Comparison of six Aspergillus-specific IgG assays for the diagnosis of chronic pulmonary aspergillosis (CPA)
Open accessAbstract
Objectives Chronic pulmonary aspergillosis (CPA) is estimated to affect 3 million persons worldwide. Aspergillus-specific IgG is a key component in CPA diagnosis. We aimed to establish the optimal diagnostic cut offs for CPA and the comparative performance of six assays in this context. Methods Sera from 241 patients with CPA and 100 healthy blood donors were tested using five Aspergillus-specific IgG assays plus precipitin testing using Microgen Aspergillus antigens. Results Receiver operating characteristic (ROC) curve area under the curve (AUC) results were as follows: ThermoFisher Scientific ImmunoCAP 0.996 (95% confidence interval 0.992-1), Siemens Immulite 0.991 (0.982-1), Serion 0.973 (0.960-0.987), Dynamiker 0.918 (0.89-0.946) and Genesis 0.902 (0.871-0.933). Optimal CPA diagnostic cut-offs were; ImmunoCAP 20 mg/L (96% sensitivity, 98% specificity), Immulite 10 mg/L (96% sensitivity, 98% specificity), Serion 35 U/ml (90% sensitivity, 98% specificity), Dynamiker 65 AU/ml (77% sensitivity, 97% specificity) and Genesis 20 U/ml (75% sensitivity, 99% specificity). The precipitin test was 59% sensitive and 100% specific. Conclusions ImmunoCAP and Immulite were statistically significantly superior to the other assays. Precipitins testing performed poorly. The currently accepted ImmunoCAP cut-off of 40 mg/L appears sub-optimal for CPA diagnosis and may require revision in this context.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The text we found for this paper looks like another document, so the self-check wasn’t run.
Cites
The meaning and use of the area under a receiver operating characteristic (ROC) curve.
Hanley, J. A., & McNeil, B. J. (1982) · Radiology · doi:10.1148/radiology.143.1.7063747 · Cited by 21,856 · see citing works
Basic principles of ROC analysis
Metz, C. E. (1978) · Seminars in Nuclear Medicine · doi:10.1016/s0001-2998(78)80014-2 · Cited by 6,058 · see citing works
Chronic pulmonary aspergillosis: rationale and clinical guidelines for diagnosis and management
Denning, D. W., Cadranel, J., Beigelman-Aubry, C., Ader, F., Chakrabarti, A., Blot, S., Ullmann, A. J., Dimopoulos, G., & Lange, C. (2016) · European Respiratory Journal · doi:10.1183/13993003.00583-2015 · Cited by 1,030 · see citing works
Self-citationAgarwal, R., Chakrabarti, A., Shah, A., Gupta, D., Meis, J. F., Guleria, R., Moss, R., Denning, D. W., & ABPA complicating asthma ISHAM working group (2013) · Clinical & Experimental Allergy · doi:10.1111/cea.12141 · Cited by 896 · see citing works
Self-citationDenning, D. W., Riniotis, K., Dobrashian, R., & Sambatakou, H. (2003) · Clinical Infectious Diseases · doi:10.1086/376526 · Cited by 551 · see citing works
Self-citationDenning, D. W., Pleuvry, A., & Cole, D. C. (2013) · Medical Mycology · doi:10.3109/13693786.2012.738312 · Cited by 495 · see citing works
Self-citationChakrabarti, A., Denning, D. W., Ferguson, B. J., Ponikau, J. U., Buzina, W., Kita, H., Marple, B. F., Panda, N. K., Vlaminck, S., Kauffmann‐Lacroix, C., et al. (2009) · The Laryngoscope · doi:10.1002/lary.20520 · Cited by 482 · see citing works
Self-citationUnderlying conditions in chronic pulmonary aspergillosis including simple aspergilloma
Smith, N. L., & Denning, D. W. (2011) · European Respiratory Journal · doi:10.1183/09031936.00054810 · Cited by 449 · see citing works
Self-citationGlobal burden of chronic pulmonary aspergillosis as a sequel to pulmonary tuberculosis
Denning, D., Pleuvry, A., & Cole, D. (2011) · Bulletin of the World Health Organization · doi:10.2471/blt.11.089441 · Cited by 420 · see citing works
Self-citationNovel immunologic classification of aspergillosis in adult cystic fibrosis
Baxter, C. G., Dunn, G., Jones, A. M., Webb, A. K., Gore, R. B., Richardson, M. D., & Denning, D. W. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.04.007 · Cited by 213 · see citing works
Self-citationGlobal burden of chronic pulmonary aspergillosis complicating sarcoidosis
Denning, D. W., Pleuvry, A., & Cole, D. C. (2012) · European Respiratory Journal · doi:10.1183/09031936.00226911 · Cited by 179 · see citing works
Agarwal, R., Gella, V., Aggarwal, A. N., Garg, M. K., Gupta, D., & Chakrabarti, A. (2013) · Mycoses · doi:10.1111/myc.12075 · Cited by 147 · see citing works
Efficacy and Safety of Posaconazole for Chronic Pulmonary Aspergillosis
Felton, T., Baxter, C. G., Moore, C. B., Roberts, S. A., Hope, W. W., & Denning, D. W. (2010) · Clinical Infectious Diseases · doi:10.1086/657306 · Cited by 139 · see citing works
Self-citationClinical characteristics and prognosis of chronic pulmonary aspergillosis
Ohba, H., Miwa, S., Shirai, M., Kanai, M., Eifuku, T., Suda, T., Hayakawa, H., & Chida, K. (2012) · Respiratory Medicine · doi:10.1016/j.rmed.2012.01.014 · Cited by 138 · see citing works
Farid, S., Mohamed, S., Devbhandari, M. P., Kneale, M., Richardson, M. D., Soon, S. Y., Jones, M. T., Krysiak, P., Shah, R. D., Denning, D. W., et al. (2013) · Journal of Cardiothoracic Surgery · doi:10.1186/1749-8090-8-180 · Cited by 131 · see citing works
Self-citationChronic pulmonary aspergillosis
Schweer, K. E., Bangard, C., Hekmat, K., & Cornely, O. A. (2013) · Mycoses · doi:10.1111/myc.12152 · Cited by 111 · see citing works
Clinical characteristics and treatment outcomes of chronic pulmonary aspergillosis
Jhun, B. W., Jeon, K., Eom, J. S., Lee, J. H., Suh, G. Y., Kwon, O. J., & Koh, W. (2013) · Medical Mycology · doi:10.3109/13693786.2013.806826 · Cited by 110 · see citing works
Antibody testing in aspergillosis—quo vadis?
Page, I. D., Richardson, M. D., & Denning, D. W. (2015) · Medical Mycology · doi:10.1093/mmy/myv020 · Cited by 108 · see citing works
Self-citationBaxter, C. G., Denning, D. W., Jones, A. M., Todd, A., Moore, C. B., & Richardson, M. D. (2012) · Clinical Microbiology and Infection · doi:10.1111/1469-0691.12133 · Cited by 99 · see citing works
Self-citationAspergillus bronchitis without significant immunocompromise
Chrdle, A., Mustakim, S., Bright-Thomas, R. J., Baxter, C. G., Felton, T., & Denning, D. W. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06816.x · Cited by 98 · see citing works
Self-citationFraczek, M. G., Kirwan, M., Moore, C. B., Morris, J., Denning, D. W., & Richardson, M. D. (2013) · Mycoses · doi:10.1111/myc.12103 · Cited by 83 · see citing works
Self-citationAl-shair, K., Atherton, G. T., Harris, C. M., Ratcliffe, L., Newton, P. J., & Denning, D. W. (2013) · Clinical Infectious Diseases · doi:10.1093/cid/cit411 · Cited by 82 · see citing works
Self-citationSurgical treatment for pulmonary aspergilloma: a 35-year experience in the Chinese population
Chen, Q., Jiang, G.-N., & Ding, J. (2012) · Interactive Cardiovascular and Thoracic Surgery · doi:10.1093/icvts/ivs130 · Cited by 77 · see citing works
Hoeyveld, E. V., Dupont, L., & Bossuyt, X. (2006) · Clinical Chemistry · doi:10.1373/clinchem.2006.067546 · Cited by 67 · see citing works
Prevalence of chronic pulmonary aspergillosis in patients with tuberculosis from Iran
Hedayati, M. T., Azimi, Y., Droudinia, A., Mousavi, B., Khalilian, A., Hedayati, N., & Denning, D. W. (2015) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-015-2409-7 · Cited by 62 · see citing works
Self-citationChronic pulmonary aspergillosis
Weerakkody, Y., Campos, A., & Niknejad, M. T. (2017) · Radiopaedia.org · doi:10.53347/rid-56927 · Cited by 61 · see citing works
Barton, R., Hobson, R. P., Denton, M., Peckham, D. G., Brownlee, K. G., Conway, S., & Kerr, M. A. (2008) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2008.06.018 · Cited by 58 · see citing works
Guitard, J., Sendid, B., Thorez, S., Gits‐Muselli, M., & Hennequin, C. (2011) · Journal of Clinical Microbiology · doi:10.1128/jcm.01257-11 · Cited by 51 · see citing works
Antigens and allergens of Aspergillus fumigatus
Longbottom, J. L., & Austwick, P. K. C. (1986) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(86)90108-9 · Cited by 47 · see citing works
van Toorenenbergen, A. W. (2012) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2012.07.002 · Cited by 30 · see citing works
Stability Studies of Binding and Functional Anti-Vaccine Antibodies
Hendriks, J., Stals, C., Versteilen, A. M. G., Mommaas, B., Verhoeven, M., Tirion, F. H., ter Haak, M., Ribbens, W., Bosch, M., Trommel, M., et al. (2014) · Bioanalysis · doi:10.4155/bio.14.96 · Cited by 26 · see citing works
Long‐term Stability of West Nile Virus IgM and IgG Antibodies in Diluted Sera Stored at 4°C
Wong, S. J., & SELIGMAN, S. J. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb02721.x · Cited by 5 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Aspergillus fumigatus and Aspergillosis in 2019
Latgé, J.-P., & Chamilos, G. (2019) · Clinical Microbiology Reviews · doi:10.1128/cmr.00140-18 · Cited by 1,400 · see citing works
Agarwal, R., Sehgal, I. S., Muthu, V., Denning, D. W., Chakrabarti, A., Kathirvel, S., Garg, M. K., Rudramurthy, S. M., Dhooria, S., Armstrong-James, D. P. H., et al. (2024) · European Respiratory Journal · doi:10.1183/13993003.00061-2024 · Cited by 267 · see citing works
Self-citationPredictors of mortality in chronic pulmonary aspergillosis
Lowes, D., Al-Shair, K., Newton, P. J., Morris, J., Harris, C., Rautemaa-Richardson, R., & Denning, D. W. (2017) · European Respiratory Journal · doi:10.1183/13993003.01062-2016 · Cited by 194 · see citing works
Self-citationPage, I. D., Byanyima, R. K., Hosmane, S. R., Onyachi, N., Opira, C., Richardson, M. D., Sawyer, R., Sharman, A., & Denning, D. W. (2019) · European Respiratory Journal · doi:10.1183/13993003.01184-2018 · Cited by 170 · see citing works
Self-citationAllergic bronchopulmonary aspergillosis
Agarwal, R., Sehgal, I. S., Dhooria, S., Muthu, V., Prasad, K., Bal, A., Aggarwal, A., & Chakrabarti, A. (2020) · The Indian Journal of Medical Research · doi:10.4103/ijmr.ijmr_1187_19 · Cited by 149 · see citing works
Case Definition of Chronic Pulmonary Aspergillosis in Resource-Constrained Settings
Denning, D. W., Page, I. D., Chakaya, J., Jabeen, K., Jude, C. M., Cornet, M., Alastruey-Izquierdo, A., Bongomin, F., Bowyer, P., Chakrabarti, A., et al. (2018) · Emerging Infectious Diseases · doi:10.3201/eid2408.171312 · Cited by 144 · see citing works
Self-citationPulmonary and sinus fungal diseases in non-immunocompromised patients
Denning, D. W., & Chakrabarti, A. (2017) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(17)30309-2 · Cited by 143 · see citing works
Self-citationJenks, J. D., & Hoenigl, M. (2018) · Journal of Fungi · doi:10.3390/jof4030098 · Cited by 141 · see citing works
Denning, D. W. (2016) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2015.0468 · Cited by 117 · see citing works
Self-citationDenning, D. W., Perlin, D. S., Muldoon, E. G., Colombo, A. L., Chakrabarti, A., Richardson, M. D., & Sorrell, T. C. (2016) · Emerging infectious diseases · doi:10.3201/eid2302.152042 · Cited by 95 · see citing works
Self-citationTwelve-month clinical outcomes of 206 patients with chronic pulmonary aspergillosis
Bongomin, F., Harris, C., Hayes, G., Kosmidis, C., & Denning, D. W. (2018) · PLoS ONE · doi:10.1371/journal.pone.0193732 · Cited by 91 · see citing works
Self-citationRole of Serological Tests in the Diagnosis of Mold Infections
Richardson, M. D., & Page, I. D. (2018) · Current Fungal Infection Reports · doi:10.1007/s12281-018-0321-1 · Cited by 90 · see citing works
Self-citationAllergic Bronchopulmonary Aspergillosis
Tracy, M. C., Okorie, C. U. A., Foley, E., & Moss, R. B. (2016) · Journal of Fungi · doi:10.3390/jof2020017 · Cited by 90 · see citing works
Agarwal, R., Dua, D., Choudhary, H., Aggarwal, A. N., Sehgal, I. S., Dhooria, S., Garg, M. K., Behera, D., & Chakrabarti, A. (2016) · Mycoses · doi:10.1111/myc.12541 · Cited by 86 · see citing works
The Management of Chronic Pulmonary Aspergillosis: The UK National Aspergillosis Centre Approach
Maghrabi, F., & Denning, D. W. (2017) · Current Fungal Infection Reports · doi:10.1007/s12281-017-0304-7 · Cited by 83 · see citing works
Self-citationChronic Pulmonary Aspergillosis—Where Are We? and Where Are We Going?
Hayes, G., & Novak-Frazer, L. (2016) · Journal of Fungi · doi:10.3390/jof2020018 · Cited by 77 · see citing works
Recent Advances in Diagnosing Chronic Pulmonary Aspergillosis
Takazono, T., & Izumikawa, K. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01810 · Cited by 71 · see citing works
Sehgal, I. S., Choudhary, H., Dhooria, S., Aggarwal, A. N., Garg, M. K., Chakrabarti, A., & Agarwal, R. (2018) · Mycoses · doi:10.1111/myc.12815 · Cited by 72 · see citing works
Chronic pulmonary aspergillosis update: A year in review
Barac, A. M., Kosmidis, C., Alastruey‐Izquierdo, A., Salzer, H. J. F., & CPAnet (2018) · Medical Mycology · doi:10.1093/mmy/myy070 · Cited by 72 · see citing works
Post tuberculosis treatment infectious complications
Hsu, D., Irfan, M., Jabeen, K., Iqbal, N., Hasan, R., Migliori, G. B., Zumla, A. I., Visca, D., Centis, R., & Tiberi, S. (2020) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2020.02.032 · Cited by 68 · see citing works
Bongomin, F., Asio, L. G., Baluku, J. B., Kwizera, R., & Denning, D. W. (2020) · Journal of Fungi · doi:10.3390/jof6020075 · Cited by 71 · see citing works
Self-citationSehgal, I. S., Dhooria, S., Choudhary, H., Aggarwal, A. N., Garg, M. K., Chakrabarti, A., & Agarwal, R. (2019) · Journal of Clinical Microbiology · doi:10.1128/jcm.01821-18 · Cited by 64 · see citing works
Non-surgical treatment options for pulmonary aspergilloma
Lang, M., Lang, A. L., Chauhan, N. R., & Gill, A. (2020) · Respiratory Medicine · doi:10.1016/j.rmed.2020.105903 · Cited by 60 · see citing works
Thornton, C. R. (2019) · Advances in applied microbiology · doi:10.1016/bs.aambs.2019.10.003 · Cited by 59 · see citing works
Aspergillusserology: Have we arrived yet?
Richardson, M. D., & Page, I. D. (2016) · Medical Mycology · doi:10.1093/mmy/myw116 · Cited by 58 · see citing works
Self-citationHunter, E. S., Richardson, M. D., & Denning, D. W. (2019) · Journal of Clinical Microbiology · doi:10.1128/jcm.00538-19 · Cited by 53 · see citing works
Self-citationMulticenter Evaluation of a Novel Immunochromatographic Test for Anti-aspergillus IgG Detection
Piarroux, R., Romain, T., Martin, A., Vainqueur, D., Vitte, J., Lachaud, L., Gangneux, J., Gabriel, F., Fillaux, J., & Ranque, S. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00012 · Cited by 51 · see citing works
Bronchiectasis andAspergillus: How are they linked?
Soyza, A. D., & Aliberti, S. (2016) · Medical Mycology · doi:10.1093/mmy/myw109 · Cited by 50 · see citing works
Page, I. D., Baxter, C. G., Hennequin, C., Richardson, M. D., Hoeyveld, E. V., van Toorenenbergen, A. W., & Denning, D. W. (2018) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2018.01.001 · Cited by 50 · see citing works
Self-citationSalzer, H. J. F., Heyckendorf, J., Kalsdorf, B., Rolling, T., & Lange, C. G. (2016) · Mycoses · doi:10.1111/myc.12589 · Cited by 49 · see citing works
An overview of the available treatments for chronic cavitary pulmonary aspergillosis
Sehgal, I. S., Dhooria, S., Muthu, V., Prasad, K. T., & Agarwal, R. (2020) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2020.1750956 · Cited by 48 · see citing works
Valtonen, V. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00951 · Cited by 48 · see citing works
The Burden of Fungal Infections in Ethiopia
Tufa, T. B., & Denning, D. W. (2019) · Journal of Fungi · doi:10.3390/jof5040109 · Cited by 43 · see citing works
Self-citationCurrent Infections of the Orofacial Region: Treatment, Diagnosis, and Epidemiology
Tahmasebi, E., Keshvad, A., Alam, M. M. R., Abbasi, K., Rahimi, S., Nouri, F., Yazdanıan, M., Tebyanian, H., Heboyan, A. G., & Fernandes, G. V. O. (2023) · Life · doi:10.3390/life13020269 · Cited by 45 · see citing works
Sehgal, I. S., Dhooria, S., Choudhary, H., Aggarwal, A. N., Garg, M. K., Chakrabarti, A., & Agarwal, R. (2019) · Mycoses · doi:10.1111/myc.12987 · Cited by 44 · see citing works
Carsin, A., Romain, T., Ranque, S., Reynaud‐Gaubert, M., Dubus, J. ‐., Mège, J., & Vitte, J. (2017) · Allergy · doi:10.1111/all.13204 · Cited by 43 · see citing works
Li, H., Rui, Y., Zhou, W., Liu, L., He, B., Shi, Y. P., & Su, X. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01438 · Cited by 43 · see citing works
Nguyen, N. T. B., Ngoc, H. L., Nhung, N. V., Dinh, L. V., Nhung, N. V., Nguyen, H. T., & Denning, D. W. (2021) · Journal of Fungi · doi:10.3390/jof7070532 · Cited by 40 · see citing works
Self-citationAllergic and Noninvasive Infectious Pulmonary Aspergillosis Syndromes
Muldoon, E. G., Strek, M. E., & Patterson, K. C. (2017) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2017.04.012 · Cited by 39 · see citing works
Severe interstitial pulmonary fibrosis in a patient with chronic ulcerative colitis.
McKee, A. L., Rajapaksa, A., Kalish, P. E., & Pitchumoni, C. S. (1983) · PubMed · Cited by 38 · see citing works
Godet, C., Alastruey‐Izquierdo, A., Flick, H., Hennequin, C., Mikilps-Mikgelbs, R., Munteanu, O., Page, I. D., Seidel, D., Salzer, H. J. F., & CPAnet (2017) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkx390 · Cited by 37 · see citing works
Self-citationInnate and Adaptive Immune Defects in Chronic Pulmonary Aspergillosis
Bongomin, F., Harris, C., Foden, P., Kosmidis, C., & Denning, D. W. (2017) · Journal of Fungi · doi:10.3390/jof3020026 · Cited by 36 · see citing works
Self-citationTashiro, M., Takazono, T., & Izumikawa, K. (2024) · Therapeutic Advances in Infectious Disease · doi:10.1177/20499361241253751 · Cited by 38 · see citing works
Harada, K., Oguma, T., Saito, A., Fukutomi, Y., Tanaka, J., Tomomatsu, K., Taniguchi, M., & Asano, K. (2018) · Allergology International · doi:10.1016/j.alit.2018.04.009 · Cited by 34 · see citing works
Lee, M., Huang, H.-L., Chen, L.-C., Yang, H., Ko, J., Cheng, M., Chong, I., Lee, L., Wang, J., & Dimopoulos, G. (2020) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2019.12.009 · Cited by 34 · see citing works
Ray, A., Chowdhury, M., Sachdev, J., Sethi, P., Meena, V. P., Singh, G., Xess, I., Vyas, S., Khan, M. A., Sinha, S., et al. (2022) · Journal of Fungi · doi:10.3390/jof8040400 · Cited by 31 · see citing works
Self-citationImproving the rates ofAspergillusdetection: an update on current diagnostic strategies
Jenks, J. D., Salzer, H. J. F., & Hoenigl, M. (2018) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2018.1558054 · Cited by 33 · see citing works
Chronic pulmonary aspergillosis is common among patients with presumed tuberculosis relapse in Ghana
Ocansey, B. K., Otoo, B., Adjei, A., Gbadamosi, H., Kotey, F. C. N., Kosmidis, C., Afriyie-Mensah, J. S., Denning, D. W., & Opintan, J. A. (2022) · Medical Mycology · doi:10.1093/mmy/myac063 · Cited by 30 · see citing works
Self-citationNon-invasive and invasive diagnoses of aspergillosis in a rat model by mass spectrometry
Luptáková, D., Pluháček, T., Petřík, M., Novák, J., Palyzová, A., Sokolová, L., Škríba, A., Šedivá, B., Lemr, K., & Havlı́ček, V. (2017) · Scientific Reports · doi:10.1038/s41598-017-16648-z · Cited by 29 · see citing works
Volpe‐Chaves, C. E., de Oliveira, S. M. D. V. L., Venturini, J., Grande, A. J., Sylvestre, T. F., Mendes, R. P., & Paniago, A. M. M. (2020) · PLoS ONE · doi:10.1371/journal.pone.0222738 · Cited by 29 · see citing works
Yu, Q., He, J., Xing, B., Li, X., Qian, H., Zhang, H., Xu, M., & Peng, H. (2020) · BMC Pulmonary Medicine · doi:10.1186/s12890-020-1125-y · Cited by 28 · see citing works
Hunter, E. S., Wilopo, B. A. P., Richardson, M. D., Kosmidis, C., & Denning, D. W. (2021) · Respiratory Medicine · doi:10.1016/j.rmed.2020.106290 · Cited by 28 · see citing works
Self-citationImmunoproteomics of Aspergillus for the development of biomarkers and immunotherapies
Kniemeyer, O., Ebel, F., Krüger, T., Bächer, P., Scheffold, A., Luo, T., Straßburger, M., & Brakhage, A. A. (2016) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201600053 · Cited by 27 · see citing works
Aspergillus-specific antibodies – Targets and applications
Schubert, M., Spiegel, H., Schillberg, S., & Nölke, G. (2018) · Biotechnology Advances · doi:10.1016/j.biotechadv.2018.03.016 · Cited by 26 · see citing works
Ma, X., Wang, K., Zhao, X., Liu, Y., Li, Y., Yu, X., Li, C., Denning, D. W., & Xie, L. (2019) · BMC Infectious Diseases · doi:10.1186/s12879-019-4303-x · Cited by 26 · see citing works
Self-citationSiemens Immulite Aspergillus-specific IgG assay for chronic pulmonary aspergillosis diagnosis
Page, I. D., Richardson, M. D., & Denning, D. W. (2018) · Medical Mycology · doi:10.1093/mmy/myy024 · Cited by 25 · see citing works
Self-citationZhong, H., Wang, Y., Gu, Y., Ni, Y., Wang, Y., Shen, K., Shi, Y. P., & Su, X. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.811807 · Cited by 25 · see citing works
Lu, Y., Liu, L., Li, H., Chen, B., Gu, Y., Wang, L., Feng, C., Chen, C., Chen, Y., Sun, W., et al. (2023) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2023.02.002 · Cited by 25 · see citing works
Martín-Gómez, M. T., Goterris, L., Martínez‐Martí, A., Sampol, J., Roldán, E., Almirante, B., & Ruíz-Camps, I. (2019) · Mycoses · doi:10.1111/myc.12950 · Cited by 24 · see citing works
Jaca, A., Ndze, V. N., & Wiysonge, C. S. (2019) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2019.1631567 · Cited by 24 · see citing works
Diagnostic Aspects of Chronic Pulmonary Aspergillosis: Present and New Directions
Wilopo, B. A. P., Richardson, M. D., & Denning, D. W. (2019) · Current Fungal Infection Reports · doi:10.1007/s12281-019-00361-7 · Cited by 23 · see citing works
Self-citationChronic Pulmonary Aspergillosis: A Brief Review.
Zarif, A., Thomas, A., & Vayro, A. (2021) · PubMed Central · doi:10.17863/cam.80907 · Cited by 23 · see citing works
Salzer, H. J. F., Wassilew, N., Köhler, N., Olaru, I. D., Günther, G., Herzmann, C., Kalsdorf, B., Carballo, P. M. S., Terhalle, E., Rolling, T., et al. (2016) · Respiration · doi:10.1159/000449037 · Cited by 22 · see citing works
Shinfuku, K., Suzuki, J., Takeda, K., Kawashima, M., Morio, Y., Sasaki, Y., Nagai, H., Watanabe, A., Matsui, H., & Kamei, K. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.03435-22 · Cited by 22 · see citing works
Clinical Characteristics and Treatment Outcomes of Pathologically Confirmed Aspergillus Nodules
Kang, N., Park, J., & Jhun, B. W. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9072185 · Cited by 20 · see citing works
Aspergillus-Associated Endophenotypes in Bronchiectasis
Jaggi, T. K., Ter, S. K., Aogáin, M. M., & Chotirmall, S. H. (2021) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-0041-1730947 · Cited by 19 · see citing works
Serological evidence of chronic pulmonary Aspergillosis in tuberculosis patients in Kenya
Mohamed, A., Obanda, B. A., Njeri, H. K., Loroyokie, S. N., Mashedi, O., Ouko, T. T., Gatumwa, E. M., Korir, R. K., Yaguchi, T., & Bii, C. C. (2022) · BMC Infectious Diseases · doi:10.1186/s12879-022-07782-9 · Cited by 19 · see citing works
Larkin, P. M. K., Multani, A., Beaird, O. E., Dayo, A. J., Fishbein, G. A., & Yang, S. (2020) · Journal of Fungi · doi:10.3390/jof6030106 · Cited by 20 · see citing works
Anan, K., Kataoka, Y., Okabayashi, S., Yamamoto, R., Namkoong, H., & Yamamoto, Y. (2021) · Mycoses · doi:10.1111/myc.13253 · Cited by 18 · see citing works
Setianingrum, F., Rozaliyani, A., Sjam, R., Adawıyah, R., Tugiran, M., Sari, C. Y. I., Burhan, E., Wahyuningsih, R., Rautemaa‐Richardson, R., & Denning, D. W. (2020) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2020.115124 · Cited by 18 · see citing works
Self-citationSehgal, I., Soundappan, K., Agarwal, R., Muthu, V., Dhooria, S., Prasad, K., Salzer, H. J. F., Cornely, O., Aggarwal, A., & Chakrabarti, A. (2025) · Mycoses (Berlin) · doi:10.1111/myc.70060 · Cited by 15 · see citing works
Rodríguez, N. B., Juan-Galán, J. L. S., Andreu, C. M. F., Yera, D. M., Pita, M. B., Lancha, M. R. P., Martínez, R. E. V., Zaragozí, M. T. I., & Machín, G. F. M. (2019) · Journal of Fungi · doi:10.3390/jof5010018 · Cited by 17 · see citing works
Takeda, K., Suzuki, J., Watanabe, A., Narumoto, O., Kawashima, M., Sasaki, Y., Nagai, H., Kamei, K., & Matsui, H. (2021) · Journal of Clinical Microbiology · doi:10.1128/jcm.02018-21 · Cited by 16 · see citing works
Developments in Fungal Serology
White, P. L. (2023) · Current Fungal Infection Reports · doi:10.1007/s12281-023-00462-4 · Cited by 16 · see citing works
Niu, Y., Li, J., Shui, W., Li, D., Yu, C., Fu, X., & Zhang, C. (2020) · Journal de Mycologie Médicale · doi:10.1016/j.mycmed.2020.101041 · Cited by 16 · see citing works
Lee, M., Huang, H., Keng, L., Chang, H., Sheu, C., Fu, P., Wang, J., Chong, I., Shih, J., & Yu, C. (2021) · Journal of Fungi · doi:10.3390/jof7060480 · Cited by 16 · see citing works
Awareness of predictors of mortality may help improve outcome in chronic pulmonary aspergillosis
Salzer, H. J. F., & Cornely, O. A. (2017) · European Respiratory Journal · doi:10.1183/13993003.02520-2016 · Cited by 15 · see citing works
ELISA Test for the Serological Detection of Scedosporium/Lomentospora in Cystic Fibrosis Patients
Martin–Souto, L., Buldain, I., Areitio, M., Aparicio-Fernandez, L., Antoran, A., Bouchara, J., Martín-Gómez, M. T., Rementerı́a, A., Hernando, F. L., & Ramirez‐Garcia, A. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.602089 · Cited by 15 · see citing works
Comparison of Aspergillus-specific antibody cut-offs for the diagnosis of aspergillosis
Hsiao, C.-W., Yen, T., Wu, Y.-C., Chen, J., Chen, Y., Huang, W., Chen, Y., & Chen, Y. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1060727 · Cited by 15 · see citing works
Singh, S., Choudhary, H., Agnihotri, S., Sehgal, I. S., Agarwal, R., Kaur, H., Ghosh, A. K., Chakrabarti, A., & Rudramurthy, S. M. (2022) · Indian Journal of Medical Microbiology · doi:10.1016/j.ijmmb.2022.03.002 · Cited by 15 · see citing works
Jabeen, K., Farooqi, J. Q., Iqbal, N., Wahab, K., & Irfan, M. (2020) · Journal of Fungi · doi:10.3390/jof6040249 · Cited by 14 · see citing works
Zhu, R., Zhou, L., Cheng, J.-H., Luo, Y., Qiu, W., Huang, J.-T., Jiang, Y., Zhao, H., Wang, X., Chen, Z., et al. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.00264-23 · Cited by 14 · see citing works
Aspergillus-Nachweis im Atemwegsmaterial
Salzer, H. J. F., Lange, C. G., & Hönigl, M. (2017) · Der Internist · doi:10.1007/s00108-017-0334-9 · Cited by 14 · see citing works
Chronic Cavitary Infections Other than Tuberculosis
Holt, M. R., & Chan, E. D. (2018) · Journal of Thoracic Imaging · doi:10.1097/rti.0000000000000345 · Cited by 13 · see citing works
Yao, Y., Zhou, H., Shen, Y., Yang, Q., Ye, J., Fu, Y., Lu, G., Lou, H., Yu, Y., & Zhou, J. (2018) · The Clinical Respiratory Journal · doi:10.1111/crj.12957 · Cited by 12 · see citing works
Ndze, V. N., Jaca, A., & Wiysonge, C. S. (2019) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2019.1623998 · Cited by 11 · see citing works
Seroprevalence of Aspergillus-Specific IgG Antibody among Mozambican Tuberculosis Patients
Salzer, H. J. F., Massango, I., Bhatt, N., Machonisse, E., Reimann, M., Heldt, S., Lange, C. G., Höelscher, M., Khosa, C., & Rachow, A. (2021) · Journal of Fungi · doi:10.3390/jof7080595 · Cited by 11 · see citing works
Persat, F., Hennequin, C., Gangneux, J., & for the Société Française de Mycologie Médicale – SFMM Study group (2016) · Medical Mycology · doi:10.1093/mmy/myw078 · Cited by 11 · see citing works
Huang, S., Li, S., Chan, Y., Huang, Y., Yang, Y., & Wang, F. (2020) · Mycoses · doi:10.1111/myc.13143 · Cited by 10 · see citing works
Sehgal, I. S., Dhooria, S., Sachdeva, N. K., Rudramurthy, S. M., Prasad, K. T., Muthu, V., Aggarwal, A. N., Garg, M. K., Chakrabarti, A., & Agarwal, R. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e15356 · Cited by 9 · see citing works
Mei, Z., Han, J.-F., Yu, H., Zhang, Y., Ji, P., Xie, Y., & Hsueh, P. (2023) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-023-04637-2 · Cited by 9 · see citing works
Yao, Y., Zhou, H., Yang, Q., Lu, G., Yu, Y., Shen, Y., & Zhou, J. (2017) · The Clinical Respiratory Journal · doi:10.1111/crj.12702 · Cited by 8 · see citing works
Wilopo, B. A. P., Hunter, E. S., Richardson, M. D., & Denning, D. W. (2020) · Journal of Microbiological Methods · doi:10.1016/j.mimet.2020.106021 · Cited by 8 · see citing works
Self-citationLiu, A., Chen, W., Wei, Y., Liang, J., Liao, S.-H., Chen, Y., Li, Y., Wang, X., Chen, W., Qiu, Y., et al. (2023) · BMC Pulmonary Medicine · doi:10.1186/s12890-023-02620-3 · Cited by 7 · see citing works
Improving Diagnostic Sensitivity of Chronic Pulmonary Aspergillosis Using Species‐Specific IgG
Sehgal, I. S., Agarwal, R., Muthu, V., Dhooria, S., Prasad, K. T., Rudramurthy, S. M., Aggarwal, A. N., Garg, M. K., & Chakrabarti, A. (2025) · Mycoses · doi:10.1111/myc.70107 · Cited by 7 · see citing works
Dewi, I. M. W., Fauziah, N., Ekawardhani, S., Andriyoko, B., Adawıyah, R., Hartantri, Y., Soeroto, A. Y., Alisjahbana, B., Denning, D. W., & Wahyuningsih, R. (2023) · Medical Mycology · doi:10.1093/mmy/myad036 · Cited by 7 · see citing works
Self-citationStandardization of Aspergillus IgG diagnostic cutoff in Nigerians
Oladele, R. O., Otu, A. A., Balogun, O. J., Babalola, M. O., Nwosu, A. O., Osaigbovo, I. I., Gbaja-Biamila, T. A., Irurhe, N., Fayemiwo, S. A., Shettima, S. A., et al. (2021) · Therapeutic Advances in Infectious Disease · doi:10.1177/20499361211050158 · Cited by 7 · see citing works
Self-citationSennekamp, J., Lehmann, E., & Joest, M. (2022) · Allergo Journal International · doi:10.1007/s40629-022-00208-7 · Cited by 7 · see citing works
Maruguchi, N., Tanaka, E., Okagaki, N., Tanaka, Y., Sakamoto, H., Takeda, A., Yamamoto, R., Nakamura, S., Matsumura, K., Ueyama, M., et al. (2023) · Internal Medicine · doi:10.2169/internalmedicine.0836-22 · Cited by 7 · see citing works
Keng, L., Lin, C.-C., Wu, C. W., Liu, C.-J., Chang, L., Lee, M., Chen, J., & Wang, J. (2024) · Pathogens and Global Health · doi:10.1080/20477724.2024.2424489 · Cited by 5 · see citing works
- Authors
- Page, I. D., Richardson, M. D., & Denning, D. W.
- Affiliations
- Manchester Academic Health Science Centre (GB)
- Corresponding author
- Page, Iain D.
- Richardson, Malcolm D.
- Denning, David W.
- Venue
- Journal of Infection
- Publisher
- Elsevier BV
- Published
- 2016-02
- Volume
- 72
- Issue
- 2
- Pages
- 240-249
- ISSN
- 0163-4453 (ISSN-L)
- OpenAlex
- W2239408616
- Cited by
- 161
- References
- 32
- Citations by year
- 2026: 14 · 2025: 15 · 2024: 12 · 2023: 18 · 2022: 12 · 2021: 13 · 2020: 16 · 2019: 15 · 2018: 18 · 2017: 15 · 2016: 12
- FWCI
- 11.68
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Journal of Infection (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion, other-oa)
- Funders
- National Institute for Health Research Respiratory and Allergy Clinical Research Facility
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Keywords
- chronic pulmonary aspergillosis, Aspergillus-specific IgG, serological diagnosis, diagnostic thresholds, ImmunoCAP, Immulite, Genesis, precipitin test, sensitivity and specificity, Aspergillus antigen
- MeSH terms
- Adult, Aged, Aged, 80 and over, Antibodies, Fungal, Aspergillus, Chronic Disease, Female, Humans, Immunoglobulin G, Male, Middle Aged, Sensitivity and Specificity, Serologic Tests, Pulmonary Aspergillosis, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
