The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Comparative efficacy of Rubini, Jeryl-Lynn and Urabe mumps vaccine in an Asian population
Abstract
Objective The comparative efficacy of the three mumps vaccine strains (Jeryl-Lynn, Urabe and Rubini) was conducted in an Asian population from data arising from an epidemiological investigation of seven institutional outbreaks of mumps in Singapore.Methods Demographic information (gender, age, ethnic group), clinical presentation and vaccination history (date and place of mumps vaccination, type of mumps vaccine received) of all children who attended the six childcare centres and one primary school where outbreaks of 20 or more cases of mumps occurred in 1999 were collected. The attack rate of the unvaccinated group and the attack rates of the vaccine groups (for each vaccine strain) were determined and the vaccine efficacy of the three vaccines calculated.Results The vaccine efficacy of the Jeryl-Lynn strain, Urabe strain and Rubini strain mumps vaccine were 80.7, 54.4 and -55.3%, respectively.Conclusion Rubini strain mumps vaccine conferred no protection and has since been deregistered in Singapore.
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In Ong 2005, vaccine effectiveness of at least one dose of MMR Urabe vaccine against mumps was 54% (95% CI -16.2 to 81.7) and did not reach statistical relevance.
“the estimate from the Ong 2005 study did not reach statistical relevance (VE 54%; 95% CI -16.2 to 81.7)”
From Vaccines for measles, mumps and rubella in children (2012) · cites this paper as Ong 2005
In Ong 2005, the Rubini strain-containing MMR vaccine was highly ineffective in preventing clinical mumps cases (VE -55.3%; 95% CI -121.8 to -8.8).
“The Rubini strain-containing MMR vaccine was highly ineffective in preventing clinical mumps cases in the Ong 2005 study (VE -55.3%; 95% CI -121.8 to -8.8)”
From Vaccines for measles, mumps and rubella in children (2012) · cites this paper as Ong 2005
For at least one dose of Jeryl Lynn strain-containing MMR vaccine, vaccine effectiveness against mumps was 80.7% (95% CI 57.8 to 90.8) in Ong 2005 and 78% (95% CI 64 to 82) in Schlegel 1999.
“VE 80.7%; 95% CI 57.8 to 90.8 (Ong 2005) and 78% (95% CI 64 to 82) (Schlegel 1999)”
From Vaccines for measles, mumps and rubella in children (2012) · cites this paper as Ong 2005
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Metadata
- Authors
- Ong, G., Goh, K. T., Ma, S., & Chew, S. K.
- Affiliations
- Ministry of Health (SG)
- Corresponding author
- Ong, Gary
- ORCID
- Ma, Stefan
- Venue
- Journal of Infection
- Publisher
- Elsevier BV
- Published
- 2005-11
- Volume
- 51
- Issue
- 4
- Pages
- 294-298
- ISSN
- 0163-4453 (ISSN-L)
- OpenAlex
- W2002844109
- Cited by
- 50
- References
- 19
- Citations by year
- 2025: 1 · 2023: 1 · 2021: 3 · 2020: 8 · 2019: 4 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 3 · 2013: 4 · 2012: 3
- FWCI
- 0.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Infection (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
- Social Sciences › Health › Vaccine Coverage and Hesitancy
- Keywords
- mumps vaccine, Jeryl Lynn strain, vaccine efficacy, mumps outbreak, daycare centers, attack rate, vaccine safety, Singapore
- MeSH terms
- Child, Child, Preschool, Disease Outbreaks, Humans, Mumps, Mumps Vaccine, Mumps virus, Serotyping, Singapore, Time Factors, Treatment Outcome, Vaccines, Combined, Sentinel Surveillance, Measles-Mumps-Rubella Vaccine
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