The DOI matches its Crossref record; 98 of the 98 references it cites were found in a registry or an index.
Targeting the mTOR pathway in hepatocellular carcinoma: Current state and future trends
Open accessAbstract
Mechanistic target of rapamycin (mTOR) regulates cell growth, metabolism and aging in response to nutrients, cellular energy stage and growth factors. mTOR is frequently up-regulated in cancer including hepatocellular carcinoma (HCC) and is associated with bad prognosis, poorly differentiated tumors, and earlier recurrence. Blocking mTOR with rapamycin and first generation mTOR inhibitors, called rapalogs, has shown promising reduction of HCC tumor growth in preclinical models. Currently, rapamycin/rapalogs are used in several clinical trials for the treatment of advanced HCC, and as adjuvant therapy in HCC patients after liver transplantation and TACE. A second generation of mTOR pathway inhibitors has been developed recently and is being tested in various clinical trials of solid cancers, and has been used in preclinical HCC models. The results of series of clinical trials using mTOR inhibitors in HCC treatment will emerge in the near future.
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정, 재. (2008) · Cited by 5,586
TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival
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EASL Clinical Practice Guidelines: Management of chronic hepatitis B virus infection
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Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB
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Cited by
From NASH to HCC: current concepts and future challenges
Anstee, Q. M., Reeves, H. L., Kotsiliti, E., Govaere, O., & Heikenwalder, M. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0145-7 · Cited by 1,392
EASL Clinical Practice Guidelines: Liver transplantation
(2016) · Journal of Hepatology · doi:10.1016/j.jhep.2015.10.006 · Cited by 1,082
Mehta, N., Heimbach, J., Harnois, D. M., Sapisochin, G., Dodge, J. L., Lee, D., Burns, J. M., Sanchez, W., Greig, P. D., Grant, D. R., et al. (2017) · JAMA Oncology · doi:10.1001/jamaoncol.2016.5116 · Cited by 398
Hepatic stellate cell autophagy inhibits extracellular vesicle release to attenuate liver fibrosis
Gao, J., Wei, B., de Assuncao, T. M., Liu, Z., Hu, X., Ibrahim, S., Cooper, S. A., Cao, S., Shah, V. H., & Kostallari, E. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.04.044 · Cited by 288
Targeting the PI3K/Akt/mTOR Pathway in Hepatocellular Carcinoma
Sun, E. J., Wankell, M., Palamuthusingam, P., McFarlane, C., & Hebbard, L. (2021) · Biomedicines · doi:10.3390/biomedicines9111639 · Cited by 281
Metadata
- Authors
- Matter, M. S., Decaens, T., Andersen, J. B., & Thorgeirsson, S. S.
- Venue
- Journal of Hepatology
- Publisher
- Elsevier BV
- Published
- 2014-04
- Volume
- 60
- Issue
- 4
- Pages
- 855-865
- ISSN
- 0168-8278 (ISSN-L)
- OpenAlex
- W2018992554
- Cited by
- 314
- References
- 98
- FWCI
- 6.59
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Matter, M. S., Decaens, T., Andersen, J. B., & Thorgeirsson, S. S. (2014). Targeting the mTOR pathway in hepatocellular carcinoma: Current state and future trends. Journal of Hepatology. https://doi.org/10.1016/j.jhep.2013.11.031
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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