Role of mangiferin on biochemical alterations and antioxidant status in isoproterenol-induced myocardial infarction in rats
Abstract
The current study dealt with the protective role of mangiferin, a polyphenol from Mangifera indica Linn. (Anacardiaceae), on isoproterenol (ISPH)-induced myocardial infarction (MI) in rats through its antioxidative mechanism. Subcutaneous injection of ISPH (200 mg/kg body weight in 1 ml saline) to rats for 2 consecutive days caused myocardial damage in rat heart, which was determined by the increased activity of serum lactate dehydrogenase (LDH) and creatine phosphokinase isoenzymes (CK-MB), increased uric acid level and reduced plasma iron binding capacity. The protective role of mangiferin was analyzed by triphenyl tetrazolium chloride (TTC) test used for macroscopic enzyme mapping assay of the ischemic myocardium. The heart tissue antioxidant enzymes such as superoxide dismutase, catalase, glutathione peroxidase, glutathione transferase and glutathione reductase activities, non-enzymic antioxidants such as cerruloplasmin, Vitamin C, Vitamin E and glutathione levels were altered in MI rats. Upon pretreatment with mangiferin (100 mg/kg body weight suspended in 2 ml of dimethyl sulphoxide) given intraperitoneally for 28 days to MI rats protected the above-mentioned parameters to fall from the normal levels. Activities of heart tissue enzymic antioxidants and serum non-enzymic antioxidants levels rose significantly upon mangiferin administration as compared to ISPH-induced MI rats. From the present study it is concluded that mangiferin exerts a beneficial effect against ISPH-i…
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Pretreatment with mangiferin (100 mg/kg) for 28 days regulates the tissue defense system against cardiac damage in ISPH-induced MI rats.
“Prabhu et al (76) demonstrated that pretreatment with mangiferin (100 mg/kg) for 28 days regulates the tissues defense system against cardiac damage.”
From Mangiferin: An effective therapeutic agent against several disorders (Review) (2018) · cites this paper as [76]
Mangiferin exerts beneficial effects due to its antioxidant potential, which reduces myocardial oxygen consumption and relieves angina pectoris.
“It was concluded that mangiferin exerts its beneficial effects due to its antioxidant potential, which reduces myocardial oxygen consumption and relieves angina pectoris (76).”
From Mangiferin: An effective therapeutic agent against several disorders (Review) (2018) · cites this paper as [76]
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Mangiferin: An effective therapeutic agent against several disorders (Review)
Du, S., Liu, H., Lei, T., Xie, X., Wang, H., He, X., Tong, R., & Wang, Y. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9529 · Cited by 139 · see citing works
“…Nrf2, nuclear factor erythroid 2-related factor 2; NLRP3, NLR family pyrin domain containing 3; GSH, glutathione. glutathione transferase and glutathione reductase, as well as non-enzymic antioxidants such as cerruloplasmin, Vitamin C, Vitamin E and glutathione, were all notably upregulated (76).”
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- Authors
- Prabhu, S., Jainu, M., Sabitha, K. E., & Devi, C. S. S.
- Affiliations
- University of Madras (IN)
- Corresponding author
- Prabhu, S.
- Venue
- Journal of Ethnopharmacology
- Publisher
- Elsevier BV
- Published
- 2006-08
- Volume
- 107
- Issue
- 1
- Pages
- 126-133
- ISSN
- 0378-8741 (ISSN-L)
- OpenAlex
- W2018485248
- Cited by
- 103
- References
- 1
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 10 · 2022: 5 · 2021: 3 · 2020: 5 · 2019: 2 · 2018: 5 · 2017: 4 · 2016: 12 · 2015: 6 · 2014: 7 · 2013: 7 · 2012: 6
- FWCI
- 10.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Ethnopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
- Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- mangiferin, isoproterenol-induced myocardial infarction, cardioprotection, antioxidant enzymes, non-enzymatic antioxidants, oxidative stress, mango, polyphenols, superoxide dismutase, catalase, glutathione peroxidase, glutathione, lactate dehydrogenase, creatine kinase-MB, uric acid, iron-binding capacity, myocardial ischemia
- MeSH terms
- Animals, Antioxidants, Electrophoresis, Agar Gel, Isoproterenol, L-Lactate Dehydrogenase, Male, Myocardial Infarction, Rats, Wistar, Xanthones, Rats, Creatine Kinase, MB Form
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