Isolation and characterization of staphyloferrin A, a compound with siderophore activity from Staphylococcus hyicus DSM 20459
Open accessAbstract
A highly hydrophilic compound was isolated from low iron culture broth of Staphylococcus hyicus DSM 20459 which exhibits siderophore activity to the producer and 37 other staphylococci. The previously unknown metabolite was designated staphyloferrin A and consists of two molecules of citric acid, each linked to D-ornitine by an amide bond. Using an ion-pair HPLC-system we detected staphyloferrin A and a second iron regulated compound (staphyloferrin B) in the culture fluid of several Staphylococcus strains. We found no evidence that staphylococci synthesize catecholor hydroxamate-type siderophores.
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S. aureus produces two polycarboxylate siderophores, staphyloferrin A and staphyloferrin B, initially isolated from Staphylococcus hyicus.
“S. aureus produces two polycarboxylate-type siderophores, staphyloferrin A and staphyloferrin B, which were initially isolated and characterized from Staphylococcus hyicus [45].”
From Metal ion acquisition in Staphylococcus aureus: overcoming nutritional immunity (2012) · cites this paper as [45]
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- Authors
- Meiwes, J., Fiedler, H.-P., Haag, H., Zähner, H., Konetschny-Rapp, S., & Jung, G.
- Affiliations
- University of Tübingen (DE)
- Corresponding author
- Zähner, H.
- Venue
- FEMS Microbiology Letters
- Publisher
- Oxford University Press (OUP)
- Published
- 1990-01
- Volume
- 67
- Issue
- 1-2
- Pages
- 201-206
- ISSN
- 0378-1097 (ISSN-L)
- OpenAlex
- W1974861151
- Cited by
- 140
- References
- 18
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 7 · 2020: 4 · 2019: 3 · 2018: 4 · 2017: 2 · 2016: 4 · 2015: 3 · 2014: 7 · 2013: 3 · 2012: 8
- FWCI
- 5.44
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEMS Microbiology Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Keywords
- siderophores, Staphylococcus hyicus, iron regulation, citric acid, D-ornithine, iron acquisition, siderophore biosynthesis
- MeSH terms
- Chromatography, High Pressure Liquid, Citrates, Iron Chelating Agents, Ornithine, Species Specificity, Staphylococcus, Molecular Structure, Siderophores
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