Intra-islet glucagon-like peptide 1

Biology of Incretins: GLP-1 and GIP

Baggio, L. L., & Drucker, D. J. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.054 · Cited by 3,639 · see citing works

The Physiology of Glucagon-like Peptide 1

Holst, J. J. (2007) · Physiological Reviews · doi:10.1152/physrev.00034.2006 · Cited by 3,371 · see citing works

A role for glucagon-like peptide-1 in the central regulation of feeding

Turton, M. D., O'Shea, D., Gunn, I., Beak, S. A., Edwards, C. M. B., Meeran, K., Choi, S. J., Taylor, G. M., Heath, M. M., Lambert, P. D., et al. (1996) · Nature · doi:10.1038/379069a0 · Cited by 1,950 · see citing works

The Glucagon-Like Peptides

Kieffer, T. J., & Habener, J. F. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.6.0385 · Cited by 1,056 · see citing works

Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells

Ellingsgaard, H., Hauselmann, I., Schuler, B., Habib, A. M., Baggio, L. L., Meier, D. T., Eppler, E., Bouzakri, K., Wueest, S., Muller, Y. D., et al. (2011) · Nature Medicine · doi:10.1038/nm.2513 · Cited by 922 · see citing works

Interleukin-6 Increases Insulin-Stimulated Glucose Disposal in Humans and Glucose Uptake and Fatty Acid Oxidation In Vitro via AMP-Activated Protein Kinase

Carey, A. L., Steinberg, G. R., Macaulay, S. L., Thomas, W. G., Holmes, A. G., Ramm, G., Prelovsek, O., Hohnen-Behrens, C., Watt, M. J., James, D. E., et al. (2006) · Diabetes · doi:10.2337/db05-1404 · Cited by 898 · see citing works

Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas.

Mojsov, S., Weir, G. C., & Habener, J. F. (1987) · Journal of Clinical Investigation · doi:10.1172/jci112855 · Cited by 882 · see citing works

Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-translational processing

Mojsov, S., Heinrich, G., Wilson, I. B., Ravazzola, M., Orci, L., & Habener, J. F. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)67324-7 · Cited by 724 · see citing works

Glucagon‐like peptide‐1 cells in the gastrointestinal tract and pancreas of rat, pig and man

EISSELE, R., GÖKE, R., WILLEMER, S., HARTHUS, H. ‐., VERMEER, H., ARNOLD, R., & GÖKE, B. (1992) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1992.tb01464.x · Cited by 654 · see citing works

Hamster preproglucagon contains the sequence of glucagon and two related peptides

Bell, G. I., Santerre, R. F., & Mullenbach, G. T. (1983) · Nature · doi:10.1038/302716a0 · Cited by 649 · see citing works

How Obesity Causes Diabetes: Not a Tall Tale

Lazar, M. A. (2005) · Science · doi:10.1126/science.1104342 · Cited by 570 · see citing works

Physiology of Proglucagon Peptides: Role of Glucagon and GLP-1 in Health and Disease

Sandoval, D. A., & D'Alessio, D. A. (2015) · Physiological Reviews · doi:10.1152/physrev.00013.2014 · Cited by 498 · see citing works

Glucagon-Like Peptides GLP-1 and GLP-2, Predicted Products of the Glucagon Gene, Are Secreted Separately from Pig Small Intestine but Not Pancreas*

Ørskov, C., Holst, J. J., Knuhtsen, S., Baldissera, F. G. A., Poulsen, S. S., & Nielsen, O. V. (1986) · Endocrinology · doi:10.1210/endo-119-4-1467 · Cited by 484 · see citing works

Incretin therapies: highlighting common features and differences in the modes of action of glucagon‐like peptide‐1 receptor agonists and dipeptidyl peptidase‐4 inhibitors

Nauck, M. (2016) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.12591 · Cited by 429 · see citing works

Normalization of glucose concentrations and deceleration of gastric emptying after solid meals during intravenous glucagon-like peptide 1 in patients with type 2 diabetes

Meier, J. J., Gallwitz, B., Salmen, S., Goetze, O., Holst, J. J., Schmidt, W. E., & Nauck, M. A. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030049 · Cited by 369 · see citing works

GLP-1 Receptor Activation Indirectly Reduces Hepatic Lipid Accumulation But Does Not Attenuate Development of Atherosclerosis in Diabetic Male ApoE−/− Mice

Panjwani, N., Mulvihill, E. E., Longuet, C., Yusta, B., Campbell, J. E., Brown, T. J., Streutker, C., Holland, D., Cao, X., Baggio, L. L., et al. (2013) · Endocrinology · doi:10.1210/en.2012-1937 · Cited by 346 · see citing works

Insulinotropic hormone glucagon-like peptide-I(7-37) stimulation of proinsulin gene expression and proinsulin biosynthesis in insulinoma beta TC-1 cells

Fehmann, H. C., & Habener, J. F. (1992) · Endocrinology · doi:10.1210/endo.130.1.1309325 · Cited by 337 · see citing works

Evidence that Intestinal Glucagon-Like Peptide-1 Plays a Physiological Role in Satiety

Williams, D. L., Baskin, D. G., & Schwartz, M. W. (2009) · Endocrinology · doi:10.1210/en.2008-1045 · Cited by 300 · see citing works

Pancreatic preproglucagon cDNA contains two glucagon-related coding sequences arranged in tandem

Lund, P. K., Goodman, R. H., Dee, P. C., & Habener, J. F. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.2.345 · Cited by 295 · see citing works

Glucagonlike Peptide I (7–37) Actions on Endocrine Pancreas

Weir, G. C., Mojsov, S., Hendrick, G. K., & Habener, J. F. (1989) · Diabetes · doi:10.2337/diab.38.3.338 · Cited by 274 · see citing works

Interleukin-6 regulates pancreatic α-cell mass expansion

Ellingsgaard, H., Ehses, J. A., Hammar, E. B., Van Lommel, L., Quintens, R., Martens, G., Kerr-Conte, J., Pattou, F., Berney, T., Pipeleers, D., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801059105 · Cited by 269 · see citing works

A local glucagon-like peptide 1 (GLP-1) system in human pancreatic islets

Marchetti, P., Lupi, R., Bugliani, M., Kirkpatrick, C. L., Sebastiani, G., Grieco, F. A., Guerra, S. D., D’Aleo, V., Piro, S., Marselli, L., et al. (2012) · Diabetologia · doi:10.1007/s00125-012-2716-9 · Cited by 259 · see citing works

Differential Processing of Proglucagon by the Subtilisin-like Prohormone Convertases PC2 and PC3 to Generate either Glucagon or Glucagon-like Peptide

Rouillé, Y., Martin, S., & Steiner, D. F. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.44.26488 · Cited by 245 · see citing works

Role of prohormone convertases in the tissue-specific processing of proglucagon

Dhanvantari, S., Seidah, N. G., & BRUBAKER, P. L. (1996) · Molecular Endocrinology · doi:10.1210/mend.10.4.8721980 · Cited by 242 · see citing works

Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, inhibits glucagon secretion via somatostatin (receptor subtype 2) in the perfused rat pancreas

de Heer, J., Rasmussen, C. E., Coy, D. H., & Holst, J. J. (2008) · Diabetologia · doi:10.1007/s00125-008-1149-y · Cited by 238 · see citing works

Mammalian pancreatic preproglucagon contains three glucagon-related peptides.

Lopez, L. C., Frazier, M. L., Su, C. J., Kumar, A., & Saunders, G. F. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.18.5485 · Cited by 234 · see citing works

Proglucagon is processed to glucagon by prohormone convertase PC2 in alpha TC1-6 cells.

Rouillé, Y., Westermark, G. T., Martin, S. K., & Steiner, D. F. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.8.3242 · Cited by 221 · see citing works

GLP-1 Secretion Is Increased by Inflammatory Stimuli in an IL-6–Dependent Manner, Leading to Hyperinsulinemia and Blood Glucose Lowering

Kahles, F., Meyer, C., Möllmann, J., Diebold, S., Findeisen, H. M., Lebherz, C., Trautwein, C., Koch, A., Tacke, F., Marx, N., et al. (2014) · Diabetes · doi:10.2337/db14-0100 · Cited by 212 · see citing works

Complete Sequences of Glucagon-like Peptide-1 from Human and Pig Small Intestine

Ørskov, C., Bersani, M., Johnsen, A. H., Højrup, P., & Holst, J. J. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)51561-1 · Cited by 210 · see citing works

Pancreatic and intestinal processing of proglucagon in man

Ørskov, C., Holst, J. J., Poulsen, S. S., & Kirkegaard, P. O. (1987) · Diabetologia · doi:10.1007/bf00274797 · Cited by 210 · see citing works

Glucagon gene sequence. Four of six exons encode separate functional domains of rat pre-proglucagon

Heinrich, G., Gros, P., & Habener, J. F. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)89859-3 · Cited by 207 · see citing works

Glucose Ingestion Attenuates Interleukin‐6 Release from Contracting Skeletal Muscle in Humans

Febbraio, M. A., Steensberg, A., Keller, C., Starkie, R. L., Nielsen, H. B., Krustrup, P., Ott, P., Secher, N. H., & Pedersen, B. K. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.042374 · Cited by 202 · see citing works

Proglucagon processing in porcine and human pancreas.

Holst, J. J., Bersani, M., Johnsen, A. H., Kofod, H., Hartmann, B., & Ørskov, C. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32241-x · Cited by 181 · see citing works

Processing of proglucagon to GLP-1 in pancreatic α-cells: is this a paracrine mechanism enabling GLP-1 to act on β-cells?

Whalley, N., Pritchard, L. E., Smith, D. M., & White, A. E. (2011) · Journal of Endocrinology · doi:10.1530/joe-11-0094 · Cited by 178 · see citing works

Regulation of pancreatic PC1 and PC2 associated with increased glucagon-like peptide 1 in diabetic rats

Nie, Y., Nakashima, M., Brubaker, P. L., Li, Q., Perfetti, R., Jansen, E., Zambre, Y., PIPELEERS, D. G., & Friedman, T. C. (2000) · Journal of Clinical Investigation · doi:10.1172/jci7456 · Cited by 170 · see citing works

Lipopolysaccharides-Mediated Increase in Glucose-Stimulated Insulin Secretion: Involvement of the GLP-1 Pathway

Nguyen, A. T., Mandard, S., Dray, C., Deckert, V., Valet, P., Besnard, P., Drucker, D. J., Lagrost, L., & Grober, J. (2014) · Diabetes · doi:10.2337/db13-0903 · Cited by 161 · see citing works

Both amidated and nonamidated forms of glucagon-like peptide I are synthesized in the rat intestine and the pancreas.

Mojsov, S., Kopczynski, M. G., & Habener, J. F. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39030-1 · Cited by 159 · see citing works

Identification and processing of proglucagon in pancreatic islets

Patzelt, C., Tager, H. S., Carroll, R. J., & Steiner, D. F. (1979) · Nature · doi:10.1038/282260a0 · Cited by 146 · see citing works

Proprotein convertases (PC1/PC3 and PC2) in normal and neoplastic human tissues: their use as markers of neuroendocrine differentiation

Scopsi, L., Gullo, M., Rilke, F. O., Martin, S., & Steiner, D. F. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.1.7829629 · Cited by 141 · see citing works

Intraislet production of GLP-1 by activation of prohormone convertase 1/3 in pancreatic α-cells in mouse models of β-cell regeneration

Kilimnik, G., Kim, A., Steiner, D. F., Friedman, T. C., & Hara, M. (2010) · Islets · doi:10.4161/isl.2.3.11396 · Cited by 137 · see citing works

Localization of glucagon-like peptide (GLP) immunoreactants in human gut and pancreas using light and electron microscopic immunocytochemistry.

Varndell, I. M., Bishop, A. E., Sikri, K. L., UTTENTHAL, L. O., Bloom, S. R., & Polak, J. M. (1985) · Journal of Histochemistry & Cytochemistry · doi:10.1177/33.10.3900195 · Cited by 130 · see citing works

Conversion of proglucagon in pancreatic alpha cells: the major endproducts are glucagon and a single peptide, the major proglucagon fragment, that contains two glucagon-like sequences.

Patzelt, C., & Schiltz, E. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.16.5007 · Cited by 118 · see citing works

Comparison of the Effects of Various C-Terminal and NTerminal Fragment Peptides of Glucagon-Like Peptide-1 on Insulin and Glucagon Release from the Isolated Perfused Rat Pancreas*

Suzuki, S., Kawai, K., Ohashi, S., Mukai, H., & Yamashita, K. (1989) · Endocrinology · doi:10.1210/endo-125-6-3109 · Cited by 110 · see citing works

Improving function and survival of pancreatic islets by endogenous production of glucagon-like peptide 1 (GLP-1)

Wideman, R. D., Yu, I. L. Y., Webber, T. D., Verchere, C. B., Johnson, J. D., Cheung, A. T., & Kieffer, T. J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600655103 · Cited by 108 · see citing works

Regulation of Islet Hormone Release and Gastric Emptying by Endogenous Glucagon-Like Peptide 1 after Glucose Ingestion

Salehi, M., Vahl, T. P., & D'Alessio, D. A. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0605 · Cited by 108 · see citing works

Cell-specific post-translational processing of preproglucagon expressed from a metallothionein-glucagon fusion gene.

Drucker, D. J., Mojsov, S., & Habener, J. F. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)67561-1 · Cited by 105 · see citing works

Glucagon-like peptides 1 and 2 in health and disease: A review

Marathe, C. S., Rayner, C. K., Jones, K. L., & Horowitz, M. (2013) · Peptides · doi:10.1016/j.peptides.2013.01.014 · Cited by 100 · see citing works

Upregulation of alpha cell glucagon-like peptide 1 (GLP-1) in Psammomys obesus—an adaptive response to hyperglycaemia?

Hansen, A. M., Bodvarsdottir, T. B., Nordestgaard, D. N. E., Heller, R., Gotfredsen, C., Maedler, K., Fels, J., Holst, J. J., & Karlsen, A. E. (2011) · Diabetologia · doi:10.1007/s00125-011-2080-1 · Cited by 93 · see citing works

Stromal cell-derived factor-1 (SDF-1)/chemokine (C-X-C motif) receptor 4 (CXCR4) axis activation induces intra-islet glucagon-like peptide-1 (GLP-1) production and enhances beta cell survival

Liu, Z., Stanojevic, V., Avadhani, S., Yano, T., & Habener, J. F. (2011) · Diabetologia · doi:10.1007/s00125-011-2181-x · Cited by 93 · see citing works

Role of Endogenous GLP-1 and GIP in Beta Cell Compensatory Responses to Insulin Resistance and Cellular Stress

Vasu, S., Moffett, R. C., Thorens, B., & Flatt, P. R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101005 · Cited by 92 · see citing works

Proglucagon processing in islet and intestinal cell lines

Tucker, J. D., Dhanvantari, S., & Brubaker, P. L. (1996) · Regulatory Peptides · doi:10.1016/0167-0115(95)00167-0 · Cited by 88 · see citing works

The role of prohormone convertases in insulin biosynthesis: evidence for inherited defects in their action in man and experimental animals.

Steiner, D. F., Rouillé, Y., Gong, Q., Martin, S., Carroll, R., & Chan, S. J. (1996) · PubMed · Cited by 86 · see citing works

α-cell role in β-cell generation and regeneration

Habener, J. F., & Stanojevic, V. (2012) · Islets · doi:10.4161/isl.20500 · Cited by 79 · see citing works

Processing of Mouse Proglucagon by Recombinant Prohormone Convertase 1 and Immunopurified Prohormone Convertase 2 in Vitro

Rothenberg, M. E., Eilertson, C. D., Klein, K., Zhou, Y., Lindberg, I., McDonald, J. K., Mackin, R. B., & Noe, B. D. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.17.10136 · Cited by 76 · see citing works

Incretin Receptor Null Mice Reveal Key Role of GLP-1 but Not GIP in Pancreatic Beta Cell Adaptation to Pregnancy

Moffett, R. C., Vasu, S., Thorens, B., Drucker, D. J., & Flatt, P. R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096863 · Cited by 75 · see citing works

Intra-islet regulation of hormone secretion by glucagon-like peptide-1-(7--36) amide

Heller, R. S., & Aponte, G. W. (1995) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1995.269.6.g852 · Cited by 73 · see citing works

Glucose-Dependent Insulinotropic Peptide Stimulates Glucagon-Like Peptide 1 Production by Pancreatic Islets via Interleukin 6, Produced by α Cells

Timper, K., Dalmas, É., Dror, E., Rütti, S., Thienel, C., Sauter, N. S., Bouzakri, K., Bédat, B., Pattou, F. N., Kerr-Conte, J. A., et al. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.03.003 · Cited by 73 · see citing works

A Switch From Prohormone Convertase (PC)-2 to PC1/3 Expression in Transplanted α-Cells Is Accompanied by Differential Processing of Proglucagon and Improved Glucose Homeostasis in Mice

Wideman, R. D., Covey, S. D., Webb, G. C., Drucker, D. J., & Kieffer, T. J. (2007) · Diabetes · doi:10.2337/db07-0563 · Cited by 70 · see citing works

Molecular forms of glucagon‐like peptides in man

George, S. K., UTTENTHAL, L. O., Ghiglione, M., & Bloom, S. R. (1985) · FEBS Letters · doi:10.1016/0014-5793(85)80124-1 · Cited by 64 · see citing works

Basal Receptor Activation by Locally Produced Glucagon-Like Peptide-1 Contributes to Maintaining β-Cell Function

Masur, K., Tibaduiza, E. C., Chen, C., Ligon, B., & Beinborn, M. (2005) · Molecular Endocrinology · doi:10.1210/me.2004-0350 · Cited by 62 · see citing works

Immunohistochemical localization of glucagon-like peptide 1

Kauth, T., & Metz, J. (1987) · Histochemistry and Cell Biology · doi:10.1007/bf00500625 · Cited by 61 · see citing works

Glucagon-related peptides in the human gastrointestinal mucosa

Baldissera, F. G. A., & Holst, J. J. (1984) · Diabetologia · doi:10.1007/bf00252412 · Cited by 58 · see citing works

Glucose Dependence of the Regulated Secretory Pathway in αTC1-6 Cells

McGirr, R., Ejbick, C. E., Carter, D. E., Andrews, J. D., Nie, Y., Friedman, T. C., & Dhanvantari, S. (2005) · Endocrinology · doi:10.1210/en.2005-0402 · Cited by 55 · see citing works

Molecular Forms of Glucagon-Like Peptide-1 in Human Pancreas and Glucagonomas

UTTENTHEL, L. O., Ghiglione, M., George, S. K., Bishop, A. E., Polak, J. M., & Bloom, S. R. (1985) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-61-3-472 · Cited by 51 · see citing works

Levels of the conversion endoproteases PC1 (PC3) and PC2 distinguish between insulin-producing pancreatic islet β cells and non-β cells

Neerman‐Arbez, M., Cirulli, V., & Halban, P. A. (1994) · Biochemical Journal · doi:10.1042/bj3000057 · Cited by 51 · see citing works

Progressive change of intra‐islet GLP‐1 production during diabetes development

O’Malley, T. J., Fava, G. E., Zhang, Y., Fonseca, V. A., & Wu, H. (2014) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2534 · Cited by 47 · see citing works

Proglucagon Processing in an Islet Cell Line: Effects of PC1 Overexpression and PC2 Depletion1

Dhanvantari, S., & Brubaker, P. L. (1998) · Endocrinology · doi:10.1210/endo.139.4.5936 · Cited by 44 · see citing works

Endogenous GLP-1 as a key self-defense molecule against lipotoxicity in pancreatic islets

HUANG, C., YUAN, L., & CAO, S. (2015) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2015.2207 · Cited by 41 · see citing works

Interleukin-6 predicts inflammation-induced increase of Glucagon-like peptide-1 in humans in response to cardiac surgery with association to parameters of glucose metabolism

Lebherz, C., Kahles, F., Piotrowski, K., Vogeser, M., Foldenauer, A. C., Nassau, K., Kilger, E., Marx, N., Parhofer, K. G., & Lehrke, M. (2016) · Cardiovascular Diabetology · doi:10.1186/s12933-016-0330-8 · Cited by 39 · see citing works

The Role of Prohormone Convertases Pc1 (PC3) and PC2 in the Cell-Specific Processing of Proglucagon

Mineo, I., Matsumura, T., Shingu, R., Namba, M., Kuwajima, M., & Matsuzawa, Y. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.1236 · Cited by 28 · see citing works

Peptidomic Profiling of Secreted Products from Pancreatic Islet Culture Results in a Higher Yield of Full-length Peptide Hormones than Found using Cell Lysis Procedures

Taylor, S. W., Nikoulina, S. E., Andon, N. L., & Lowe, C. (2013) · Journal of Proteome Research · doi:10.1021/pr400115q · Cited by 26 · see citing works

Tumour Risk with Once-Weekly Glucagon-Like Peptide-1 Receptor Agonists in Type 2 Diabetes Mellitus Patients: A Systematic Review

Guo, X. N., Yang, Q., Dong, J., Liao, L., Zhang, W., & Liu, F. (2016) · Clinical Drug Investigation · doi:10.1007/s40261-016-0389-8 · Cited by 23 · see citing works

Release of glucagon-like peptide 1 immunoreactivity from the perfused rat pancreas

Shima, K., Hirota, M., Ohboshi, C., Sato, M., & Nishino, T. (1987) · European Journal of Endocrinology · doi:10.1530/acta.0.1140531 · Cited by 19 · see citing works

A large molecular form of glucagon-like peptide-1(GLP-1) immunoreactivity is co-released with glucagon from pancreas by arginine in normal subjects

Hirota, M., Shimizu, I., Ohboshi, C., Nishino, T., & Shima, K. (1987) · Clinica Chimica Acta · doi:10.1016/0009-8981(87)90349-4 · Cited by 17 · see citing works

Alpha cell regulation of beta cell function

Moede, T., Leibiger, I., & Berggren, P. (2020) · Diabetologia · doi:10.1007/s00125-020-05196-3 · Cited by 103 · see citing works

GLP-1 Receptor in Pancreatic α-Cells Regulates Glucagon Secretion in a Glucose-Dependent Bidirectional Manner

Zhang, Y., Parajuli, K. R., Fava, G. E., Gupta, R., Xu, W., Nguyen, L. U., Zakaria, A. F., Fonseca, V. A., Wang, H., Mauvais-Jarvis, F., et al. (2019) · Diabetes · doi:10.2337/db18-0317 · Cited by 104 · see citing works

Dissecting the Physiology and Pathophysiology of Glucagon-Like Peptide-1

Paternoster, S., & Falasca, M. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00584 · Cited by 91 · see citing works

Contribution of Oxidative Stress and Impaired Biogenesis of Pancreatic β-Cells to Type 2 Diabetes

Ježek, P., Jabůrek, M., & Plecitá‐Hlavatá, L. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2018.7656 · Cited by 88 · see citing works

New Insights into Beta-Cell GLP-1 Receptor and cAMP Signaling

Tomás, A., Jones, B. J., & Leech, C. A. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.08.009 · Cited by 83 · see citing works

Human islets contain a subpopulation of glucagon-like peptide-1 secreting α cells that is increased in type 2 diabetes

Campbell, S. A., Golec, D. P., Hubert, M., Johnson, J., Salamon, N., Barr, A., MacDonald, P. E., Philippaert, K., & Light, P. E. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101014 · Cited by 83 · see citing works

Gut-pancreas-liver Axis as a target for treatment of NAFLD/NASH

Svegliati-Baroni, G., Patrício, B., Lioci, G., Macedo, M. P., & Gastaldelli, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165820 · Cited by 66 · see citing works

Irisin and Incretin Hormones: Similarities, Differences, and Implications in Type 2 Diabetes and Obesity

Marrano, N., Biondi, G., Borrelli, A., Cignarelli, A., Perrini, S., Laviola, L., Giorgino, F., & Natalicchio, A. (2021) · Biomolecules · doi:10.3390/biom11020286 · Cited by 56 · see citing works

Intra-islet GLP-1, but not CCK, is necessary for β-cell function in mouse and human islets

de Souza, A. H., Tang, J., Yadev, A. K., Saghafi, S. T., Kibbe, C. R., Linnemann, A. K., Merrins, M. J., & Davis, D. B. (2020) · Scientific Reports · doi:10.1038/s41598-020-59799-2 · Cited by 52 · see citing works

Superior metabolic improvement of polycystic ovary syndrome traits after GLP1-based multi-agonist therapy

Sanchez-Garrido, M. A., Serrano-López, V., Ruíz-Pino, F., Vazquez, M. J., Rodríguez-Martín, A., Torres, E., Velasco, I., Rodríguez, A., Chicano‐Gálvez, E., Mora-Ortiz, M., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-52898-y · Cited by 47 · see citing works

Astragalus polysaccharide alleviates type 2 diabetic rats by reversing the glucose transporters and sweet taste receptors/GLP-1/GLP-1 receptor signaling pathways in the intestine-pancreatic axis

Yang, Z., Wang, Y., & Chen, S. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.104310 · Cited by 45 · see citing works

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Hamza, A. A., Fikry, E. M., Hassan, W. A., & Amin, A. (2018) · Scientific Reports · doi:10.1038/s41598-018-28029-1 · Cited by 41 · see citing works

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Galsgaard, K. D. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9124049 · Cited by 39 · see citing works

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Guida, C., & Ramracheya, R. D. (2020) · Clinical Medicine Insights Endocrinology and Diabetes · doi:10.1177/1179551419892985 · Cited by 38 · see citing works

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EL, K. M., Capozzi, M. E., & Campbell, J. E. (2020) · Endocrinology · doi:10.1210/endocr/bqaa169 · Cited by 31 · see citing works

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Nakashima, K., Kaneto, H., Shimoda, M., Kimura, T., & Kaku, K. (2018) · Scientific Reports · doi:10.1038/s41598-018-21751-w · Cited by 28 · see citing works

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Qiao, L., Saget, S., Lu, C., Zang, T., Dzyuba, B., Hay, W. W., & Shao, J. (2022) · Diabetes · doi:10.2337/db21-0923 · Cited by 20 · see citing works

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Marinho, T. D. S., Borges, C. C., Águila, M. B., & Mandarim‐de‐Lacerda, C. A. (2019) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2019.107497 · Cited by 15 · see citing works

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Zhang, Y., Wu, M., Htun, W., Dong, E. W., Mauvais‐Jarvis, F., Fonseca, V. A., & Wu, H. (2017) · Scientific Reports · doi:10.1038/s41598-017-08271-9 · Cited by 13 · see citing works

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Liu, P., Song, J., Liu, H., Yan, F., He, T.-Y., Wang, L.-S., Shen, H.-Y., Hou, X.-G., & Chen, L. (2018) · Endocrine · doi:10.1007/s12020-018-1684-3 · Cited by 13 · see citing works

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Zheng, H., López‐Ferreras, L., Krieger, J.-P., Fasul, S., Salazar, V. C., Pena, N. V., Skibicka, K. P., & Rinaman, L. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101631 · Cited by 12 · see citing works

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Mof regulates glucose level via altering different α-cell subset mass and intra-islet glucagon-like peptide-1, glucagon secretion

Guo, X., Li, D., Song, J., Yang, Q., Wang, M., Yang, Y., Wang, L., Hou, X., Chen, L., & Li, X. (2020) · Metabolism · doi:10.1016/j.metabol.2020.154290 · Cited by 9 · see citing works

Diet-induced obesity enhances postprandial glucagon-like peptide-1 secretion in Wistar rats, but not in diabetic Goto-Kakizaki rats

Pinyo, J., Hara, H., & Hira, T. (2020) · British Journal Of Nutrition · doi:10.1017/s000711452000433x · Cited by 8 · see citing works

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Wang, R., Mijiti, S., Xu, Q., Liu, Y., Deng, C., Huang, J., Yasheng, A., Tian, Y., Cao, Y., & Su, Y. (2024) · Obesity Surgery · doi:10.1007/s11695-024-07378-z · Cited by 6 · see citing works

Noncanonical Regulation of cAMP-dependent Insulin Secretion and Its Implications in Type 2 Diabetes

Ramanadham, S., Turk, J., & Bhatnagar, S. (2023) · Comprehensive Physiology · doi:10.1002/j.2040-4603.2023.tb00278.x · Cited by 10 · see citing works

Differentiation of Human Deceased Donor, Adipose-Derived, Mesenchymal Stem Cells into Functional Beta Cells

Rao, P. N., Deo, D. D., & Marchioni, M. A. (2020) · Journal of Stem Cells and Regenerative Medicine · doi:10.46582/jsrm.1602010 · Cited by 6 · see citing works

Noncanonical Regulation of cAMP‐Dependent Insulin Secretion and Its Implications in Type 2 Diabetes

Ramanadham, S., TURK, J. W., & Bhatnagar, S. (2023) · Comprehensive physiology · doi:10.1002/cphy.c220031 · Cited by 6 · see citing works

Peptidylglycine monooxygenase activity of monomeric species of growth hormone

Donlon, J., & Ryan, P. (2019) · Heliyon · doi:10.1016/j.heliyon.2019.e02436 · Cited by 5 · see citing works

Obesity: The Crossroads of Opinion, Knowledge, and Opportunity

Ruyatkina, L. A., & Ruyatkin, D. S. (2020) · Meditsinskiy sovet = Medical Council · doi:10.21518/2079-701x-2020-7-108-120 · Cited by 5 · see citing works

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Tyurenkov, I. N., Faibisovich, T. I., Дубровина, М. А., Bakulin, D. A., & Куркин, Д. В. (2023) · Успехи физиологических наук · doi:10.31857/s030117982302008x · Cited by 3 · see citing works

Immunohistochemical study on the expression of biologically active substances in the endocrine pancreas of the European bison

Mozel, S., Szymańczyk, S., Krzysiak, M. K., Puzio, I., Zacharko-Siembida, A., & Arciszewski, M. B. (2020) · Polish Journal of Veterinary Sciences · doi:10.24425/pjvs.2020.133650 · Cited by 1 · see citing works

Huanglian-Renshen-Decoction Maintains Islet β-Cell Identity in T2DM Mice through Regulating GLP-1 and GLP-1R in Both Islet and Intestine

Wu, W., Gao, F., Tang, Y., Wang, H.-Z., Dong, H., Lu, F., & Yuan, F. (2024) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-024-3915-1 · Cited by 1 · see citing works

Effects of Linagliptin on Pancreatic α Cells of Type 1 Diabetic Mice

Zhang, Y., Fava, G. E., Wu, M., Htun, W., Klein, T., Fonseca, V. A., & Wu, H. (2017) · Journal of the Endocrine Society · doi:10.1210/js.2017-00253 · Cited by 1 · see citing works

Glucagon-like peptide-1 and beta cell glucose sensitivity - a glucose ramp study in mice

Åhrén, B. (2021) · Peptides · doi:10.1016/j.peptides.2021.170650 · Cited by 1 · see citing works

Generation and use of new tools for the characterisation of gut hormone receptors

Biggs, E. K. (2018) · Apollo (University of Cambridge) · doi:10.17863/cam.37487

The effects of (a combined exercise programme aerobic and resistance) on blood glucose and incretin hormone that could control the diabetes in type 2 diabetes.

Alsubaie, N., Alharbi, B., Sahota, T. S., & Taylor, M. J. (2019) · DMU Open Research Archive (De Montfort University) · doi:10.4172/2167-0943.1000246

Huanglian-Renshen-Decoction maintains islet β cell identity in T2DM mice through regulating GLP-1/GLP-1R signaling pathway in both islet and intestinePreprint

Wu, W. B., Gao, F., Tang, Y. H., Wang, H. Z., Dong, H., Lu, F., & Yuan, F. (2023) · Research Square · doi:10.21203/rs.3.rs-2516174/v1

A new link between insulinoma and congenital glucose-galactose malabsorption

Prinzi, A., Kuiper, J., van der Wiel, A. M., van Velthuysen, M. F., van Cruchten, R. T. P., Brosens, L. A. A., de Herder, W. W., & Hofland, J. (2025) · Endocrine Oncology · doi:10.1530/eo-25-0030

Endoplasmic reticulum as a pharmacological target in metabolic diseases

Silva-Veiga, F. M., Fernandes‐da‐Silva, A., Souza-Tavares, H., Santana-Oliveira, D. A., & Souza‐Mello, V. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-27370-4.00015-9

Intra‐Islet Paracrine Regulation of Glucagon Secretion During Hypoglycemia, Euglycemia, and Hyperglycemia

FATEHI, S., Rocheleau, J. V., & Riddell, M. C. (2026) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.70384

Physiology and therapeutic insights of incretins in 2026: An update

Hirlemann, M., Phan, A., Carette, C., Beyec, J. L., Ledoux, S., & Gall, M. L. (2026) · Cahiers de Nutrition et de Diététique · doi:10.1016/j.cnd.2026.08.106

Evidence for the existence and potential roles of intra-islet glucagon-like peptide-1

Campbell, S. A., Johnson, J., & Light, P. (2021) · Islets · doi:10.1080/19382014.2021.1889941 · Cited by 31 · see citing works

Pancreatic Glucagon-Like Peptide 1: What is known?

Fava, G. E. (2014) · Journal of Diabetes & Metabolism · doi:10.4172/2155-6156.1000397 · Cited by 3 · see citing works

The History of GLP-1 and the Debate Regarding Its Tissue-Specific Expression

Fava, G. E., & Wu, H. (2014)

Locally produced GLP-1 and its relevance for regulation and islet function in the pancreas

Klöpper, N., & Düfer, M. (2024) · Diabetologie und Stoffwechsel · doi:10.1055/s-0044-1785336

A local glucagon-like peptide 1 (GLP-1) system in human pancreatic islets

Marchetti, P., Lupi, R., Bugliani, M., Kirkpatrick, C. L., Sebastiani, G., Grieco, F. A., Guerra, S. D., D’Aleo, V., Piro, S., Marselli, L., et al. (2012) · Diabetologia · doi:10.1007/s00125-012-2716-9 · Cited by 259 · see citing works