Cited by 441Liver Disease Diagnosis and TreatmentMitochondrial Function and PathologyDiet, Metabolism, and Disease

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NASH: a mitochondrial disease

Pessayre, Dominique, Fromenty, Bernard·2005·Journal of Hepatology

DOI 10.1016/j.jhep.2005.03.004

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Mootha, V. K., Lindgren, C. M., Eriksson, K.-F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstråle, M., Laurila, E., et al. (2003) · Nature Genetics · doi:10.1038/ng1180 · Cited by 10,197
Leptin and the regulation of body weight in mammals
Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405
Obesity as a medical problem
Kopelman, P. G. (2000) · Nature · doi:10.1038/35007508 · Cited by 4,795
β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes
Butler, A. E., Janson, J., Bonner-Weir, S., Ritzel, R., Rizza, R. A., & Butler, P. C. (2003) · Diabetes · doi:10.2337/diabetes.52.1.102 · Cited by 4,011
Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes
Özcan, U., Cao, Q., Yilmaz, E., Lee, A.-H., Iwakoshi, N. N., Özdelen, E., Tuncman, G., Görgün, C., Glimcher, L. H., & Hotamisligil, G. S. (2004) · Science · doi:10.1126/science.1103160 · Cited by 3,844
A central role for JNK in obesity and insulin resistance
Hirosumi, J., Tuncman, G., Chang, L., Görgün, C. Z., Uysal, K. T., Maeda, K., Karin, M., & Hotamisligil, G. S. (2002) · Nature · doi:10.1038/nature01137 · Cited by 3,359
Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF.
Fadok, V. A., Bratton, D. L., Konowal, A., Freed, P. W., Westcott, J. Y., & Henson, P. M. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1112 · Cited by 3,166 · cited 2×
“[114] Fadok VA, Bratton DL, Konowal A, Freed PW, Westcott JY, Henson PM.”
Background
Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes
Kelley, D. E., He, J., Menshikova, E. V., & Ritov, V. B. (2002) · Diabetes · doi:10.2337/diabetes.51.10.2944 · Cited by 2,321
Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes
Petersen, K. F., Dufour, S., Befroy, D., Garcia, R., & Shulman, G. I. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031314 · Cited by 2,193
Mitochondrial dysfunction in the elderly: possible role in insulin resistance
Petersen, K. F., Befroy, D., Dufour, S., Dziura, J., Ariyan, C., Rothman, D. L., DiPietro, L., Cline, G. W., & Shulman, G. I. (2003) · Science · doi:10.1126/science.1082889 · Cited by 2,107
Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities
Sanyal, A. J., Campbell–Sargent, C., Mirshahi, F., Rizzo, W. B., Contos, M. J., Sterling, R. K., Luketic, V. A., Shiffman, M. L., & Clore, J. N. (2001) · Gastroenterology · doi:10.1053/gast.2001.23256 · Cited by 2,078
Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1
Patti, M. E., Butte, A. J., Crunkhorn, S., Cusi, K., Berria, R., Kashyap, S., Miyazaki, Y., Kohane, I., Costello, M., Saccone, R., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1032913100 · Cited by 1,952
Molecular mediators of hepatic steatosis and liver injury
Browning, J. D., & Horton, J. D. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200422422 · Cited by 1,772
Peroxisome proliferator–activated receptor α mediates the adaptive response to fasting
Kersten, S., Seydoux, J., Peters, J. M., Gonzalez, F. J., Desvergne, B., & Wahli, W. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6223 · Cited by 1,649
The mitochondrial genome: structure, transcription, translation and replication
Taanman, J.-W. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(98)00161-3 · Cited by 1,635
Topology of superoxide production from different sites in the mitochondrial electron transport chain
St-Pierre, J., Buckingham, J. A., Roebuck, S. J., & Brand, M. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207217200 · Cited by 1,545
Regulation of hepatic fatty acid oxidation and ketone body production
McGarry, J. D., & Foster, D. W. (1980) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.49.070180.002143 · Cited by 1,460 · cited 2×
“The entry of long-chain FFAs into the mitochondria is critically dependent on carnitine palmitoyl transferase I (CPT-I), an outer membrane enzyme whose activity is inhibited by malonyl-CoA [12].”
Background
Atherogenic lipoprotein phenotype. A proposed genetic marker for coronary heart disease risk
Austin, M. A., King, M. C., Vranizan, K. M., & Krauss, R. M. (1990) · Circulation · doi:10.1161/01.cir.82.2.495 · Cited by 1,411 · cited 2×
“Similarly, plasma very low density lipoproteins and triglycerides can be increased in insulin-resistant patients [64,65].”
Background
The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase
Kern, P. A., Saghizadeh, M., Ong, J. M., Bosch, R. J., Deem, R., & Simsolo, R. B. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117899 · Cited by 1,305
Glucose Transporters and Insulin Action — Implications for Insulin Resistance and Diabetes Mellitus
Shepherd, P. R., & Kahn, B. B. (1999) · New England Journal of Medicine · doi:10.1056/nejm199907223410406 · Cited by 1,295
Peroxisome proliferator–activated receptor γ coactivator-1 promotes cardiac mitochondrial biogenesis
Lehman, J. J., Barger, P. M., Kovacs, A., Saffitz, J. E., Medeiros, D. M., & Kelly, D. P. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10268 · Cited by 1,285
The Coactivator PGC-1 Cooperates with Peroxisome Proliferator-Activated Receptor α in Transcriptional Control of Nuclear Genes Encoding Mitochondrial Fatty Acid Oxidation Enzymes
Vega, R. B., Huss, J. M., & Kelly, D. P. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.5.1868-1876.2000 · Cited by 1,195
Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation
Du, X.-L., Edelstein, D., Rossetti, L., Fantus, I. G., Goldberg, H. J., Ziyadeh, F. N., Wu, J., & Brownlee, M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.22.12222 · Cited by 1,152
Mutation in mitochondrial tRNALeu(UUR) gene in a large pedigree with maternally transmitted type II diabetes mellitus and deafness
van den Ouweland, J. M. W., Lemkes, H. H. P. J., Ruitenbeek, W., Sandkuijl, L. A., de Vijlder, M. F., Struyvenberg, P. A. A., van de Kamp, J. J. P., & Maassen, J. A. (1992) · Nature Genetics · doi:10.1038/ng0892-368 · Cited by 1,135
Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis
Feldstein, A. E., Canbay, A., Angulo, P., Taniai, M., Burgart, L. J., Lindor, K. D., & Gores, G. J. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00907-7 · Cited by 1,085
AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation
Zong, H., Ren, J. M., Young, L. H., Pypaert, M., Mu, J., Birnbaum, M. J., & Shulman, G. I. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.252625599 · Cited by 1,036
Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease
Li, Z., Yang, S., Lin, H., Huang, J., Watkins, P. A., Moser, A. B., Desimone, C., Song, X.-Y., & Diehl, A. M. (2003) · Hepatology · doi:10.1053/jhep.2003.50048 · Cited by 930
Nonalcoholic fatty liver disease
Clark, J. M., Brancati, F. L., & Diehl, A. M. (2002) · Gastroenterology · doi:10.1053/gast.2002.33573 · Cited by 929
Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents.
Perseghin, G., Scifo, P., De Cobelli, F., Pagliato, E., Battezzati, A., Arcelloni, C., Vanzulli, A., Testolin, G., Pozza, G., Del Maschio, A., et al. (1999) · Diabetes · doi:10.2337/diabetes.48.8.1600 · Cited by 877
Free fatty acids promote hepatic lipotoxicity by stimulating TNF-α expression via a lysosomal pathway
Feldstein, A. E., Werneburg, N. W., Canbay, A. E., Guicciardi, M. E., Bronk, S. F., Rydzewski, R. M., Burgart, L. J., & Gores, G. J. (2004) · Hepatology · doi:10.1002/hep.20283 · Cited by 851
Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis
Iizuka, K., Bruick, R. K., Liang, G., Horton, J. D., & Uyeda, K. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401516101 · Cited by 834
Dietary Habits and Their Relations to Insulin Resistance and Postprandial Lipemia in Nonalcoholic Steatohepatitis
Musso, G., Gambino, R., Michieli, F. D., Cassader, M., Rizzetto, M., Durazzo, M., Fagà, E., Silli, B., & Pagano, G. (2003) · Hepatology · doi:10.1053/jhep.2003.50132 · Cited by 772
CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis
Leclercq, I. A., Farrell, G. C., Field, J., Bell, D., Gonzalez, F. J., & Robertson, G. R. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8814 · Cited by 763
Defective hepatic mitochondrial respiratory chain in patients with nonalcoholic steatohepatitis.
Pérez-Carreras, M., Del Hoyo, P., Martín, M. A., Rubio, J. C., Martín, A., Castellano, G., Colina, F., Arenas, J., & Solis-Herruzo, J. A. (2003) · Hepatology · doi:10.1002/hep.1840380426 · Cited by 734
Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscle
Winder, W. W., Holmes, B. F., Rubink, D. S., Jensen, E. B., Chen, M., & Holloszy, J. O. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.88.6.2219 · Cited by 709
Gene expression of tumor necrosis factor α and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients
Crespo, J., Cayón, A., Fernández-Gil, P. L., Hernández‐Guerra, M., Mayorga, M., Domínguez‐Díez, A., Fernández-Escalante, J. C., & Pons‐Romero, F. (2001) · Hepatology · doi:10.1053/jhep.2001.29628 · Cited by 708
Complex I-mediated reactive oxygen species generation: modulation by cytochrome c and NAD(P)+ oxidation–reduction state
Kushnareva, Y., Murphy, A. N., & Andreyev, A. Y. (2002) · Biochemical Journal · doi:10.1042/bj20021121 · Cited by 696
Regulation of mitochondrial biogenesis in skeletal muscle by CaMK
Wu, H., Kanatous, S. B., Thurmond, F. A., Gallardo, T., Isotani, E., Bassel-Duby, R., & Williams, R. S. (2002) · Science · doi:10.1126/science.1071163 · Cited by 684
A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver
Yamashita, H., Takenoshita, M., Sakurai, M., Bruick, R. K., Henzel, W. J., Shillinglaw, W., Arnot, D., & Uyeda, K. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.161284298 · Cited by 682
Inhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicity
Fromenty, B., & Pessayre, D. (1995) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(95)00012-6 · Cited by 665
Self-citation
Cardiovascular risk factors emerge after artificial selection for low aerobic capacity.
Wisløff, U., Najjar, S. M., Ellingsen, Ø., Haram, P. M., Swoap, S., Al-Share, Q., Fernström, M., Rezaei, K., Lee, S. J., Koch, L. G., et al. (2005) · Science · doi:10.1126/science.1108177 · Cited by 657
Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis
Weltman, M., Farrell, G. C., Hall, P. D. L. Μ., Ingelman‐Sundberg, M., & Liddle, C. (1998) · Hepatology · doi:10.1002/hep.510270121 · Cited by 613
Mitochondrial origins.
Yang, D., Oyaizu, Y., Oyaizu, H., Olsen, G. J., & Woese, C. R. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.13.4443 · Cited by 609
Maternally transmitted diabetes and deafness associated with a 10.4 kb mitochondrial DNA deletion
Ballinger, S. W., Shoffner, J. M., Hedaya, E. V., Trounce, I. A., Polak, M. A., Koontz, D. A., & Wallace, D. C. (1992) · Nature Genetics · doi:10.1038/ng0492-11 · Cited by 606
Non-Insulin-Dependent Diabetes Mellitus — A Genetically Programmed Failure of the Beta Cell to Compensate for Insulin Resistance
Polonsky, K. S., Sturis, J., & Bell, G. I. (1996) · New England Journal of Medicine · doi:10.1056/nejm199603213341207 · Cited by 595
Saturated Fatty Acids Synergize with Elevated Glucose to Cause Pancreatic β-Cell Death
El-Assaad, W., Buteau, J., Peyot, M., Nolan, C. J., Roduit, R., Hardy, S., Joly, E. C., Dbaibo, G. S., Rosenberg, L. C., & Prentki, M. (2003) · Endocrinology · doi:10.1210/en.2003-0410 · Cited by 586
Vitamin E treatment of nonalcoholic steatohepatitis in children: A pilot study
Lavine, J. E. (2000) · The Journal of Pediatrics · doi:10.1016/s0022-3476(00)05040-x · Cited by 564
Mitochondrial function in normal and diabetic β-cells
Maechler, P., & Wollheim, C. B. (2001) · Nature · doi:10.1038/414807a · Cited by 519
PKC-θ knockout mice are protected from fat-induced insulin resistance
Kim, J. K., Fillmore, J. J., Sunshine, M. J., Albrecht, B., Higashimori, T., Kim, D.-W., Liu, Z.-X., Soos, T. J., Cline, G. W., O’Brien, W. R., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200422230 · Cited by 500
Mitochondrial abnormalities in non-alcoholic steatohepatitis
Caldwell, S. H., Swerdlow, R. H., Khan, E. M., Iezzoni, J. C., Hespenheide, E. E., Parks, J. K., & Parker, W. D. (1999) · Journal of Hepatology · doi:10.1016/s0168-8278(99)80033-6 · Cited by 495
Markers of capacity to utilize fatty acids in human skeletal muscle: relation to insulin resistance and obesity and effects of weight loss.
Simoneau, J., Veerkamp, J. H., Turcotte, L. P., & Kelley, D. E. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.14.2051 · Cited by 491
Alterations in Liver ATP Homeostasis in Human Nonalcoholic Steatohepatitis
Cortez‐Pinto, H., Chatham, J. C., Chacko, V. P., Arnold, C., Rashid, A., & Diehl, A. M. (1999) · JAMA · doi:10.1001/jama.282.17.1659 · Cited by 487
Uncoupling Protein 2, in Vivo Distribution, Induction upon Oxidative Stress, and Evidence for Translational Regulation
Pecqueur, C., Alves‐Guerra, M., Gelly, C., Lévi-Meyrueis, C., Couplan, E., Collins, S., Ricquier, D., Bouillaud, F., & Miroux, B. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006938200 · Cited by 483
Bax and Bak Coalesce into Novel Mitochondria-Associated Clusters during Apoptosis
Nechushtan, A., Smith, C. L., Lamensdorf, I., Yoon, S., & Youle, R. J. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.6.1265 · Cited by 480
Obesity Induces Expression of Uncoupling Protein-2 in Hepatocytes and Promotes Liver ATP Depletion
Chavin, K. D., Yang, S., Lin, H. Z., Chatham, J. C., Chacko, V. P., Hoek, J. B., Walajtys-Rode, E., Rashid, A., Chen, C., Huang, C., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.9.5692 · Cited by 443
Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes
Wolfrum, C., Asilmaz, E., Luca, E., Friedman, J. M., & Stoffel, M. (2004) · Nature · doi:10.1038/nature03047 · Cited by 442
Apoptotic Body Engulfment by a Human Stellate Cell Line Is Profibrogenic
Canbay, A., Taimr, P., Torok, N., Higuchi, H., Friedman, S., & Gores, G. J. (2003) · Laboratory Investigation · doi:10.1097/01.lab.0000069036.63405.5c · Cited by 417 · cited 2×
“[115] Canbay A, Taimr P, Torok N, Higuchi H, Friedman S, Gores GJ.”
Background
Leptin is essential for the hepatic fibrogenic response to chronic liver injury
Leclercq, I. A., Farrell, G. C., Schriemer, R., & Robertson, G. R. (2002) · Journal of Hepatology · doi:10.1016/s0168-8278(02)00102-2 · Cited by 407
Superoxide-mediated activation of uncoupling protein 2 causes pancreatic β cell dysfunction
Krauss, S., Zhang, C., Scorrano, L., Dalgaard, L. T., St‐Pierre, J., Grey, S. T., & Lowell, B. B. (2003) · Journal of Clinical Investigation · doi:10.1172/jci19774 · Cited by 405
Superoxide-mediated activation of uncoupling protein 2 causes pancreatic β cell dysfunction
Krauss, S., Zhang, C.-Y., Scorrano, L., Dalgaard, L. T., St-Pierre, J., Grey, S. T., & Lowell, B. B. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319774 · Cited by 401
Mitochondria in Steatohepatitis
Pessayre, D., Berson, A., Fromenty, B., & Mansouri, A. (2001) · Seminars in Liver Disease · doi:10.1055/s-2001-12929 · Cited by 390
Self-citation
Leptin receptor–mediated signaling regulates hepatic fibrogenesis and remodeling of extracellular matrix in the rat
Ikejima, K., Takei, Y., Honda, H., Hirose, M., Yoshikawa, M., Zhang, Y., Lang, T., Fukuda, T., Yamashina, S., Kitamura, T., et al. (2002) · Gastroenterology · doi:10.1053/gast.2002.32995 · Cited by 386
Functional and morphological alterations of mitochondria in pancreatic beta cells from type 2 diabetic patients
Anello, M., Lupi, R., Spampinato, D., Piro, S., Masini, M., Boggi, U., Del Prato, S., Rabuazzo, A. M., Purrello, F., & Marchetti, P. (2005) · Diabetologia · doi:10.1007/s00125-004-1627-9 · Cited by 385
Leptin in hepatic fibrosis: evidence for increased collagen production in stellate cells and lean littermates of ob/ob mice
Saxena, N. K., Ikeda, K., Rockey, D. C., Friedman, S. L., & Anania, F. A. (2002) · Hepatology · doi:10.1053/jhep.2002.32029 · Cited by 382
Mitochondrial Adaptations to Obesity-Related Oxidant Stress
Yang, S., Zhu, H., Li, Y., Lin, H., Gabrielson, K., Trush, M. A., & Diehl, A. M. (2000) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2000.1829 · Cited by 367
A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans
Esterbauer, H., Schneitler, C., Oberkofler, H., Ebenbichler, C. F., Paulweber, B., Sandhofer, F., Ladurner, G., Hell, E., Strosberg, A. D., Patsch, J. R., et al. (2001) · Nature Genetics · doi:10.1038/88911 · Cited by 357
Hepatic Cytochrome P450 2E1 Activity in Nondiabetic Patients With Nonalcoholic Steatohepatitis
Chalasani, N., Gorski, J. C., Asghar, M. S., Asghar, A., FORESMAN, B. H., Hall, S. D., & Crabb, D. W. (2003) · Hepatology · doi:10.1053/jhep.2003.50095 · Cited by 346
Apolipoprotein synthesis in nonalcoholic steatohepatitis
Charlton, M., Raghavakaimal, S., Rasmussen, D. L., Lindor, K. D., & Nair, S. K. (2002) · Hepatology · doi:10.1053/jhep.2002.32527 · Cited by 332
Stimulation of Lipid Peroxidation or 4-Hydroxynonenal Treatment Increases Procollagen α1 (I) Gene Expression in Human Liver Fat-Storing Cells
Parola, M., Pinzani, M., Casini, A., Albano, E., Poli, G., Gentilini, A., Geñtilini, P., & Mu, D. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.1927 · Cited by 330
Diet associated hepatic steatosis sensitizes to Fas mediated liver injury in mice
Feldstein, A. E., Canbay, A. E., Guicciardi, M. E., Higuchi, H., Bronk, S. F., & Gores, G. J. (2003) · Journal of Hepatology · doi:10.1016/s0168-8278(03)00460-4 · Cited by 321
Skeletal muscle utilization of free fatty acids in women with visceral obesity.
Colberg, S. R., Simoneau, J. A., Thaete, F. L., & Kelley, D. E. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117864 · Cited by 320
Up-Regulation of Peroxisome Proliferator-Activated Receptors (PPAR-α) and PPAR-γ Messenger Ribonucleic Acid Expression in the Liver in Murine Obesity: Troglitazone Induces Expression of PPAR-γ-Responsive Adipose Tissue-Specific Genes in the Liver of Obese Diabetic Mice**This work was supported by grants from the Research Service of the Department of Veterans Affairs (to C.G. and K.R.F.), NIH Grant DK-49448 (to C.G.), and Merck Research Laboratories (to L.H.T. and K.N.).
Memon, R. A., Tecott, L. H., Nonogaki, K., Beigneux, A. P., Moser, A. H., Grünfeld, C., & Feingold, K. R. (2000) · Endocrinology · doi:10.1210/endo.141.11.7771 · Cited by 302
Mutation analysis of peroxisome proliferator-activated receptor-γ coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus
Ek, J., Andersen, G., Urhammer, S. A., Gæde, P. H., Drivsholm, T., Borch-Johnsen, K., Hansen, T., & Pedersen, O. (2001) · Diabetologia · doi:10.1007/s001250100032 · Cited by 293
Acute and chronic hepatic steatosis lead to in vivo lipid peroxidation in mice
Lettéron, P., Fromenty, B., Terris, B., Degott, C., & Pessayre, D. (1996) · Journal of Hepatology · doi:10.1016/s0168-8278(96)80030-4 · Cited by 272
Self-citation
Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication
Wang, Y., Michikawa, Y., Mallidis, C., Bai, Y., Woodhouse, L. J., Yarasheski, K. E., Miller, C. A., Askanas, V., Engel, W. K., Bhasin, S., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.061013598 · Cited by 272
Role of calcium and AMP kinase in the regulation of mitochondrial biogenesis and GLUT4 levels in muscle
Ojuka, E. O. (2004) · Proceedings of The Nutrition Society · doi:10.1079/pns2004339 · Cited by 271
The ins and outs of mitochondrial dysfunction in NASH
Fromenty, B., Robin, M., Igoudjil, A., Mansouri, A., & Pessayre, D. (2004) · Diabetes & Metabolism · doi:10.1016/s1262-3636(07)70098-8 · Cited by 270
Self-citation
Nuclear Control of Respiratory Chain Expression in Mammalian Cells
Scarpulla, R. C. (1997) · Journal of Bioenergetics and Biomembranes · doi:10.1023/a:1022681828846 · Cited by 269
The lipid peroxidation end product 4‐hydroxy‐2,3‐nonenal up‐regulates transforming growth factor β1 expression in the macrophage lineage: a link between oxidative injury and fibrosclerosis 1
Leonarduzzi, G., Scavazza, A., Biasi, F., Chiarpotto, E., Camandola, S., Vogl, S., Dargel, R., & Poli, G. (1997) · The FASEB Journal · doi:10.1096/fasebj.11.11.9285483 · Cited by 264
Non-Esterified Fatty Acids in the Blood of Obese and Lean Subjects
GORDON, E. S. (1960) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/8.5.740 · Cited by 244
Uncoupling Protein 2: A Possible Link Between Fatty Acid Excess and Impaired Glucose-Induced Insulin Secretion?
Davis‐Lameloise, N., Muzzin, P., Prentki, M., & Assimacopoulos‐Jeannet, F. (2001) · Diabetes · doi:10.2337/diabetes.50.4.803 · Cited by 228
Increased hepatic lipogenesis but decreased expression of lipogenic gene in adipose tissue in human obesity
Diraison, F., Dusserre, E., Vidal, H., Sothier, M., & Beylot, M. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2002.282.1.e46 · Cited by 228
Triacylglycerol-rich lipoproteins and the generation of small, dense low-density lipoprotein
Packard, C. J. (2003) · Biochemical Society Transactions · doi:10.1042/bst0311066 · Cited by 225
A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes
Hara, K., Tobe, K., Okada, T., Kadowaki, H., Akanuma, Y., Ito, C., Kimura, S., & Kadowaki, T. (2002) · Diabetologia · doi:10.1007/s00125-002-0803-z · Cited by 224
Free Fatty Acid-induced β-Cell Defects Are Dependent on Uncoupling Protein 2 Expression
Joseph, J. W., Koshkin, V., Saleh, M. C., Sivitz, W. I., Zhang, C.-Y., Lowell, B. B., Chan, C. B., & Wheeler, M. B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409189200 · Cited by 206
Comparison of serum concentrations of α-tocopherol and β-carotene in a cross-sectional sample of obese and nonobese children (NHANES III)
Strauss, R. S. (1999) · The Journal of Pediatrics · doi:10.1016/s0022-3476(99)70409-9 · Cited by 198
A PROPOSED GENETIC MARKER FOR CORONARY HEART DISEASE RISK
Austin, King, M., VRANIZAN, K. M., & Krauss, R. M. (1990) · Cited by 194
The Human Genome Project Reveals a Continuous Transfer of Large Mitochondrial Fragments to the Nucleus
Mourier, T., Hansen, A. J., Willerslev, E., & Arctander, P. (2001) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a003971 · Cited by 191
Dietary choline restriction causes complex I dysfunction and increased H2O2 generation in liver mitochondria
Hensley, K. (2000) · Carcinogenesis · doi:10.1093/carcin/21.5.983 · Cited by 182
PKCλ in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity
Matsumoto, M., Ogawa, W., Akimoto, K., Inoue, H., Miyake, K., Furukawa, K., Hayashi, Y., Iguchi, H., Matsuki, Y., Hiramatsu, R., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18816 · Cited by 176
Mitochondrial injury in steatohepatitis
Pessayre, D., Fromenty, B., & Mansouri, A. (2004) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200411000-00003 · Cited by 166
Self-citation
A Bax-Induced Pro-Oxidant State Is Critical for Cytochrome c Release during Programmed Neuronal Death
Kirkland, R. A., Windelborn, J. A., Kasprzak, J. M., & Franklin, J. L. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-15-06480.2002 · Cited by 165
5′-AMP-activated protein kinase activity and protein expression are regulated by endurance training in human skeletal muscle
Frøsig, C., Jørgensen, S. B., Hardie, D. G., Richter, E. A., & Wojtaszewski, J. F. P. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00317.2003 · Cited by 161
Inhibition of cytochrome c oxidase activity by 4-hydroxynonenal (HNE)
Chen, J., Schenker, S., Frosto, T. A., & Henderson, G. I. (1998) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(98)00002-6 · Cited by 150
Hepatic Mitochondrial Beta-Oxidation in Patients With Nonalcoholic Steatohepatitis Assessed by 13C-Octanoate Breath Test
Miele, L., Grieco, A., Armuzzi, A., Candelli, M., Forgione, A., Gasbarrini, A., & Gasbarrini, A. (2003) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2003.07725.x · Cited by 142
A Gly482Ser Missense Mutation in the Peroxisome Proliferator-Activated Receptor γ Coactivator-1 Is Associated With Altered Lipid Oxidation and Early Insulin Secretion in Pima Indians
Muller, Y. L., Bogardus, C., Pedersen, O. B., & Baier, L. J. (2003) · Diabetes · doi:10.2337/diabetes.52.3.895 · Cited by 142
Oxidative DNA damage and DNA repair enzyme expression are inversely related in murine models of fatty liver disease
Gao, D., Wei, C., Chen, L., Huang, J., Yang, S., & Diehl, A. M. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00228.2004 · Cited by 140
Opening of the mitochondrial permeability transition pore causes matrix expansion and outer membrane rupture in fas-mediated hepatic apoptosis in mice
Feldmann, G., Haouzi, D., Moreau, A., Durand‐Schneider, A., Bringuier, A. F., Berson, A., Mansouri, A., Fau, D., & Pessayre, D. (2000) · Hepatology · doi:10.1002/hep.510310318 · Cited by 138
Self-citation
Mechanism for Peroxisome Proliferator-activated Receptor-α Activator-induced Up-regulation of UCP2 mRNA in Rodent Hepatocytes
Nakatani, T., Tsuboyama-Kasaoka, N., Takahashi, M. M., Miura, S., & Ezaki, O. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110132200 · Cited by 132
A Common Polymorphism in the Promoter of UCP2 Contributes to the Variation in Insulin Secretion in Glucose-Tolerant Subjects
Sesti, G., Cardellini, M., Marini, M. A., Frontoni, S., D’Adamo, M., Guerra, S. D., Lauro, D., de Nicolais, P., Sbraccia, P., Prato, S. D., et al. (2003) · Diabetes · doi:10.2337/diabetes.52.5.1280 · Cited by 131
Regulation of carnitine palmitoyltransferase by insulin results in decreased activity and decreased apparent Ki values for malonyl-CoA.
Cook, G. A., & Gamble, M. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)61616-3 · Cited by 130
Muscle fat oxidative capacity is not impaired by age but by physical inactivity: association with insulin sensitivity
Rimbert, V., Boirie‌, Y., Bedu, M., Hocquette, J.-F. J.-F., Ritz, P., & Morio, B. (2004) · The FASEB Journal · doi:10.1096/fj.03-1104fje · Cited by 128
Increased expression of mitochondrial-encoded genes in skeletal muscle of humans with diabetes mellitus.
Antonetti, D. A., Reynet, C., & Kahn, C. R. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117790 · Cited by 120
Hepatic Expression of Microsomal Triglyceride Transfer Protein and In Vivo Secretion of Triglyceride-Rich Lipoproteins Are Increased in Obese Diabetic Mice
Bartels, E. D., Lauritsen, M. L., & Nielsen, L. B. (2002) · Diabetes · doi:10.2337/diabetes.51.4.1233 · Cited by 120
Induction of apoptosis by transforming growth factor-β1 in the rat hepatoma cell line MCA-RH7777: A possible association with tissue transglutaminase expression
Fukuda, K., Kojiro, M., & Chiu, J. (1993) · Hepatology · doi:10.1002/hep.1840180428 · Cited by 113
Intracellular Assembly of Very Low Density Lipoproteins Containing Apolipoprotein B100 in Rat Hepatoma McA-RH7777 Cells
Tran, K. T., Thorne‐Tjomsland, G., DeLong, C. J., Cui, Z., Shan, J., Burton, L., Jamieson, J. C., & Yao, Z. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200249200 · Cited by 107
Uncoupling Protein 2 Promoter Polymorphism −866G/A Affects Its Expression in β-Cells and Modulates Clinical Profiles of Japanese Type 2 Diabetic Patients
Sasahara, M., Nishi, M., Kawashima, H., Ueda, K., Sakagashira, S., Furuta, H., Matsumoto, E., Hanabusa, T., Sasaki, H., & Nanjo, K. (2004) · Diabetes · doi:10.2337/diabetes.53.2.482 · Cited by 101
Elevated hepatic mitochondrial and peroxisomal oxidative capacities in fed and starved adult obese (ob/ob) mice
Brady, L. J., Brady, P. S., Romsos, D. R., & Hoppel, C. L. (1985) · Biochemical Journal · doi:10.1042/bj2310439 · Cited by 92
Thalidomide prevents alcoholic liver injury in rats through suppression of Kupffer cell sensitization and TNF-α production
Enomoto, N., Takei, Y., Hirose, M., Ikejima, K., Miwa, H., Kitamura, T., & Sato, N. (2002) · Gastroenterology · doi:10.1053/gast.2002.34161 · Cited by 89
Formation of Malondialdehyde Adducts in Livers of Rats Exposed to Ethanol: Role in Ethanol-Mediated Inhibition of Cytochrome c Oxidase
Chen, J., Petersen, D. R., Schenker, S., & Henderson, G. I. (2000) · Alcoholism Clinical and Experimental Research · doi:10.1097/00000374-200004000-00030 · Cited by 84
Understanding adipose tissue development from transgenic animal models
Valet, P., Tavernier, G., Castan‐Laurell, I., Saulnier‐Blache, J. S., & Langin, D. (2002) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)30458-2 · Cited by 70
Insulin modulation of newly synthesized apolipoproteins B‐100 and B‐48 in human fetal intestine: Gene expression and mRNA editing are not involved
Levy, E. H., Sinnett, D., Thibault, L., Nguyen, T. D., DELVIN, E. E., & Ménard, D. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00896-4 · Cited by 67
Leptin enhances the effect of transforming growth factor β in increasing type I collagen formation
Tang, M. K., Potter, J. J., & Mezey, E. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02300-8 · Cited by 67
Alterations of peroxisomes in steatosis of the human liver: A quantitative study
Craemer, D. D., Pauwels, M., & Branden, C. V. D. (1995) · Hepatology · doi:10.1002/hep.1840220309 · Cited by 50
Hepatic peroxisomal abnormalities in abetalipoproteinemia
Collins, J. C., Scheinberg, I. H., Giblin, D. R., & Sternlieb, I. (1989) · Gastroenterology · doi:10.1016/0016-5085(89)90651-3 · Cited by 46
Obese Zucker (fa/fa) Rats Are Resistant to Insulin′s Inhibitory Effect on Hepatic APO B Secretion
Sparks, J. D., & Sparks, C. E. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.2681 · Cited by 46
Apoptosis and Its Modulation by Drugs
(2000) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-57075-9 · Cited by 34
REGULATION OF HEPATIC FATTY ACID OXIDATION AND KETONE BODY PRODUCTION
r, N. F. T. (2002) · Cited by 33
Hepatocyte Apoptosis Triggered by Natural Substances (Cytokines, Other Endogenous Molecules and Foreign Toxins)
Pessayre, D., Feldmann, G., Haouzi, D., Fau, D., Moreau, A., & Neuman, M. G. (2000) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-57075-9_3 · Cited by 28
Self-citation
Outfoxing insulin resistance?
Montminy, M., & Koo, S. (2004) · Nature · doi:10.1038/432958a · Cited by 19
New lipoprotein profiles and coronary heart disease. Improving precision of risk.
Nestel, P. J. (1990) · Circulation · doi:10.1161/01.cir.82.2.649 · Cited by 9
Demonstration of cross-linked cytokeratin polypeptides in transplantable rat hepatoma cells
Fukuda, K., Xie, R., & Chiu, J. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(91)90943-2 · Cited by 7
Nonalcoholic-steatohepatitis (NASH) and hepatic mitochondrial beta-oxidation
Miele, L., Grieco, A., Armuzzi, A., Candelli, M., Zocco, M. A., Forgione, A., Alfei, B., Rapaccini, G. L., Gasbarrini, G., & Gasbarrini, A. (2003) · Journal of Hepatology · doi:10.1016/s0168-8278(03)80059-4 · Cited by 5
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Fromenty, B., & Pessayre, D. (2004) · Wiley eBooks · doi:10.1002/9780470987438.ch11 · Cited by 3
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Authors: Pessayre, D., & Fromenty, B.
Affiliations: Inserm (FR)
Corresponding author: Pessayre, Dominique
ORCID: Fromenty, Bernard
Venue: Journal of Hepatology
Publisher: Elsevier BV
Published: 2005-06
Volume: 42
Issue: 6
Pages: 928-940
ISSN: 0168-8278 (ISSN-L)
DOI: 10.1016/j.jhep.2005.03.004
OpenAlex: W2022657181
Cited by: 441
References: 123
Citations by year: 2026: 9 · 2025: 14 · 2024: 17 · 2023: 19 · 2022: 27 · 2021: 33 · 2020: 25 · 2019: 20 · 2018: 29 · 2017: 21 · 2016: 11 · 2015: 19 · 2014: 26 · 2013: 20 · 2012: 19
FWCI: 14.65
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Hepatology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Keywords: nonalcoholic steatohepatitis, mitochondrial disease, obesity, mitochondrial dysfunction, fat deposition, energy expenditure
MeSH terms: Animals, Fatty Liver, Humans, Mitochondrial Diseases

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