The DOI matches its Crossref record; 21 of the 22 references it cites were found in a registry or an index.
Machine learning in the electrocardiogram
Abstract
The electrocardiogram is the most widely used diagnostic tool that records the electrical activity of the heart and, therefore, its use for identifying markers for early diagnosis and detection is of paramount importance. In the last years, the huge increase of electronic health records containing a systematised collection of different type of digitalised medical data, together with new tools to analyse this large amount of data in an efficient way have re-emerged the field of machine learning in healthcare innovation. This review describes the most recent machine learning-based systems applied to the electrocardiogram as well as pros and cons in the use of these techniques. Machine learning, including deep learning, have shown to be powerful tools for aiding clinicians in patient screening and risk stratification tasks. However, they do not provide the physiological basis of classification outcomes. Computational modelling and simulation can help in the interpretation and understanding of key physiologically meaningful ECG biomarkers extracted from machine learning techniques.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In this regard, wearable ECG sensors continuously monitor heart activity and facilitate early detection of arrhythmias and cardiovascular abnormalities [181].”
From The emergence of AI-based wearable sensors for digital health technology: a review (2023) · cites this paper as [181]
In the citing paper
“Additionally, multimodal sensing, combining ECG data with other physiological and environmental parameters, such as EOG, EMG, temperature, strain, humidity, and bacterial infection, facilitated a comprehensive health profile [8,181,237] (Figure 7c).”
From The emergence of AI-based wearable sensors for digital health technology: a review (2023) · cites this paper as [181]
In the citing paper
“Integrating AI and ML algorithms into wearable ECG sensors has substantially enhanced the accuracy of ECG analysis [181].”
From The emergence of AI-based wearable sensors for digital health technology: a review (2023) · cites this paper as [181]
Citations
Cites
LeCun, Y., Bengio, Y., & Hinton, G. (2015) · Nature · doi:10.1038/nature14539 · Cited by 84,126
Book Review: Pattern Recognition and Machine Learning
Nasrabadi, N. M. (2007) · Journal of Electronic Imaging · doi:10.1117/1.2819119 · Cited by 22,066
(2016) · Cited by 11,679
The UK Biobank resource with deep phenotyping and genomic data
Bycroft, C., Freeman, C., Petkova, D., Band, G., Elliott, L. T., Sharp, K., Motyer, A., Vukcevic, D., Delaneau, O., O’Connell, J., et al. (2018) · Nature · doi:10.1038/s41586-018-0579-z · Cited by 8,876
Pattern Recognition and Machine Learning
(2007) · Kybernetes · doi:10.1108/03684920710743466 · Cited by 8,545
The impact of the MIT-BIH Arrhythmia Database
Moody, G. B., & Mark, R. G. (2001) · IEEE Engineering in Medicine and Biology Magazine · doi:10.1109/51.932724 · Cited by 4,834
Hannun, A. Y., Rajpurkar, P., Haghpanahi, M., Tison, G. H., Bourn, C., Turakhia, M. P., & Ng, A. Y. (2019) · Nature Medicine · doi:10.1038/s41591-018-0268-3 · Cited by 3,148
Real-Time Patient-Specific ECG Classification by 1-D Convolutional Neural Networks
Serkan Kiranyaz, B., İnce, T., & Gabbouj, M. (2015) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2015.2468589 · Cited by 1,997
A Wavelet-Based ECG Delineator: Evaluation on Standard Databases
Martínez, J. P., Almeida, R., Olmos, S. C., Rocha, A. P., & Laguna, P. (2004) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2003.821031 · Cited by 1,653
Attia, Z. I., Kapa, S., Lopez-Jimenez, F., McKie, P. M., Ladewig, D. J., Satam, G., Pellikka, P. A., Enriquez-Sarano, M., Noseworthy, P. A., Munger, T. M., et al. (2019) · Nature Medicine · doi:10.1038/s41591-018-0240-2 · Cited by 1,389
Flagged first, then by citations
1 of the 22 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 101–147 of 147
A Human-in-the-Loop Method for Annotation of Events in Biomedical Signals
Seeuws, N., Vos, M. D., & Bertrand, A. (2024) · IEEE Journal of Biomedical and Health Informatics · doi:10.1109/jbhi.2024.3460533 · Cited by 2
ECG classification using Artificial Intelligence: Model Optimization and Robustness Assessment
Escrivães, I., Barbosa, L. C. N., Torres, H. R., Oliveira, B., Vilaça, J. L., & Morais, P. (2022) · SeGAH ... IEEE ... International Conference on Serious Games and Applications for Health/IEEE International Conference on Serious Games and Applications for Health · doi:10.1109/segah54908.2022.9978589 · Cited by 2
Feature Detection Algorithm Combined with Machine Learning Applied to Abnormal ECG Diagnosis System
Zhang, S., Sun, Q., Yao, L., Zhang, A., & Zhang, R. (2023) · Smart innovation, systems and technologies · doi:10.1007/978-981-19-7184-6_17 · Cited by 2
Gunturu, L. N., Dornadula, G., & Nimbagal, R. N. (2023) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815080445123020014 · Cited by 1
“Pre-Train, Prompt” Framework to Boost Graph Neural Networks Performance in EEG Analysis
Cui, C.-M., Chen, H.-Y., Chen, M.-S., Li, J., Tong, Z., Fang, C., Wang, C.-D., & Cai, Y. (2025) · IEEE Journal of Biomedical and Health Informatics · doi:10.1109/jbhi.2025.3541058 · Cited by 1
Leveraging Fuzzy C-Means and EfficientNetB0 for Improved ECG Image Classification
Mahmood, M. A., Alsalem, K. O., Elbashir, M. K., El-Ghany, S. A., & El-Aziz, A. A. A. (2025) · International Journal of Computers Communications & Control · doi:10.15837/ijccc.2025.4.7050 · Cited by 1
Gupta, V., Kanagala, S. G., Bhavanam, S., Garg, S., Bhavsar, J., Mendpara, V. A., Aggarwal, K., Anamika, F., & Jain, R. (2025) · Turkish Journal of Internal Medicine · doi:10.46310/tjim.1559779 · Cited by 1
da Costa, L. J., Uemoto, V. R., Marchi, M. F. N. D., Hortegal, R. A., & de Freitas, R. V. (2026) · Clinics · doi:10.1016/j.clinsp.2025.100856 · Cited by 1
Ji, R. Q., Riek, N. T., Gokhale, T., Bouzid, Z., Kraevsky-Phillips, K., Zègre‐Hemsey, J. K., Saba, S., Martin‐Gill, C., Callaway, C. W., Akçakaya, M., et al. (2026) · European Heart Journal - Digital Health · doi:10.1093/ehjdh/ztag062 · Cited by 1
Prasad, V. K., Raj, K. M. N., Muthya, S., & Nair, R. S. (2021) · IEEE International Conference on Healthcare Informatics (ICHI) · doi:10.1109/ichi52183.2021.00026 · Cited by 1
(2023) · Advances in Machine Learning & Artificial Intelligence · doi:10.33140/amlai.04.02.05 · Cited by 1
Herbert, P. (2024) · doi:10.3390/engproc2024065004 · Cited by 1
Enyedi, S. (2024) · IEEE International Conference on Automation, Quality and Testing, Robotics (AQTR) · doi:10.1109/aqtr61889.2024.10554095 · Cited by 1
Machine Learning Methods for ECG Arrhythmia Beat Classification
Prasad, K. H. K., & Krishna, B. T. (2023) · International Conference on Ubiquitous Computing and Intelligent Information Systems (ICUIS) · doi:10.1109/icuis60567.2023.00017 · Cited by 1
Robustness for ECG Classification by Adversarial Training Over Clinical Features
Jain, S., Sangroya, A., Vig, L., & Anantaram, C. (2023) · Studies in computational intelligence · doi:10.1007/978-3-031-36938-4_18 · Cited by 2
The use of Spindle Feature Vectors in Wearable Devices for Sleep Monitoring and Analysis
Krilis, I., & Antonakopoulos, T. A. (2020) · International Conference on Consumer Electronics · doi:10.1109/icce-berlin50680.2020.9352177
New Insights on Implementing and Evaluating Artificial Intelligence in Cardiovascular Care
Dykstra, S., White, J. A., & Gavrilova, M. L. (2021) · Intelligent systems reference library · doi:10.1007/978-3-030-79161-2_17
Classification of Impaired Waist to Height Ratio and Waist to Hip Ratio Using Support Vector Machine
Severeyn, É., Cruz, A. L., & Huerta, M. (2021) · IEEE Ecuador Technical Chapters Meeting (ETCM) · doi:10.1109/etcm53643.2021.9590823
Heart Response to Harmonic Music Interval Stimuli Via Deep Learning Structures
Idrobo-Ávila, E., Correa, H. L., Muñoz-Bolaños, F., van Noorden, L., & Vargas-Cañas, R. (2022) · International Journal on Advanced Science Engineering and Information Technology · doi:10.18517/ijaseit.12.4.16033
Duchateau, N., Cámara, Ó., Sebastián, R., & King, A. P. (2023) · Springer eBooks · doi:10.1007/978-3-031-05071-8_10
Computer modeling of cardiac rhythm based on vector of stationary random sequences
Lupenko, S. A., Lytvynenko, I., Onyskiv, P., Лупенко, А. М., Volianyk, O. V., & Tsytsiura, O. (2022) · Scientific journal of the Ternopil national technical university · doi:10.33108/visnyk_tntu2022.04.131
Enhancing Impaired Waist-to-Height Ratio Classification Using Neural Networks
Severeyn, É., Cruz, A. L., & Huerta, M. (2023) · Communications in computer and information science · doi:10.1007/978-3-031-46739-4_20
Meurer, S. M., Zanco, D. G. D. P., Kuhn, E. V., & Maia, R. (2023) · Anais de XXXV Simpósio Brasileiro de Telecomunicações e Processamento de Sinais · doi:10.14209/sbrt.2023.1570907043
Nuryani, N., Purnama, B., Legowo, B., Utari, U., Riyatun, R., Suharno, S., Yunianto, M., & Lestari, W. I. (2023) · SEMAR (Jurnal Ilmu Pengetahuan Teknologi dan Seni bagi Masyarakat) · doi:10.20961/semar.v12i2.75521
Study of Multi-class Arrhythmia Detection and Classification from ECG data using Deep learning
Akash, A. H., & Ahamed, R. (2023) · International Conference on Computer and Information Technology (ICCIT) · doi:10.1109/iccit60459.2023.10441043
Eini-Porat, B., Eytan, D., & Shalit, U. (2024) · PubMed Central
Egea, R. C. P., & Moreno-Martínez, D. (2024) · doi:10.2196/preprints.66586
Limitations and Challenges of AI-ECG
Zhang, Q., Chung, C. T., Li, Y.-E., Liu, T., Lv, Z., & Xie, J. (2024) · Springer eBooks · doi:10.1007/978-981-97-8359-5_4
Detection of Deaths Caused by Hyperkalemia
Żulicka, M., Sobczak, K., Kowalczyk, D., Sikorska, S., Arendt, W., & Hałas‐Wiśniewska, M. (2025) · Biomedicines · doi:10.3390/biomedicines13010222
Cohen, M. S., Hochstein, D., Barda, N., Bleiweiss, A., Aflalo, E., Bar, N., Zimlichman, E., Klang, E., Rahman, N., Sela, T. C., et al. (2025) · Heliyon · doi:10.1016/j.heliyon.2025.e42968
RetractedAdvancing Healthcare for Travelers
Ratheesh, N., Jain, E., & Lakshmi, D. (2025) · IGI Global eBooks · doi:10.4018/979-8-3693-8774-0.ch014
Enhancing Telemedicine Deep Learning-Based Classification of ECG Heartbeats
Babu, C. V. S., & William, M. P. (2025) · Advances in medical technologies and clinical practice book series · doi:10.4018/979-8-3693-6094-1.ch004
Heart Disease Classification using FusionNet to Extract SpatioTemporal Features from ECG Signal
Ha, T.-O., Jeong, H., & Doan, H.-G. (2025) · IEEE International Conference on Advanced Video and Signal Based Surveillance (AVSS) · doi:10.1109/avss65446.2025.11149856
Baj, G., Gandin, I., Scagnetto, A., Bortolussi, L., Cappelletto, C., Di Lenarda, A., & Barbati, G. (2024) · Figshare · doi:10.6084/m9.figshare.26606002
Sankaranarayanan, A. K., AlNajjar, F. J. K., Musa, A. M., Kuthbudeen, M. W., & Wahab, A. G. A. (2026) · Cureus · doi:10.7759/cureus.101785
Multimodal Deep Learning Model based on ECG and Clinical Notes for Arrhythmia Classification
Agnew, S., & Fahim, M. (2025) · IEEE International Conference on e-Health Networking, Applications and Services (Healthcom) · doi:10.1109/healthcom60686.2025.11342609
Machine Learning-Based ECG Signal Classification Using 1D Representation of the PTB-XL Dataset
Choudhary, P., & Saini, I. (2026) · International Conference on Artificial Intelligence & Machine Learning in Communication and Power Systems (AIMLCPS) · doi:10.1109/aimlcps68702.2026.11542297
Noh, H. G., Bae, S., Yun, Y., Park, J., & Lee, S. (2026) · Advanced Intelligent Systems · doi:10.1002/aisy.70474
Daphin Lilda, S., Jayaparvathy, R., Kumar, S. P., & Vedachalam, N. (2026) · Physical and Engineering Sciences in Medicine · doi:10.1007/s13246-026-01760-0
Electrocardiogram-Based Myocardial Infarction Detection System Using Ensemble Learning
Gimbi, A. D. A., & Jain, P. (2026) · IEEE International Conference on Signals and Systems (ICSigSys) · doi:10.1109/icsigsys71160.2026.11613876
Learning Cardiac Features: ECG Biometrics Across Time and Exercise
Thiebaud, L., Chauchat, P., Ouladsine, M., & Delliaux, S. (2026) · Lecture notes in computer science · doi:10.1007/978-3-032-35387-0_7
ECG Signal Processing: From Conventional Methods to AI-Driven Approaches
Panda, S. K., Gupta, V., & Kathania, H. K. (2026) · IEEE Guwahati Subsection Conference (GCON) · doi:10.1109/gcon69192.2026.11649013
rPPG-Guided Multi-Task Cascaded Learning for Joint Heart Rate and SpO₂ Estimation
Li, J., Jiang, X., Tu, X., Gao, Y., & Huang, H. (2026) · IEEE Access · doi:10.1109/access.2026.3735373
Machine Learning Based Classification of Athletes Using ECG Signals
Divya, S., Rani, S. G., Sowmya, V., & Vinayakumar, R. (2026) · Springer series in reliability engineering · doi:10.1007/978-3-032-21331-0_15
Biaosheng, H., Liu, J., Tian, X., Tuerhong, A., Lv, X., Li, H., Hu, Z., Li, M., & Ding, X. (2026) · Electronics · doi:10.3390/electronics15204599
The Digital Pillbox: Evaluating the Impact of Digital Health on Medication Compliance
Patil, P. Y. (2026) · Asian Journal of Pharmaceutical Research · doi:10.52711/2231-5691.2026.00071
A lightweight 1D-CNN for multi-class ECG arrhythmia classification on the MIT-BIH database
Li, Y., Luo, H., 王敬民, & Su, J. D. (2026) · PeerJ Computer Science · doi:10.7717/peerj-cs.4139
Metadata
- Authors
- Mincholé, A., Camps, J., Lyon, A., & Rodríguez, B.
- Affiliations
- University of Oxford (GB)
- Maastricht University (NL)
- Corresponding author
- Mincholé, Ana
- Venue
- Journal of Electrocardiology
- Publisher
- Elsevier BV
- Published
- 2019-11
- Volume
- 57
- Pages
- S61-S64
- ISSN
- 0022-0736 (ISSN-L)
- OpenAlex
- W2968959539
- Cited by
- 147
- References
- 22
- Citations by year
- 2026: 17 · 2025: 19 · 2024: 24 · 2023: 33 · 2022: 20 · 2021: 17 · 2020: 15 · 2019: 2
- FWCI
- 9.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Electrocardiology (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion)
- Research Publications (Maastricht University) (submittedVersion)
- Funders
- Engineering and Physical Sciences Research Council
- Horizon 2020 Framework Programme
- Wellcome Trust
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › ECG Monitoring and Analysis
- Physical Sciences › Computer Science › Artificial Intelligence › Machine Learning in Healthcare
- Health Sciences › Health Professions › Health Information Management › Artificial Intelligence in Healthcare
- Keywords
- electrocardiogram, machine learning, deep learning, ECG biomarkers, risk stratification, patient screening, early diagnosis, electronic health records, computational modelling, clinical decision support
- MeSH terms
- Machine Learning, Computer Simulation, Electrocardiography, Humans, Electronic Health Records
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review