NASH: a mitochondrial disease

PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

Mootha, V. K., Lindgren, C. M., Eriksson, K.-F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstråle, M., Laurila, E., et al. (2003) · Nature Genetics · doi:10.1038/ng1180 · Cited by 10,197

Leptin and the regulation of body weight in mammals

Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405

Obesity as a medical problem

Kopelman, P. G. (2000) · Nature · doi:10.1038/35007508 · Cited by 4,795

β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes

Butler, A. E., Janson, J., Bonner-Weir, S., Ritzel, R., Rizza, R. A., & Butler, P. C. (2003) · Diabetes · doi:10.2337/diabetes.52.1.102 · Cited by 4,011

Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes

Özcan, U., Cao, Q., Yilmaz, E., Lee, A.-H., Iwakoshi, N. N., Özdelen, E., Tuncman, G., Görgün, C., Glimcher, L. H., & Hotamisligil, G. S. (2004) · Science · doi:10.1126/science.1103160 · Cited by 3,844

A central role for JNK in obesity and insulin resistance

Hirosumi, J., Tuncman, G., Chang, L., Görgün, C. Z., Uysal, K. T., Maeda, K., Karin, M., & Hotamisligil, G. S. (2002) · Nature · doi:10.1038/nature01137 · Cited by 3,359

Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF.

Fadok, V. A., Bratton, D. L., Konowal, A., Freed, P. W., Westcott, J. Y., & Henson, P. M. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1112 · Cited by 3,166 · cited 2×

Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes

Kelley, D. E., He, J., Menshikova, E. V., & Ritov, V. B. (2002) · Diabetes · doi:10.2337/diabetes.51.10.2944 · Cited by 2,321

Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes

Petersen, K. F., Dufour, S., Befroy, D., Garcia, R., & Shulman, G. I. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031314 · Cited by 2,193

Mitochondrial dysfunction in the elderly: possible role in insulin resistance

Petersen, K. F., Befroy, D., Dufour, S., Dziura, J., Ariyan, C., Rothman, D. L., DiPietro, L., Cline, G. W., & Shulman, G. I. (2003) · Science · doi:10.1126/science.1082889 · Cited by 2,107

The metabolism and function of phospholipids in Mitochondria

Dong, J., Ye, F., Lin, J., He, H., & Song, Z. (2022) · Mitochondrial Communications · doi:10.1016/j.mitoco.2022.10.002 · Cited by 41

Mitochondrial stress protein HSP60 regulates ER stress-induced hepatic lipogenesis

Xiao, T., Liang, X., Liu, H., Zhang, F., Meng, W., & Hu, F. (2020) · Journal of Molecular Endocrinology · doi:10.1530/jme-19-0207 · Cited by 35

Mediterranean Diet: The Beneficial Effects of Lycopene in Non-Alcoholic Fatty Liver Disease

Abenavoli, L., Procopio, A. C., Paravati, M. R., Costa, G., Milić, N., Alcaro, S., & Luzza, F. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11123477 · Cited by 37

Magnolia officinalis Reverses Alcoholic Fatty Liver by Inhibiting the Maturation of Sterol Regulatory Element–Binding Protein-1c

Yin, H., Je, Y.-T., Kim, Y., Shin, Y. K., Sung, S.-H., Lee, K., Jeong, G.-S., Kim, Y., & Lee, B. (2009) · Journal of Pharmacological Sciences · doi:10.1254/jphs.08182fp · Cited by 35

The effects of 48 weeks of rosiglitazone on hepatocyte mitochondria in human nonalcoholic steatohepatitis

Caldwell, S. H., Patrie, J. T., Brunt, E. M., Redick, J. A., Davis, C. A., Park, S. H., & Neuschwander‐Tetri, B. A. (2007) · Hepatology · doi:10.1002/hep.21813 · Cited by 33

Mitochondria Matter: Systemic Aspects of Nonalcoholic Fatty Liver Disease (NAFLD) and Diagnostic Assessment of Liver Function by Stable Isotope Dynamic Breath Tests

Ciaula, A. D., Calamita, G., Shanmugam, H., Khalil, M., Bonfrate, L., Wang, D. Q. ‐., Baffy, G., & Portincasa, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147702 · Cited by 34

Inhibited peroxidase activity of peroxiredoxin 1 by palmitic acid exacerbates nonalcoholic steatohepatitis in male mice

Yin, W., Xu, H., Bai, Z., Wu, Y., Zhang, Y., Liu, R., Wang, Z., Zhang, B., Shen, J., Zhang, H., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-55939-2 · Cited by 36

SIRT1 activation by methylene blue, a repurposed drug, leads to AMPK-mediated inhibition of steatosis and steatohepatitis

Shin, S. Y., Kim, T. H., Wu, H., Choi, Y. H., & Kim, S. G. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.01.035 · Cited by 35

Fatty Liver Disease

TINIAKOS, D. G., Anstee, Q. M., & Burt, A. D. (2017) · Elsevier eBooks · doi:10.1016/b978-0-7020-6697-9.00005-4 · Cited by 35

Hepatic Deficiency of Augmenter of Liver Regeneration Predisposes to Nonalcoholic Steatohepatitis and Fibrosis

Kumar, S., Verma, A. K., Rani, R., Sharma, A., Wang, J., Shah, S. A., Behari, J., Gonzalez, R. S., Kohli, R., & Gandhi, C. R. (2020) · Hepatology · doi:10.1002/hep.31167 · Cited by 35

Taurine Protects against the Fatty Liver Hemorrhagic Syndrome in Laying Hens through the Regulation of Mitochondrial Homeostasis

San, J., Hu, J., Pang, H., Zuo, W., Su, N., Guo, Z., Wu, G., & Yang, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241210360 · Cited by 33

Application of localized 31P MRS saturation transfer at 7 T for measurement of ATP metabolism in the liver: reproducibility and initial clinical application in patients with non-alcoholic fatty liver disease

Valkovič, L., Gajdošík, M., Traussnigg, S., Wolf, P. S., Chmelík, M., Kienbacher, C., Bogner, W., Krebs, M., Trauner, M., Trattnig, S., et al. (2014) · European Radiology · doi:10.1007/s00330-014-3141-x · Cited by 35

Environmental and Genetic Determinants of Fatty Liver in Humans

Kantartzis, K., Schick, F., Häring, H., & Stefan, N. (2010) · Digestive Diseases · doi:10.1159/000282082 · Cited by 32

KLF15‐activating Twist2 ameliorated hepatic steatosis by inhibiting inflammation and improving mitochondrial dysfunction via NF‐κB‐FGF21 or SREBP1c‐FGF21 pathway

Zhou, L., Zhao, L., Chen, A., Liu, N., Chen, N., Chen, X., Zhu, L., Xia, B., Gong, Y., & Chen, X. (2019) · The FASEB Journal · doi:10.1096/fj.201901347rr · Cited by 32

Curcumin prevents the non-alcoholic fatty hepatitis via mitochondria protection and apoptosis reduction.

Wang, L., Lv, Y., Yao, H., Yin, L., & Shang, J. (2015) · PubMed Central · Cited by 31

Impaired hepatic mitochondrial function during early lactation in dairy cows: Association with protein lysine acetylation

García-Roche, M., Casal, A., Mattiauda, D. A., Ceriani, M., Jasinsky, A., Mastrogiovanni, M., Trostchansky, A., Carriquiry, M., Cassina, A., & Quijano, C. (2019) · PLoS ONE · doi:10.1371/journal.pone.0213780 · Cited by 31

Critical Role for Hepatocyte-Specific eNOS in NAFLD and NASH

Cunningham, R. P., Moore, M. P., Dashek, R. J., Meers, G. M.-E., Takahashi, T., Sheldon, R. D., Wheeler, A. A., Diaz‐Arias, A. A., Ibdah, J. A., Parks, E. J., et al. (2021) · Diabetes · doi:10.2337/db20-1228 · Cited by 31

Key hepatoprotective roles of mitochondria in liver regeneration

Lamanilao, G. G., Doğan, M., Patel, P. S., Azim, S., Patel, D. S., Bhattacharya, S. K., Eason, J. D., Kuscu, C., Kuscu, C., & Bajwa, A. (2023) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00220.2022 · Cited by 30

NASH may be trash: Table 1

Cassiman, D. M., & Jaeken, J. (2008) · Gut · doi:10.1136/gut.2007.123240 · Cited by 30

Inhibition of Colon Carcinogenesis by Dietary Non-Nutritive Compounds

Tanaka, T., & Sugie, S. (2007) · Journal of Toxicologic Pathology · doi:10.1293/tox.20.215 · Cited by 30

Effects of Carnitine on Peripheral Blood Mitochondrial DNA Copy Number and Liver Function in Non-Alcoholic Fatty Liver Disease

Lim, C. Y., Jun, D. W., Jang, S. S., Cho, W. K., Chae, J. D., & Jun, J. H. (2010) · Korean Journal of Gastroenterology · doi:10.4166/kjg.2010.55.6.384 · Cited by 29

Rooibos tea (Aspalathus linearis) ameliorates the CCl4-induced injury to mitochondrial respiratory function and energy production in rat liver

Uličná, O., Vančová, O., Kucharská, J., Janega, P., & Waczulı́ková, I. (2019) · General Physiology and Biophysics · doi:10.4149/gpb_2018037 · Cited by 28

Ablation of catalase promotes non-alcoholic fatty liver via oxidative stress and mitochondrial dysfunction in diet-induced obese mice

Shin, S.-K., Cho, H.-W., Song, S.-E., Bae, J., Im, S., Hwang, I., Ha, H., & Song, D. (2019) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-018-02250-3 · Cited by 27

Acute Elevated Resistin Exacerbates Mitochondrial Damage and Aggravates Liver Steatosis Through AMPK/PGC-1α Signaling Pathway in Male NAFLD Mice

Wen, F., Shi, Z., Liu, X., Tan, Y., Wei, L., Zhu, X., Zhang, H., Zhu, X., Meng, X., Ji, W., et al. (2020) · Hormone and Metabolic Research · doi:10.1055/a-1293-8250 · Cited by 27

Human Mesenchymal Stromal Cells Resolve Lipid Load in High Fat Diet-Induced Non-Alcoholic Steatohepatitis in Mice by Mitochondria Donation

Nickel, S., Christ, M., Schmidt, S., Kosacka, J., Kühne, H., Roderfeld, M., Longerich, T., Tietze, L., Bosse, I., Hsu, M., et al. (2022) · Cells · doi:10.3390/cells11111829 · Cited by 28

Proteomic analysis of liver mitochondria from rats with nonalcoholic steatohepatitis

Li, L. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i16.4778 · Cited by 27

Silibinin Ameliorates O-GlcNAcylation and Inflammation in a Mouse Model of Nonalcoholic Steatohepatitis

Lee, S. J., Nam, M. J., Lee, D. E., Park, J., Kang, B. S., Lee, D., Lee, H., & Kwon, O. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082165 · Cited by 27

Fatty liver disease

Brunt, E. M., Neuschwander‐Tetri, B. A., & Burt, A. D. (2011) · Elsevier eBooks · doi:10.1016/b978-0-7020-3398-8.00006-4 · Cited by 27

The Emerging Role of Hepatocellular eNOS in Non-alcoholic Fatty Liver Disease Development

Cunningham, R. P., Sheldon, R. D., & Rector, R. S. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00767 · Cited by 28

Protocols for Mitochondria as the Target of Pharmacological Therapy in the Context of Nonalcoholic Fatty Liver Disease (NAFLD)

Grattagliano, I., Ciaula, A. D., Baj, J., Molina‐Molina, E., Shanmugam, H., Garruti, G., Wang, D. Q. ‐., & Portincasa, P. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1433-4_12 · Cited by 28

Increased hepatic UCP2 expression in rats with nonalcoholic steatohepatitis is associated with upregulation of Sp1 binding to its motif within the proximal promoter region

Jiang, Y., Zhang, H., Dong, L., Wang, D., & An, W. (2008) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21827 · Cited by 26

Targeting mitochondrial alterations to prevent type 2 diabetes— E vidence from studies of dietary redox‐active compounds

Cheng, Z., Schmelz, E. M., Liu, D., & Hulver, M. W. (2014) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300747 · Cited by 26

Nonalcoholic Fatty Liver Disease and Staging of Hepatic Fibrosis

Engin, A. (2024) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-63657-8_18 · Cited by 28

PNPLA3-I148M Variant Promotes the Progression of Liver Fibrosis by Inducing Mitochondrial Dysfunction

Gou, Y., Wang, L., Zhao, J., Xu, X., Xu, H., Xie, F. X., Wang, Y., Feng, Y., Zhang, J., & Zhang, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119681 · Cited by 25

Emerging drugs for non-alcoholic fatty liver disease

Federico, A., Niosi, M., Blanco, C. D. V., & Loguercio, C. (2008) · Expert Opinion on Emerging Drugs · doi:10.1517/14728214.13.1.145 · Cited by 25

Niemann-Pick Type C2 Protein Regulates Free Cholesterol Accumulation and Influences Hepatic Stellate Cell Proliferation and Mitochondrial Respiration Function

Wang, Y.-H., Twu, Y., Wang, C.-K., Lin, F.-Z., Lee, C.-Y., & Liao, Y. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061678 · Cited by 25

Fat and Sugar—A Dangerous Duet. A Comparative Review on Metabolic Remodeling in Rodent Models of Nonalcoholic Fatty Liver Disease

Simões, I. C. M., Janikiewicz, J., Bauer, J., Karkucińska‐Więckowska, A., Kalinowski, P., Dobrzyń, A., Wolski, A., Pronicki, M., Zieniewicz, K., Dobrzyń, P., et al. (2019) · Nutrients · doi:10.3390/nu11122871 · Cited by 27

Review: Non-alcoholic fatty liver disease: natural history, pathogenesis and treatment

McAvoy, N. C., Ferguson, J., Campbell, I. W., & Hayes, P. C. (2006) · The British Journal of Diabetes · doi:10.1177/14746514060060060201 · Cited by 26

Drug‐Associated Mitochondrial Toxicity

Mehta, R., Chan, K., Lee, O., Tafazoli, S., & O’Brien, P. J. (2008) · Wiley eBooks · doi:10.1002/9780470372531.ch3 · Cited by 25

Protective effects of Lactobacillus acidophilus NX2-6 against oleic acid-induced steatosis, mitochondrial dysfunction, endoplasmic reticulum stress and inflammatory responses

Tang, C., Meng, F., Pang, X., Chen, M., Zhou, L., Lu, Z., & Lu, Y. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.104206 · Cited by 24

Interrelationships Between Paraoxonase-1 and Monocyte Chemoattractant Protein-1 in the Regulation of Hepatic Inflammation

Camps, J., Marsillach, J., Rull, A., Alonso‐Villaverde, C., & Joven, J. (2009) · Advances in experimental medicine and biology · doi:10.1007/978-1-60761-350-3_2 · Cited by 23

A growing burden: the pathogenesis, investigation and management of non-alcoholic fatty liver disease

Riley, P., O’Donohue, J., & Crook, M. A. (2007) · Journal of Clinical Pathology · doi:10.1136/jcp.2006.044891 · Cited by 23

Nrf1 gene expression in the liver: A single gene linking oxidative stress to NAFLD, NASH and hepatic tumours

Parola, M., & Novo, E. (2005) · Journal of Hepatology · doi:10.1016/j.jhep.2005.09.008 · Cited by 23

Mitochondrial uncoupling proteins: New insights from functional and proteomic studies

Douette, P., & Sluse, F. E. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.12.010 · Cited by 23

Uncoupling proteins and non-alcoholic fatty liver disease

Cortez‐Pinto, H., & Machado, M. V. (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2009.02.019 · Cited by 22

Beyond Discrete Diagnoses: Conceptualizing Obesity-associated Metabolic Disorders as a Unified, Dynamic Continuum

Xie, C., Yuan, Y., Wang, Y., Qi, C., Wang, W., An, C., Aikepaer, A., Zhang, Y., Zhang, G., Feng, X., et al. (2025) · Current Obesity Reports · doi:10.1007/s13679-025-00673-5 · Cited by 28

Effect of BI-1 on insulin resistance through regulation of CYP2E1

Lee, G., Oh, K., Kim, H., Han, H.-S., Lee, H.-Y., Park, K., Nam, K., Koo, S., & Chae, H. (2016) · Scientific Reports · doi:10.1038/srep32229 · Cited by 21

Glutaminolysis-ammonia-urea Cycle Axis, Non-alcoholic Fatty Liver Disease Progression and Development of Novel Therapies

Rojas, Á., García-Lozano, M. D. R., Gil‐Gómez, A., Romero‐Gómez, M., & Ampuero, J. (2022) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2021.00247 · Cited by 21

Melatonin role preventing steatohepatitis and improving liver transplantation results

Zubero, E. E., García‐Gil, F. A., López‐Pingarrón, L., Alatorre-Jiménez, M. A., Rodríguez, J. M. ́., Tan, D., García, J. J., & Reiter, R. J. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2185-2 · Cited by 21

Pre-and postnatal exposition to fluorides induce changes in rats liver morphology by impairment of antioxidant defense mechanisms and COX induction

Dec, K., Łukomska, A., Baranowska‐Bosiacka, I., Pilutin, A., Maciejewska, D., Skonieczna‐Żydecka, K., Derkacz, R., Goschorska, M., Wąsik, A., Rębacz‐Maron, E., et al. (2018) · Chemosphere · doi:10.1016/j.chemosphere.2018.07.145 · Cited by 22

The Nuclear Envelope in Lipid Metabolism and Pathogenesis of NAFLD

Östlund, C., Hernández‐Ono, A., & Shin, J. (2020) · Biology · doi:10.3390/biology9100338 · Cited by 21

Spontaneously hypertensive rats develop pronounced hepatic steatosis induced by choline‐deficient diet: Evidence for hypertension as a potential enhancer in non‐alcoholic steatohepatitis

Ikuta, T., Kanno, K., Arihiro, K., Matsuda, S., Kishikawa, N., Fujita, K., & Tazuma, S. (2011) · Hepatology Research · doi:10.1111/j.1872-034x.2011.00920.x · Cited by 21

Multiple MicroRNAs Ameliorate Hepatocyte Steatosis and Injury by Suppressing FABP1 Expression

Wu, Y., Zhu, Y., Huang, R.-D., Peng, X., & Lin, X. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000486058 · Cited by 21

Mitochondrial dysfunction in nonalcoholic steatohepatitis (NASH): are there drugs able to improve it?

Begriche, K., Knockaert, L., Massart, J., Robin, M., & Fromenty, B. (2009) · Drug Discovery Today Disease Mechanisms · doi:10.1016/j.ddmec.2009.02.002 · Cited by 21

Functional compartmentalization of hepatic mitochondrial subpopulations during MASH progression

Talari, N. K., Mattam, U., Rahman, A. P., Hemmelgarn, B. K., Wyder, M. A., Sylvestre, P. B., Greis, K. D., & Krishnan, K. C. (2025) · Communications Biology · doi:10.1038/s42003-025-07713-9 · Cited by 20

Sex and BNIP3 genotype, rather than acute lipid injection, modulate hepatic mitochondrial function and steatosis risk in mice

Fuller, K. N. Z., McCoin, C. S., Allen, J., Bell-Glenn, S., Koestler, D. C., Dorn, G. W., & Thyfault, J. P. (2020) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00035.2020 · Cited by 19

Cytochromecrelease from rat liver mitochondria is compromised by increased saturated cardiolipin species induced by sucrose feeding

Ruiz‐Ramírez, A., Barrios-Maya, M. A., López-Acosta, O., Molina‐Ortiz, D., & El‐Hafidi, M. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00617.2014 · Cited by 20

The Tumor Microenvironment of Hepatocellular Carcinoma: Untying an Intricate Immunological Network

Volponi, C., Gazzillo, A., & Bonavita, E. (2022) · Cancers · doi:10.3390/cancers14246151 · Cited by 20

A porcine placental extract prevents steatohepatitis by suppressing activation of macrophages and stellate cells in mice

Xu, L., Nagata, N., Nagashimada, M., Zhuge, F., Ni, Y., Chen, G., Kamei, J., Ishikawa, H., Komatsu, Y., Kaneko, S., et al. (2018) · Oncotarget · doi:10.18632/oncotarget.24587 · Cited by 19

The PPARα Agonist Fenofibrate Prevents Formation of Protein Aggregates (Mallory-Denk bodies) in a Murine Model of Steatohepatitis-like Hepatotoxicity

Nikam, A. P., Patankar, J. V., Somlapura, M., Lahiri, P., Sachdev, V., Kratky, D., Denk, H., Zatloukal, K., & Abuja, P. M. (2018) · Scientific Reports · doi:10.1038/s41598-018-31389-3 · Cited by 20

DPP-4 Inhibition with Anagliptin Reduces Lipotoxicity-Induced Insulin Resistance and Steatohepatitis in Male Mice

Sakai, Y., Chen, G., Ni, Y., Zhuge, F., Xu, L., Nagata, N., Kaneko, S., Ota, T., & Nagashimada, M. (2020) · Endocrinology · doi:10.1210/endocr/bqaa139 · Cited by 19

Cannabinoid receptor type 1 mediates high-fat diet-induced insulin resistance by increasing forkhead box O1 activity in a mouse model of obesity

Chen, C.-C., Lee, T.-Y., Kwok, C., Hsu, Y.-P., Shih, K., Lin, Y., & Ho, L.-T. (2016) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2016.2475 · Cited by 21

New treatments for nonalcoholic fatty liver disease

Harrison, S. A. (2006) · Current Gastroenterology Reports · doi:10.1007/s11894-006-0060-2 · Cited by 19

Involvement of ferroptosis in metabolic dysfunction-associated steatohepatitis-related liver diseases

Liu, Y., Zhang, M., Huang, Y., Zhang, Y., Chen, Z., Guan, J., Xia, S., & Liao, J. (2025) · Journal of Molecular Medicine · doi:10.1007/s00109-025-02599-w · Cited by 23

Non-Alcoholic Fatty Liver Disease and Extrahepatic Cancers: A Wolf in Sheep’s Clothing?

Mitsala, A., Tsalikidis, C., Romanidis, Κ., & Pitiakoudis, M. S. (2022) · Current Oncology · doi:10.3390/curroncol29070356 · Cited by 22

Redox cell signaling and hepatic progenitor cells

di Bello, G., Vendemiale, G., & Bellanti, F. (2018) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2018.09.004 · Cited by 18

Icaritin ameliorates hepatic steatosis via promoting fatty acid β-oxidation and insulin sensitivity

Xiong, Y., Chen, Y., Huang, X., Yang, Z., Zhang, J., Yu, X., Ji, F., Tao, J., You, K., Cheng, Z., et al. (2021) · Life Sciences · doi:10.1016/j.lfs.2020.119000 · Cited by 18

Dual effect of red wine on liver redox status: a concise and mechanistic review

Silva, P., Fernandes, E. G. R., & Carvalho, F. D. (2015) · Archives of Toxicology · doi:10.1007/s00204-015-1538-1 · Cited by 19

Reprint of “In utero exposure to benzo[a]pyrene increases adiposity and causes hepatic steatosis in female mice, and glutathione deficiency is protective”

Ortiz, L., Nakamura, B. N., Li, X., Blumberg, B., & Luderer, U. (2013) · Toxicology Letters · doi:10.1016/j.toxlet.2013.11.017 · Cited by 18

Supplementation of Chlorogenic Acid Alleviates the Effects of H2O2-Induced Oxidative Stress on Laying Performance, Egg Quality, Antioxidant Capacity, Hepatic Inflammation, Mitochondrial Dysfunction, and Lipid Accumulation in Laying Hens

Zhao, H., Li, Z., Sun, Y., Yan, M., Wang, Y., Li, Y., Zhang, Y., & Zhu, M. (2024) · Antioxidants · doi:10.3390/antiox13111303 · Cited by 17

In vivo identification of the pharmacodynamic ingredients of Polygonum cuspidatum for remedying the mitochondria to alleviate metabolic dysfunction–associated fatty liver disease

Yu, L., Li, Y., Li, Y., Zi, L., Tao, Y.-X., Hao, J.-J., Zhang, M., Gu, W., Zhang, F., Yu, J., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113849 · Cited by 17

Major urinary protein 1 interacts with cannabinoid receptor type 1 in fatty acid-induced hepatic insulin resistance in a mouse hepatocyte model

Chen, C.-C., Lee, T.-Y., Kwok, C., Hsu, Y.-P., Shih, K., Lin, Y., & Ho, L.-T. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.03.155 · Cited by 17

The aggravation of mitochondrial dysfunction in nonalcoholic fatty liver disease accompanied with type 2 diabetes mellitus

Liu, X., Zhang, J., Ming, Y., Chen, X., Zeng, M., & Mao, Y. (2015) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365521.2015.1030687 · Cited by 16

Phytosterols increase circulating endothelial progenitor cells and insulin-like growth factor-1 levels in patients with nonalcoholic fatty liver disease: A randomized crossover study

Chen, D.-L., Huang, P., Chiang, C.-H., Leu, H., Chen, J., & Lin, S. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2014.12.025 · Cited by 16

Mitochondrial metabolism and calcium homeostasis in the development of NAFLD leading to hepatocellular carcinoma

Bhowmick, S., Singh, V., Jash, S., Lal, M., & Roy, S. S. (2021) · Mitochondrion · doi:10.1016/j.mito.2021.01.007 · Cited by 16

The role of RIPK3 in liver mitochondria bioenergetics and function

Islam, T., Afonso, M. B., & Rodrigues, C. M. P. (2021) · European Journal of Clinical Investigation · doi:10.1111/eci.13648 · Cited by 16

A fatty acid analogue targeting mitochondria exerts a plasma triacylglycerol lowering effect in rats with impaired carnitine biosynthesis

Lindquist, C., Bjørndal, B., Rossmann, C. R., Svardal, A. M., Hallström, S., & Berge, R. K. (2018) · PLoS ONE · doi:10.1371/journal.pone.0194978 · Cited by 16

Intervention by picroside II on FFAs induced lipid accumulation and lipotoxicity in HepG2 cells

Dhami-Shah, H., Vaidya, R., Talwadekar, M., Shaw, E., Udipi, S., Kolthur-Seetharam, U., & Vaidya, A. D. B. (2021) · Journal of Ayurveda and Integrative Medicine · doi:10.1016/j.jaim.2021.04.007 · Cited by 15

Ashwagandha (Withania somnifera) supercritical CO2 extract derived withanolides mitigates Bisphenol A induced mitochondrial toxicity in HepG2 cells

Vidyashankar, S., Thiyagarajan, O. S., Varma, R. S., Kumar, L. M. S., Babu, U. V., & Patki, P. S. (2014) · Toxicology Reports · doi:10.1016/j.toxrep.2014.06.008 · Cited by 15

Insulin resistance and hepatocarcinogenesis

Sasaki, Y. (2010) · Clinical Journal of Gastroenterology · doi:10.1007/s12328-010-0177-6 · Cited by 15

D-galactose-induced aging in rats – The effect of metformin on bioenergetics of brain, skeletal muscle and liver

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The Epidemic of Type 2 Diabetes Mellitus: Its Links to Obesity, Insulin Resistance, and Lipotoxicity

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The liver protective effect of methylprednisolone on a new experimental acute-on-chronic liver failure model in rats

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Non‐Alcoholic Fatty Liver Disease and Nutrition

Caldwell, S. H., & Argo, C. K. (2011) · Wiley eBooks · doi:10.1002/9781444341294.ch28 · Cited by 16

Serum metabolomic profiling reveals an increase in homocitrulline in Chinese patients with nonalcoholic fatty liver disease: a retrospective study

Yang, Y., Huang, Z., Yang, Z., Qi, Y., Shi, H., Zhou, Y., Wang, F., & Yang, M. (2021) · PeerJ · doi:10.7717/peerj.11346 · Cited by 14

Modelling porcine NAFLD by deletion of leptin and defining the role of AMPK in hepatic fibrosis

Tan, T., Song, Z., Li, W., Wang, R., Zhu, M., Liang, Z., Bai, Y., Wang, Q., Wu, H., Hu, X., et al. (2023) · Cell & Bioscience · doi:10.1186/s13578-023-01124-1 · Cited by 14

Hepatokine ITIH3 protects against hepatic steatosis by downregulating mitochondrial bioenergetics and de novo lipogenesis

Talari, N. K., Mattam, U., Kamińska, D., Sotomayor-Rodriguez, I., Rahman, A. P., Péterfy, M., Pajukanta, P., Pihlajamäki, J., & Krishnan, K. C. (2024) · iScience · doi:10.1016/j.isci.2024.109709 · Cited by 16

Hepatic‐specific Pgc‐1α ablation drives fibrosis in a MASH model

Arconzo, M., Piccinin, E., Pasculli, E., Cariello, M., Loiseau, N., Bertrand‐Michel, J., Guillou, H., Matrella, M. L., Villani, G., & Moschetta, A. (2024) · Liver International · doi:10.1111/liv.16052 · Cited by 14

Placental extract ameliorates liver fibrosis in a methionine- and choline-deficient diet-induced mouse model of non-alcoholic steatohepatitis

Yamauchi, A., Takahiro, T. O. N. E., de TOLEDO, A., Igarashi, K., SUGIMOTO, K., MIYAI, H., Dawei, D. E. N. G., Nakamura, J., Hong Seok, L. I. M., Kaku, T., et al. (2020) · Biomedical Research · doi:10.2220/biomedres.41.1 · Cited by 14

Oxidative Stress in Nonalcoholic Fatty Liver Disease

Marí, M., Morales, A., Colell, A., García‐Ruiz, C., & Fernández-Checa, J. C. (2015) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-3-319-15539-5_12 · Cited by 14

Nonalcoholic Steatohepatitis in a Patient with Ataxia-Telangiectasia

Caballero, T., Molina, M. C., Salmerón, J., & Gómez‐Morales, M. (2014) · Case Reports in Hepatology · doi:10.1155/2014/761250 · Cited by 14

Flame Retardants-Mediated Interferon Signaling in the Pathogenesis of Nonalcoholic Fatty Liver Disease

Negi, C. K., Khan, S., Dirven, H. A. A. M., Bajard, L., & Bláha, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084282 · Cited by 14

Consuming a Linoleate-Rich Diet Increases Concentrations of Tetralinoleoyl Cardiolipin in Mouse Liver and Alters Hepatic Mitochondrial Respiration

Mahler, C. A., Snoke, D. B., Cole, R. M., Angelotti, A., Sparagna, G. C., Baskin, K. K., Ni, A., & Belury, M. A. (2023) · Journal of Nutrition · doi:10.1016/j.tjnut.2023.12.037 · Cited by 12

The newly proposed plasma-glycosylated hemoglobin A1c/High-Density lipoprotein cholesterol ratio serves as a simple and practical indicator for screening metabolic associated fatty liver disease: an observational study based on a physical examination population

He, S., Lu, S., Yu, C., Kuang, M., Qiu, J., Sheng, G., & Zou, Y. (2024) · BMC Gastroenterology · doi:10.1186/s12876-024-03362-0 · Cited by 12

Is there any progress in the treatment of non-alcoholic fatty liver disease?

Tsochatzis, E. A. (2011) · World Journal of Gastrointestinal Pharmacology and Therapeutics · doi:10.4292/wjgpt.v2.i1.1 · Cited by 13

Enhancing hepatic fibrosis in spontaneously hypertensive rats fed a choline‐deficient diet: a follow‐up report on long‐term effects of oxidative stress in non‐alcoholic fatty liver disease

Yamamoto, H., Kanno, K., Ikuta, T., Arihiro, K., Sugiyama, A., Kishikawa, N., & Tazuma, S. (2016) · Journal of Hepato-Biliary-Pancreatic Sciences · doi:10.1002/jhbp.333 · Cited by 13

Clinical characteristics and prognosis of non-B, non-C hepatocellular carcinoma: The impact of patient sex on disease-free survival - A retrospective cohort study

Hashimoto, M., Tashiro, H., Kobayashi, T., Kuroda, S., Hamaoka, M., & Ohdan, H. (2017) · International Journal of Surgery · doi:10.1016/j.ijsu.2017.01.110 · Cited by 12

The Role of Mitochondria in Sex-Dependent Differences in Hepatic Steatosis and Oxidative Stress in Response to Cafeteria Diet-Induced Obesity in Mice

Mewes, J. M., Gasparin, F. R. S., Yoshida, T., da Silva, M. A. D., Natali, M. R. M., Bizerra, P. F. V., Utsunomiya, K. S., Gilglioni, E. H., Mito, M. S., Mantovanelli, G. C., et al. (2019) · Nutrients · doi:10.3390/nu11071618 · Cited by 13

Usefulness of Technetium‐99 m‐2‐methoxy‐isobutyl‐isonitrile liver scintigraphy for evaluating disease activity of non‐alcoholic fatty liver disease

Masuda, K., Ono, M., Fukumoto, M., Hirose, A., Munekage, K., Ochi, T., Okamoto, N., Akagi, N., Ogawa, Y., & Saibara, T. (2012) · Hepatology Research · doi:10.1111/j.1872-034x.2011.00923.x · Cited by 13

Mitochondrial Actions for Fat Browning and Energy Expenditure in White Adipose Tissue

de Andrade, P. B. M., Lopes, A. B., & Alonso‐Vale, M. I. C. (2016) · Journal of Obesity and Overweight · doi:10.15744/2455-7633.2.201 · Cited by 4

FORUM REVIEW ARTICLE Mitochondrial Fatty Acid Oxidation in Obesity

Serra, D., Mera, P., Mal, M. I., Mir, J. F., & Herrero, L. (2016)

Mitochondrial genetics and obesity: evolutionary adaptation and contemporary disease susceptibility

Dunham‐Snary, K. J., & Ballinger, S. W. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.09.007 · Cited by 27

Mitochondrial fatty acid oxidation in obesity

Serra, D., Mera, P., Malandrino, M. I., Mir, J. F., & Herrero, L. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4875 · Cited by 246

The Role of Impaired Mitochondrial Lipid Oxidation in Obesity

Rogge, M. M. (2009) · Biological Research For Nursing · doi:10.1177/1099800408329408 · Cited by 142