NASH: a mitochondrial disease

PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

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Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes

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A central role for JNK in obesity and insulin resistance

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Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF.

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Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes

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Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes

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Mechanisms of NAFLD development and therapeutic strategies

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The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)

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Role of Mitochondrial Dysfunction in Insulin Resistance

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Triglyceride Metabolism in the Liver

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Mitochondrial and metabolic dysfunction in ageing and age-related diseases

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Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease

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Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis

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Nonalcoholic Fatty Liver Disease: Pathology and Pathogenesis

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Mitochondrial Dysfunction and Signaling in Chronic Liver Diseases

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Mitochondrial dysfunction in Nash: causes, consequences and possible means to prevent it

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Apoptosis and Necrosis in the Liver: A Tale of Two Deaths?

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Excessive Hepatic Mitochondrial TCA Cycle and Gluconeogenesis in Humans with Nonalcoholic Fatty Liver Disease

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Non-alcoholic fatty liver disease and obesity: Biochemical, metabolic and clinical presentations

Milić, S. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i28.9330 · Cited by 619

Drug-induced toxicity on mitochondria and lipid metabolism: Mechanistic diversity and deleterious consequences for the liver

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Causes and Metabolic Consequences of Fatty Liver

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Oxidative stress, cardiolipin and mitochondrial dysfunction in nonalcoholic fatty liver disease

Paradies, G. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i39.14205 · Cited by 525

Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases

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Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model

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Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver

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Redox mechanisms in hepatic chronic wound healing and fibrogenesis

Novo, E., & Parola, M. (2008) · Fibrogenesis & Tissue Repair · doi:10.1186/1755-1536-1-5 · Cited by 417

Non-alcoholic fatty liver disease: The diagnosis and management

El-Kader, S. M. A. (2015) · World Journal of Hepatology · doi:10.4254/wjh.v7.i6.846 · Cited by 398

Nonalcoholic fatty liver disease and mitochondrial dysfunction

Wei, Y., Rector, R. S., Thyfault, J. P., & Ibdah, J. A. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.193 · Cited by 384

Apoptosis and Necrosis in the Liver

Guicciardi, M. E., Malhi, H., Mott, J. L., & Gores, G. J. (2013) · Comprehensive physiology · doi:10.1002/cphy.c120020 · Cited by 403

Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance

Matthews, V. B., Allen, T. L., Risis, S., Chan, M. H. S., Henstridge, D. C., Watson, N., Zaffino, L. A., Babb, J. R., Boon, J., Meikle, P. J., et al. (2010) · Diabetologia · doi:10.1007/s00125-010-1865-y · Cited by 334

Drug-induced liver injury through mitochondrial dysfunction: Mechanisms and detection during preclinical safety studies

Labbe, G., Pessayre, D., & Fromenty, B. (2008) · Fundamental & Clinical Pharmacology · doi:10.1111/j.1472-8206.2008.00608.x · Cited by 317

Systematic review: the diagnosis and staging of non‐alcoholic fatty liver disease and non‐alcoholic steatohepatitis

Dowman, J. K., Tomlinson, J., & Newsome, P. N. (2010) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2010.04556.x · Cited by 316

Oxidative mechanisms in the pathogenesis of alcoholic liver disease

Albano, E. (2007) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2007.09.004 · Cited by 303

Histological assessment of non‐alcoholic fatty liver disease

Hübscher, S. G. (2006) · Histopathology · doi:10.1111/j.1365-2559.2006.02416.x · Cited by 292

Understanding the Role of the Gut Microbiome and Microbial Metabolites in Non-Alcoholic Fatty Liver Disease: Current Evidence and Perspectives

Vallianou, N. G., Christodoulatos, G. S., Karampela, Ι., Tsilingiris, D., Magkos, F., Stratigou, T., Kounatidis, D. C., & Dalamaga, Μ. (2021) · Biomolecules · doi:10.3390/biom12010056 · Cited by 305

Hepatic Selective Insulin Resistance at the Intersection of Insulin Signaling and Metabolic Dysfunction-Associated Steatotic Liver Disease

Bo, T., Gao, L., Yao, Z., Shao, S., Wang, X., Proud, C. G., & Zhao, J. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.04.006 · Cited by 293

Liver transplantation using fatty livers: Always feasible?

McCormack, L., Dutkowski, P., El‐Badry, A. M., & Clavien, P. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.11.004 · Cited by 281

Role of mitochondria in non‐alcoholic fatty liver disease

Pessayre, D. (2007) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2006.04640.x · Cited by 287

Central role of mitochondria in drug-induced liver injury

Pessayre, D., Fromenty, B., Berson, A., Robin, M.-A., Lettéron, P., Moreau, R., & Mansouri, A. (2012) · Drug Metabolism Reviews · doi:10.3109/03602532.2011.604086 · Cited by 277

Liver zonation: Novel aspects of its regulation and its impact on homeostasis

Gebhardt, R. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i26.8491 · Cited by 275

Role of Insulin Resistance and Lipotoxicity in Non-Alcoholic Steatohepatitis

Cusi, K. J. (2009) · Clinics in Liver Disease · doi:10.1016/j.cld.2009.07.009 · Cited by 270

Mitochondrial Quality Control as a Therapeutic Target

Suliman, H. B., & Piantadosi, C. A. (2015) · Pharmacological Reviews · doi:10.1124/pr.115.011502 · Cited by 267

Pathogenesis and management issues for non-alcoholic fatty liver disease

Duvnjak, M. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i34.4539 · Cited by 266

Metabolic disturbances in non-alcoholic fatty liver disease

Byrne, C. D., Olufadi, R., Bruce, K. D., Cagampang, F. R. A., & Ahmed, M. H. (2009) · Clinical Science · doi:10.1042/cs20080253 · Cited by 258

Reprogramming of hepatic fat accumulation and 'browning' of adipose tissue by the short-chain fatty acid acetate

Sahuri-Arisoylu, M., Brody, L., Parkinson, J. R. C., Parkes, H. G., Navaratnam, N., Miller, A. D., Thomas, E. L., Frost, G. S., & Bell, J. D. (2016) · International Journal of Obesity · doi:10.1038/ijo.2016.23 · Cited by 258

Non-Alcoholic Fatty Liver Disease

Engin, A. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-48382-5_19 · Cited by 253

CYP2E1 in Alcoholic and Non-Alcoholic Liver Injury. Roles of ROS, Reactive Intermediates and Lipid Overload

Harjumäki, R., Pridgeon, C. S., & Ingelman‐Sundberg, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158221 · Cited by 248

Mitochondrial dysfunction in rat with nonalcoholic fatty liver

Petrosillo, G., Portincasa, P., Grattagliano, I., Casanova, G., Matera, M., Ruggiero, F. M., Ferri, D., & Paradies, G. (2007) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2007.07.011 · Cited by 214

Uncoupling protein-2 (UCP2) induces mitochondrial proton leak and increases susceptibility of non-alcoholic steatohepatitis (NASH) liver to ischaemia–reperfusion injury

Serviddio, G., Bellanti, F., Tamborra, R., Rollo, T., Capitanio, N., Romano, A. D., Sastre, J., Vendemiale, G., & Altomare, E. (2008) · Gut · doi:10.1136/gut.2007.147496 · Cited by 214

COMMON PATHOGENIC MECHANISM IN DEVELOPMENT PROGRESSION OF LIVER INJURY CAUSED BY NON-ALCOHOLIC OR ALCOHOLIC STEATOHEPATITIS

Nagata, K., Suzuki, H., & Sakaguchi, S. (2007) · The Journal of Toxicological Sciences · doi:10.2131/jts.32.453 · Cited by 215

Urea cycle dysregulation in non-alcoholic fatty liver disease

Chiara, F. D., Heebøll, S., Marrone, G., Montoliu, C., Hamilton-Dutoit, S. J., Ferrandez, A., Andreola, F., Rombouts, K., Grønbæk, H., Felipo, V., et al. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2018.06.023 · Cited by 216

Mitochondrial Oxidative Stress and Antioxidants Balance in Fatty Liver Disease

García‐Ruiz, C., & Fernández-Checa, J. C. (2018) · Hepatology Communications · doi:10.1002/hep4.1271 · Cited by 202

Non-alcoholic steatohepatitis: From cell biology to clinical practice

Cortez‐Pinto, H., de Moura, M. C., & Day, C. P. (2005) · Journal of Hepatology · doi:10.1016/j.jhep.2005.09.002 · Cited by 194

The SOD2 C47T polymorphism influences NAFLD fibrosis severity: Evidence from case-control and intra-familial allele association studies

Al‐Serri, A., Anstee, Q. M., Valenti, L. V. C., Nobili, V., Leathart, J. B. S., Dongiovanni, P., Patch, J., Fracanzani, A. L., Fargion, S. R., Day, C. P., et al. (2011) · Journal of Hepatology · doi:10.1016/j.jhep.2011.05.029 · Cited by 192

Low concentrations of bisphenol A induce lipid accumulation mediated by the production of reactive oxygen species in the mitochondria of HepG2 cells

Laurence Therese, H. U. C., Lemarié, A., Guéraud, F., & Héliès‐Toussaint, C. (2012) · Toxicology in Vitro · doi:10.1016/j.tiv.2012.03.017 · Cited by 188

Mitochondrial metabolic dysfunction and non-alcoholic fatty liver disease: new insights from pathogenic mechanisms to clinically targeted therapy

Zheng, Y., Wang, S., Wu, J., & Wang, Y. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04367-1 · Cited by 197

Current concepts in the pathogenesis of nonalcoholic fatty liver disease

Méndez‐Sánchez, N., Arrese, M. A., Zamora‐Valdés, D., & Uribe, M. (2007) · Liver International · doi:10.1111/j.1478-3231.2007.01483.x · Cited by 189

The Use of Fatty Liver Grafts in Modern Allocation Systems

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Antioxidant dietary approach in treatment of fatty liver: New insights and updates

Ferramosca, A., Giacomo, M. D., & Zara, V. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i23.4146 · Cited by 184

The Evolving Role of Leptin and Adiponectin in Chronic Liver Diseases

Tsochatzis, E. A., Papatheodoridis, G., & Archimandritis, A. J. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00848.x · Cited by 190

From fatty liver to fibrosis: A tale of “second hit”

Başaranoğlu, M. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i8.1158 · Cited by 177

Mitochondrial Dysfunction Plays Central Role in Nonalcoholic Fatty Liver Disease

Ramanathan, R., Ali, A. H., & Ibdah, J. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137280 · Cited by 190

Nonalcoholic Fatty Liver Disease: Pathogenesis and Therapeutics from a Mitochondria-Centric Perspective

Gusdon, A. M., Song, K., & Qu, S. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/637027 · Cited by 172

New role of irisin in hepatocytes: the protective effect of hepatic steatosis in vitro

Park, M.-J., Kim, D.-I., Choi, J.-H., Heo, Y.-R., & Park, S.-H. (2015) · Cellular Signalling · doi:10.1016/j.cellsig.2015.04.010 · Cited by 168

Palmitate-induced Activation of Mitochondrial Metabolism Promotes Oxidative Stress and Apoptosis in H4IIEC3 Rat Hepatocytes

Egnatchik, R. A., Leamy, A. K., Noguchi, Y., Shiota, M., & Young, J. D. (2014) · Metabolism · doi:10.1016/j.metabol.2013.10.009 · Cited by 161

Mitochondrial Roles and Cytoprotection in Chronic Liver Injury

Esposti, D. D., Hamelin, J., Bosselut, N., Saffroy, R., Sebagh, M., Pommier, A., Martel, C., & Lemoine, A. (2012) · Biochemistry Research International · doi:10.1155/2012/387626 · Cited by 165

Ellagic acid attenuates high-carbohydrate, high-fat diet-induced metabolic syndrome in rats

Panchal, S. K., Ward, L. C., & Brown, L. (2012) · European Journal of Nutrition · doi:10.1007/s00394-012-0358-9 · Cited by 158

Integration of Multi-omics Data from Mouse Diversity Panel Highlights Mitochondrial Dysfunction in Non-Alcoholic Fatty Liver Disease

Krishnan, K. C., Kurt, Z., Barrere‐Cain, R., Sabir, S., Das, A., Floyd, R. R., Vergnes, L., Zhao, Y., Che, N., Charugundla, S., et al. (2018) · Cell Systems · doi:10.1016/j.cels.2017.12.006 · Cited by 151

Regulation of fat metabolism in the liver: link to non-alcoholic hepatic steatosis and impact of physical exercise

Lavoie, J.-M., & Gauthier, M. (2006) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-006-6600-y · Cited by 152

Redox Balance in the Pathogenesis of Nonalcoholic Fatty Liver Disease: Mechanisms and Therapeutic Opportunities

Gambino, R., Musso, G., & Cassader, M. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.3058 · Cited by 147

High-Lard and High-Fish-Oil Diets Differ in Their Effects on Function and Dynamic Behaviour of Rat Hepatic Mitochondria

Lionetti, L., Mollica, M. P., Donizzetti, I., Gifuni, G., Sica, R., Pignalosa, A., Cavaliere, G., Gaita, M., Filippo, C. D., Antonio Zorzano, A., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092753 · Cited by 148

Mitochondrial UCPs: New insights into regulation and impact

Sluse, F. E., Jarmuszkiewicz, W., Navet, R., Douette, P., Mathy, G., & Sluse‐Goffart, C. M. (2006) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2006.02.004 · Cited by 150

The relationship between oxidative stress and nonalcoholic fatty liver disease: Its effects on the development of nonalcoholic steatohepatitis

Ucar, F., Sezer, S., Erdogan, S., Akyol, S., Armutcu, F., & Akyol, O. (2013) · Redox Report · doi:10.1179/1351000213y.0000000050 · Cited by 143

Tamoxifen Inhibits Topoisomerases, Depletes Mitochondrial DNA, and Triggers Steatosis in Mouse Liver

Larosche, I., Lettéron, P., Fromenty, B., Vadrot, N., Abbey‐Toby, A., Feldmann, G., Pessayre, D., & Mansouri, A. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.114546 · Cited by 142

Progression of Alcoholic and Non-alcoholic Steatohepatitis: Common Metabolic Aspects of Innate Immune System and Oxidative Stress

Sakaguchi, S., Takahashi, S., Sasaki, T., Kumagai, T., & Nagata, K. (2010) · Drug Metabolism and Pharmacokinetics · doi:10.2133/dmpk.dmpk-10-rv-087 · Cited by 144

Adipokines in Nonalcoholic Steatohepatitis: From Pathogenesis to Implications in Diagnosis and Therapy

Tsochatzis, E. A., Papatheodoridis, G., & Archimandritis, A. J. (2009) · Mediators of Inflammation · doi:10.1155/2009/831670 · Cited by 147

Dietary fructose as a risk factor for non-alcoholic fatty liver disease (NAFLD)

Alwahsh, S. M., & Gebhardt, R. (2016) · Archives of Toxicology · doi:10.1007/s00204-016-1892-7 · Cited by 143

Mitochondrial Involvement in Drug-Induced Liver Injury

Pessayre, D., Mansouri, A., Berson, A., & Fromenty, B. (2009) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-00663-0_11 · Cited by 142

The Effect oftert-Butyl Hydroperoxide-Induced Oxidative Stress on Lean and Steatotic Rat HepatocytesIn Vitro

Kučera, O., Endlicher, R., Roušar, T., Lotková, H., Garnol, T., Drahota, Z., & Červinková, Z. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/752506 · Cited by 145

Metabolic reprogramming of the intestinal microbiome with functional bile acid changes underlie the development of NAFLD

Smirnova, E., Muthiah, M. D., Narayan, N., Siddiqui, M. S., Puri, P., Luketic, V. A., Contos, M. J., Idowu, M. O., Chuang, J.-C., Billin, A. N., et al. (2022) · Hepatology · doi:10.1002/hep.32568 · Cited by 138

ACACA reduces lipid accumulation through dual regulation of lipid metabolism and mitochondrial function via AMPK- PPARα- CPT1A axis

Dong, J., Li, M., Peng, R., Zhang, Y., Qiao, Z., & Sun, N. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-04942-0 · Cited by 136

NOX family NADPH oxidases in liver and in pancreatic islets: a role in the metabolic syndrome and diabetes?

Guichard, C., Moreau, R., Pessayre, D., Epperson, T. K., & Krause, K. (2008) · Biochemical Society Transactions · doi:10.1042/bst0360920 · Cited by 138

Lipid oxidation products in the pathogenesis of non-alcoholic steatohepatitis

Bellanti, F., Villani, R., Facciorusso, A., Vendemiale, G., & Serviddio, G. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.01.023 · Cited by 136

Nonalcoholic Fatty Liver Disease (NAFLD). Mitochondria as Players and Targets of Therapies?

Ciaula, A. D., Passarella, S., Shanmugam, H., Noviello, M., Bonfrate, L., Wang, D. Q. ‐., & Portincasa, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105375 · Cited by 142

Non-alcoholic steatohepatitis and metabolic syndrome

Machado, M. V., & Cortez‐Pinto, H. (2006) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/01.mco.0000241677.40170.17 · Cited by 133

Maternal high-fat intake predisposes nonalcoholic fatty liver disease in C57BL/6 offspring

Gregório, B. M., Souza‐Mello, V., de Carvalho, J. J., Mandarim‐de‐Lacerda, C. A., & Águila, M. B. (2010) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2010.06.042 · Cited by 132

Cardiolipin and Mitochondrial Function in Health and Disease

Paradies, G., Paradies, V., Ruggiero, F. M., & Petrosillo, G. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5280 · Cited by 137

Role of mitochondria in nonalcoholic fatty liver disease-from origin to propagation

Grattagliano, I., de Bari, O., Bernardo, T. C., Oliveira, P. J., Wang, D. Q. ‐., & Portincasa, P. (2012) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2012.03.024 · Cited by 128

Role of mitochondria in liver metabolic health and diseases

Morio, B., Panthu, B., Bassot, A., & Rieusset, J. (2020) · Cell Calcium · doi:10.1016/j.ceca.2020.102336 · Cited by 136

Update on non-alcoholic fatty liver disease in children

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