The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Melanocytes Sense Blue Light and Regulate Pigmentation through Opsin-3
Open accessAbstract
The shorter wavelengths of the visible light spectrum have been recently reported to induce a long-lasting hyperpigmentation but only in melano-competent individuals. Here, we provide evidence showing that OPN3 is the key sensor in melanocytes responsible for hyperpigmentation induced by the shorter wavelengths of visible light. The melanogenesis induced through OPN3 is calcium dependent and further activates CAMKII followed by CREB, extracellular signal-regulated kinase, and p38, leading to the phosphorylation of MITF and ultimately to the increase of the melanogenesis enzymes: tyrosinase and dopachrome tautomerase. Furthermore, blue light induces the formation of a protein complex that we showed to be formed by tyrosinase and dopachrome tautomerase. This multimeric tyrosinase/tyrosinase-related protein complex is mainly formed in dark-skinned melanocytes and induces a sustained tyrosinase activity, thus explaining the long-lasting hyperpigmentation that is observed only in skin type III and higher after blue light irradiation. OPN3 thus functions as the sensor for visible light pigmentation. OPN3 and the multimeric tyrosinase/tyrosinase-related protein complex induced after its activation appear as new potential targets for regulating melanogenesis but also to protect dark skins against blue light in physiological conditions and in pigmentary disorders.
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Cites
Central role of p53 in the suntan response and pathologic hyperpigmentation
Cui, R., Widlund, H. R., Feige, E., Lin, J. Y., Wilensky, D. L., Igras, V. E., D'Orazio, J., Fung, C. Y., Schanbacher, C. F., Granter, S. R., et al. (2007) · Cell · doi:10.1016/j.cell.2006.12.045 · Cited by 657
MAP kinase links the transcription factor Microphthalmia to c-Kit signalling in melanocytes
Hemesath, T. J., Price, E. R., Takemoto, C., Badalian, T., & Fisher, D. E. (1998) · Nature · doi:10.1038/34681 · Cited by 630
Irradiation of Skin with Visible Light Induces Reactive Oxygen Species and Matrix-Degrading Enzymes
Liebel, F., Kaur, S., Ruvolo, E., Kollias, N., & Southall, M. D. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.476 · Cited by 439
Impact of Long-Wavelength UVA and Visible Light on Melanocompetent Skin
Mahmoud, B. H., Ruvolo, E., Hexsel, C. L., Liu, Y., Owen, M. R., Kollias, N., Lim, H. W., & Hamzavi, I. H. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.95 · Cited by 403
Duteil, L., Cardot‐Leccia, N., Queille‐Roussel, C., Maubert, Y., Harmelin, Y., Boukari, F., Ambrosetti, D., Lacour, J., & Passeron, T. (2014) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.12273 · Cited by 200
Self-citationRegazzetti, C., Joly, F., Marty, C., Rivier, M., Mehul, B., Reiniche, P., Mounier, C., Rival, Y., Piwnica, D., Cavalié, M., et al. (2015) · Journal of Investigative Dermatology · doi:10.1038/jid.2015.335 · Cited by 194
Self-citationHomologs of vertebrate Opn3 potentially serve as a light sensor in nonphotoreceptive tissue
Koyanagi, M., Takada, E., Nagata, T., Tsukamoto, H., & Terakita, A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219416110 · Cited by 188
Boukari, F., Jourdan, E., Fontas, E., Montaudié, H., Castela, E., Lacour, J.-P., & Passeron, T. (2015) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2014.08.023 · Cited by 170
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Opsin Expression in Human Epidermal Skin
Haltaufderhyde, K. D., Özdeşlik, R. N., Wicks, N. L., Najera, J. A., & Oancea, E. (2014) · Photochemistry and Photobiology · doi:10.1111/php.12354 · Cited by 141
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Chen, J., Liu, Y., Zhao, Z., & Qiu, J. (2021) · International Journal of Cosmetic Science · doi:10.1111/ics.12728 · Cited by 351
Del Bino, S., Duval, C., & Bernerd, F. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092668 · Cited by 315
Self-citationLawrence, K. P., Douki, T., Sarkany, R. P. E., Acker, S., Herzog, B., & Young, A. R. (2018) · Scientific Reports · doi:10.1038/s41598-018-30738-6 · Cited by 143
Photoaging: a Review of Current Literature
Huang, A. H., & Chien, A. L. (2020) · Current Dermatology Reports · doi:10.1007/s13671-020-00288-0 · Cited by 131
Sadowska, M., Narbutt, J., & Lesiak, A. (2021) · Life · doi:10.3390/life11070670 · Cited by 74
Metadata
- Authors
- Regazzetti, C., Sormani, L., Debayle, D., Bernerd, F., Tulic, M. K., De Donatis, G. M., Chignon-Sicard, B., Rocchi, S., & Passeron, T.
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2018-01
- Volume
- 138
- Issue
- 1
- Pages
- 171-178
- ISSN
- 0022-202X (ISSN-L)
- OpenAlex
- W2748912324
- Cited by
- 336
- References
- 15
- FWCI
- 10.52
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Regazzetti, C., Sormani, L., Debayle, D., Bernerd, F., Tulic, M. K., De Donatis, G. M., Chignon-Sicard, B., Rocchi, S., & Passeron, T. (2018). Melanocytes Sense Blue Light and Regulate Pigmentation through Opsin-3. Journal of Investigative Dermatology. https://doi.org/10.1016/j.jid.2017.07.833
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