Probiotics and Lung Diseases
Abstract
Increasing awareness of the role of intestinal commensal bacteria in the development and modulation of the immune system has led to great interest in the therapeutic potential of probiotics and other bacteria-based strategies for a range of immune-related disorders. Studies in animal models have identified strong immunomodulatory effects of many nonpathogenic bacteria and provided evidence that intestinal microbes can activate a common mucosal immune response and, thus, influence sites distant to the intestine, including the respiratory tract. Respiratory effects of probiotics in animal models have included attenuating allergic airway responses and protecting against respiratory pathogens. Dendritic cells appear central to directing the beneficial immune response to probiotic bacteria and in translating microbial signals from the innate to the adaptive immune system, whereas regulatory T cells are emerging as potentially key effectors of probiotic-mediated responses, particularly in the reduction of allergic inflammation. Despite progress in basic research, clinical trials of probiotics in allergy/asthma and respiratory infection have been highly variable at best, leading to an undermining of confidence in this potential therapeutic strategy. It is clear that there is still much to learn regarding the determinants of the diverse immune responses elicited by different bacterial strains. A deeper knowledge of the interactions between administered probiotics and the existing microbiota, together with an understanding of how the dialogue between microbes and the innate immune system is translated into beneficial/protective responses, will be required before we can achieve clinically effective bacteria-based strategies that maintain and promote respiratory health.
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Probiotic treatment may modulate immune response in the lung; in particular gut microbial stimulation can enhance T regulatory response in the airway, which emphasizes the potential role of probiotics in the pulmonary inflammatory response.
“It is also important to note that probiotic treatment may modulate immune response in the lung; in particular gut microbial stimulation can enhance T regulatory response in the airway, which emphasizes the potential role of probiotics in the pulmonary inflammatory response [89] .”
From Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis (2014) · cites this paper as [89]
Cites
Ido expression by dendritic cells: tolerance and tryptophan catabolism
Mellor, A. L., & Munn, D. H. (2004) · Nature Reviews Immunology · doi:10.1038/nri1457 · Cited by 2,341 · see citing works
A microbial symbiosis factor prevents intestinal inflammatory disease
Mazmanian, S. K., Round, J. L., & Kasper, D. L. (2008) · Nature · doi:10.1038/nature07008 · Cited by 2,340 · see citing works
Kalliomäki, M. A., Salminen, S., Poussa, T. A., Arvilommi, H. S., & Isolauri, E. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13490-3 · Cited by 1,340 · see citing works
Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing
Kalliomäki, M., Kirjavainen, P., Eerola, E., Kero, P., Salminen, S., & Isolauri, E. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.111237 · Cited by 1,255 · see citing works
The Foxp3+ regulatory T cell: a jack of all trades, master of regulation
Tang, Q., & Bluestone, J. A. (2008) · Nature Immunology · doi:10.1038/ni1572 · Cited by 1,026 · see citing works
Christensen, H. R., Frøkiær, H., & Pestka, J. J. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.1.171 · Cited by 905 · see citing works
Hatakka, K., Savilahti, E., Pönkä, A., Meurman, J. H., Poussa, T., Näse, L., Saxelin, M., & Korpela, R. (2001) · BMJ · doi:10.1136/bmj.322.7298.1327 · Cited by 645 · see citing works
Kwon, H., Lee, C., So, J., Chae, C.-S., Hwang, J.-S., Sahoo, A., Nam, J. H., Rhee, J. H., Hwang, K.-C., & Im, S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904055107 · Cited by 627 · see citing works
Suppression of allergic airway inflammation by helminth-induced regulatory T cells
Wilson, M. S., Taylor, M. D., Balic, A., Finney, C. A. M., Lamb, J. R., & Maizels, R. M. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20042572 · Cited by 611 · see citing works
Grangette, C., Nutten, S., Palumbo, E., Morath, S., Hermann, C., Dewulf, J., Pot, B., Härtung, T., Pascal Hols, A., & Mercenier, A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504084102 · Cited by 443 · see citing works
Kuitunen, M., Kukkonen, A. K., Juntunen‐Backman, K., Korpela, R., Poussa, T. A., Tuure, T., Haahtela, T., & Savilahti, E. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.11.019 · Cited by 408 · see citing works
Effects of probiotics on atopic dermatitis: a randomised controlled trial
Weston, S. (2005) · Archives of Disease in Childhood · doi:10.1136/adc.2004.060673 · Cited by 408 · see citing works
The ‘microflora hypothesis’ of allergic diseases
Noverr, M. C., & Huffnagle, G. B. (2005) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2005.02379.x · Cited by 394 · see citing works
Commensal-Induced Regulatory T Cells Mediate Protection against Pathogen-Stimulated NF-κB Activation
O’Mahony, C., Scully, P., O'Mahony, D., Murphy, S., O'Brien, F., Lyons, A., Sherlock, G., MacSharry, J. A., Kiely, B., Shanahan, F., et al. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.1000112 · Cited by 365 · see citing works
Karimi, K., Inman, M. D., Bienenstock, J., & Forsythe, P. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200806-951oc · Cited by 361 · see citing works
Self-citationProbiotic Prophylaxis of Ventilator-associated Pneumonia: A Blinded, Randomized, Controlled Trial
Morrow, L. E., Kollef, M. H., & Casale, T. B. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200912-1853oc · Cited by 347 · see citing works
Inhibition of experimental asthma by indoleamine 2,3-dioxygenase
Hayashi, T., Beck, L., Rossetto, C. C., Gong, X., Takikawa, O., Takabayashi, K., Broide, D. H., Carson, D. A., & Raz, E. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21275 · Cited by 344 · see citing works
Feleszko, W., Jaworska, J., Rha, R.-D., Steinhausen, S., Avagyan, A., Jaudszus, A., Ahrens, B., Groneberg, D. A., Wahn, U., & Hamelmann, E. H. (2006) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2006.02629.x · Cited by 339 · see citing works
Oral Treatment with Live Lactobacillus reuteri Inhibits the Allergic Airway Response in Mice
Forsythe, P., Inman, M. D., & Bienenstock, J. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200606-821oc · Cited by 306 · see citing works
Self-citationValdéz, J. C., Peral, M. C., Rachid, M., Santana, M., & Perdigón, G. (2005) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2005.01142.x · Cited by 301 · see citing works
A Key Role of Dendritic Cells in Probiotic Functionality
Foligné, B., Ζουμποπούλου, Γ., Dewulf, J., Younes‐Chennoufi, A. B., Chareyre, F., Sirard, J., Pot, B., & Grangette, C. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000313 · Cited by 278 · see citing works
Lyons, A., O'Mahony, D., O'Brien, F., MacSharry, J. A., Sheil, B., Ceddia, M. A., Russell, W. M., Forsythe, P., Bienenstock, J., Kiely, B., et al. (2010) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2009.03437.x · Cited by 233 · see citing works
Self-citationClinical Indications for Probiotics: An Overview
Goldin, B., & Gorbach, S. L. (2008) · Clinical Infectious Diseases · doi:10.1086/523333 · Cited by 231 · see citing works
Lactobacillus GG in the Prevention of Nosocomial Gastrointestinal and Respiratory Tract Infections
Hojsak, I., Abdović, S., Szajewska, H., Milošević, M., Krznarić, Ž., & Kolaček, S. (2010) · PEDIATRICS · doi:10.1542/peds.2009-2568 · Cited by 214 · see citing works
de Vrese, M., Winkler, P., Rautenberg, P., Harder, T., Noah, C., Laue, C., Ott, S., Hampe, J., Schreiber, S., Heller, K., et al. (2006) · Vaccine · doi:10.1016/j.vaccine.2006.05.048 · Cited by 201 · see citing works
Effects of intestinal microflora and the environment on the development of asthma and allergy
n, B. B. R. (2004) · Springer Seminars in Immunopathology · doi:10.1007/s00281-003-0142-2 · Cited by 187 · see citing works
Harata, G., He, F., Hiruta, N., Kawase, M., Kubota, A., Hiramatsu, M., & Yausi, H. (2010) · Letters in Applied Microbiology · doi:10.1111/j.1472-765x.2010.02844.x · Cited by 186 · see citing works
Oyama, N., Sudo, N., Sogawa, H., & Kubo, C. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.111142 · Cited by 179 · see citing works
Bifidobacterium longum lysate, a new ingredient for reactive skin
Guéniche, A., Bastien, P., Ovigne, J.-M., Kermici, M., Courchay, G., Chevalier, V., Breton, L., & Castiel‐Higounenc, I. (2009) · Experimental Dermatology · doi:10.1111/j.1600-0625.2009.00932.x · Cited by 169 · see citing works
Blümer, N., Sel, S., Virna, S., Patrascan, C. C., Zimmermann, S., Herz, U., Renz, H. E., & Garn, H. (2007) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2007.02671.x · Cited by 168 · see citing works
Hougee, S., Vriesema, A. J. M., Wijering, S. C., Knippels, L. M. J., Folkerts, G., Nijkamp, F. P., Knol, J., & Garssen, J. (2009) · International Archives of Allergy and Immunology · doi:10.1159/000236000 · Cited by 162 · see citing works
Pérez-Cano, F. J., Dong, H., & Yaqoob, P. (2010) · Immunobiology · doi:10.1016/j.imbio.2010.01.004 · Cited by 156 · see citing works
Vliagoftis, H., Kouranos, V., Betsi, G. I., & Falagas, M. E. (2008) · Annals of Allergy Asthma & Immunology · doi:10.1016/s1081-1206(10)60219-0 · Cited by 146 · see citing works
Izumo, T., Maekawa, T., Ida, M., Noguchi, A., Kitagawa, Y., Shibata, H., Yasui, H., & Kiso, Y. (2010) · International Immunopharmacology · doi:10.1016/j.intimp.2010.06.012 · Cited by 134 · see citing works
Sudo, N., Yu, X.-N., Aiba, Y., Oyama, N., Sonoda, J., Koga, Y., & Kubo, C. (2002) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.2002.01430.x · Cited by 130 · see citing works
Immunomodulatory function of lactic acid bacteria
Yasui, H., Shida, K., Matsuzaki, T., & Yokokura, T. (1999) · Springer eBooks · doi:10.1007/978-94-017-2027-4_24 · Cited by 126 · see citing works
Distinct gut-derived lactic acid bacteria elicit divergent dendritic cell-mediated NK cell responses
Fink, L. N., Zeuthen, L., Christensen, H. R., Morandi, B., Frøkiær, H., & Ferlazzo, G. (2007) · International Immunology · doi:10.1093/intimm/dxm103 · Cited by 115 · see citing works
Ghadimi, D., de Vrese, M., Heller, K. J., & Schrezenmeir, J. (2010) · International Immunopharmacology · doi:10.1016/j.intimp.2010.03.014 · Cited by 110 · see citing works
Immunomodulatory function of lactic acid bacteria
Yasui, H., Shida, K., Matsuzaki, T., & Yokokura, T. (1999) · Antonie van Leeuwenhoek · doi:10.1023/a:1002041616085 · Cited by 106 · see citing works
Alvarez, S., Herrero, C., Bru, E., & Perdigón, G. (2001) · Journal of Food Protection · doi:10.4315/0362-028x-64.11.1768 · Cited by 104 · see citing works
Lactobacillus casei Improves Resistance to Pneumococcal Respiratory Infection in Malnourished Mice
Villena, J., Racedo, S., Agüero, G., Bru, E., Medina, M., & Alvarez, S. (2005) · Journal of Nutrition · doi:10.1093/jn/135.6.1462 · Cited by 102 · see citing works
de LeBlanc, A. D. M., Chaves, S., Carmuega, E., Weill, R., Antoine, J. M., & Perdigón, G. (2007) · Immunobiology · doi:10.1016/j.imbio.2007.07.002 · Cited by 98 · see citing works
Leech, M. D., Benson, R. A., deVries, A., Fitch, P. M., & Howie, S. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.10.7050 · Cited by 97 · see citing works
Probiotics as Drugs Against Human Gastrointestinal Infections
Sanz, Y., Nadal, I., & Sánchez, E. (2007) · Recent Patents on Anti-Infective Drug Discovery · doi:10.2174/157489107780832596 · Cited by 96 · see citing works
Maassen, C. B. M., Boersma, W. J. A., van Holten-Neelen, C., Claassen, E., & Laman, J. D. (2003) · Vaccine · doi:10.1016/s0264-410x(03)00220-2 · Cited by 96 · see citing works
von Bubnoff, D., Fimmers, R., Bogdanow, M., Matz, H., Koch, S., & Bieber, T. R. M. (2004) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2004.01984.x · Cited by 80 · see citing works
Koizumi, S.-I., Wakita, D., Sato, T., Mitamura, R., Izumo, T., Shibata, H., Kiso, Y., Chamoto, K., Togashi, Y., Kitamura, H., et al. (2008) · Immunology Letters · doi:10.1016/j.imlet.2008.06.003 · Cited by 76 · see citing works
Ezendam, J., & Loveren, H. V. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507803412 · Cited by 61 · see citing works
Villena, J., Barbieri, N., Salva, S., Herrera, M., & Alvarez, S. (2009) · Microbiology and Immunology · doi:10.1111/j.1348-0421.2009.00171.x · Cited by 56 · see citing works
Microbial Manipulation of Immune Function for Asthma Prevention: Inferences from Clinical Trials
Yoo, J., Tcheurekdjian, H., Lynch, S. V., Cabana, M. D., & Boushey, H. A. (2007) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200702-033aw · Cited by 55 · see citing works
Chapter 5 Immune Pathways for Translating Viral Infection into Chronic Airway Disease
Holtzman, M. J., Byers, D. E., Benoît, L. A., Battaile, J. T., You, Y., Agapov, E. V., Park, C., Grayson, M. H., Kim, E. Y., & Patel, A. C. (2009) · Advances in immunology · doi:10.1016/s0065-2776(09)01205-x · Cited by 46 · see citing works
Harata, G., He, F., Kawase, M., Hosono, A., Takahashi, K., & Kaminogawa, S. (2009) · Microbiology and Immunology · doi:10.1111/j.1348-0421.2009.00146.x · Cited by 41 · see citing works
Liu, K., Leu, S., Su, C., Chiang, B., Chen, Y., & Lee, Y. (2009) · Immunology · doi:10.1111/j.1365-2567.2009.03175.x · Cited by 28 · see citing works
Dyella jejuensis sp. nov., isolated from soil of Hallasan Mountain in Jeju Island
Kim, M., Hyun, D., Kim, J. Y., Kim, S., Bae, J., & Park, E. J. (2014) · The Journal of Microbiology · doi:10.1007/s12275-014-3670-7 · Cited by 22 · see citing works
Kim, D. W., Cho, S. B., Yun, C., Jeong, H. Y., Chung, W. T., Choi, C. W., Lee, H. J., Nam, I. S., Suh, G. H., Lee, S., et al. (2007) · PubMed · Cited by 18 · see citing works
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Russell, S. L., Gold, M. J., Hartmann, M., Willing, B. P., Thorson, L., Wlodarska, M., Gill, N., Blanchet, M., Mohn, W. W., McNagny, K. M., et al. (2012) · The EMBO Reports · doi:10.1038/embor.2012.32 · Cited by 883 · see citing works
Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis
Tojo, R. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i41.15163 · Cited by 533 · see citing works
Regulation of lung immunity and host defense by the intestinal microbiota
Samuelson, D. R., Welsh, D. A., & Shellito, J. E. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.01085 · Cited by 434 · see citing works
The role of the bacterial microbiome in lung disease
Dickson, R. P., Erb‐Downward, J. R., & Huffnagle, G. B. (2013) · Expert Review of Respiratory Medicine · doi:10.1586/ers.13.24 · Cited by 412 · see citing works
Pediococcus spp.: An important genus of lactic acid bacteria and pediocin producers
Porto, M. C. W., Kuniyoshi, T. M., Azevedo, P. O. S., Vitolo, M., & Oliveira, R. P. S. (2017) · Biotechnology Advances · doi:10.1016/j.biotechadv.2017.03.004 · Cited by 262 · see citing works
A Clinician's Primer on the Role of the Microbiome in Human Health and Disease
Khanna, S., & Tosh, P. K. (2014) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2013.10.011 · Cited by 231 · see citing works
The Innate Immune Protein Nod2 Binds Directly to MDP, a Bacterial Cell Wall Fragment
Grimes, C. L., Ariyananda, L. D. Z., Melnyk, J. E., & O’Shea, E. K. (2012) · Journal of the American Chemical Society · doi:10.1021/ja303883c · Cited by 194 · see citing works
Assembly of a Three-Dimensional Multitype Bronchiole Coculture Model Using Magnetic Levitation
Tseng, H., Gage, J. A., Raphael, R. M., Moore, R. H., Killian, T. C., Grande-Allen, K. J., & Souza, G. R. (2013) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2012.0157 · Cited by 138 · see citing works
Gut microbiota in various childhood disorders: Implication and indications
Saeed, N. K., Al‐Beltagi, M., Bediwy, A. S., El-Sawaf, Y., & Toema, O. (2022) · World Journal of Gastroenterology · doi:10.3748/wjg.v28.i18.1875 · Cited by 147 · see citing works
Limosilactobacillus reuteri in Health and Disease
Abuqwider, J., Altamimi, M., & Mauriello, G. (2022) · Microorganisms · doi:10.3390/microorganisms10030522 · Cited by 124 · see citing works
SARS-CoV-2 microbiome dysbiosis linked disorders and possible probiotics role
Din, A. U., Mazhar, M., Waseem, M., Ahmad, W., Bibi, A., Hassan, A., Ali, N., Wang, G., Gao, Q., Ullah, R., et al. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110947 · Cited by 119 · see citing works
Non dairy probiotic beverages.
Vasudha, S., & Mishra, H. (2013) · International Food Research Journal · Cited by 116 · see citing works
Perinatal Programming of Asthma: The Role of Gut Microbiota
Azad, M. B., & Kozyrskyj, A. L. (2011) · Clinical and Developmental Immunology · doi:10.1155/2012/932072 · Cited by 102 · see citing works
Human Pharyngeal Microbiome May Play A Protective Role in Respiratory Tract Infections
Gao, Z., Kang, Y., Yu, J. M., & Ren, L. (2014) · Genomics Proteomics & Bioinformatics · doi:10.1016/j.gpb.2014.06.001 · Cited by 95 · see citing works
Wang, X., Yan, H., Zhao, L., Hao, Y., Guo, H., & Ren, F. (2017) · PLoS ONE · doi:10.1371/journal.pone.0171721 · Cited by 85 · see citing works
Fu, G., Zhao, K., Chen, H., Wang, Y., Nie, L., Wei, H., & Wan, C. (2019) · Journal of Dairy Science · doi:10.3168/jds.2018-15683 · Cited by 86 · see citing works
Bui, V. T., Tseng, H.-C., Kozłowska, A. K., Maung, P. O., Kaur, K., Topchyan, P., & Jewett, A. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00576 · Cited by 83 · see citing works
Gut Microbiota: the Emerging Link to Lung Homeostasis and Disease
Zhou, A., Lei, Y., Tang, L., Hu, S., Yang, M., Wu, L., Yang, S., & Tang, B. (2020) · Journal of Bacteriology · doi:10.1128/jb.00454-20 · Cited by 78 · see citing works
The impact of gut microbes in allergic diseases
Russell, S., & Finlay, B. B. (2012) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e3283573017 · Cited by 74 · see citing works
Carvalho, J. L., Miranda, M., FIALHO, A. K. C. D. S., Castro-Faria-Neto, H., Anatriello, E., Keller, A. C., & Aimbire, F. (2020) · PLoS ONE · doi:10.1371/journal.pone.0225560 · Cited by 73 · see citing works
Liu, K., Zhu, Y., Zhang, J., Tao, L., Lee, J. W., Wang, X., & Qu, J. (2012) · Critical Care · doi:10.1186/cc11398 · Cited by 72 · see citing works
Lactobacillus reuteri ATCC55730 in Cystic Fibrosis
Nardo, G. D., Oliva, S., Menichella, A., Pistelli, R., Biase, R. V. D., Patriarchi, F., Cucchiara, S., & Stronati, L. (2013) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000000187 · Cited by 71 · see citing works
The Airway Microbiome and Disease
Marsland, B. J., Yadava, K., & Nicod, L. P. (2013) · CHEST Journal · doi:10.1378/chest.12-2854 · Cited by 69 · see citing works
Daniel, S., Phillippi, D., Schneider, L. J., Nguyen, K. N., Mirpuri, J., & Lund, A. K. (2021) · Particle and Fibre Toxicology · doi:10.1186/s12989-020-00393-9 · Cited by 67 · see citing works
The Murine Lung Microbiome Changes During Lung Inflammation and Intranasal Vancomycin Treatment
Barfod, K. K., Vrankx, K., Mirsepasi‐Lauridsen, H. C., Hansen, J. S., Hougaard, K. S., Larsen, S. T., Ouwenhand, A. C., & Krogfelt, K. A. (2015) · The Open Microbiology Journal · doi:10.2174/1874285801509010167 · Cited by 64 · see citing works
Probiotics: A new way to fight bacterial pulmonary infections?
Alexandre, Y., Blay, G. L., Boisramé, S., Gall, F. L., Héry-Arnaud, G., Gouriou, S., Vallet, S., & Berre, R. L. (2013) · Médecine et Maladies Infectieuses · doi:10.1016/j.medmal.2013.05.001 · Cited by 64 · see citing works
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Gallacher, D. J., & Kotecha, S. (2016) · Frontiers in Pediatrics · doi:10.3389/fped.2016.00010 · Cited by 64 · see citing works
Zhang, B., An, J., Shimada, T., Liu, S., & Maeyama, K. (2012) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2012.1010 · Cited by 61 · see citing works
Sagar, S., Vos, A. P., Morgan, M. E., Garssen, J., Georgiou, N., Boon, L., Kraneveld, A. D., & Folkerts, G. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.01.005 · Cited by 60 · see citing works
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Ahanchian, H., Jones, C. M., Chen, Y.-S., & Sly, P. D. (2012) · BMC Pediatrics · doi:10.1186/1471-2431-12-147 · Cited by 59 · see citing works
Emerging importance of holobionts in evolution and in probiotics
Singh, Y., Ahmad, J., Musarrat, J., Ehtesham, N. Z., & Hasnain, S. E. (2013) · Gut Pathogens · doi:10.1186/1757-4749-5-12 · Cited by 58 · see citing works
Gut microbiota and hematopoietic stem cell transplantation: where do we stand?
Zama, D., Biagi, E., Masetti, R., Gasperini, P., Prete, A., Candela, M., Brigidi, P., & Pession, A. (2016) · Bone Marrow Transplantation · doi:10.1038/bmt.2016.173 · Cited by 60 · see citing works
Anatriello, E., da Cunha, M., Nogueira, J. D. S., Carvalho, J. L., Sá, A. K., Miranda, M., Castro-Faria-Neto, H., Keller, A. C., & Aimbire, F. (2019) · Cellular Immunology · doi:10.1016/j.cellimm.2019.103928 · Cited by 51 · see citing works
Gut microbiome a promising target for management of respiratory diseases
Trivedi, R., & Barve, K. H. (2020) · Biochemical Journal · doi:10.1042/bcj20200426 · Cited by 51 · see citing works
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Ranucci, G., Buccigrossi, V., de Freitas, M. B., Guarino, A., & Giannattasio, A. (2017) · Journal of Immunology Research · doi:10.1155/2017/8450496 · Cited by 48 · see citing works
Lira, G. V. D. A. G., de Oliveira, M. H., Peixoto, D. M., & SARINHO, E. S. C. (2015) · Jornal de Pediatria · doi:10.1016/j.jped.2015.03.002 · Cited by 48 · see citing works
Lee, S.-C., Yang, Y., Chuang, S., Huang, S., & Pan, W. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512004692 · Cited by 46 · see citing works
Metagenome and Metatranscriptome Profiling of Moderate and Severe COPD Sputum in Taiwanese Han Males
Lee, S., Kuan, C.-S., Wu, L. S., & Weng, J. T.-Y. (2016) · PLoS ONE · doi:10.1371/journal.pone.0159066 · Cited by 45 · see citing works
Dietary Plasma Proteins Modulate the Adaptive Immune Response in Mice with Acute Lung Inflammation
Maijó, M., Miró, L., Polo, J., Campbell, J. M., Russell, L., Crenshaw, J., Weaver, E. M., Moretó, M., & Pérez‐Bosque, A. (2012) · Journal of Nutrition · doi:10.3945/jn.111.149070 · Cited by 41 · see citing works
Engineered Bacteria for Disease Diagnosis and Treatment Using Synthetic Biology
Jin, K., Huang, Y. B., Che, H., & Wu, Y. (2025) · Microbial Biotechnology · doi:10.1111/1751-7915.70080 · Cited by 43 · see citing works
Oral Probiotics Alter Healthy Feline Respiratory Microbiota
Vientós‐Plotts, A. I., Ericsson, A. C., Rindt, H., & Reinero, C. R. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01287 · Cited by 38 · see citing works
Acid-Suppressive Therapy and Risk of Infections: Pros and Cons
Fisher, L., & Fisher, A. (2017) · Clinical Drug Investigation · doi:10.1007/s40261-017-0519-y · Cited by 34 · see citing works
Lu, H., Zhang, C., Qian, G., Hu, X., Zhang, H., Chen, C., Liang, W., Gao, H., Yang, Y., & Li, L. (2014) · BMC Infectious Diseases · doi:10.1186/1471-2334-14-359 · Cited by 32 · see citing works
Bacteria in COPD; their potential role and treatment
King, P. T., MacDonald, M., & Bardin, P. G. (2013) · Translational Respiratory Medicine · doi:10.1186/2213-0802-1-13 · Cited by 33 · see citing works
The mucosal microbiome in shaping health and disease
Pfefferle, P. I., & Renz, H. E. (2014) · F1000Prime Reports · doi:10.12703/p6-11 · Cited by 31 · see citing works
Reiprich, M., Rudzok, S., Schütze, N., Simon, J. C., Lehmann, I., Trump, S., & Polte, T. (2013) · Allergy · doi:10.1111/all.12121 · Cited by 31 · see citing works
Alsayed, A. R., Abed, A. I., Khader, H. A., Al-Shdifat, L., Hasoun, L., Al‐Rshaidat, M. M. D., Alkhatib, M., & Zihlif, M. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24044086 · Cited by 29 · see citing works
Dietary Supplementation with Probiotics Improves Hematopoiesis in Malnourished Mice
Salva, S., Merino, M. C., Agüero, G., Gruppi, A., & Alvarez, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031171 · Cited by 30 · see citing works
A Critical Review on the Role of Probiotics in Lung Cancer Biology and Prognosis
Ashique, S., Mishra, N., Garg, A., Kumar, N., Khan, Z., Mohanto, S., Chellappan, D. K., Farid, A., & Taghizadeh‐Hesary, F. (2024) · Archivos de Bronconeumología · doi:10.1016/j.arbres.2024.04.030 · Cited by 29 · see citing works
Panwar, H., Calderwood, D., Gillespie, A. L., Wylie, A. R., Graham, S. F., Grant, I. R., Grover, S., & Green, B. D. (2016) · Journal of Functional Foods · doi:10.1016/j.jff.2016.02.040 · Cited by 27 · see citing works
The Effect of Probiotic Treatment on Patients Infected with the H7N9 Influenza Virus
Hu, X., Zhang, H., Lu, H., Qian, G., Lv, L., Zhang, C., Guo, J., Jiang, H., Zheng, B., Yang, F., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0151976 · Cited by 24 · see citing works
Ren, J., Zhao, Y., Yang, F., Lv, D., Hung, S., Zhang, J., Lin, P., Liu, S., Zhang, N., & Bachert, C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0140018 · Cited by 23 · see citing works
Ballarini, S., Rossi, G. A., Principi, N., & Esposito, S. (2021) · Microorganisms · doi:10.3390/microorganisms9020448 · Cited by 22 · see citing works
Guo, Z., Wang, Q., Zhao, J., Xu, Y., Mu, G., & Zhu, X. (2023) · Food Bioscience · doi:10.1016/j.fbio.2023.103055 · Cited by 22 · see citing works
Lu, H., Qian, G., Ren, Z., Zhang, C., Zhang, H., Xu, W., Ye, P., Yang, Y., & Li, L. (2015) · BMC Infectious Diseases · doi:10.1186/s12879-015-0977-x · Cited by 22 · see citing works
del Giudice, M. M., Leonardi, S., Ciprandi, G., Galdo, F., Gubitosi, A., Rosa, M. L., Salpietro, C. D., Marseglia, G. L., & Perrone, L. (2012) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e318266fea7 · Cited by 19 · see citing works
Effects of lysed Enterococcus faecalis FK-23 on experimental allergic rhinitis in a murine model
Luping, Z., Takashi, S., Ruoxi, C., Lu, M., Qingzhao, Z., Wenmin, L., Yin, M., Enomoto, T., & Lei, C. (2012) · Journal of Biomedical Research · doi:10.7555/jbr.26.20120023 · Cited by 19 · see citing works
Probiotics/Prebiotics in Viral Respiratory Infections: Implication for Emerging Pathogens
Heidari, Z., Tajbakhsh, A., Hayat, S. M. G., Moattari, A., Razban, V., Berenjian, A., Savardashtaki, A., & Negahdaripour, M. (2021) · Recent Patents on Biotechnology · doi:10.2174/1872208315666210419103742 · Cited by 17 · see citing works
Lactiplantibacillus brownii sp. nov., a novel psychrotolerant species isolated from sauerkraut
Heng, Y. C., Silvaraju, S., Lee, J. K. Y., & Kittelmann, S. (2023) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/ijsem.0.006194 · Cited by 15 · see citing works
Montuori‐Andrade, A. C. M., Nolasco, A., Malacco, N. L. S. D. O., Vaz, L. G., Afonso, L., Russo, R. C., Vieira, L. Q., & dos Santos, L. M. (2022) · Immunobiology · doi:10.1016/j.imbio.2022.152284 · Cited by 15 · see citing works
Challenges in understanding lung microbiome: It is NOT like the gut microbiome
Chang, D., Cruz, C. S. D., & Sharma, L. (2019) · Respirology · doi:10.1111/resp.13759 · Cited by 14 · see citing works
Nanotechnology in tissue engineering and regenerative medicine
Rajendran, A. K., Kim, H. D., Kim, J., Bae, J. W., & Hwang, N. S.-Y. (2023) · Korean Journal of Chemical Engineering · doi:10.1007/s11814-022-1363-1 · Cited by 14 · see citing works
Olimpio, F. R. D. S., da Silva, J. R. M., Vieira, R. P., Oliveira, C. R., & Aimbire, F. (2022) · Clinics · doi:10.1016/j.clinsp.2022.100021 · Cited by 13 · see citing works
Immune Tolerance by Induced Regulatory T Cells in Asthma
Choi, I. S. (2012) · Allergy Asthma and Immunology Research · doi:10.4168/aair.2012.4.3.113 · Cited by 13 · see citing works
Satia, I., Cusack, R. P., Stevens, C., Schlatman, A., Wattie, J. N., Mian, F., Killian, K. J., O’Byrne, P. M., Bienenstock, J., Forsythe, P., et al. (2021) · Clinical & Experimental Allergy · doi:10.1111/cea.13976 · Cited by 12 · see citing works
Self-citationProgramming of the lung by early-life infection
Hansbro, P. M., Starkey, M. R., Kim, R., Stevens, R. L., Foster, P. S., & Horvat, J. C. (2012) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174412000050 · Cited by 12 · see citing works
Li, M., Pan, T., Yu, J., Wang, X., Gao, R., Wang, Y., Zhao, D., Zhou, X., Li, H., Guo, J., et al. (2025) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-025-10520-7 · Cited by 11 · see citing works
Gut microecological regulation on bronchiolitis and asthma in children: A review
Xue, S., Abdullahi, R., Wu, N., Zheng, J., Su, M., & Xu, M. (2023) · The Clinical Respiratory Journal · doi:10.1111/crj.13622 · Cited by 11 · see citing works
Liu, Y., Zhou, X., Ye, W., Liu, Y., Luo, J., Tang, X., Wang, J., Liu, C., & Zhou, H. (2024) · Journal of Functional Foods · doi:10.1016/j.jff.2024.106045 · Cited by 10 · see citing works
Hu, X., Hong, B., & Sun, M. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/2090478 · Cited by 10 · see citing works
Probiotics and diseases of altered IgE regulation: A short review
Smith-Norowitz, T. A., & Bluth, M. H. (2015) · Journal of Immunotoxicology · doi:10.3109/1547691x.2015.1044053 · Cited by 10 · see citing works
Lung Microbiota and Ventilator-Associated Pneumonia in the Neonatal Period
Rodrigo, F. G., Martí, L. U., Onrubia, M. S., Borges-Luján, M., Henríquez, G. G., & Suárez, D. R. (2024) · Pathogens · doi:10.3390/pathogens13030220 · Cited by 8 · see citing works
Lira, G. V. D. A. G., de Oliveira, M. H., Peixoto, D. M., & SARINHO, E. S. C. (2015) · Jornal de Pediatria (Versão em Português) · doi:10.1016/j.jpedp.2015.07.005 · Cited by 9 · see citing works
Lee, Y., Park, G.-S., Ko, S., Yang, W., Seo, H.-J., Kim, S., Jeong, N., & Kang, J. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1145546 · Cited by 8 · see citing works
Adinatha, Y., Subanada, I. B., Arimbawa, I. M., Nilawati, G. A. P., Gunawijaya, E., & Hartawan, I. N. B. (2020) · Bali Medical Journal · doi:10.15562/bmj.v9i1.1773 · Cited by 8 · see citing works
Mucosal and Cutaneous Immunity
Mak, T. W., & Saunders, M. E. (2006) · Elsevier eBooks · doi:10.1016/b978-012088451-3.50022-3 · Cited by 8 · see citing works
Olimpio, F. R. D. S., Carvalho, J., Kaminsky, V., & Aimbire, F. (2022) · Microbial Pathogenesis · doi:10.1016/j.micpath.2022.105831 · Cited by 7 · see citing works
Chen, X.-X., Qiu, D., Wang, Y., Ju, Q., Zhao, C.-L., Zhang, Y.-S., Wang, M., Zhang, Y., & Zhang, J. (2024) · Microbiology Spectrum · doi:10.1128/spectrum.00719-24 · Cited by 7 · see citing works
Caramori, G., Papadopoulos, N. G., Contoli, M., Marku, B., Forini, G., Pauletti, A., Johnston, S. L., & Papi, A. A. (2012) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2012.06.009 · Cited by 7 · see citing works
The airway microbiome in cystic fibrosis: challenges for therapy
Gillanders, L. J., Elborn, J. S., Gilpin, D. F., Schneiders, T., & Tunney, M. M. (2011) · Therapy · doi:10.2217/thy.11.81 · Cited by 7 · see citing works
Probiotics: An adjuvant treatment strategy for chronic respiratory diseases
Verma, B., Kumar, N., Ashique, S., Debnath, B., Garg, A., Mishra, N., Mojgani, N., Kaurav, M., Gupta, M., Bhowmick, M., et al. (2025) · Respiratory Medicine · doi:10.1016/j.rmed.2025.108268 · Cited by 6 · see citing works
Claassen-Weitz, S., Wiysonge, C. S., Machingaidze, S., Thabane, L., Horsnell, W. G. C., Zar, H. J., Nicol, M. P., & Kaba, M. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00838 · Cited by 6 · see citing works
Microbiota-Mediated Immunomodulation and Asthma: Current and Future Perspectives
Boutin, R. C. T., & Finlay, B. B. (2016) · Current Treatment Options in Allergy · doi:10.1007/s40521-016-0087-z · Cited by 6 · see citing works
Kauppi, P., Kuokkanen, M., Kukkonen, A. K., Laitinen, T., & Kuitunen, M. (2014) · Allergologia et Immunopathologia · doi:10.1016/j.aller.2013.10.001 · Cited by 5 · see citing works
The Pulmonary Microbiome, Mechanical Ventilation, and Trauma
Smith, A. D., Zhang, Y., & Shewale, S. (2012) · Biological Systems Open Access · doi:10.4172/2329-6577.1000116 · Cited by 5 · see citing works
Hamid, I. S., Ekowati, J., Solfaine, R., Chhetri, S., & Purnama, M. T. E. (2022) · Pharmacognosy Journal · doi:10.5530/pj.2022.14.76 · Cited by 4 · see citing works
Lima-Engelmann, K., & Schneider, M. (2022) · Current Nutraceuticals · doi:10.2174/2665978604666221122112434 · Cited by 4 · see citing works
Effros, R. M., Casaburi, R. H., Pórszász, J., & Rehan, V. K. (2011) · CHEST Journal · doi:10.1378/chest.11-0974 · Cited by 4 · see citing works
Endotoxin and asthma: friends or foes?
Beloglazov, V. A., Popenko, Y. O., Гордиенко, А. И., & Tumanova, E. L. (2020) · Nauchno-prakticheskii zhurnal «Patogenez» · doi:10.25557/2310-0435.2020.01.17-28 · Cited by 3 · see citing works
The Effect of Probiotics on Bacterial Pneumonia
Najafi, A., Sharif, A., Sharif, M. R., & Gilasi, H. (2021) · Archives of Clinical Infectious Diseases · doi:10.5812/archcid.97851 · Cited by 3 · see citing works
Zakharova, I. N., Berezhnaya, I. V., Klimov, L., Каsyanova, A. N., Dedikova, O. V., & Анатольевич, К. К. (2019) · Meditsinskiy sovet = Medical Council · doi:10.21518/2079-701x-2019-2-173-182 · Cited by 3 · see citing works
Lee, D., Lee, Y., Park, G.-S., Park, J., Ko, S.-H., Lee, Y.-K., Jeong, D. Y., Lee, Y. H., & Kang, J. (2025) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.2506.06004 · Cited by 2 · see citing works
A review on millet based probiotic beverages
Mali, S., Toshniwal, H. D. D., & Ar, S. (2020) · International Journal of Chemical Studies · doi:10.22271/chemi.2020.v8.i2o.8892 · Cited by 2 · see citing works
Gut-lung cross talk in COVID-19 pathology and fatality rate
El-Ansary, A. K., Balto, H. A. G., & Al‐Hadlaq, S. M. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90769-9.00037-2 · Cited by 2 · see citing works
Microbial therapy for cystic fibrosis
Bruzzese, E., Buccigrossi, V., Ranucci, G., & Guarino, A. (2016) · doi:10.1002/9781118982907.ch32 · Cited by 2 · see citing works
Gut microbiota and the immune system: A regulatory axis through host MicroRNA modulation
Khosrojerdi, M., Azad, F. J., Haghbin, A., & Azimian, A. (2026) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2026.105996 · Cited by 1 · see citing works
Bayas, R. L., & Gayatri, Y. (2014) · Research and Reviews: Journal of Microbiology and Biotechnology · Cited by 1 · see citing works
The Impact of Probiotics in Respiratory Diseases
Askandar, R. H., & Ebrahimi, N. (2020) · Polytechnic Journal · doi:10.25156/ptj.v10n1y2020.pp148-156 · Cited by 1 · see citing works
There is no association between serum endotoxin levels and inflammation in asthma
Candan, O., Toptaş, T., Demir, S., & Erdenen, F. (2024) · Journal of Asthma · doi:10.1080/02770903.2024.2311233 · Cited by 1 · see citing works
Foumani, A. A., Jafari, A., Nejad, A. T., Jafarinejhad, A., Ziyapour, S., Keivanlou, M., & Afzalipour, M. (2023) · PubMed Central · Cited by 1 · see citing works
- Authors
- Forsythe, P.
- Affiliations
- McMaster University (CA)
- Corresponding author
- Forsythe, Paul
- ORCID
- Forsythe, Paul
- Venue
- Chest
- Publisher
- Elsevier BV
- Published
- 2011-04
- Volume
- 139
- Issue
- 4
- Pages
- 901-908
- ISSN
- 0012-3692 (ISSN-L)
- OpenAlex
- W2126492324
- Cited by
- 131
- References
- 55
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 6 · 2023: 13 · 2022: 11 · 2021: 8 · 2020: 9 · 2019: 4 · 2018: 2 · 2017: 6 · 2016: 9 · 2015: 10 · 2014: 13 · 2013: 12 · 2012: 15
- FWCI
- 2.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- CHEST Journal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- probiotics, lung disease, lung immunity, intestinal commensal bacteria, mucosal immunity, allergic airway inflammation, asthma, respiratory infections, dendritic cells, regulatory T cells, gut microbiota
- MeSH terms
- Animals, Humans, Immunity, Cellular, Lung Diseases, Immunity, Mucosal, Probiotics
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