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The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Inhibition of β-Catenin Signaling in the Skin Rescues Cutaneous Adipogenesis in Systemic Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Trial of C-82

Lafyatis, Robert, Mantero, Julio C., Gordon, Jessica, Kishore, Nina, Carns, Mary, Dittrich, Howard, Spiera, Robert, Simms, Robert W., Varga, John·2017·Journal of Investigative Dermatology
DOI 10.1016/j.jid.2017.06.032PMC PMC5701831
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  • Both TMEM97 and PGRMC1 were regulated at the transcript level in skin cells by the topically applied Wnt/beta-catenin inhibitor C-82, suggesting that Wnt signaling regulates TMEM97.

    “Both TMEM97 and PGRMC1 were regulated at the transcript level in skin cells by the topically applied Wnt/beta-catenin inhibitor C-82 under investigation in a clinical trial in individuals with systemic sclerosis, suggesting that Wnt signaling regulates TMEM97 [79].”

    From Sigma-2 Receptors—From Basic Biology to Therapeutic Target: A Focus on Age-Related Degenerative Diseases (2023) · cites this paper as [79]

  • Increased expression of TMEM97 correlated with a rise in expression of genes involved in lipid metabolism, and these genes were significantly associated with the gene ontology terms cellular lipid, isoprenoid, cholesterol, and long-chain fatty-acyl-CoA biosynthetic processes.

    “Interestingly, increased expression of TMEM97 correlated with a rise in expression of genes involved in lipid metabolism, and these genes were significantly associated with the gene ontology terms cellular lipid, isoprenoid, cholesterol, and long-chain fatty-acyl-CoA biosynthetic processes [79]”

    From Sigma-2 Receptors—From Basic Biology to Therapeutic Target: A Focus on Age-Related Degenerative Diseases (2023) · cites this paper as [79]

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Metadata

Authors
Lafyatis, R., Mantero, J. C., Gordon, J., Kishore, N., Carns, M., Dittrich, H., Spiera, R., Simms, R. W., & Varga, J.
Venue
Journal of Investigative Dermatology
Publisher
Elsevier BV
Published
2017-12
Volume
137
Issue
12
Pages
2473-2483
ISSN
0022-202X
DOI
10.1016/j.jid.2017.06.032
PMC
PMC5701831
Cited by
59
References
7
Language
en
Licence
Funders
  • PRISM Biolab
  • Merck
  • Bristol Myers Squibb
  • Biocon
  • Formation
  • Genentech/Roche
  • UCB
  • Sanofi
  • Elpidera and Regeneron
  • National Institutes of Arthritis Musculoskeletal and Skin Disease grants
  • Scleroderma Center of Research Translation (1P50AR060780))
  • Department of Defense Award (PR110276)

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