Engineered commensal bacteria reprogram intestinal cells into glucose-responsive insulin-secreting cells for the treatment of diabetes

Biology of Incretins: GLP-1 and GIP

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Differentiation of Embryonic Stem Cells to Insulin-Secreting Structures Similar to Pancreatic Islets

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Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice.

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Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia

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Expression of Pax4 in embryonic stem cells promotes differentiation of nestin-positive progenitor and insulin-producing cells

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Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells

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Cross-Talk between Probiotic Bacteria and the Host Immune System1,

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Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development.Preprint

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Reversal of hyperglycemia in mice by using human expandable insulin-producing cells differentiated from fetal liver progenitor cells

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Reversal of hyperglycemia in diabetic mouse models using induced-pluripotent stem (iPS)-derived pancreatic β-like cells

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Signals from lateral plate mesoderm instruct endoderm toward a pancreatic fate

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Lactobacillus farciminis treatment suppresses stress induced visceral hypersensitivity: a possible action through interaction with epithelial cell cytoskeleton contraction

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The Onecut transcription factor HNF-6 (OC-1) is required for timely specification of the pancreas and acts upstream of Pdx-1 in the specification cascade.

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Foxa2 Controls Pdx1 Gene Expression in Pancreatic β-Cells In Vivo

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Probiotics and irritable bowel syndrome: a rationale for their use and an assessment of the evidence to date

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Glucagon-like peptide 1 (1–37) converts intestinal epithelial cells into insulin-producing cells

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Modulation of allergic immune responses by mucosal application of recombinant lactic acid bacteria producing the major birch pollen allergen Bet v 1

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Genetically modified probiotics in foods

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A vHNF1/TCF2-HNF6 cascade regulates the transcription factor network that controls generation of pancreatic precursor cells.

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Intestinal immunity ofEscherichia coliNISSLE 1917: a safe carrier for therapeutic molecules

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Persistent expression of HNF6 in islet endocrine cells causes disrupted islet architecture and loss of beta cell function

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Secretion of insulinotropic proteins by commensal bacteria: rewiring the gut to treat diabetes

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Maturation of Adult β-Cells Revealed Using a Pdx1/Insulin Dual-Reporter Lentivirus

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Glucose activates free fatty acid receptor 1 gene transcription via phosphatidylinositol-3-kinase-dependent O -GlcNAcylation of pancreas-duodenum homeobox-1

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Spatio-temporal patterns of intestine-specific transcription factor expression during postnatal mouse gut development

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Efficient production and secretion of bovine β-lactoglobulin by Lactobacillus casei

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Stem Cells for the Treatment of Diabetes

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Engineering of the gut commensal bacterium Bacteroides ovatus to produce and secrete biologically active murine interleukin-2 in response to xylan

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Differentiation of Mouse Embryonic Stem Cells into Pancreatic and Hepatic Cells

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Interrupting Vibrio cholerae infection of human epithelial cells with engineered commensal bacterial signaling

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Engineering commensal bacteria for prophylaxis against infection

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Synthetic signaling networks for therapeutic applications

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Sustained Expression of Hepatocyte Nuclear Factor-6 Leads to Loss of Pancreatic Beta-cells by Apoptosis

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Genetically Engineered Probiotic Competition

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Gut microbiota in human metabolic health and disease

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The Human Intestinal Microbiome in Health and Disease

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Regulation of Intestinal Barrier Function by Microbial Metabolites

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Gut microbiota, obesity and diabetes

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Engineered probiotic Escherichia coli can eliminate and prevent Pseudomonas aeruginosa gut infection in animal models

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Engineering bacteria for diagnostic and therapeutic applications

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Role of the gut microbiota in type 2 diabetes and related diseases

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An engineered <i>E. coli</i> Nissle improves hyperammonemia and survival in mice and shows dose-dependent exposure in healthy humans

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Engineered commensal microbes for diet-mediated colorectal-cancer chemoprevention

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Anti-diabetic Effects of Clostridium butyricum CGMCC0313.1 through Promoting the Growth of Gut Butyrate-producing Bacteria in Type 2 Diabetic Mice

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Linking microbiota to human diseases: a systems biology perspective

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Probiotics as Complementary Treatment for Metabolic Disorders

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Promises of microbiome-based therapies

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Neuroprotective effects of an engineered commensal bacterium in the 1‐methyl‐4‐phenyl‐1, 2, 3, 6‐tetrahydropyridine Parkinson disease mouse model via producing glucagon‐like peptide‐1

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Targeting nonalcoholic fatty liver disease via gut microbiome-centered therapies

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Direct reprogramming 101

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Biophysical regulation of cell reprogramming

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Advances in Reprogramming to Pluripotency

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