Blue Light in Dermatology
Open accessAbstract
Phototherapy is an important method of dermatological treatments. Ultraviolet (280–400 nm) therapy is of great importance; however, there are concerns of its long-term use, as it can lead to skin aging and carcinogenesis. This review aims to evaluate the role and the mechanism of action of blue light (400–500 nm), a UV-free method. The main mediators of cellular responses to blue light are nitric oxide (NO) and reactive oxygen species (ROS). However, the detailed mechanism is still not fully understood. It was demonstrated that blue light induces an anti-inflammatory and antiproliferative effect; thus, it may be beneficial for hyperproliferative and chronic inflammatory skin diseases such as atopic dermatitis, eczema, and psoriasis. It was also found that blue light might cause the reduction of itching. It may be beneficial on hair growth and may be used in the treatment of acne vulgaris by reducing follicular colonization of Propionibacterium acnes. Further studies are needed to develop accurate protocols, as the clinical effects depend on the light parameters as well as the treatment length. There are no major adverse effects observed yet, but long-term safety should be monitored as there are no studies considering the long-term effects of blue light on the skin.
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Due to penetration, red light (635 nm) is usually used to activate protoporphyrin IX for skin cancer treatments.
“However, due to penetration, red light (635 nm) is usually used to activate protoporphyrin IX for skin cancer treatments.111”
From Effect of skin color on optical properties and the implications for medical optical technologies: a review (2024) · cites this paper as [111]
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Blue Light Therapy in Dermatological Practice: A Review
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Photoinitiated Nitric Oxide Release as an Antibacterial Treatment for Chronic Wounds
Johnson, C. R., & Schoenfisch, M. H. (2025) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.4c01955 · Cited by 8 · see citing works
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Modulation of Photosensitizing Responses in Cell Culture Environments by Different Medium Components
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Visible Blue Light Does Not Induce DNA Damage in Human Dermal Fibroblasts
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The inhibitory and inactivating effects of visible light on SARS-CoV-2: A narrative update
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Prospective Clinical Study: Full-Body Blue Irradiation in the Treatment of Atopic Dermatitis
Sadowska, M., Narbutt, J., Nolberczak, D., Ciążyńska, M. A., Skibińska, M., Sobolewska-Sztychny, D., Aubert, D., & Lesiak, A. (2024) · Dermatology and Therapy · doi:10.1007/s13555-024-01248-3 · Cited by 5 · see citing works
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Photocatalytic Micro/Nanomotors Functioning in the Near‐Infrared Window for Biomedical Applications
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LIFTLASER DUAL-WAVE – TÉCNICA EMPREGANDO LASERS DE DIODO CIRÚRGICOS PARA HARMONIZAÇÃO OROFACIAL
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Catalase Deactivation Increases Dermatophyte Sensitivity to ROS Sources
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Reducing the impact of artificial blue light on the skin: A spectroscopic study
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PHOTOTHERAPY IN ANTI-AGING MEDICINE: EXPANDING HORIZONS FROM SKIN HEALTH TO SYSTEMIC REJUVENATION
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Antimicrobial Blue Light and Acne Vulgaris: Unraveling Therapeutic Insights
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Microneedles meet photomedicine: emerging strategies for diagnosis and therapy of skin diseases
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Supportive design Therapeutic effects of color and light of inpatient spaces
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Unveiling the Hidden Dangers: The Impact of Blue Light on Skin Health and Aging
Szerej, K., Kot, A., Wojtczak, M., Myśliwiec, N., Różycki, A., Pniak, M., Miklis, P., Mawlichanów, M., Ciesielska, A., & Sieradzka, A. (2024) · Quality in Sport · doi:10.12775/qs.2024.30.56775 · Cited by 1 · see citing works
Exploring the Role of Artificial Light and Tanning for Skin Cancer
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Light therapy in medicine: where do we stand?
Oyama, Y., Witowski, A., Adamzik, M., Bartels, K., & de la Garza Eckle, T. (2026) · Annals of Translational Medicine · doi:10.21037/atm-2026-0041
“Blue light has shown no major adverse effects to date, though long-term studies are needed (127).”
LASERTERAPIA NO TRATAMENTO DE ACNE
Rodrigues, F. M., Khachikian, L. C., & Bello, L. T. (2023) · AESTHETIC OROFACIAL SCIENCE · doi:10.51670/aos.v4i1.142
A case of verruca plana juvenile responding to blue light phototherapy
Baytimur, H., & Temel, A. B. (2023) · Turkish Journal of Dermatology · doi:10.4103/tjd.tjd_60_23
Phototherapy: safe and effective use of light in neonatal care
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Blue Light Facial Therapy Device using IoT Interface
Wijaya, N. H., Kartika, W., & Sukwono, D. (2023) · International Workshop on Artificial Intelligence and Image Processing (IWAIIP) · doi:10.1109/iwaiip58158.2023.10462803
Dähnhardt, D., Dähnhardt‐Pfeiffer, S., Simon, I., Ditgen, D., Holland, I., Segger, D., & Staib, P. (2024) · Journal of Cosmetics Dermatological Sciences and Applications · doi:10.4236/jcdsa.2024.143015
Exploring the Role of Artificial Light and Tanning for Skin Cancer
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Benefits of Using Blue-Violet/Blue Diode Lasers in Dentistry
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Should we be optimistic for the development of new psoriasis therapies?
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The color blue: symbolism, evolution, and interdisciplinary connections
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Quercetin: A Light in the Fight Against MRSA
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Digital Exposure and Skin Health in Children and Adolescents: A State-of-the-Art Review
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Blue Light‐Mediated Nitric Oxide‐Releasing Formulation for the Multimodal Treatment of Acne Vulgaris
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A low‐cost handheld device for monitoring cutaneous photosensitivity
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Case Report: Acne related to electric welding, a new type of occupational acne
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- Authors
- Sadowska, M., Narbutt, J., & Lesiak, A.
- Affiliations
- Medical University of Lodz (PL)
- Corresponding author
- Sadowska, Magdalena
- Venue
- Life
- Publisher
- MDPI AG
- Published
- 2021-07-08
- Volume
- 11
- Issue
- 7
- Pages
- 670
- ISSN
- 2075-1729 (ISSN-L)
- PMC
- PMC8307003
- OpenAlex
- W3183085338
- Cited by
- 74
- References
- 75
- Citations by year
- 2026: 15 · 2025: 12 · 2024: 25 · 2023: 15 · 2022: 7
- FWCI
- 1.89
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Life (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Uniwersytet Łódzki
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Keywords
- blue light therapy, nitric oxide, reactive oxygen species, anti-inflammatory activity, antiproliferative activity, atopic dermatitis, psoriasis, hair growth, acne, Propionibacterium acnes, chronic inflammatory skin disease, long-term safety
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