Transient activation of β-catenin signaling in cutaneous keratinocytes is sufficient to trigger the active growth phase of the hair cycle in mice
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Wnts have key roles in many developmental processes, including hair follicle growth and differentiation. Stabilization of β-catenin is essential in the canonical Wnt signaling pathway. We developed transgenic mice expressing a regulated form of β-catenin in the skin. Chronic activation of β-catenin in resting (telogen) hair follicles resulted in changes consistent with induction of an exaggerated, aberrant growth phase (anagen). Transient activation of β-catenin produced a normal anagen. Our data lend strong support to the notion that a Wnt/β-catenin signal operating on hair follicle precursor cells serves as a crucial proximal signal for the telogen–anagen transition.
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TERT's enhancement of Wnt signaling explains its activation of bulge stem cells, since β-catenin overexpression in mouse skin causes a similar stem cell activation phenotype.
“The ability of TERT to enhance Wnt signaling explains how TERT activates bulge stem cells since overexpression of b-catenin in mouse skin causes a very similar stem cell-activation phenotype (150-152).”
From Telomeres and telomerase in cancer (2010) · cites this paper as [150]
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- Authors
- Van Mater, D., Kolligs, F. T., Dlugosz, A. A., & Fearon, E. R.
- Affiliations
- University of Michigan (US)
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2003-05-15
- Volume
- 17
- Issue
- 10
- Pages
- 1219-1224
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- PMC
- PMC196062
- OpenAlex
- W2170319506
- Cited by
- 263
- References
- 21
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 5 · 2023: 10 · 2022: 8 · 2021: 6 · 2020: 12 · 2019: 3 · 2018: 8 · 2017: 13 · 2016: 9 · 2015: 11 · 2014: 13 · 2013: 14 · 2012: 22
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Michigan (T32GM07863)
- National Cancer Institute (CA87837, CA46592, R01CA085463, CA85463, R01CA087837, P30CA046592)
- National Institute of General Medical Sciences (T 32 GM07863, T32GM007863)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR045973)
- Topics
- Health Sciences › Medicine › Urology › Hair Growth and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › dental development and anomalies
- Keywords
- β-catenin signaling, Wnt signaling, hair cycle, anagen induction, hair follicle, keratinocytes, transgenic mice, canonical Wnt pathway
- MeSH terms
- Animals, Cell Differentiation, Cytoskeletal Proteins, Epithelium, Hair, Mice, Transgenic, Signal Transduction, Trans-Activators, Keratinocytes, Hair Follicle, beta Catenin, Mice
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