Siderophore-mediated iron acquisition in the staphylococci

Beasley, Federico C.; Heinrichs, David E.

doi:10.1016/j.jinorgbio.2009.09.011

Cited by 90Bacterial Genetics and BiotechnologyAntimicrobial Resistance in StaphylococcusIron Metabolism and Disorders

Siderophore-mediated iron acquisition in the staphylococci

Beasley, Federico C., Heinrichs, David E.·2010·Journal of Inorganic Biochemistry

DOI 10.1016/j.jinorgbio.2009.09.011

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Abstract

Iron is frequently a growth-limiting nutrient due to its propensity to interact with oxygen to form insoluble precipitates and, therefore, biological systems have evolved specialized uptake mechanisms to obtain this essential nutrient. Many pathogenic bacteria are capable of obtaining stringently sequestered iron from animal hosts by one or both of the following mechanisms: extraction of heme from host erythrocyte and serum hemoproteins, or through the use of high affinity, iron-scavenging molecules termed siderophores. This review summarizes our current knowledge of siderophore-mediated iron acquisition systems in the genus Staphylococcus.

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Staphyloferrin B is structurally different from staphyloferrin A but is also a hydrophilic NIS siderophore.
“Staphyloferrin B is structurally distinct from staphyloferrin A but like staphyloferrin A is a hydrophilic NIS siderophore.”
From A battle for iron: host sequestration and Staphylococcus aureus acquisition (2012) · cites this paper as [61]
After binding iron, staphyloferrin A and staphyloferrin B are imported into the cytoplasm by HtsABC and SirABC, respectively.
“Upon binding iron, both staphyloferrin A and staphyloferrin B are transported into the cytoplasm through the ABC transporters HtsABC and the staphylococcal iron regulated transporter (SirABC), respectively [61].”
From A battle for iron: host sequestration and Staphylococcus aureus acquisition (2012) · cites this paper as [61]
Siderophore-iron complexes are taken back into the cytoplasm by dedicated ABC transporters.
“Siderophore-iron complexes are then transported back into the cytoplasm through dedicated ABC transporters [61].”
From A battle for iron: host sequestration and Staphylococcus aureus acquisition (2012) · cites this paper as [61]
The sbn locus contains the genes for staphyloferrin B synthesis and has a consensus Fur box in its operator region.
“The genes encoding the enzymatic machinery required for staphyloferrin B synthesis lie within the sbn locus which has a consensus fur box within the operator region for the operon [61].”
From A battle for iron: host sequestration and Staphylococcus aureus acquisition (2012) · cites this paper as [61]
S. aureus makes two siderophores, staphyloferrin A and staphyloferrin B, both through the NIS pathway, and secretes them.
“S. aureus encodes for two siderophores, staphyloferrin A and staphyloferrin B, and both are synthesized through the NIS pathway and then secreted into the extracellular milieu.”
From A battle for iron: host sequestration and Staphylococcus aureus acquisition (2012) · cites this paper as [61]

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Authors: Beasley, F. C., & Heinrichs, D. E.
Affiliations: Western University (CA)
Corresponding author: Heinrichs, David E.
ORCID: Heinrichs, David E.
Venue: Journal of Inorganic Biochemistry
Publisher: Elsevier BV
Published: 2010-03
Volume: 104
Issue: 3
Pages: 282-288
ISSN: 0162-0134 (ISSN-L)
DOI: 10.1016/j.jinorgbio.2009.09.011
OpenAlex: W2000785657
Cited by: 90
References: 76
Citations by year: 2026: 2 · 2025: 7 · 2024: 8 · 2023: 1 · 2022: 4 · 2021: 2 · 2020: 1 · 2019: 7 · 2018: 4 · 2017: 6 · 2016: 7 · 2015: 7 · 2014: 10 · 2013: 4 · 2012: 7
FWCI: 3.88
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Inorganic Biochemistry (publishedVersion)
PubMed (publishedVersion)
Funders: Canadian Institutes of Health Research
Natural Sciences and Engineering Research Council of Canada
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Keywords: siderophores, iron acquisition, Staphylococcus, heme acquisition, heme proteins, bacterial pathogenicity, host-pathogen interaction
MeSH terms: Animals, Bacterial Proteins, Citrates, Humans, Iron, Models, Molecular, Ornithine, Protein Conformation, Staphylococcus, Molecular Structure, Siderophores

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Siderophore-mediated iron acquisition in the staphylococci

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