Cited by 554Hepatitis B Virus StudiesHepatitis C virus researchLiver physiology and pathology

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Control of cccDNA function in hepatitis B virus infection

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Levrero, Massimo, Pollicino, Teresa, Petersen, Jorg, Belloni, Laura, Raimondo, Giovanni, Dandri, Maura·2009·Journal of Hepatology

DOI 10.1016/j.jhep.2009.05.022

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Abstract

The template of hepatitis B virus (HBV) transcription, the covalently closed circular DNA (cccDNA), plays a key role in the life cycle of the virus and permits the persistence of infection. Novel molecular techniques have opened new possibilities to investigate the organization and the activity of the cccDNA minichromosome in vivo, and recent advances have started to shed light on the complexity of the mechanisms controlling cccDNA function. Nuclear cccDNA accumulates in hepatocyte nuclei as a stable minichromosome organized by histone and non-histone viral and cellular proteins. Identification of the molecular mechanisms regulating cccDNA stability and its transcriptional activity at the RNA, DNA and epigenetic levels in the course of chronic hepatitis B (CH-B) infection may reveal new potential therapeutic targets for anti-HBV drugs and hence assist in the design of strategies aimed at silencing and eventually depleting the cccDNA reservoir.

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Authors: Levrero, M., Pollicino, T., Petersen, J., Belloni, L., Raimondo, G., & Dandri, M.
Affiliations: Policlinico Umberto I (IT)
University of Messina (IT)
Sapienza University of Rome (IT)
University Medical Center Hamburg-Eppendorf (DE)
Corresponding author: Levrero, Massimo
ORCID: Levrero, Massimo
Pollicino, Teresa
Raimondo, Giovanni
Dandri, Maura
Venue: Journal of Hepatology
Publisher: Elsevier BV
Published: 2009-09
Volume: 51
Issue: 3
Pages: 581-592
ISSN: 0168-8278 (ISSN-L)
DOI: 10.1016/j.jhep.2009.05.022
OpenAlex: W2003692477
Cited by: 552
References: 90
Citations by year: 2026: 14 · 2025: 19 · 2024: 23 · 2023: 19 · 2022: 28 · 2021: 30 · 2020: 29 · 2019: 38 · 2018: 40 · 2017: 45 · 2016: 48 · 2015: 59 · 2014: 53 · 2013: 31 · 2012: 29
FWCI: 3.10
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor, 1414 d)
Locations: Journal of Hepatology (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
INFM-OAR (INFN Catania) (submittedVersion, cc-by-nc-nd)
Funders: Deutsche Forschungsgemeinschaft
Ministero dell’Istruzione, dell’Università e della Ricerca
Associazione Italiana per la Ricerca sul Cancro
Topics: Health Sciences › Medicine › Epidemiology › Hepatitis B Virus Studies
Health Sciences › Medicine › Hepatology › Hepatitis C virus research
Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Keywords: hepatitis B virus, covalently closed circular DNA, chronic hepatitis B, viral persistence, viral transcription, epigenetic regulation, histone proteins, non-histone proteins
MeSH terms: Antiviral Agents, DNA, Circular, DNA, Viral, Hepatitis B, Hepatitis B virus, Humans, Virus Replication, Epigenesis, Genetic

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Control of cccDNA function in hepatitis B virus infection

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