Polydopamine-mediated surface modifications of poly l-lactic acid with hydroxyapatite, heparin and bone morphogenetic protein-2 and their effects on osseointegration
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Use of modified composite PLLA/pDA/HA/Hep/BMP-2 improved bone formation of the in vivo system at the interface.
“Their findings suggest that the use of modified composite PLLA/pDA/HA/Hep/BMP-2 improved bone formation of the in vivo system at the interface.”
From Strategies for Using Polydopamine to Induce Biomineralization of Hydroxyapatite on Implant Materials for Bone Tissue Engineering (2020) · cites this paper as [66]
PLLA/PDA/HA/Hep/BMP-2 improves ALP activity (~0.5-fold at day 21).
“ALP activity (~0.5-fold at day 21)”
From Strategies for Using Polydopamine to Induce Biomineralization of Hydroxyapatite on Implant Materials for Bone Tissue Engineering (2020) · cites this paper as [66]
Bone volume/tissue volume (BV/TV) ratio of PLLA/pDA/HA/Hep/BMP-2 was 3.21-fold greater than PLLA alone.
“The bone volume (BV) and bone volume/tissue volume (BV/TV) ratio of PLLA/pDA/HA/Hep/BMP-2 was 3.18- and 3.21-fold greater than PLLA alone [66].”
From Strategies for Using Polydopamine to Induce Biomineralization of Hydroxyapatite on Implant Materials for Bone Tissue Engineering (2020) · cites this paper as [66]
PLLA/PDA/HA/Hep/BMP-2 improves OCN gene expression (~4-fold at day 21).
“OCN gene expression (~4-fold at day 21)”
From Strategies for Using Polydopamine to Induce Biomineralization of Hydroxyapatite on Implant Materials for Bone Tissue Engineering (2020) · cites this paper as [66]
PLLA/PDA/HA/Hep/BMP-2 increases adhesion and cell proliferation (~1.2-fold at day 7) of MG-63 osteosarcoma cells on the modified surface.
“thereby increasing the adhesion and cell proliferation (~1.2-fold at day 7) of the osteosarcoma (MG-63) cell line on the modified surface.”
From Strategies for Using Polydopamine to Induce Biomineralization of Hydroxyapatite on Implant Materials for Bone Tissue Engineering (2020) · cites this paper as [66]
PLLA/PDA/HA/Hep/BMP-2 improves calcium deposition (~2.2-fold at day 21).
“calcium deposition (~2.2-fold at day 21)”
From Strategies for Using Polydopamine to Induce Biomineralization of Hydroxyapatite on Implant Materials for Bone Tissue Engineering (2020) · cites this paper as [66]
Bone volume (BV) of PLLA/pDA/HA/Hep/BMP-2 was 3.18-fold greater than PLLA alone.
“The bone volume (BV) and bone volume/tissue volume (BV/TV) ratio of PLLA/pDA/HA/Hep/BMP-2 was 3.18- and 3.21-fold greater than PLLA alone [66].”
From Strategies for Using Polydopamine to Induce Biomineralization of Hydroxyapatite on Implant Materials for Bone Tissue Engineering (2020) · cites this paper as [66]
PLLA/PDA/HA/Hep/BMP-2 has elevated surface roughness (~48%) and wettability compared to pristine PLLA.
“The modified materials, so-called PLLA/PDA/HA/Hep/BMP-2, expressed elevated surface roughness (~48%) and wettability compared to pristine PLLA”
From Strategies for Using Polydopamine to Induce Biomineralization of Hydroxyapatite on Implant Materials for Bone Tissue Engineering (2020) · cites this paper as [66]
Cites
Polydopamine-Assisted Surface Modification for Bone Biosubstitutes
Huang, S., Liang, N., Hu, Y., Zhou, X., & Abidi, N. (2016) · BioMed Research International · doi:10.1155/2016/2389895 · Cited by 97 · see citing works
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Kaushik, N., Nhat Nguyen, L., Kim, J. H., Choi, E. H., & Kumar Kaushik, N. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186544 · Cited by 76 · see citing works
“Reprinted with permission from reference [66].”
Method
- Authors
- Yun, Y. J., Kim, H.-J., Lee, D.-W., Um, S., & Chun, H. J.
- Affiliations
- Catholic University of Korea (KR)
- Konkuk University (KR)
- Kyung Hee University (KR)
- Seoul National University (KR)
- Corresponding author
- Chun, Heung Jae
- Venue
- Journal of Industrial and Engineering Chemistry
- Publisher
- Elsevier BV
- Published
- 2018-11
- Volume
- 67
- Pages
- 244-254
- ISSN
- 1226-086X (ISSN-L)
- OpenAlex
- W2818885830
- Cited by
- 10
- References
- 1
- Citations by year
- 2026: 2 · 2025: 2 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 2
- FWCI
- 0.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Industrial and Engineering Chemistry (publishedVersion)
- Funders
- Ministry of Trade, Industry and Energy (MOTIE) (10047811)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Engineering › Mechanical Engineering › Surface Treatment and Coatings
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Keywords
- polydopamine coating, poly(L-lactic acid), hydroxyapatite, heparin, BMP-2, osseointegration, surface modification, bone formation, alkaline phosphatase activity, osteocalcin gene expression, osteosarcoma cells, bone-anchored implants, calcium deposition
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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