The DOI matches its Crossref record; 296 of the 296 references it cites were found in a registry or an index.
Lipid alterations in chronic liver disease and liver cancer
Open accessAbstract
Lipids are a complex and diverse group of molecules with crucial roles in many physiological processes, as well as in the onset, progression, and maintenance of cancers. Fatty acids and cholesterol are the building blocks of lipids, orchestrating these crucial metabolic processes. In the liver, lipid alterations are prevalent as a cause and consequence of chronic hepatitis B and C virus infections, alcoholic hepatitis, and non-alcoholic fatty liver disease and steatohepatitis. Recent developments in lipidomics have also revealed that dynamic changes in triacylglycerols, phospholipids, sphingolipids, ceramides, fatty acids, and cholesterol are involved in the development and progression of primary liver cancer. Accordingly, the transcriptional landscape of lipid metabolism suggests a carcinogenic role of increasing fatty acids and sterol synthesis. However, limited mechanistic insights into the complex nature of the hepatic lipidome have so far hindered the development of effective therapies.
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Metabolic reprogramming in the tumor microenvironment of liver cancer
Lin, J., Rao, D., Zhang, M., & Gao, Q. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01527-8 · Cited by 251
“High-cholesterol diets induce HCC in mice, partly through dysregulation of metabolism and calcium signaling [55–57].”
BackgroundKohlhepp, M. S., Liu, H., Tacke, F., & Guillot, A. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1129831 · Cited by 27
Xiao, M.-Y., Pei, W.-J., Li, S., Li, F.-F., Xie, P., Luo, H.-T., Hyun Yoo, H., & Piao, X.-L. (2024) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2024.107539 · Cited by 26
Metadata
- Authors
- Paul, B., Lewinska, M., & Andersen, J. B.
- Venue
- JHEP Reports
- Publisher
- Elsevier BV
- Published
- 2022-06
- Volume
- 4
- Issue
- 6
- Pages
- 100479
- ISSN
- 2589-5559 (ISSN-L)
- OpenAlex
- W4220874523
- Cited by
- 308
- References
- 296
- FWCI
- 23.27
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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