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Cited by 13Virology and Viral DiseasesPharmacovigilance and Adverse Drug ReactionsBacterial Infections and Vaccines

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

No demonstrable association between the Leningrad-Zagreb mumps vaccine strain and aseptic meningitis in a large clinical trial in Egypt

Open access
Sharma, H.J., Aly Oun, S., Abou Bakr, S.S., Kapre, S.V., Jadhav, S.S., Dhere, R.M., Bhardwaj, S.·2010·Clinical Microbiology and Infection
DOI 10.1111/j.1469-0691.2010.03121.x
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Abstract

To address the claim that the Leningrad-Zagreb (L-Z) mumps vaccine strain is causally associated with aseptic meningitis, a prospective, post-marketing safety study was conducted with a measles-mumps-rubella vaccine (MMR) (TRESIVAC(R); Serum Institute of India Ltd., Pune, India), which uses the L-Z strain as its mumps component in Egypt. In all, 453 119 children (65 423 children aged 16-24 months and 329 211 children aged 5-7 years) received MMR. The control groups which, as a result of local health regulations, were slightly younger than vaccinees, comprised 12 253 and 46 232 children, respectively. Using questionnaires, the parents recorded solicited local, systemic and neurological adverse events for up to 42 days post-vaccination. All data were analysed externally on an intention-to-treat basis by individuals not participating in the study. Local and/or systemic reactions were reported in a small percentage of participants, with pain, fever and parotitis being the most common signs among vaccinees in both age groups. No case of aseptic meningitis, encephalitis, anaphylaxis or convulsions was observed in any participant. Thus, in this series of more than 450 000 Egyptian children, the L-Z mumps vaccine strain in this vaccine did not cause aseptic meningitis. The vaccine is considerably cheaper than Western competitors and a valid alternative to other MMR vaccines.

Overview

Integrity signals

Registry

Crossref · 10.1111/j.1469-0691.2010.03121.x

Cites

27 of 27 references verified0 citation errors · 0 not checkable

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Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • In the Sharma 2010 cohort, among older children, fever was reported with slightly higher frequency among unvaccinated children than among MMR-immunised children.

    “This trend appeared to be different when the older population was considered; fever had been reported with slightly higher frequency among unvaccinated children.”

    From Vaccines for measles, mumps and rubella in children (2012) · cites this paper as Sharma 2010

  • In the Sharma 2010 cohort, among younger children aged 16 to 24 months, fever during the 42 days postvaccination was reported more frequently among individuals immunised with MMR than among unvaccinated individuals.

    “Considering the cohort of Sharma 2010 only within the subgroup of younger children (16 to 24 months of age), fever during the 42 days postvaccination had been reported more frequently among individuals immunised with MMR than among unvaccinated individuals.”

    From Vaccines for measles, mumps and rubella in children (2012) · cites this paper as Sharma 2010

Citations

Cites

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Research works printed but not linked: 3

  1. Pan American Health Organization (PAHO), 1999, Special program for vaccines and immunization. Evaluation of the Bahamas’ MMR campaign, EPI Newsl, 21, 4
  2. MMWR, 1989, Mumps prevention, Morb Mortal Wkly Rep, 38, 388
  3. CDC Update, 2006, Multistate outbreak of mumps – United States, January 1 – May 2, 2006, Morb Mortal Wkly Rep, 55, 559

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Metadata

Authors
Sharma, H. J., Aly Oun, S., Abou Bakr, S. S., Kapre, S. V., Jadhav, S. S., Dhere, R. M., & Bhardwaj, S.
Affiliations
Serum Institute of India (India) (IN)
Corresponding author
Sharma, H.J.
ORCID
Venue
Clinical Microbiology and Infection
Publisher
Elsevier BV
Published
2010-04
Volume
16
Issue
4
Pages
347-352
ISSN
1198-743X (ISSN-L)
DOI
10.1111/j.1469-0691.2010.03121.x
OpenAlex
W1565014722
Cited by
13
References
27
Citations by year
2026: 1 · 2024: 1 · 2023: 1 · 2021: 1 · 2020: 2 · 2018: 1 · 2017: 1 · 2015: 1 · 2013: 2 · 2012: 2
FWCI
0.93
Type
journal article
Language
en
Open access
Licence
Locations
  • Clinical Microbiology and Infection (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
  • Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
Keywords
aseptic meningitis, MMR vaccine, vaccine safety, post-marketing surveillance, adverse events, parotitis, Egyptian children
MeSH terms
Child, Child, Preschool, Egypt, Encephalitis, Female, Humans, Infant, Male, Meningitis, Aseptic, Product Surveillance, Postmarketing, Surveys and Questionnaires, Measles-Mumps-Rubella Vaccine

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