Cited by 270Hair Growth and DisordersWnt/β-catenin signaling in development and cancerdental development and anomalies

Transient activation of β-catenin signaling in cutaneous keratinocytes is sufficient to trigger the active growth phase of the hair cycle in mice

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Van Mater, David, Kolligs, Frank T., Dlugosz, Andrzej A., Fearon, Eric R.·2003·Genes & Development

Abstract

Wnts have key roles in many developmental processes, including hair follicle growth and differentiation. Stabilization of β-catenin is essential in the canonical Wnt signaling pathway. We developed transgenic mice expressing a regulated form of β-catenin in the skin. Chronic activation of β-catenin in resting (telogen) hair follicles resulted in changes consistent with induction of an exaggerated, aberrant growth phase (anagen). Transient activation of β-catenin produced a normal anagen. Our data lend strong support to the notion that a Wnt/β-catenin signal operating on hair follicle precursor cells serves as a crucial proximal signal for the telogen–anagen transition.

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  • TERT's enhancement of Wnt signaling explains its activation of bulge stem cells, since β-catenin overexpression in mouse skin causes a similar stem cell activation phenotype.

    “The ability of TERT to enhance Wnt signaling explains how TERT activates bulge stem cells since overexpression of b-catenin in mouse skin causes a very similar stem cell-activation phenotype (150-152).”

    From Telomeres and telomerase in cancer (2010) · cites this paper as [150]

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Authors
Van Mater, D., Kolligs, F. T., Dlugosz, A. A., & Fearon, E. R.
Affiliations
University of Michigan (US)
Venue
Genes & Development
Published
2003-05-15
Volume
17
Issue
10
Pages
1219-1224
ISSN
  • 0890-9369 (ISSN-L)
  • 1549-5477
OpenAlex
W2170319506
Cited by
263
References
21
Citations by year
2026: 2 · 2025: 6 · 2024: 5 · 2023: 10 · 2022: 8 · 2021: 6 · 2020: 12 · 2019: 3 · 2018: 8 · 2017: 13 · 2016: 9 · 2015: 11 · 2014: 13 · 2013: 14 · 2012: 22
Type
posted content
Language
en
Open access
Locations
  • Genes & Development (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • University of Michigan (T32GM07863)
  • National Cancer Institute (CA87837, CA46592, R01CA085463, CA85463, R01CA087837, P30CA046592)
  • National Institute of General Medical Sciences (T 32 GM07863, T32GM007863)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR045973)
Topics
  • Health Sciences › Medicine › Urology › Hair Growth and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › dental development and anomalies
Keywords
β-catenin signaling, Wnt signaling, hair cycle, anagen induction, hair follicle, keratinocytes, transgenic mice, canonical Wnt pathway
MeSH terms
Animals, Cell Differentiation, Cytoskeletal Proteins, Epithelium, Hair, Mice, Transgenic, Signal Transduction, Trans-Activators, Keratinocytes, Hair Follicle, beta Catenin, Mice

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