Orthosiphon stamineus as a potential antidiabetic drug in maternal hyperglycemia in streptozotocin-induced diabetic rats
Open accessAbstract
Maternal hyperglycemia is associated with increased risk of adverse outcomes for both mother and offspring. Insulin is the standard treatment of hyperglycemia with the aim to reduce risks of complications, however, due to several restrictions, the search for more effective drugs from traditional medicinal plants continues. The antidiabetic effects of Orthosiphon stamineus (O.stamineus) in non-pregnant and pregnant streptozotocin-induced Sprague Dawley rats were identified. The effect of different concentrations of O. stamineouson insulin level using isolated pancreatic islets in response to low and high concentrations of glucose was identified. Oral glucose tolerance test was performed in both pregnant and non-pregnant rats prior to and after treatment with O. stamineus (0.1 g/100 g of body weight). O. stamineus was given orally daily for 2 weeks in non-pregnant and 10 days in pregnant rats. Oral glucose tolerance test indicated that treatment with O. stamineus in non-pregnant and pregnant rats significantly reduced blood glucose level and stimulated glucose-induced insulin secretion. No mortality was recorded throughout the study and no signs of toxicity during the experimental period including in both mother and foetus. For plasma analysis, the interactions of peptides such as GLP-1 and ghrelin level might contribute to the glucose lowering effect by O. stamineus via stimulation of insulin. The incubation of islets showed that O. stamineussignificantly stimulated insulin release in response to high glucose. O. stamineus could be a potential source of a specific oral hypoglycaemic agent to treat glucose intolerance in pregnancy.
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Pancreatic islets incubated with Orthosiphon stamineus were significantly more sensitive to glucose-stimulated insulin release.
“Pancreatic islets incubated with Orthosiphon stamineus also were significantly more sensitive to glucose-stimulated insulin release [48].”
From Evaluating Traditional Chinese Medicine and Herbal Products for the Treatment of Gestational Diabetes Mellitus (2019) · cites this paper as [48]
In both nonpregnant and pregnant diabetic rats, oral administration of Orthosiphon stamineus stimulated glucose-induced insulin secretion, which translated to an increase in ghrelin and glucagon-like peptide 1, and an overall lowering of glucose.
“In both nonpregnant and pregnant diabetic rats, oral administration of Orthosiphon stamineus stimulated glucose-induced insulin secretion, which translated to an increase in ghrelin and glucagon-like peptide 1, and an overall lowering of glucose [48].”
From Evaluating Traditional Chinese Medicine and Herbal Products for the Treatment of Gestational Diabetes Mellitus (2019) · cites this paper as [48]
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- Authors
- Lokman, E. F., Saparuddin, F., Muhammad, H., Omar, M. H., & Zulkapli, A.
- Affiliations
- Ministry of Health (MY)
- Corresponding author
- Lokman, Ezarul Faradianna
- ORCID
- Venue
- Integrative Medicine Research
- Publisher
- Elsevier BV
- Published
- 2019-09
- Volume
- 8
- Issue
- 3
- Pages
- 173-179
- ISSN
- 2213-4220 (ISSN-L)
- PMC
- PMC6624239
- OpenAlex
- W2948553931
- Cited by
- 36
- References
- 36
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 5 · 2023: 6 · 2022: 6 · 2021: 6 · 2020: 3 · 2019: 1
- FWCI
- 3.24
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Integrative Medicine Research (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Institute of Health, Malaysia
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Keywords
- Orthosiphon stamineus, maternal hyperglycemia, gestational diabetes mellitus, antidiabetic activity, streptozotocin-induced diabetes, oral glucose tolerance, insulin secretion, pancreatic islets, glucagon-like peptide-1, ghrelin, traditional medicinal plants, antidiabetic drugs
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