Evidence that Intestinal Glucagon-Like Peptide-1 Plays a Physiological Role in Satiety

Biology of Incretins: GLP-1 and GIP

Baggio, L. L., & Drucker, D. J. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.054 · Cited by 3,639 · see citing works

A role for glucagon-like peptide-1 in the central regulation of feeding

Turton, M. D., O'Shea, D., Gunn, I., Beak, S. A., Edwards, C. M. B., Meeran, K., Choi, S. J., Taylor, G. M., Heath, M. M., Lambert, P. D., et al. (1996) · Nature · doi:10.1038/379069a0 · Cited by 1,950 · see citing works

Cholecystokinin decreases food intake in rats.

Gibbs, J., Young, R. C., & Smith, G. P. (1973) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0034870 · Cited by 1,498 · see citing works

Distribution of glucagon-like peptide-1 and other preproglucagon-derived peptides in the rat hypothalamus and brainstem

Larsen, P. J., Tang-Christensen, M., Holst, J. J., & Ørskov, C. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00434-4 · Cited by 663 · see citing works

The inhibitory effects of peripheral administration of peptide YY3–36 and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal–brainstem–hypothalamic pathway

Abbott, C. R., Monteiro, M. P., Small, C. J., Sajedi, A., Smith, K. L., Parkinson, J. R. C., Ghatei, M. A., & Bloom, S. R. (2005) · Brain Research · doi:10.1016/j.brainres.2005.03.011 · Cited by 599 · see citing works

A Recombinant Human Glucagon-Like Peptide (GLP)-1–Albumin Protein (Albugon) Mimics Peptidergic Activation of GLP-1 Receptor–Dependent Pathways Coupled With Satiety, Gastrointestinal Motility, and Glucose Homeostasis

Baggio, L. L., Huang, Q., Brown, T. J., & Drucker, D. J. (2004) · Diabetes · doi:10.2337/diabetes.53.9.2492 · Cited by 388 · see citing works

Gastrointestinal satiety signals II. Cholecystokinin

Moran, T. H., & Kinzig, K. P. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00434.2003 · Cited by 346 · see citing works

Peripheral Oxyntomodulin Reduces Food Intake and Body Weight Gain in Rats

Dakin, C. L., Small, C. J., Batterham, R. L., Neary, N. M., Cohen, M. A., Patterson, M., Ghatei, M. A., & Bloom, S. R. (2004) · Endocrinology · doi:10.1210/en.2003-1338 · Cited by 342 · see citing works

Gastrointestinal Satiety Signals

Chaudhri, O. B., Salem, V., Murphy, K. G., & Bloom, S. R. (2007) · Annual Review of Physiology · doi:10.1146/annurev.physiol.70.113006.100506 · Cited by 340 · see citing works

Glucagon-like peptide-1 (GLP-1) receptors expressed on nerve terminals in the portal vein mediate the effects of endogenous GLP-1 on glucose tolerance in rats

Vahl, T. P., Tauchi, M., Durler, T. S., Elfers, E. E., Fernandes, T. M., Bitner, R. D., Ellis, K. S., Woods, S. C., Seeley, R. J., Herman, J. P., et al. (2007) · Endocrinology · doi:10.1210/en.2006-0153 · Cited by 318 · see citing works

Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage

Knauf, C. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25764 · Cited by 310 · see citing works

Peripheral Exendin-4 and Peptide YY3–36 Synergistically Reduce Food Intake through Different Mechanisms in Mice

Talsania, T., Anini, Y., Siu, S., Drucker, D. J., & Brubaker, P. L. (2005) · Endocrinology · doi:10.1210/en.2005-0473 · Cited by 306 · see citing works

Receptor gene expression of glucagon-like peptide-1, but not glucose-dependent insulinotropic polypeptide, in rat nodose ganglion cells

Nakagawa, A., 佐竹, 英., Nakabayashi, H., Nishizawa, M., Furuya, K., Nakano, S., Kigoshi, T., Nakayama, K., & Uchida, K. (2004) · Autonomic Neuroscience · doi:10.1016/j.autneu.2003.11.001 · Cited by 290 · see citing works

Vagal afferent and efferent contributions to the inhibition of food intake by cholecystokinin

Moran, T. H., Baldessarini, A. R., Salorio, C. F., Lowery, T. R., & Schwartz, G. J. (1997) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1997.272.4.r1245 · Cited by 236 · see citing works

Leptin Regulation of the Anorexic Response to Glucagon-Like Peptide-1 Receptor Stimulation

Williams, D. L., Baskin, D. G., & Schwartz, M. W. (2006) · Diabetes · doi:10.2337/db06-0558 · Cited by 178 · see citing works

Tissue distribution of rat glucagon receptor and GLP-1 receptor gene expression1This work was supported by a grant from the Crohn's and Colitis Foundation of America.1

Dunphy, J. L., Taylor, R. G., & Fuller, P. J. (1998) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(98)00096-3 · Cited by 165 · see citing works

Peripheral versus central effects of glucagon-like peptide-1 receptor agonists on satiety and body weight loss in Zucker obese rats

de Fonseca, F. R., Navarro, M. A., Álvarez, E., Roncero, I., Chowen, J. A., Maestre, O., de Heras, R. G., Muñoz, R. M., Eng, J., & Blázquez, E. (2000) · Metabolism · doi:10.1053/meta.2000.6251 · Cited by 157 · see citing works

Antiobesity action of peripheral exenatide (exendin-4) in rodents: effects on food intake, body weight, metabolic status and side-effect measures

Mack, C. M., Moore, C. X., Jodka, C. M., Bhavsar, S., Wilson, J. K., Hoyt, J. A., Roan, J. L., Vu, C., Laugero, K. D., Parkes, D. G., et al. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803284 · Cited by 137 · see citing works

Oxyntomodulin Differentially Affects Glucagon-Like Peptide-1 Receptor β-Arrestin Recruitment and Signaling through Gα

Jørgensen, R., Kubale, V., Vrecl, M., Schwartz, T. W., & Elling, C. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.120006 · Cited by 132 · see citing works

Signals that influence food intake and body weight

WOODS, S. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.08.060 · Cited by 131 · see citing works

Intravenous infusion of glucagon-like peptide-1 potently inhibits food intake, sham feeding, and gastric emptying in rats

Chelikani, P. K., Haver, A. C., & Reidelberger, R. D. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00870.2004 · Cited by 128 · see citing works

The GLP-1 agonist exendin-4 reduces food intake in nonhuman primates through changes in meal size

Scott, K. A., & Moran, T. H. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00323.2007 · Cited by 113 · see citing works

CCK-receptor antagonists attenuate suppression of sham feeding by intestinal nutrients

Yox, D. P., Brenner, L., & Ritter, R. C. (1992) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1992.262.4.r554 · Cited by 95 · see citing works

Stable expression of the rat GLP-I receptor in CHO cells: Activation and binding characteristics utilizing GLP-I(7–36)-amide, oxyntomodulin, exendin-4, and exendin(9–39)

Fehmann, H. C., Jiang, J., Schweinfurth, J., Wheeler, M. B., BOYD, A. E., & Göke, B. (1994) · Peptides · doi:10.1016/0196-9781(94)90204-6 · Cited by 85 · see citing works

Oxyntomodulin increases intrinsic heart rate in mice independent of the glucagon-like peptide-1 receptor

Sowden, G. L., Drucker, D. J., Weinshenker, D., & Swoap, S. J. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00405.2006 · Cited by 57 · see citing works

Cholecystokinin conditions flavor preferences in rats

Pérez, C., & Sclafani, A. J. (1991) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1991.260.1.r179 · Cited by 44 · see citing works

Type A CCK receptors mediate satiety effects of intestinal nutrients

Brenner, L. (1996) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(95)02210-4 · Cited by 40 · see citing works

Effects of peripheral CCK receptor blockade on food intake in rats

Reidelberger, R. D., Castellanos, D. A., & Hulce, M. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00176.2003 · Cited by 36 · see citing works

Introduction to the reviews on peptides and the control of food intake and body weight

Smith, G. P. (1999) · Neuropeptides · doi:10.1054/npep.1999.0056 · Cited by 33 · see citing works

The caudal brainstem is sufficient to mediate inhibition of gastric emptying by peripheral glucagon-like-peptide-1 receptor activation.

Hayes, M. R., & Grill, H. J. (2007) · Appetite · doi:10.1016/j.appet.2007.03.086 · Cited by 1 · see citing works

Untitled work

Merchenthaler (1999) · doi:10.1002/(sici)1096-9861(19990111)403:2

The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss

Secher, A., Jelsing, J., Baquero, A. F., Hecksher-Sørensen, J., Cowley, M. A., Dalbøge, L. S., Hansen, G., Grove, K. L., Pyke, C., Raun, K., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci75276 · Cited by 961 · see citing works

Neurobiology of food intake in health and disease

Morton, G. J., Meek, T. H., & Schwartz, M. W. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3745 · Cited by 748 · see citing works

Ghrelin, CCK, GLP-1, and PYY(3–36): Secretory Controls and Physiological Roles in Eating and Glycemia in Health, Obesity, and After RYGB

Steinert, R. E., Feinle-Bisset, C., Asarian, L., Horowitz, M., Beglinger, C., & Geary, N. (2017) · Physiological Reviews · doi:10.1152/physrev.00031.2014 · Cited by 578 · see citing works

Impact of postprandial glycaemia on health and prevention of disease

Blaak, E. E., Antoine, J. M., Benton, D., Björck, I., Bozzetto, L., Brouns, F. J. P. H., Diamant, M., Dye, L., Hulshof, T. G., Holst, J. J., et al. (2012) · Obesity Reviews · doi:10.1111/j.1467-789x.2012.01011.x · Cited by 487 · see citing works

GLP-1 Receptor Activation Modulates Appetite- and Reward-Related Brain Areas in Humans

van Bloemendaal, L., IJzerman, R. G., ten Kulve, J. S., Barkhof, F., Konrad, R. J., Drent, M. L., Veltman, D. J., & Diamant, M. (2014) · Diabetes · doi:10.2337/db14-0849 · Cited by 427 · see citing works

Peripheral and central GLP-1 receptor populations mediate the anorectic effects of peripherally administered GLP-1 receptor agonists, liraglutide and exendin-4

Kanoski, S. E., Fortin, S. M., Arnold, M., Grill, H. J., & Hayes, M. R. (2011) · Endocrinology · doi:10.1210/en.2011-0174 · Cited by 347 · see citing works

Leptin and the Central Nervous System Control of Glucose Metabolism

Morton, G. J., & Schwartz, M. W. (2011) · Physiological Reviews · doi:10.1152/physrev.00007.2010 · Cited by 338 · see citing works

Effects of glucagon-like peptide 1 on appetite and body weight: focus on the CNS

van Bloemendaal, L., ten Kulve, J. S., la Fleur, S. E., Ijzerman, R. G., & Diamant, M. (2014) · Journal of Endocrinology · doi:10.1530/joe-13-0414 · Cited by 312 · see citing works

Bile acid signaling pathways from the enterohepatic circulation to the central nervous system

Mertens, K. L., Kalsbeek, A., Soeters, M. R., & Eggink, H. M. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00617 · Cited by 287 · see citing works

Regulation of Food Intake, Energy Balance, and Body Fat Mass: Implications for the Pathogenesis and Treatment of Obesity

Guyenet, S. J., & Schwartz, M. W. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2525 · Cited by 281 · see citing works

Knockdown of GLP-1 Receptors in Vagal Afferents Affects Normal Food Intake and Glycemia

Krieger, J.-P., Arnold, M., Pettersen, K. G., Lossel, P., Langhans, W., & Lee, S. J. (2016) · Diabetes · doi:10.2337/db15-0973 · Cited by 269 · see citing works

Parabrachial CGRP Neurons Control Meal Termination

Campos, C. A., Bowen, A. J., Schwartz, M. W., & Palmiter, R. D. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.04.006 · Cited by 262 · see citing works

Glucagon-Like Peptide 1 Receptors in Nucleus Accumbens Affect Food Intake

Dossat, A. M., Lilly, N., Kay, K. E., & Williams, D. L. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3262-11.2011 · Cited by 256 · see citing works

Role of the vagus nerve in the development and treatment of diet‐induced obesity

de Lartigue, G. (2016) · The Journal of Physiology · doi:10.1113/jp271538 · Cited by 238 · see citing works

Dietary Proteins as Determinants of Metabolic and Physiologic Functions of the Gastrointestinal Tract

Jahan-Mihan, A., Luhovyy, B. L., Khoury, D. T. D. E., & Anderson, G. H. (2011) · Nutrients · doi:10.3390/nu3050574 · Cited by 237 · see citing works

Secretin-Activated Brown Fat Mediates Prandial Thermogenesis to Induce Satiation

Li, Y., Schnabl, K., Gabler, S.-M., Willershäuser, M., Reber, J., Karlas, A., Laurila, S., Lahesmaa, M., u Din, M., Bast-Habersbrunner, A., et al. (2018) · Cell · doi:10.1016/j.cell.2018.10.016 · Cited by 228 · see citing works

Endogenous Hindbrain Glucagon-Like Peptide-1 Receptor Activation Contributes to the Control of Food Intake by Mediating Gastric Satiation Signaling

Hayes, M. R., Bradley, L. E., & Grill, H. J. (2009) · Endocrinology · doi:10.1210/en.2008-1479 · Cited by 228 · see citing works

GLP-1 and energy balance: an integrated model of short-term and long-term control

Barrera, J. G., Sandoval, D. A., D'Alessio, D. A., & Seeley, R. J. (2011) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.77 · Cited by 220 · see citing works

Regulation of energy balance by a gut–brain axis and involvement of the gut microbiota

Bauer, P. V., Hamr, S. C., & Duca, F. A. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2083-z · Cited by 221 · see citing works

Tolerability of nausea and vomiting and associations with weight loss in a randomized trial of liraglutide in obese, non-diabetic adults

on behalf of the NN8022-1807 Investigators, Lean, M. E. J., Carraro, R., Finer, N., Hartvig, H., Lindegaard, M. L., Rössner, S., Van Gaal, L., & Astrup, A. (2014) · International Journal of Obesity · doi:10.1038/ijo.2013.149 · Cited by 210 · see citing works

Inulin Can Alleviate Metabolism Disorders in ob/ob Mice by Partially Restoring Leptin-Related Pathways Mediated by Gut Microbiota

Song, X., Zhong, L., Lyu, N., Liu, F., Li, B., Hao, Y., Xue, Y., Li, J., Feng, Y., Ma, Y., et al. (2019) · Genomics Proteomics & Bioinformatics · doi:10.1016/j.gpb.2019.03.001 · Cited by 207 · see citing works

The metabolic impact of small intestinal nutrient sensing

Duca, F. A., Waise, T. M. Z., Peppler, W. T., & Lam, T. K. T. (2021) · Nature Communications · doi:10.1038/s41467-021-21235-y · Cited by 207 · see citing works

Preproglucagon neurons project widely to autonomic control areas in the mouse brain

Llewellyn-Smith, I. J., Reimann, F., Gribble, F. M., & Trapp, S. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.02.023 · Cited by 194 · see citing works

The endocrinology of food intake

Begg, D. P., & Woods, S. C. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.136 · Cited by 199 · see citing works

Incretin hormones and the satiation signal

Holst, J. J. (2013) · International Journal of Obesity · doi:10.1038/ijo.2012.208 · Cited by 189 · see citing works

Glucagon-like peptide 1 and appetite

Dailey, M. J., & Moran, T. H. (2013) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2012.11.008 · Cited by 187 · see citing works

Hippocampal GLP-1 Receptors Influence Food Intake, Meal Size, and Effort-Based Responding for Food through Volume Transmission

Hsu, T. M., Hahn, J. D., Konanur, V. R., Lam, A., & Kanoski, S. E. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2014.175 · Cited by 176 · see citing works

Liraglutide: short‐lived effect on gastric emptying—long lasting effects on body weight

Jelsing, J., Vrang, N., Hansen, G., Raun, K., Tang‐Christensen, M., & Knudsen, L. B. (2012) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2012.01557.x · Cited by 175 · see citing works

Role of the glucagon-like-peptide-1 receptor in the control of energy balance

Hayes, M. R., De Jonghe, B. C., & Kanoski, S. E. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.02.029 · Cited by 173 · see citing works

The physiological control of eating: signals, neurons, and networks

Watts, A. G., Kanoski, S. E., Sanchez-Watts, G., & Langhans, W. (2022) · Physiological Reviews · doi:10.1152/physrev.00028.2020 · Cited by 168 · see citing works

The development of Byetta (exenatide) from the venom of the Gila monster as an anti-diabetic agent

Furman, B. L. (2012) · Toxicon · doi:10.1016/j.toxicon.2010.12.016 · Cited by 166 · see citing works

N-acylethanolamines, anandamide and food intake

Hansen, H. S., & Diep, T. A. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.04.024 · Cited by 165 · see citing works

Liraglutide modulates appetite and body weight through glucagon-like peptide 1 receptor-expressing glutamatergic neurons

Adams, J. M., Pei, H., Sandoval, D. A., Seeley, R. J., Chang, R. B., Liberles, S. D., & Olson, D. P. (2018) · Diabetes · doi:10.2337/db17-1385 · Cited by 159 · see citing works

Molecular mechanisms underlying nutrient-stimulated incretin secretion

Parker, H. E., Reimann, F., & Gribble, F. M. (2010) · Expert Reviews in Molecular Medicine · doi:10.1017/s146239940900132x · Cited by 155 · see citing works

Brain GLP-1 and the regulation of food intake: GLP-1 action in the brain and its implications for GLP-1 receptor agonists in obesity treatment

Trapp, S., & Brierley, D. I. (2022) · British Journal of Pharmacology · doi:10.1111/bph.15638 · Cited by 154 · see citing works

Hyperphagia and Increased Fat Accumulation in Two Models of Chronic CNS Glucagon-Like Peptide-1 Loss of Function

Barrera, J. G., Jones, K. R., Herman, J. P., D’Alessio, D. A., Woods, S. C., & Seeley, R. J. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.2212-10.2011 · Cited by 154 · see citing works

Leptin Directly Depolarizes Preproglucagon Neurons in the Nucleus Tractus Solitarius

Hisadome, K., Reimann, F. M., Gribble, F. M., & Trapp, S. (2010) · Diabetes · doi:10.2337/db10-0128 · Cited by 150 · see citing works

Liraglutide and obesity: a review of the data so far

Ladenheim, E. E. (2015) · Drug Design Development and Therapy · doi:10.2147/dddt.s58459 · Cited by 147 · see citing works

The role of glucagon‐like peptide‐1 impairment in obesity and potential therapeutic implications

Madsbad, S. (2014) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.12119 · Cited by 146 · see citing works

The metabolic role of vagal afferent innervation

Waise, T. M. Z., Dranse, H. J., & Lam, T. K. T. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0062-1 · Cited by 140 · see citing works

Preproglucagon derived peptides GLP-1, GLP-2 and oxyntomodulin in the CNS: Role of peripherally secreted and centrally produced peptides

Vrang, N., & Larsen, P. J. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.07.003 · Cited by 134 · see citing works

Glucagon-like peptide-1 (GLP-1) signalling in the brain: From neural circuits and metabolism to therapeutics

Kabahizi, A., Wallace, B., Lieu, L., Chau, D., Dong, Y., Hwang, E., & Williams, K. W. (2022) · British Journal of Pharmacology · doi:10.1111/bph.15682 · Cited by 126 · see citing works

Physiology of Incretins in Health and Disease

Deacon, C. F., & Åhrén, B. (2011) · The Review of Diabetic Studies · doi:10.1900/rds.2011.8.293 · Cited by 128 · see citing works

Glucagon-Like Peptide 1 Interacts with Ghrelin and Leptin to Regulate Glucose Metabolism and Food Intake through Vagal Afferent Neuron Signaling ,

Ronveaux, C. C., Tomé, D., & Raybould, H. E. (2015) · The Journal of Nutrition · doi:10.3945/jn.114.206029 · Cited by 124 · see citing works

A hippocampus to prefrontal cortex neural pathway inhibits food motivation through glucagon-like peptide-1 signaling

Hsu, T. M., Noble, E. E., Liu, C. M., Cortella, A. M., Konanur, V., Suarez, A. N., Reiner, D. J., Hahn, J. D., Hayes, M. R., & Kanoski, S. E. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.91 · Cited by 123 · see citing works

Roles of bile acids signaling in neuromodulation under physiological and pathological conditions

Chen, X., Huang, X., Wang, D., Yu, D., Hou, S., Cui, H., & Song, L. (2023) · Cell & Bioscience · doi:10.1186/s13578-023-01053-z · Cited by 120 · see citing works

Revisiting the role of protein-induced satiation and satiety

Morell, P., & Fiszman, S. (2016) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2016.08.003 · Cited by 117 · see citing works

Incretin Hormones and Type 2 Diabetes—Mechanistic Insights and Therapeutic Approaches

Boer, G. A., & Holst, J. J. (2020) · Biology · doi:10.3390/biology9120473 · Cited by 122 · see citing works

Central Nervous System Mechanisms Linking the Consumption of Palatable High-Fat Diets to the Defense of Greater Adiposity

Ryan, K. K., Woods, S. C., & Seeley, R. J. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2011.12.013 · Cited by 112 · see citing works

Experience with the high-intensity sweetener saccharin impairs glucose homeostasis and GLP-1 release in rats

Swithers, S. E., Laboy, A. F., Clark, K., Cooper, S., & Davidson, T. L. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.04.024 · Cited by 113 · see citing works

GLP-1, the Gut-Brain, and Brain-Periphery Axes

Cabou, C., & Burcelin, R. (2011) · The Review of Diabetic Studies · doi:10.1900/rds.2011.8.418 · Cited by 110 · see citing works

Endogenous GLP-1 mediates postprandial reductions in activation in central reward and satiety areas in patients with type 2 diabetes

ten Kulve, J. S., Veltman, D. J., van Bloemendaal, L., Barkhof, F., Deacon, C. F., Holst, J. J., Konrad, R. J., Sloan, J. H., Drent, M. L., Diamant, M., et al. (2015) · Diabetologia · doi:10.1007/s00125-015-3754-x · Cited by 110 · see citing works

The modulatory role of high fat feeding on gastrointestinal signals in obesity

Duca, F. A., Sakar, Y., & Covașă, M. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.05.005 · Cited by 107 · see citing works

Nutrient-Induced Cellular Mechanisms of Gut Hormone Secretion

Lu, V. B., Gribble, F. M., & Reimann, F. M. (2021) · Nutrients · doi:10.3390/nu13030883 · Cited by 105 · see citing works

Endogenous glucagon-like peptide-1 receptor signaling in the nucleus tractus solitarius is required for food intake control

Alhadeff, A. L., Mergler, B. D., Zimmer, D. J., Turner, C. A., Reiner, D. J., Schmidt, H. D., Grill, H. J., & Hayes, M. R. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.246 · Cited by 102 · see citing works

Liraglutide Reduces CNS Activation in Response to Visual Food Cues Only After Short-term Treatment in Patients With Type 2 Diabetes

ten Kulve, J. S., Veltman, D. J., van Bloemendaal, L., Barkhof, F., Drent, M. L., Diamant, M., & IJzerman, R. G. (2016) · Diabetes Care · doi:10.2337/dc15-0772 · Cited by 102 · see citing works

A Role for GLP-1 in Treating Hyperphagia and Obesity

Grill, H. J. (2020) · Endocrinology · doi:10.1210/endocr/bqaa093 · Cited by 101 · see citing works

Meal-Anticipatory Glucagon-Like Peptide-1 Secretion in Rats

Vahl, T. P., Drazen, D. L., Seeley, R. J., D’Alessio, D. A., & Woods, S. C. (2009) · Endocrinology · doi:10.1210/en.2009-1002 · Cited by 100 · see citing works

Gut microbiota, nutrient sensing and energy balance

Duca, F. A., & Lam, T. K. T. (2014) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12340 · Cited by 103 · see citing works

PPG neurons of the lower brain stem and their role in brain GLP-1 receptor activation

Trapp, S., & Cork, S. C. (2015) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00333.2015 · Cited by 100 · see citing works

Homeostatic regulation of food intake

Cifuentes, L., & Acosta, A. J. (2021) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2021.101794 · Cited by 100 · see citing works

Glucagon-like peptides 1 and 2 in health and disease: A review

Marathe, C. S., Rayner, C. K., Jones, K. L., & Horowitz, M. (2013) · Peptides · doi:10.1016/j.peptides.2013.01.014 · Cited by 100 · see citing works

Minireview: Finding the Sweet Spot: Peripheral Versus Central Glucagon-Like Peptide 1 Action in Feeding and Glucose Homeostasis

Williams, D. L. (2009) · Endocrinology · doi:10.1210/en.2009-0220 · Cited by 98 · see citing works

Decreased intestinal nutrient response in diet-induced obese rats: role of gut peptides and nutrient receptors

Duca, F. A., Swartz, T. D., Sakar, Y., & Covașă, M. (2012) · International Journal of Obesity · doi:10.1038/ijo.2012.45 · Cited by 98 · see citing works

CCK Stimulation of GLP-1 Neurons Involves α1-Adrenoceptor–Mediated Increase in Glutamatergic Synaptic Inputs

Hisadome, K., Reimann, F. M., Gribble, F. M., & Trapp, S. (2011) · Diabetes · doi:10.2337/db11-0489 · Cited by 97 · see citing works

Intestinal glucagon-like peptide-1 effects on food intake: physiological relevance and emerging mechanisms

Krieger, J.-P. (2020) · Peptides · doi:10.1016/j.peptides.2020.170342 · Cited by 91 · see citing works

Reappraising the role of the vagus nerve in GLP-1-mediated regulation of eating

Brierley, D. I., & de Lartigue, G. (2022) · British Journal of Pharmacology · doi:10.1111/bph.15603 · Cited by 92 · see citing works

Integration of Satiety Signals by the Central Nervous System

Chambers, A. P., Sandoval, D. A., & Seeley, R. J. (2013) · Current Biology · doi:10.1016/j.cub.2013.03.020 · Cited by 91 · see citing works

Exendin-4, a Glucagon-Like Peptide-1 Receptor Agonist, Reduces Alzheimer Disease-Associated Tau Hyperphosphorylation in the Hippocampus of Rats with Type 2 Diabetes

Xu, W., Yang, Y., Yuan, G., Zhu, W., Ma, D., & Hu, S. (2015) · Journal of Investigative Medicine · doi:10.1097/jim.0000000000000129 · Cited by 90 · see citing works

Diabetes and obesity: therapeutic targeting and risk reduction – a complex interplay

Niswender, K. D. (2009) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2009.01175.x · Cited by 85 · see citing works

An application of Pavlovian principles to the problems of obesity and cognitive decline

Davidson, T. L., Sample, C. H., & Swithers, S. E. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.07.014 · Cited by 86 · see citing works

Molecular mechanisms underlying physiological and receptor pleiotropic effects mediated by GLP ‐ 1R activation

Pabreja, K., Mohd, M. A., Koole, C., Wootten, D. L., & Furness, S. G. B. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12313 · Cited by 84 · see citing works

Glucagon-Like Peptide-1 (GLP-1) in the Integration of Neural and Endocrine Responses to Stress

Diz-Chaves, Y., Herrera-Pérez, S., González-Matías, L. C., Lamas, J. A., & Mallo, F. (2020) · Nutrients · doi:10.3390/nu12113304 · Cited by 84 · see citing works

Efficacy and safety of liraglutide in patients with type 2 diabetes mellitus and severe obstructive sleep apnea

Jiang, W., Li, W., Cheng, J., Li, W., & Cheng, F. (2022) · Sleep And Breathing · doi:10.1007/s11325-022-02768-y · Cited by 86 · see citing works

Glucagon-like peptide-1 receptor agonists suppress water intake independent of effects on food intake

McKay, N. J., Kanoski, S. E., Hayes, M. R., & Daniels, D. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00472.2011 · Cited by 79 · see citing works

Intestinal feedback signaling and satiety

Moran, T. H., & Dailey, M. J. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.02.005 · Cited by 79 · see citing works

The Functional and Neurobiological Properties of Bad Taste

Schier, L. A., & Spector, A. C. (2018) · Physiological Reviews · doi:10.1152/physrev.00044.2017 · Cited by 75 · see citing works

Maintenance on a high-fat diet impairs the anorexic response to glucagon-like-peptide-1 receptor activation

Williams, D. L., Hyvarinen, N., Lilly, N., Kay, K. E., Dossat, A. M., Parise, E. M., & Torregrossa, A. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.04.005 · Cited by 78 · see citing works

GLP‐1R and amylin agonism in metabolic disease: complementary mechanisms and future opportunities

Roth, J. D., Erickson, M. R., Chen, S., & Parkes, D. G. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01537.x · Cited by 74 · see citing works

Neural integration of satiation and food reward: Role of GLP-1 and orexin pathways

Williams, D. L. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.03.013 · Cited by 74 · see citing works

Hindbrain Oxytocin Receptors Contribute to the Effects of Circulating Oxytocin on Food Intake in Male Rats

Ho, J. M., Anekonda, V. T., Thompson, B. W., Zhu, M., Curry, R. W., Hwang, B. H., Morton, G. J., Schwartz, M. W., Baskin, D. G., Appleyard, S. M., et al. (2014) · Endocrinology · doi:10.1210/en.2014-1148 · Cited by 74 · see citing works

Vagal Afferents Mediate Early Satiation and Prevent Flavour Avoidance Learning in Response to Intraperitoneally Infused Exendin‐4

Labouesse, M. A., Weber‐Stadlbauer, U., Weber, E., Arnold, M., Langhans, W., & Pacheco‐López, G. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02364.x · Cited by 70 · see citing works

Regulation of systemic metabolism by the autonomic nervous system consisting of afferent and efferent innervation.

Imai, J., & Katagiri, H. (2021) · International Immunology · doi:10.1093/intimm/dxab023 · Cited by 63 · see citing works

Vagal mediation of GLP-1's effects on food intake and glycemia

Krieger, J.-P., Langhans, W., & Lee, S. J. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.06.001 · Cited by 67 · see citing works

Clinical Impact of Liraglutide as a Treatment of Obesity

Alruwaili, H., Dehestani, B., & le Roux, C. W. (2021) · Clinical Pharmacology Advances and Applications · doi:10.2147/cpaa.s276085 · Cited by 73 · see citing works

Roux-en-Y gastric bypass in rats increases sucrose taste-related motivated behavior independent of pharmacological GLP-1-receptor modulation

Mathes, C. M., Bueter, M., Smith, K., Lutz, T. A., le Roux, C. W., & Spector, A. C. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00214.2011 · Cited by 67 · see citing works

Intestinal GLP-1 and satiation: from man to rodents and back

Steinert, R. E., Beglinger, C., & Langhans, W. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.172 · Cited by 67 · see citing works

Dose combinations of exendin-4 and salmon calcitonin produce additive and synergistic reductions in food intake in nonhuman primates

Bello, N. T., Kemm, M. H., Ofeldt, E. M., & Moran, T. H. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00275.2010 · Cited by 66 · see citing works

Endogenous GLP1 and GLP1 analogue alter CNS responses to palatable food consumption

ten Kulve, J. S., Veltman, D. J., van Bloemendaal, L., Groot, P. F. C., Ruhé, H. G., Barkhof, F., Diamant, M., & IJzerman, R. G. (2016) · Journal of Endocrinology · doi:10.1530/joe-15-0461 · Cited by 66 · see citing works

Obesity - an indication for GLP-1 treatment? Obesity pathophysiology and GLP-1 treatment potential

Torekov, S. S., Madsbad, S., & Holst, J. J. (2011) · Obesity Reviews · doi:10.1111/j.1467-789x.2011.00860.x · Cited by 65 · see citing works

Energy intake and obesity: Ingestive frequency outweighs portion size

Mattes, R. D. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.11.012 · Cited by 65 · see citing works

Central glucagon-like peptide 1 receptor-induced anorexia requires glucose metabolism-mediated suppression of AMPK and is impaired by central fructose

Burmeister, M. A., Ayala, J., Drucker, D. J., & Ayala, J. E. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00446.2012 · Cited by 64 · see citing works

Hepatic‐Portal Vein Infusions of Glucagon‐Like Peptide‐1 Reduce Meal Size and Increase c‐Fos Expression in the Nucleus Tractus Solitarii, Area Postrema and Central Nucleus of the Amygdala in Rats

Baumgartner, I., Pacheco‐López, G., Rüttimann, E. B., Arnold, M., Asarian, L., Langhans, W., Geary, N., & Hillebrand, J. J. G. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.01995.x · Cited by 64 · see citing works

Combination of Obesity and High-Fat Feeding Diminishes Sensitivity to GLP-1R Agonist Exendin-4

Duca, F. A., Sakar, Y., & Covașă, M. (2013) · Diabetes · doi:10.2337/db12-1204 · Cited by 64 · see citing works

Peripheral signalling involved in energy homeostasis control

Lancha, A., Frühbeck, G., & Gómez‐Ambrosi, J. (2012) · Nutrition Research Reviews · doi:10.1017/s0954422412000145 · Cited by 65 · see citing works

Peripheral interleukin-2 level is associated with negative symptoms and cognitive performance in schizophrenia

Asevedo, E. D. M., Rizzo, L. B., Gadelha, A., Mansur, R. B., Ota, V., Berberian, A. D. A., Scarpato, B. S., Teixeira, A. L., Bressan, R. A., & Brietzke, E. M. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.02.032 · Cited by 63 · see citing works

The physiological role of the brain GLP-1 system in stress

Holt, M. K., & Trapp, S. (2016) · Cogent Biology · doi:10.1080/23312025.2016.1229086 · Cited by 63 · see citing works

Peripheral Glucagon-like Peptide-1 (GLP-1) and Satiation

Punjabi, M., Arnold, M., Geary, N., Langhans, W., & Pacheco‐López, G. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.02.038 · Cited by 62 · see citing works

Preproglucagon (PPG) neurons innervate neurochemicallyidentified autonomic neurons in the mouse brainstem

Llewellyn‐Smith, I., Gnanamanickam, G. J. E., Reimann, F. M., Gribble, F. M., & Trapp, S. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.09.071 · Cited by 61 · see citing works

Circulating glucagon-like peptide-1 (GLP-1) inhibits eating in male rats by acting in the hindbrain and without inducing avoidance

Punjabi, M., Arnold, M., Rüttimann, E., Graber, M., Geary, N., Pacheco-López, G., & Langhans, W. (2014) · Endocrinology · doi:10.1210/en.2013-1447 · Cited by 59 · see citing works

The role of intestinal glucagon-like peptide 1 in satiety.

Williams, D. L., Baskin, D. G., & Schwartz, M. W. (2007) · Appetite · doi:10.1016/j.appet.2007.03.216

Peripheral glucagon-like peptide-1 and satiation

Thurnherr, A. (2010) · Zurich Open Repository and Archive (University of Zurich) · doi:10.5167/uzh-163933

Initial evidence that GLP-1 receptor blockade fails to suppress postprandial satiety or promote food intake in humans

Melhorn, S. J., Tyagi, V., Smeraglio, A., Roth, C. L., & Schur, E. A. (2014) · Appetite · doi:10.1016/j.appet.2014.07.009 · Cited by 21 · see citing works

Peripheral Glucagon-like Peptide-1 (GLP-1) and Satiation

Punjabi, M., Arnold, M., Geary, N., Langhans, W., & Pacheco‐López, G. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.02.038 · Cited by 62 · see citing works

Effect of Glucagon-like Peptide-1 Receptor Antagonism on Appetite and Food Intake in Healthy Men

Steinert, R. E., Schirra, J., Meyer-Gerspach, A. C., Kienle, P., Fischer, H., Schulte, F., Goeke, B., & Beglinger, C. (2014) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.083246 · Cited by 52 · see citing works