The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Presence and significance of microvesicular steatosis in nonalcoholic fatty liver disease
Open accessAbstract
Background/Aims Liver biopsies from patients with nonalcoholic fatty liver disease (NAFLD) sometimes exhibit non-zonal aggregates of hepatocytes with microvesicular steatosis, but its prevalence and significance are unclear. In this study, we have evaluated the frequency of microvesicular steatosis and assessed its association with histological markers of disease severity in a large sample of NAFLD liver biopsies. Methods Liver biopsies from a large cohort of adults who participated in two studies conducted by the NASH Clinical Research Network (NASH CRN) were included in this cross-sectional study. Liver histology was assessed centrally and various histological features scored in a systematic fashion. The relationship between microvesicular steatosis and various histological features that characterize NAFLD was tested by multiple logistic regression, after controlling for age, gender, race, body mass index, and diabetes. Results Among 1022 liver biopsies included, 102 (10%) had microvesicular steatosis. No demographic differences were noted between patients with or without microvesicular steatosis. The presence of microvesicular steatosis was associated with higher grades of steatosis (p<0.001), ballooning cell injury (p<0.001), presence of Mallory-Denk bodies (p<0.007), presence of megamitochondria (p<0.0001), higher NAS scores (p<0.0001), more advanced fibrosis (p<0.0001) and diagnosis of borderline or definite NASH (p<0.0001). Conclusion Microvesicular steatosis correlates with more advanced histology of NAFLD. Longitudinal studies are needed to address the role of microvesicular steatosis in mediating cellular injury and disease progression in NAFLD.
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“These cellular aggregates, known as hepatic crown-like structures (hCLSs), or lipogranulomas, are associated with the transition from simple steatosis to NASH (Ioannou et al., 2013, 2015, 2017; Kleiner et al., 2005; Tandra et al., 2011).”
Animal models of non‐alcoholic fatty liver disease: current perspectives and recent advances
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“NAFLD is histologically diagnosed when accumulation occurs in >5% of hepatocytes [9].”
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Oleuropein Induces AMPK-Dependent Autophagy in NAFLD Mice, Regardless of the Gender
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Advancements in MAFLD Modeling with Human Cell and Organoid Models
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Hepatic miR-192-3p reactivation alleviates steatosis by targeting glucocorticoid receptor
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From NAFLD to MAFLD: Aligning Translational In Vitro Research to Clinical Insights
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Metadata
- Authors
- Tandra, S., Yeh, M. M., Brunt, E. M., Vuppalanchi, R., Cummings, O. W., Ünalp-Arida, A., Wilson, L. A., & Chalasani, N.
- Venue
- Journal of Hepatology
- Publisher
- Elsevier BV
- Published
- 2011-09
- Volume
- 55
- Issue
- 3
- Pages
- 654-659
- ISSN
- 0168-8278 (ISSN-L)
- OpenAlex
- W2101530263
- Cited by
- 326
- References
- 4
- FWCI
- 3.35
- Type
- journal article
- Language
- en
- Open access
- green
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