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Modulation of the fecal bile acid profile by gut microbiota in cirrhosis

Open access
Kakiyama, Genta, Pandak, William M., Gillevet, Patrick M., Hylemon, Phillip B., Heuman, Douglas M., Daita, Kalyani, Takei, Hajime, Muto, Akina, Nittono, Hiroshi, Ridlon, Jason M., White, Melanie B., Noble, Nicole A., Monteith, Pamela, Fuchs, Michael, Thacker, Leroy R., Sikaroodi, Masoumeh, Bajaj, Jasmohan S.·2013·Journal of Hepatology
DOI 10.1016/j.jhep.2013.01.003
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Abstract

Background and Aims The 7α-dehydroxylation of primary bile acids (BAs), chenodeoxycholic (CDCA) and cholic acid (CA) into the secondary BAs, lithocholic (LCA) and deoxycholic acid (DCA) is a key function of the gut microbiota. We aimed to study the linkage between fecal BAs and gut microbiota in cirrhosis since this could help understand cirrhosis progression. Methods Fecal microbiota were analyzed by culture-independent multitagged-pyrosequencing, fecal BAs using HPLC and serum BAs using LC-MS in controls, early (Child A), and advanced cirrhotics(Child B/C). A subgroup of early cirrhotics underwent BA and microbiota analysis before/after eight weeks of rifaximin. Results Cross-sectional: 47 cirrhotics(24 advanced) and 14 controls were included. In feces, advanced cirrhotics had the lowest total, secondary, secondary/primary BA ratios, and highest primary BAs compared to early cirrhotics and controls. Secondary fecal BAs were detectable in all controls but in a significantly lower proportion of cirrhotics (p<0.002). Serum primary BAs were higher in advanced cirrhotics compared to the rest. Cirrhotics, compared to controls, had a higher Enterobacteriaceae (potentially pathogenic) but lower Lachonospiraceae, Ruminococcaceae and Blautia (7α-dehydroxylating bacteria) abundance. CDCA was positively correlated with Enterobacteriaceae(r=0.57, p<0.008) while Ruminococcaceae were positively correlated with DCA(r=0.4, p<0.05). A positive correlation between Ruminococcaceae and DCA/CA (r=0.82, p<0.012) and Blautia with LCA/CDCA (r=0.61, p<0.03) was also seen. Prospective study: Post-rifaximin, six early cirrhotics had reduction in Veillonellaceae and in the secondary/primary BA ratios. Conclusions Cirrhosis, especially advanced disease, is associated with a decreased conversion of primary to secondary fecal BAs which is linked with abundance of key gut microbiome taxa.

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Metadata

Authors
Kakiyama, G., Pandak, W. M., Gillevet, P. M., Hylemon, P. B., Heuman, D. M., Daita, K., Takei, H., Muto, A., Nittono, H., Ridlon, J. M., White, M. B., Noble, N. A., Monteith, P., Fuchs, M., Thacker, L. R., Sikaroodi, M., & Bajaj, J. S.
Venue
Journal of Hepatology
Publisher
Elsevier BV
Published
2013-05
Volume
58
Issue
5
Pages
949-955
ISSN
0168-8278 (ISSN-L)
DOI
10.1016/j.jhep.2013.01.003
OpenAlex
W2018274907
Cited by
781
References
26
FWCI
12.91
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Modulation of the fecal bile acid profile by gut microbiota in cirrhosis. https://app.cochat.ai/papers/10.1016/j.jhep.2013.01.003
The paper
Kakiyama, G., Pandak, W. M., Gillevet, P. M., Hylemon, P. B., Heuman, D. M., Daita, K., Takei, H., Muto, A., Nittono, H., Ridlon, J. M., White, M. B., Noble, N. A., Monteith, P., Fuchs, M., Thacker, L. R., Sikaroodi, M., & Bajaj, J. S. (2013). Modulation of the fecal bile acid profile by gut microbiota in cirrhosis. Journal of Hepatology. https://doi.org/10.1016/j.jhep.2013.01.003

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.