Beneficial modulation of the gut microbiota
Open accessAbstract
The human gut microbiota comprises approximately 100 trillion microbial cells and has a significant effect on many aspects of human physiology including metabolism, nutrient absorption and immune function. Disruption of this population has been implicated in many conditions and diseases, including examples such as obesity, inflammatory bowel disease and colorectal cancer that are highlighted in this review. A logical extension of these observations suggests that the manipulation of the gut microbiota can be employed to prevent or treat these conditions. Thus, here we highlight a variety of options, including the use of changes in diet (including the use of prebiotics), antimicrobial-based intervention, probiotics and faecal microbiota transplantation, and discuss their relative merits with respect to modulating the intestinal community in a beneficial way.
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As humans have co-evolved with the microbiota, it plays a key role in programming all other bodily systems.
“As we have co-evolved with this microbiota, it plays a key role in programming all other bodily systems (D' Argenio and Salvatore, 2015;Walsh et al., 2014).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Walsh et al., 2014
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- Authors
- Walsh, C. J., Guinane, C. M., O'Toole, P. W., & Cotter, P. D.
- Affiliations
- Teagasc - The Irish Agriculture and Food Development Authority (IE)
- Corresponding author
- Cotter, Paul D.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2014-03-26
- Volume
- 588
- Issue
- 22
- Pages
- 4120-4130
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2001738813
- Cited by
- 274
- References
- 25
- Citations by year
- 2026: 6 · 2025: 12 · 2024: 9 · 2023: 20 · 2022: 21 · 2021: 21 · 2020: 23 · 2019: 31 · 2018: 36 · 2017: 33 · 2016: 24 · 2015: 25 · 2014: 13
- FWCI
- 2.93
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Arrow@dit (Dublin Institute of Technology) (acceptedVersion)
- T-Stór (Teagasc) (submittedVersion, cc-by-nc-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- gut microbiota, microbiota modulation, obesity, inflammatory bowel disease, colorectal cancer, prebiotics, probiotics, fecal microbiota transplantation, antimicrobial interventions, diet, host-microbe interactions
- MeSH terms
- Animals, Anti-Infective Agents, Feces, Gastrointestinal Diseases, Humans, Probiotics, Gastrointestinal Tract, Microbiota
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