Effects of Orthosiphon stamineus aqueous extract on plasma glucose concentration and lipid profile in normal and streptozotocin-induced diabetic rats
Abstract
The objective of this study was to investigate the effects of Orthosiphon stamineus Benth. aqueous extract on plasma glucose concentration and lipid profile in normal and streptozotocin-induced diabetic rats. The chemical screening of the extract showed phenolic compound and flavonoid content were 13.24+/-0.33 mg/g and 1.73+/-0.14 microg/g, respectively. In oral glucose tolerance test, the extract (0.2-1.0 g/kg) significantly decreased plasma glucose concentration in a dose-dependent manner in both normal and diabetic rats. The extract at 1.0 g/kg was most effective in decreasing plasma glucose concentrations and the response was closed to the result of glibenclamide (5 mg/kg). After repeated daily oral administrations of the extract (0.5 g/kg) for 14 days, the extract significantly reduced plasma glucose concentration in diabetic rats at days 7 and 14. By the end of the study, plasma triglyceride concentration was lower in the extract-treated diabetic rats than untreated ones. Furthermore, plasma HDL-cholesterol concentration was significantly increased in diabetic rats treated with the extract. In perfused rat pancreas, the extract did not increase insulin secretion in the presence of 5.5 mM glucose, but 100 microg/ml extract potentiated glucose-induced insulin secretion. Our findings suggested that Orthosiphon stamineus aqueous extract is effective for alleviating hyperglycemia and improving lipid profile in diabetic rats.
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Aqueous extracts of Orthosiphon stamineus (0.2-1.0 g/kg) significantly decreased plasma glucose concentration in a dose-dependent manner in both normal and diabetic rats.
“From another study, the aqueous extracts (0.2-1.0 g/kg) significantly decreased plasma glucose concentration in a dose-dependent manner in both normal and diabetic rats [50].”
From Evaluating Traditional Chinese Medicine and Herbal Products for the Treatment of Gestational Diabetes Mellitus (2019) · cites this paper as [50]
The highest dose of Orthosiphon stamineus aqueous extract had comparable effect as the T2DM medication glyburide.
“The highest dose had comparable effect as the T2DM medication, glyburide.”
From Evaluating Traditional Chinese Medicine and Herbal Products for the Treatment of Gestational Diabetes Mellitus (2019) · cites this paper as [50]
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- Authors
- Sriplang, K., Adisakwattana, S., Rungsipipat, A., & Yibchok-anun, S.
- Affiliations
- Chulalongkorn University (TH)
- Venue
- Journal of Ethnopharmacology
- Publisher
- Elsevier BV
- Published
- 2007-02
- Volume
- 109
- Issue
- 3
- Pages
- 510-514
- ISSN
- 0378-8741 (ISSN-L)
- OpenAlex
- W2073724145
- Cited by
- 92
- References
- 17
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 4 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 6 · 2019: 6 · 2018: 4 · 2017: 3 · 2016: 5 · 2015: 8 · 2014: 3 · 2013: 4 · 2012: 11
- FWCI
- 2.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Ethnopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Sanofi
- Mahidol University
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Keywords
- Orthosiphon stamineus, aqueous plant extract, streptozotocin-induced diabetes, hyperglycemia, plasma glucose, lipid profile, triglycerides, HDL cholesterol, oral glucose tolerance, insulin secretion, phenolic compounds, flavonoids, antidiabetic activity
- MeSH terms
- Insulin Secretion, Animals, Asia, Southeastern, Blood Glucose, Diabetes Mellitus, Experimental, Flavonoids, Glucose Tolerance Test, Hypoglycemic Agents, Insulin, Cholesterol, HDL, Male, Pancreas, Phenols, Plant Extracts, Plants, Medicinal, Streptozocin, Triglycerides, Rats, Wistar, Orthosiphon, Rats
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