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Control of cccDNA function in hepatitis B virus infection
Open accessAbstract
The template of hepatitis B virus (HBV) transcription, the covalently closed circular DNA (cccDNA), plays a key role in the life cycle of the virus and permits the persistence of infection. Novel molecular techniques have opened new possibilities to investigate the organization and the activity of the cccDNA minichromosome in vivo, and recent advances have started to shed light on the complexity of the mechanisms controlling cccDNA function. Nuclear cccDNA accumulates in hepatocyte nuclei as a stable minichromosome organized by histone and non-histone viral and cellular proteins. Identification of the molecular mechanisms regulating cccDNA stability and its transcriptional activity at the RNA, DNA and epigenetic levels in the course of chronic hepatitis B (CH-B) infection may reveal new potential therapeutic targets for anti-HBV drugs and hence assist in the design of strategies aimed at silencing and eventually depleting the cccDNA reservoir.
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“In CHB patients, up to 50 copies of cccDNA exist in each infected hepatocyte, and some of them are epigenetically modified.34”
From The CRISPR/Cas9 system facilitates clearance of the intrahepatic HBV templates in vivo (2014) · cites this paper as [34]
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Metadata
- Authors
- Levrero, M., Pollicino, T., Petersen, J., Belloni, L., Raimondo, G., & Dandri, M.
- Affiliations
- Policlinico Umberto I (IT)
- University of Messina (IT)
- Sapienza University of Rome (IT)
- University Medical Center Hamburg-Eppendorf (DE)
- Corresponding author
- Levrero, Massimo
- Venue
- Journal of Hepatology
- Publisher
- Elsevier BV
- Published
- 2009-09
- Volume
- 51
- Issue
- 3
- Pages
- 581-592
- ISSN
- 0168-8278 (ISSN-L)
- OpenAlex
- W2003692477
- Cited by
- 552
- References
- 90
- Citations by year
- 2026: 14 · 2025: 19 · 2024: 23 · 2023: 19 · 2022: 28 · 2021: 30 · 2020: 29 · 2019: 38 · 2018: 40 · 2017: 45 · 2016: 48 · 2015: 59 · 2014: 53 · 2013: 31 · 2012: 29
- FWCI
- 3.10
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Hepatology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- INFM-OAR (INFN Catania) (submittedVersion, cc-by-nc-nd)
- Funders
- Deutsche Forschungsgemeinschaft
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Associazione Italiana per la Ricerca sul Cancro
- Topics
- Health Sciences › Medicine › Epidemiology › Hepatitis B Virus Studies
- Health Sciences › Medicine › Hepatology › Hepatitis C virus research
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- hepatitis B virus, covalently closed circular DNA, chronic hepatitis B, viral persistence, viral transcription, epigenetic regulation, histone proteins, non-histone proteins
- MeSH terms
- Antiviral Agents, DNA, Circular, DNA, Viral, Hepatitis B, Hepatitis B virus, Humans, Virus Replication, Epigenesis, Genetic
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