoriatic disease. What does this study add? This study unravels the gut microbiome dysbiosis present in a cohort of patients with psoriasis, compared with a healthy control group from the same geographical location. This study shows a lower bacterial diversity and different relative abundance of certain bacterial taxa in patients with psoriasis. We gain knowledge and insight into the microbiome alterations in psoriatic disease, opening new avenues for therapeutic approaches to reshape the human microbiome towards a healthy status.
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Psoriasis has been associated with the gut microbiome.
“psoriasis has been associated with the gut microbiome.”
From Probiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity (2021) · cites this paper as [100]
The gut flora of patients with psoriasis was severely dysregulated, the diversity of certain bacterial taxa reduced, and the abundance altered.
“the gut flora of patients with psoriasis was severely dysregulated, the diversity of certain bacterial taxa reduced, and the abundance altered.”
From Probiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity (2021) · cites this paper as [100]
The number of Firmicutes and Actinobacteria in the gut microbiota of patients with psoriasis increased significantly, but Proteobacteria and Bacteroides decreased.
“The number of Firmicutes and Actinobacteria in the gut microbiota of patients with psoriasis increased significantly, but Proteobacteria and Bacteroides decreased.”
From Probiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity (2021) · cites this paper as [100]
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- Authors
- Hidalgo‐Cantabrana, C., Gómez, J., Delgado, S., Requena‐López, S., Queiro‐Silva, R., Margolles, A., Coto, E., Sánchez, B., & Coto‐Segura, P.
- Affiliations
- Department of Microbiology and Biochemistry of Dairy Products Instituto de Productos Lácteos de Asturias‐Consejo Superior de Investigaciones Científicas (IPLA‐CSIC) Paseo Río Linares s/n 33300 Villaviciosa Asturias Spain
- Hospital Universitario Central de Asturias (ES)
- Consejo Superior de Investigaciones Científicas (ES)
- Dermatology andHospital Universitario Central de Asturias Oviedo Spain
- Department of Rheumatology Hospital Universitario Central de Asturias Oviedo Spain
- Hospital Vital Álvarez-Buylla (ES)
- Corresponding author
- Coto‐Segura, P.
- Venue
- British Journal of Dermatology
- Publisher
- Oxford University Press (OUP)
- Published
- 2019-07-18
- Volume
- 181
- Issue
- 6
- Pages
- 1287-1295
- ISSN
- 0007-0963 (ISSN-L)
- 1365-2133
- OpenAlex
- W2935560613
- Semantic Scholar
- 68506c59f7d1e1037eca06d4994743c4ab8f891a
- Cited by
- 236
- References
- 64
- Citations by year
- 2026: 21 · 2025: 34 · 2024: 58 · 2023: 31 · 2022: 28 · 2021: 40 · 2020: 17 · 2019: 6
- FWCI
- 7.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- British Journal of Dermatology (publishedVersion)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- Funders
- Fundación Científica Asociación Española Contra el Cáncer (PS‐2016)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- psoriasis, gut microbiota, dysbiosis, fecal microbiota, bacterial diversity, bacterial taxa, microbiota-based therapy, autoimmune skin disease, inflammatory diseases
- MeSH terms
- Gastrointestinal Microbiome, Adult, DNA, Bacterial, Feces, Female, Humans, Male, Middle Aged, Psoriasis, RNA, Ribosomal, 16S, Cohort Studies, Healthy Volunteers, Dysbiosis
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