The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Polystyrene microplastic particles: In vitro pulmonary toxicity assessment
Abstract
Microplastics (MPs) have become a global environmental concern. Recent studies have shown that MPs, of which the predominant type is often polystyrene (PS; known as PS-MPs), can extend to and affect remote, sparsely inhabited areas via atmospheric transport. Although exposure to inhaled MPs may induce lung dysfunction, further experimental verification of the pulmonary toxic potential of MPs and the mechanism underlying the toxicity is needed. Here we used normal human lung epithelial BEAS-2B cells to clarify the association between pulmonary toxicity and PS-MPs. Results revealed that PS-MPs can cause cytotoxic and inflammatory effects in BEAS-2B cells by inducing reactive oxygen species formation. PS-MPs can decrease transepithelial electrical resistance by depleting zonula occludens proteins. Indeed, decreased α1-antitrypsin levels in BEAS-2B cells suggest that exposure to PS-MPs increases the risk for chronic obstructive pulmonary disease, and high concentrations of PS-MPs can induce these adverse responses. While low PS-MP levels can only disrupt the protective pulmonary barrier, they may also increase the risk for lung disease. Collectively, our findings indicate that PS-MP inhalation may influence human respiratory health.
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Cites
The Physical Impacts of Microplastics on Marine Organisms: A Review
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Plastic and Human Health: A Micro Issue?
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Pollutants bioavailability and toxicological risk from microplastics to marine mussels
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Cited by
Micro- and nanoplastic induced cellular toxicity in mammals: A review
Banerjee, A., & Shelver, W. L. (2021) · Science of The Total Environment · doi:10.1016/j.scitotenv.2020.142518 · Cited by 492
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Microplastic Fallout in Different Indoor Environments
Zhang, Q., Zhao, Y., Du, F., Cai, H., Wang, G., & Shi, H. (2020) · Environmental Science & Technology · doi:10.1021/acs.est.0c00087 · Cited by 435
Wu, P., Lin, S., Cao, G., Wu, J., Jin, H., Wang, C., Wong, M. H., Yang, Z., & Cai, Z. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.129361 · Cited by 428
Micro(nano)plastics pollution and human health: How plastics can induce carcinogenesis to humans?
Kumar, R., Manna, C., Padha, S., Verma, A., Sharma, P., Dhar, A., Ghosh, A., & Bhattacharya, P. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2022.134267 · Cited by 411
Metadata
- Authors
- Dong, C.-D., Chen, C.-W., Chen, Y.-C., Chen, H.-H., Lee, J.-S., & Lin, C.-H.
- Venue
- Journal of Hazardous Materials
- Publisher
- Elsevier BV
- Published
- 2020-03
- Volume
- 385
- Pages
- 121575
- ISSN
- 0304-3894 (ISSN-L)
- OpenAlex
- W2987473186
- Cited by
- 711
- References
- 6
- FWCI
- 12.98
- Type
- journal article
- Language
- en
- Open access
- closed
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- Dong, C.-D., Chen, C.-W., Chen, Y.-C., Chen, H.-H., Lee, J.-S., & Lin, C.-H. (2020). Polystyrene microplastic particles: In vitro pulmonary toxicity assessment. Journal of Hazardous Materials. https://doi.org/10.1016/j.jhazmat.2019.121575
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
