The DOI matches its Crossref record; 125 of the 125 references it cites were found in a registry or an index.
Targeting the PI3K/Akt/mTOR Pathway in Hepatocellular Carcinoma
Open accessAbstract
Despite advances in the treatment of cancers through surgical procedures and new pharmaceuticals, the treatment of hepatocellular carcinoma (HCC) remains challenging as reflected by low survival rates. The PI3K/Akt/mTOR pathway is an important signaling mechanism that regulates the cell cycle, proliferation, apoptosis, and metabolism. Importantly, deregulation of the PI3K/Akt/mTOR pathway leading to activation is common in HCC and is hence the subject of intense investigation and the focus of current therapeutics. In this review article, we consider the role of this pathway in the pathogenesis of HCC, focusing on its downstream effectors such as glycogen synthase kinase-3 (GSK-3), cAMP-response element-binding protein (CREB), forkhead box O protein (FOXO), murine double minute 2 (MDM2), p53, and nuclear factor-κB (NF-κB), and the cellular processes of lipogenesis and autophagy. In addition, we provide an update on the current ongoing clinical development of agents targeting this pathway for HCC treatments.
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Cited by
Hepatocellular carcinoma: signaling pathways and therapeutic advances
Zheng, J., Wang, S., Xia, L., Sun, Z., Chan, K. M., Bernards, R., Qin, W., Chen, J., Xia, Q., & Jin, H. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02075-w · Cited by 341
Sharma, N., Singh, L., Sharma, A., Kumar, A., & Mahajan, D. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107375 · Cited by 16
The Crosstalk between Mesenchymal Stromal/Stem Cells and Hepatocytes in Homeostasis and under Stress
Kholodenko, I. V., Kholodenko, R. V., & Yarygin, K. N. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015212 · Cited by 16
Yoon, J.-S., & Lee, C.-W. (2022) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00883-0 · Cited by 14
Metadata
- Authors
- Sun, E. J., Wankell, M., Palamuthusingam, P., McFarlane, C., & Hebbard, L.
- Venue
- Biomedicines
- Publisher
- MDPI AG
- Published
- 2021-11-08
- Volume
- 9
- Issue
- 11
- Pages
- 1639
- ISSN
- 2227-9059 (ISSN-L)
- OpenAlex
- W3213378938
- Cited by
- 281
- References
- 125
- FWCI
- 10.80
- Type
- journal article
- Language
- en
- Open access
- gold
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- Sun, E. J., Wankell, M., Palamuthusingam, P., McFarlane, C., & Hebbard, L. (2021). Targeting the PI3K/Akt/mTOR Pathway in Hepatocellular Carcinoma. Biomedicines. https://doi.org/10.3390/biomedicines9111639
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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