The DOI matches its Crossref record; 77 of the 77 references it cites were found in a registry or an index.
COVID-19 and the liver
Open accessAbstract
The current coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has become a major public health crisis over the past few months. Overall case fatality rates range between 2–6%; however, the rates are higher in the elderly and those with underlying comorbidities like diabetes, hypertension and heart disease. Recent reports showed that about 2–11% of patients with COVID-19 had underlying chronic liver disease. During the previous SARS epidemic, around 60% of patients were reported to develop various degrees of liver damage. In the current pandemic, hepatic dysfunction has been seen in 14–53% of patients with COVID-19, particularly in those with severe disease. Cases of acute liver injury have been reported and are associated with higher mortality. Hepatic involvement in COVID-19 could be related to the direct cytopathic effect of the virus, an uncontrolled immune reaction, sepsis or drug-induced liver injury. The postulated mechanism of viral entry is through the host angiotensin-converting enzyme 2 (ACE2) receptors that are abundantly present in type 2 alveolar cells. Interestingly, ACE2 receptors are expressed in the gastrointestinal tract, vascular endothelium and cholangiocytes of the liver. The effects of COVID-19 on underlying chronic liver disease require detailed evaluation and, with data currently lacking, further research is warranted in this area.
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Cites
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Clinical characteristics of coronavirus disease 2019 in China
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La certeza de lo impredecible: Cultura Educación y Sociedad en tiempos de COVID19
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Cited by
Marjot, T., Moon, A. M., Cook, J. A., Abd-Elsalam, S., Aloman, C., Armstrong, M. J., Pose, E., Brenner, E. J., Cargill, T., Catana, M.-A., et al. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2020.09.024 · Cited by 518
Colonna, G. (2024) · Livers · doi:10.3390/livers4020016 · Cited by 7
Metadata
- Authors
- Jothimani, D., Venugopal, R., Abedin, M. F., Kaliamoorthy, I., & Rela, M.
- Venue
- Journal of Hepatology
- Publisher
- Elsevier BV
- Published
- 2020-11
- Volume
- 73
- Issue
- 5
- Pages
- 1231-1240
- ISSN
- 0168-8278 (ISSN-L)
- OpenAlex
- W3034561954
- Cited by
- 469
- References
- 77
- FWCI
- 12.01
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Jothimani, D., Venugopal, R., Abedin, M. F., Kaliamoorthy, I., & Rela, M. (2020). COVID-19 and the liver. Journal of Hepatology. https://doi.org/10.1016/j.jhep.2020.06.006
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
