Immunomodulatory activity of exopolysaccharide producing Leuconostoc citreum strain isolated from Pico cheese
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Some LAB strains can modulate innate and acquired immune responses by binding to specific receptors on immune cells and other tissues, and by stimulating production of cytokines, T cells, activation of dendritic cells and macrophages, and production of specific antibodies.
“Some LAB strains can modulate innate and acquired immune responses by binding to specific receptors on immune cells and other tissues such as intestinal epithelial tissue, and by stimulating the production of cytokines, T cells, the activation of dendritic cells and macrophages, and the production of specific antibodies [229,230,231].”
From Lactic Acid Bacteria in Raw-Milk Cheeses: From Starter Cultures to Probiotic Functions (2022) · cites this paper as [231]
In animal studies, oral ingestion of Ln. citreum in an asthma model resulted in immune tolerance to the allergen.
“In animal studies, oral ingestion of this bacterium in an asthma model (nasal administration of an allergen) resulted in immune tolerance to the allergen [231].”
From Lactic Acid Bacteria in Raw-Milk Cheeses: From Starter Cultures to Probiotic Functions (2022) · cites this paper as [231]
A Ln. citreum strain isolated from an artisanal cheese has an immunomodulatory effect due to its ability to decrease production of proinflammatory cytokines (IL-8) by intestinal cells.
“In one of these studies, a Ln. citreum strain isolated from an artisanal cheese was shown to have an immunomodulatory effect due to its ability to decrease the production of proinflammatory cytokines (IL-8) by intestinal cells [231].”
From Lactic Acid Bacteria in Raw-Milk Cheeses: From Starter Cultures to Probiotic Functions (2022) · cites this paper as [231]
EPS exhibit various health-promoting effects such as antitumor, antioxidant, immunomodulatory, and prebiotic effects.
“EPS exhibit various health-promoting effects such as antitumor, antioxidant, immunomodulatory, and prebiotic effects [231,299].”
From Lactic Acid Bacteria in Raw-Milk Cheeses: From Starter Cultures to Probiotic Functions (2022) · cites this paper as [231]
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- Authors
- Domingos-Lopes, M. F. P., Nagy, A., Stanton, C., Ross, P. R., Gelencsér, E., & Silva, C. C. G.
- Affiliations
- National Agricultural Research and Innovation Centre (HU)
- Teagasc - The Irish Agriculture and Food Development Authority (IE)
- Universidade dos Açores (PT)
- Corresponding author
- Silva, C.C.G.
- Venue
- Journal of Functional Foods
- Publisher
- Elsevier BV
- Published
- 2017-06
- Volume
- 33
- Pages
- 235-243
- ISSN
- 1756-4646 (ISSN-L)
- OpenAlex
- W2604578675
- Cited by
- 35
- References
- 57
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 5 · 2023: 7 · 2022: 3 · 2021: 4 · 2020: 6 · 2019: 3 · 2018: 2 · 2017: 1
- FWCI
- 3.69
- Type
- journal article
- Language
- en
- Open access
- green
- doaj.org
- Licence
- Locations
- Journal of Functional Foods (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Fundação para a Ciência e Tecnologia (PTDC/AGR-ALI/104385/2008)
- Fundo Regional da Ciência e Tecnologia (M3.1.2/F/009/2011)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Keywords
- Leuconostoc citreum, exopolysaccharides, immunomodulation, probiotics, ovalbumin-induced asthma, allergic asthma, specific IgE, interleukin-8, HT-29 cells, lipopolysaccharide, rat model
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