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Cited by 27Probiotics and Fermented FoodsGut microbiota and healthDiabetes Treatment and Management

Identification of lactic acid bacteria strains modulating incretin hormone secretion and gene expression in enteroendocrine cells

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Panwar, Harsh, Calderwood, Danielle, Gillespie, Anna L., Wylie, Alastair R., Graham, Stewart F., Grant, Irene R., Grover, Sunita, Green, Brian D.·2016·Journal of Functional Foods
DOI 10.1016/j.jff.2016.02.040
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  • Certain Lactobacillus strains stimulate GLP-1 production both in vitro and in vivo.

    “Certain Lactobacillus strains were capable of stimulating GLP-1 production both in vitro and in vivo (Balakumar et al., 2018;Panwar et al., 2016;Simon et al., 2015).”

    From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Panwar et al., 2016

    Section 3.1 reports that several Lactobacillus strains significantly stimulated GLP-1 secretion when co-cultured with enteroendocrine cells, supporting the in vitro part. The Methods (§2.4) describe cell-culture experiments, while the Conclusion (§5) says dietary intervention studies remain necessary; this paper does not establish an in vivo effect. (LLM, conf=0.90)

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Research works printed but not linked: 44

  1. Audy, J., Mathieu, O., Belvis, J., & Tompkins, T. A. (2012). Transcriptomic response of immune signalling pathways in intestinal epithelial cells exposed to lipopolysaccharides, Gram-negative bacteria or potentially probiotic microbes. Beneficial Microbes, 3(4), 273-86.
  2. Baggio, L. L., & Drucker, D. J. (2007). Biology of incretins: GLP-1 and GIP. Gastroenterology, 132(6), 2131-2157.
  3. Brown, A. J., Goldsworthy, S. M., Barnes, A. A., Eilert, M. M., Tcheang, L., Daniels, D., Muir, A. I., Wigglesworth, M. J., Kinghorn, I., Fraser, N. J., Pike, N. B., Strum, J. C., Steplewski, K. M., Murdock, P. R., Holder, J. C., Marshall, F. H., Szekeres, P. G., Wilson, S., Ignar, D. M., Foord, S. M., Wise, A., Dowell, S. J. (2003). The Orphan G Protein-coupled Receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. The Journal of Biological Chemistry, 278(13), 11312-11319.
  4. Cani, P. D., Osto, M., Geurts, L., & Everard, A. (2012). Involvement of gut microbiota in the development of low-grade inflammation and type 2 diabetes associated with obesity. Gut Microbes, 3(4), 279-288.
  5. Castellazzi, A. M., Valsecchi, C., Caimmi, S., Licari, A., Marseglia, A., Leoni, M. C., Caimmi, D., Miraglia del Giudice, M., Leonardi, S., La Rosa, M., & Marseglia, G. L. (2013). Probiotics and food allergy. Italian Journal of Pediatrics, 39(47), 1-10.
  6. Duan, F. F., Liu, J. H., & March, J. C. (2015). Engineered commensal bacteria reprogram intestinal cells into glucose-responsive insulin-secreting cells for the treatment of diabetes. Diabetes, 1-10. Doi:10.2337/db14-0635. · DOI · Paper page
  7. Dubernet, S., Desmasures, N., & Gueguen, M. (2002). A PCR based method for identification of lactobacilli at the genus level. FEMS Microbiology Letters, 214(2), 271-275. · DOI
  8. Dylag, K., Hubalewska-Mazgaj, M., Surmiak, M., Szmyd, J., & Brzozowski, T. (2014). Probiotics in the mechanism of protection against gut inflammation and therapy of gastrointestinal disorders. Current Pharmaceutical Design, 20(18), 1149-1155.
  9. Dziarski, R., Tapping, R. I., & Tobias, P. S. (1998). Binding of bacterial peptidoglycan to CD14. The Journal of Biological Chemistry 273(15), 8680-8690.
  10. Ejtahed, H. S., Mohtadi-Nia, J., Homayouni-Rad, A., Niafar, M., Asghari-Jafarabadi, M., & Mofid, V. (2012). Probiotic yogurt improves antioxidant status in type 2 diabetic patients. Nutrition, 28(5), 539-543.
  11. Flatt, P. R., & Green, B. D. (2006). Nutrient regulation of pancreatic beta cell function in diabetes problems and potential solutions. Biochemical Society Transactions, 34(5), 774-778.
  12. Flint, H. J., Scott, K. P., Louis, P., & Duncan, S. H. (2012). The role of the gut microbiota in nutrition and health. Nat. Rev. Journal of Gastroenterology and Hepatology, 9(10), 577-589. · DOI
  13. Giahi, L., Aumueller, E., Elmadfa, I., & Haslberger, A. G. (2012). Regulation of TLR4, p38 MAP kinase, IκB and miRNAs by inactivated strains of lactobacilli in human dendritic cells. Beneficial Microbes, 3(2), 91-98.
  14. Green, B. D., Gault, V. A., O'Harte, F. P. M., & Flatt, P. R. (2005). Development and therapeutic potential of incretin hormone analogues for type 2 diabetes. The British Journal of Diabetes & Vascular Disease, 5, 134-140.
  15. Hand, K. V., Giblin, L. & Green, B. D. (2012). Hormone profiling in a novel enteroendocrine cell line pGIP/neo: STC-1. Metabolism, 61(12), 1683-1686.
  16. Hardy, H., Harris, J., Lyon, E., Beal, J., & Foey, A. D. (2013). Probiotics, prebiotics and immunomodulation of gut mucosal defences: homeostasis and immunopathology. Nutrients, 5(6), 1869-1912.
  17. Hijova, E., & Soltesova, A. (2013). Effects of probiotics and prebiotics in ulcerative colitis. Bratislava Medical Journal, 114(9), 540-543.
  18. Horvath, A., & Szajewska, H. (2013). Probiotics, prebiotics, and dietary fiber in the management of functional gastrointestinal disorders. World Review of Nutrition and Dietetics, 108, 40-48.
  19. Jepeal, L. I., Boylan, M. O., & Wolfe, M. M. (2008). GATA-4 upregulates glucose dependent insulinotropic polypeptide expression in cells of pancreatic and intestinal lineage. Molecular and Cellular Endocrinology, 287(1-2), 20-29.
  20. Kamdar, K., Nguyen, V., & DePaolo, R. W. (2013). Toll-like receptor signaling and regulation of intestinal immunity. Virulence, 4(3), 207-212.
  21. Katsuma, S., Hatae, N., Yano, T., Ruike, Y., Kimura, M., Hirasawa, A., & Tsugimoto, G. (2005). Free fatty acids inhibit serum deprivation-induced apoptosis through GPR120 in a murine enteroendocrine cell line STC-1. The Journal of Biological Chemistry, 280, 19507-19515.
  22. Kelly, D., & Mulder, I. E. (2012). Microbiome and immunological interactions. Nutrition Reviews, 70, S18-830. · DOI
  23. Ley, R. E., Peterson, D. A., & Gordon, J. I. (2006). Ecological and evolutionary forces shaping microbial diversity in the human intestine. Cell, 124(4), 837-848.
  24. Licciardi, P. V., Wong, S. S., Tang, M. L., & Karagiannis, T. C. (2010). Epigenome targeting by probiotic metabolites. Gut Pathogens, 2(1), 24.
  25. Liu, Y., Fatheree, N. Y., Dingle, B. M., Tran, D. Q., & Rhoads, J. M. (2013). Lactobacillus reuteri DSM 17938 changes the frequency of Foxp3+ regulatory T cells in the intestine and mesenteric lymph node in experimental necrotizing enterocolitis. PLoS One. 8(12), e56547.
  26. Mccarthy, T., Green, B. D., Calderwood, D., Gillespie, A., Cryan, J. F., Giblin, L. (2015). STC-1 cells in Verhoeckx, K., Cotter, P., Lopez-Exposito, I., Kleiveland, C., Lea, T. (Ed.), The Impact of Food Bioactives on Health In Vitro and Ex Vivo Models: 211- 220.
  27. Macfarlane G.T., Cummings J.H. (1999). Probiotics and prebiotics: Can regulating the activities of intestinal bacteria benefit health? British Medical Journal. 318(7189), 999-1003.
  28. Molinaro, F., Paschetta, E., Cassader, M., Gambino, R., & Musso, G. (2012). Probiotics, prebiotics, energy balance, and obesity: mechanistic insights and therapeutic implications. Gastroenterology Clinics of North America, 41(4), 843-854.
  29. Naser, S. M., Dawyndt, P., Hoste, B., Gevers, D., Vandemeulebroecke, K., Cleenwerck, I., Vancanneyt, M., Swings, J. (2007). Identification of lactobacilli by pheS and rpoA gene sequence analyses. International Journal of Systematic and Evolutionary Microbiology, 57(12), 2777-2789.
  30. Neumiller, J. J. (2012). Incretin pharmacology: a review of the incretin effect and current incretin-based therapies. Cardiovascular & Hematological Agents in Medicinal chemistry, 10(4), 276-288.
  31. Panwar, H., Calderwood, D., Grant, I. R., Grover, S., & Green, B. D. (2014). Lactobacillus strains isolated from infant faeces possess potent inhibitory activity against intestinal alpha-and beta-glucosidases suggesting anti-diabetic potential. European Journal of Nutrition, 53(7), 1465-1474.
  32. Panwar, H., Calderwood, D., Grant, I. R., Grover, S., & Green, B. D. (2016). Lactobacilli possess inhibitory activity against dipeptidyl peptidase-4 (DPP-4). Annals of Microbiology 66(1), 505-509.
  33. Prakash, S., Tomaro-Duchesneau, C., Saha, S., Rodes, L., Kahouli, I., Malhotra M. (2013). Probiotics for the prevention and treatment of allergies, with an emphasis on mode of delivery and mechanism of action. Current Pharmaceutical Design, 20(6), 1025-1037.
  34. Rafferty, E. P., Wylie, A. R., Hand, K. H., Elliott, C. E., Grieve, D. J., Green, B. D. (2011). Investigating the effects of physiological bile acids on GLP-1 secretion and glucose tolerance in normal and GLP-1 R(-/-) mice. The Journal of Biological Chemistry, 392(6), 539-546.
  35. Ramshur, E. B., Rull, T. R., & Wice, B. M. (2002). Novel insulin/GIP co-producing cell lines provide unexpected insights into gut K-cell function in vivo. Journal of Cellular Physiology, 192(3), 339-350. · DOI
  36. Rasouli, M., Ahmad, Z., Omar, A. R., & Allaudin, Z. N. (2011). Engineering an L-cell line that expresses insulin under the control of the glucagon-like peptide-1 promoter for diabetes treatment. BMC Biotechnology, 11(99), 1-8.
  37. Rogall, T. J., Wolters, T. F., & Bottger, E. C. (1990). Towards a phylogeny and definition of species at the molecular level within the genus Mycobacterium. International Journal of Systematic Bacteriology, 40, 323-330.
  38. Sanz, Y., Santacruz, A., & Gauffin, P. (2010). Gut microbiota in obesity and metabolic disorders. Proceedings of the Nutrition Society, 69(3), 434-441.
  39. Speck, M., Cho, Y. M., Asadi, A., Rubino, F., & Kieffer, T. J. (2011). Duodenal-jejunal bypass protects GK rats from {beta}-cell loss and aggravation of hyperglycemia and increases enteroendocrine cells coexpressing GIP and GLP-1. American Journal of Physiology. Endocrinology and metabolism, 300(5), E923-932.
  40. Turner, S., Pryer, K. M., Miao, V. P. W., & Palmer, J. D. (1999). Investigating deep phylogenetic relationships among cyanobacteria and plastids by small subunit rRNA sequence analysis. Journal of Eukaryotic Microbiology, 46(4), 327-338. · DOI
  41. Umeki, U., Oue, K., Mochizuki, S., Shirai, Y., & Sakai, K. (2004). Effect of Lactobacillus rhamnosus KY-3 and cellobiose as synbiotics on lipid metabolism in rats. Journal of Nutritional Science and Vitaminology, 50(5), 330-334.
  42. Walter, J., & Ley, R. (2011). The human gut microbiome: Ecology and recent evolutionary changes. Annual Review of Microbiology, 65, 411-429.
  43. Wehr, H. M., & Frank, J. F. (Eds.) (2004). Standard Methods for the Examination of Dairy Products, American Public Health Association, Baltimore, United States of America 2004.
  44. Yadav, H., Lee, J. H., Lloyd, J., Walter, P., & Rane, S. G. (2013). Beneficial metabolic effects of a probiotic via butyrate-induced GLP-1 hormone secretion. The Journal of Biological Chemistry, 288(35), 25088-25097. Reference

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Authors
Panwar, H., Calderwood, D., Gillespie, A. L., Wylie, A. R., Graham, S. F., Grant, I. R., Grover, S., & Green, B. D.
Affiliations
  • Queen's University Belfast (GB)
  • Agri Food and Biosciences Institute (GB)
  • National Dairy Research Institute (IN)
Corresponding author
Green, Brian D.
ORCID
Venue
Journal of Functional Foods
Publisher
Elsevier BV
Published
2016-05
Volume
23
Pages
348-358
ISSN
1756-4646 (ISSN-L)
DOI
10.1016/j.jff.2016.02.040
OpenAlex
W2324326866
Cited by
27
References
3
Citations by year
2026: 2 · 2025: 3 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 6 · 2019: 7 · 2018: 2 · 2017: 3
FWCI
5.04
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Functional Foods (publishedVersion)
  • Research Portal (Queen's University Belfast) (acceptedVersion, cc-by-nc-nd)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Commonwealth Scholarship Commission (INCN-2011-43)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords
lactic acid bacteria, incretins, glucagon-like peptide-1, glucose-dependent insulinotropic polypeptide, enteroendocrine cells, MyD88, CD14, Toll-like receptor signaling, gut-brain axis, type 2 diabetes, probiotics, gene expression

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