NASH: a mitochondrial disease

PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

Mootha, V. K., Lindgren, C. M., Eriksson, K.-F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstråle, M., Laurila, E., et al. (2003) · Nature Genetics · doi:10.1038/ng1180 · Cited by 10,197

Leptin and the regulation of body weight in mammals

Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405

Obesity as a medical problem

Kopelman, P. G. (2000) · Nature · doi:10.1038/35007508 · Cited by 4,795

β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes

Butler, A. E., Janson, J., Bonner-Weir, S., Ritzel, R., Rizza, R. A., & Butler, P. C. (2003) · Diabetes · doi:10.2337/diabetes.52.1.102 · Cited by 4,011

Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes

Özcan, U., Cao, Q., Yilmaz, E., Lee, A.-H., Iwakoshi, N. N., Özdelen, E., Tuncman, G., Görgün, C., Glimcher, L. H., & Hotamisligil, G. S. (2004) · Science · doi:10.1126/science.1103160 · Cited by 3,844

A central role for JNK in obesity and insulin resistance

Hirosumi, J., Tuncman, G., Chang, L., Görgün, C. Z., Uysal, K. T., Maeda, K., Karin, M., & Hotamisligil, G. S. (2002) · Nature · doi:10.1038/nature01137 · Cited by 3,359

Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF.

Fadok, V. A., Bratton, D. L., Konowal, A., Freed, P. W., Westcott, J. Y., & Henson, P. M. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1112 · Cited by 3,166 · cited 2×

Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes

Kelley, D. E., He, J., Menshikova, E. V., & Ritov, V. B. (2002) · Diabetes · doi:10.2337/diabetes.51.10.2944 · Cited by 2,321

Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes

Petersen, K. F., Dufour, S., Befroy, D., Garcia, R., & Shulman, G. I. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031314 · Cited by 2,193

Mitochondrial dysfunction in the elderly: possible role in insulin resistance

Petersen, K. F., Befroy, D., Dufour, S., Dziura, J., Ariyan, C., Rothman, D. L., DiPietro, L., Cline, G. W., & Shulman, G. I. (2003) · Science · doi:10.1126/science.1082889 · Cited by 2,107

Caracterização de um modelo de esteatose hepática alcoólica induzida por etanol e dieta hiperlipídica em ratos

de Souza, C. E. A. (2013) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)

A lipoperoxidação plasmática como preditor de esteatohepatite não alcoólica em obesos mórbidos com doença hepática gordurosa não alcoólica

Maggioni, L. (2014) · Americanae (AECID Library)

카르니틴이 비알코올성 지방간 질환에서 말초혈액 미토콘드리아 DNA 단위 반복수와 간기능에 미치는 영향

임채영, 전대원, 장성수, 조원경, 채정돈, & 전진현 (2010)

The anti-obesogenic effects of nitric oxide.

Sansbury, B. E. (2014) · ThinkIR: The University of Louisville's Institutional Repository (University of Louisville) · doi:10.18297/etd/1262

THE PATHOGENESIS OF MALARIA ACUTE RESPIRATORY DISTRESS SYNDROME (MA-ARDS): MODIFICATION OF THE LIPID PROFILE, ANTIOXIDANT DEFENCES AND CYTOKINE CONTENT IN DIFFERENT TISSUES OF MALARIA INFECTED MICE

Scaccabarozzi, D. (2014) · Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) · doi:10.13130/scaccabarozzi-diletta_phd2014-02-03

Universidad Michoacana de

de Hidalgo, S. N., & Farmacobiología, F. D. Q. (2010)

Transcriptional Regulation of Mitochondrial Biogenesis and Quality Control

Suliman, H. B., & Piantadosi, C. A. (2015) · Oxidative stress and disease · doi:10.1201/b19420-6

Pathomechanism and therapeutic possibilities of mitochondrial dysfunction in ischemia-reperfusion

Strifler, G. (2017) · doi:10.14232/phd.3216

Fettlebererkrankung bei Kindern und Jugendlichen

Penke, M., Schuster, S., Händel, N., Kiess, W., & Flemming, G. M. C. (2017) · Adipositas - Ursachen Folgeerkrankungen Therapie · doi:10.1055/s-0037-1618947

Effects of Imidacloprid in the Development of Non-Alcoholic Fatty Liver Disease and the Effects of Exercise Training

Jolin-Rodrigue, G. (2019) · uO Research (University of Ottawa) · doi:10.20381/ruor-23150

Obesity-induced hepatic changes during pregnancy

Grilo, L. F. (2019) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)

Searching for biomarkers of non-alcoholic fatty liver disease and metabolic syndrome

delaCruz‐Villar, L. (2020) · Communities in ADDI (University of the Basque Country)

Priming, Triggering, Adaptation and Senescence (PTAS): A Hypothesis for a Common Damage Mechanism of Steatohepatitis

Abuja, P. M., Zatloukal, K., & Denk, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212545

E-Manuscript Article Summaries

Current Oncology Editorial Office (2011) · Current Oncology · doi:10.3747/co.v18i2.897

The role of hepatocellular eNOS in NAFLD development and hepatic mitochondrial adaptations to exercise

Cunningham, R. P. (2020) · doi:10.32469/10355/81558

The role of hepatic mitochondrial function and mitochondrial turnover in the development and progression of nonalcoholic fatty liver disease and lifestyle modifications to treat the disease

Moore, M. P. (2021) · MOspace Institutional Repository (University of Missouri) · doi:10.32469/10355/91011

The role of reck in the pathogenesis of nonalcoholic steatohepatitis

Dashek, R. J. (2022) · doi:10.32469/10355/94274

Taurine and the Liver: A Focus on Mitochondria related Liver Disease

Heidari, R., & Ommati, M. M. (2023) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815124484123010007

Nonalcoholic Fatty Liver in the Pathogenesis of Diabetes

Nogueira, C. A. V., & Leite, N. C. (2023) · Springer eBooks · doi:10.1007/978-3-031-25519-9_16

Biochemical and functional characterization of the p.A165T missense variant of mitochondrial amidoxime-reducing component 1 in HepG2 cellsPreprint

Hou, W., Watson, C., Cecconie, T., Bolaki, M. N., Brady Jennifer, J., Lu, Q., Gatto, G. J. J., & Day, T. A. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.18.562989

Non-alcoholic fatty liver disease: pathogenesis and assessing the impact of dietary bioactive compounds on the liver

Oğuz, E., & Karakoyun, B. (2024) · Marmara medical journal · doi:10.5472/marumj.1479280

NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD): DISEASE MECHANISMS AND CONTEMPORARY THERAPEUTIC APPROACHES - A LITERATURE REVIEW

Strużek, K., Kwiatkowska, A., Mączka, E., Tracz, W., Świercz, P., Teper, K., Khiralla-Gawlik, S., Strzelecka, A. A., & Basak, A. E. (2025) · International Journal of Innovative Technologies in Social Science · doi:10.31435/ijitss.3(47).2025.3662

13C-methionine breath test for the non-invasive detection of advanced metabolic dysfunction-associated steatotic liver disease

Athanasopoulos, S., & Whyte, M. (2025) · Medical Hypotheses · doi:10.1016/j.mehy.2025.111783

Mitochondrial DNA variants and susceptibility to anti-tuberculosis drug-induced liver injury in Korean patients

Pham, V. H., Kim, S., Jee, Y., Jang, T. W., Min, J., Kim, H.-S., Cho, Y., & Shin, J. (2025) · The Pharmacogenomics Journal · doi:10.1038/s41397-025-00390-1

Additional file 1 of ACACA reduces lipid accumulation through dual regulation of lipid metabolism and mitochondrial function via AMPK- PPARα- CPT1A axis

Dong, J., Li, M., Peng, R., Zhang, Y., Qiao, Z., & Sun, N. (2024) · Figshare · doi:10.6084/m9.figshare.26684799

Additional file 1 of Hepatic fibrosis: a manifestation of the liver disease evolution in patients with Ataxia-telangiectasia

Barreto, T. L. N., de Carvalho‐Filho, R. J., Shigueoka, D. C., Fonseca, F. L. A., Ferreira, A. C., Kochi, C., Aranda, C. S., & Sarni, R. O. S. (2023) · Figshare · doi:10.6084/m9.figshare.22774288

Additional file 1 of Modelling porcine NAFLD by deletion of leptin and defining the role of AMPK in hepatic fibrosis

Tan, T., Song, Z., Li, W., Wang, R., Zhu, M., Liang, Z., Bai, Y., Wang, Q., Wu, H., Hu, X., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24136382

Understanding liver and digestive diseases: a paved road to improve diagnosis, management, and treatment

Bergheim, I., Cadranel, J. F. D., Chen, J., Ding, W., Eferl, R., García‐Ruiz, C., Jaeschke, H., Kazerouni, F., Lonardo, A., Mann, D. A., et al. (2026) · Exploration of Digestive Diseases · doi:10.37349/edd.2026.1005110

Les mécanismes de réponse à l'inflammation chronique dans le foie stéatosique et les conséquences sur l'homéostasie cellulaire et la cancérogénèse

Esposti, D. D. (2011) · theses.fr (ABES) · doi:10.70675/b2a8993cz0743z4be8z979cz0a5a932b5326

Altérations de la polyploïdie hépatocytaire au cours du développement des hépatopathies stéatosiques dites non-alcooliques

Gentric, G. (2013) · theses.fr (ABES) · doi:10.70675/eb0d4c50z81dez4186zbf94zabbcd74f451f

Effets d’une co-exposition chronique au benzo[a]pyrène et à l’éthanol sur l’évolution de la NAFLD dans un modèle in vitro

Bucher, S. (2018) · theses.fr (ABES) · doi:10.70675/882ccc94z02d7z46fdzbed9z5722a414c8e8

Rôle des points de contact Réticulum Endoplasmique-Mitochondrie (MAMs) dans la régulation du métabolisme glucido-lipidique du foie et importance du Monoxyde d’Azote (NO)

Bassot, A. (2019) · theses.fr (ABES) · doi:10.70675/bf11117az778az470az8feczf040df41bbd1

Rôle de LECT2 dans les maladies stéatosiques non alcooliques du foie

Pham, S. (2020) · theses.fr (ABES) · doi:10.70675/3693bfe6z9d91z4045za9a9zc37497dc9c1b

Rôle de la kinase ATR dans la progression de la stéatose hépatique non alcoolique

Saroul-Aïnama, M. (2022) · theses.fr (ABES) · doi:10.70675/1fc5906az1637z451czab81z7529e034be63

Discovery of Non-Carboxylic Steroidal FXR Agonist as a Promising Preclinical Candidate for Metabolic Dysfunction-Associated Steatohepatitis

Zhang, Z., Zheng, X., Dong, C., Li, P., Lin, Y., Sun, Z., Li, W., Liu, X., Li, J. J., Li, S., et al. (2026) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c03220

Pre-conception exposure to low doses of malathion during the juvenile and pubertal periods impairs placentation and offspring fetal development in female Wistar rats

Frigoli, G. F., da Costa, I. R., Greghi, J. R., de Souza, M. C., Tenório, P. R., Martins, M. I. M., Seiva, F. R. F., de Andrade, F. G., Favaron, P. O., & Fernandes, G. S. A. (2026) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174426100580

Mitochondrial homeostasis and aging: Mechanisms, disease associations, and targeted intervention strategies

Bao-Sheng, W. A. N. G., & Ben, Z. H. O. U. (2026) · Shengming kexue · doi:10.3724/cbls.2026103

Reversible Subacute Liver Failure Following Revisional Malabsorptive Bariatric Surgery: A Case Report

Prada, S., Penaforte, R., Pereira, B. S., Major, M. F., & Aldomiro, F. (2026) · Cureus · doi:10.7759/cureus.112698

Insulin Resistance and Hepatocarcinogenesis

Sasaki, H., & Sasaki, Y. (2010) · Institutional Repositories DataBase (IRDB)

The clock of the MASH —A quantum-inspired approach of the thermal time theory applied to mitochondrial dysfunction in metabolic syndrome

Leclerc, É., & Voican, C. S. (2026) · Biosystems · doi:10.1016/j.biosystems.2026.105940

Mitochondrial Actions for Fat Browning and Energy Expenditure in White Adipose Tissue

de Andrade, P. B. M., Lopes, A. B., & Alonso‐Vale, M. I. C. (2016) · Journal of Obesity and Overweight · doi:10.15744/2455-7633.2.201 · Cited by 4

FORUM REVIEW ARTICLE Mitochondrial Fatty Acid Oxidation in Obesity

Serra, D., Mera, P., Mal, M. I., Mir, J. F., & Herrero, L. (2016)

Mitochondrial genetics and obesity: evolutionary adaptation and contemporary disease susceptibility

Dunham‐Snary, K. J., & Ballinger, S. W. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.09.007 · Cited by 27

Mitochondrial fatty acid oxidation in obesity

Serra, D., Mera, P., Malandrino, M. I., Mir, J. F., & Herrero, L. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4875 · Cited by 246

The Role of Impaired Mitochondrial Lipid Oxidation in Obesity

Rogge, M. M. (2009) · Biological Research For Nursing · doi:10.1177/1099800408329408 · Cited by 142