Cited by 140Microbial Natural Products and BiosynthesisBacterial Genetics and BiotechnologyIron Metabolism and Disorders

Isolation and characterization of staphyloferrin A, a compound with siderophore activity from Staphylococcus hyicus DSM 20459

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Meiwes, J., Fiedler, H.-P., Haag, H., Zähner, H., Konetschny-Rapp, S., Jung, G.·1990·FEMS Microbiology Letters

Abstract

A highly hydrophilic compound was isolated from low iron culture broth of Staphylococcus hyicus DSM 20459 which exhibits siderophore activity to the producer and 37 other staphylococci. The previously unknown metabolite was designated staphyloferrin A and consists of two molecules of citric acid, each linked to D-ornitine by an amide bond. Using an ion-pair HPLC-system we detected staphyloferrin A and a second iron regulated compound (staphyloferrin B) in the culture fluid of several Staphylococcus strains. We found no evidence that staphylococci synthesize catecholor hydroxamate-type siderophores.

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Crossref · 10.1111/j.1574-6968.1990.tb13863.x

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  • S. aureus produces two polycarboxylate siderophores, staphyloferrin A and staphyloferrin B, initially isolated from Staphylococcus hyicus.

    “S. aureus produces two polycarboxylate-type siderophores, staphyloferrin A and staphyloferrin B, which were initially isolated and characterized from Staphylococcus hyicus [45].”

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Research works printed but not linked: 2

  1. Winkelmann, G. (1986) in Biotechnology Vol. 4 (Rehm, H.-J. and Reed, G., eds). pp. 215-243.
  2. Braun, V., Fischer, E., Hantke, K. and Rotering, H, (19871 in 38. Coloquium Mosbach, Molecular Basis of Viral and 205 Microbial Pathogenesls (Ro~t. R. and Goebel, W., eds.), pp. 151-159, Springer. Berlin, Heidelberg, New York.

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Authors
Meiwes, J., Fiedler, H.-P., Haag, H., Zähner, H., Konetschny-Rapp, S., & Jung, G.
Affiliations
University of Tübingen (DE)
Corresponding author
Zähner, H.
Venue
FEMS Microbiology Letters
Published
1990-01
Volume
67
Issue
1-2
Pages
201-206
ISSN
0378-1097 (ISSN-L)
OpenAlex
W1974861151
Cited by
140
References
18
Citations by year
2026: 2 · 2025: 10 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 7 · 2020: 4 · 2019: 3 · 2018: 4 · 2017: 2 · 2016: 4 · 2015: 3 · 2014: 7 · 2013: 3 · 2012: 8
FWCI
5.44
Type
journal article
Language
en
Open access
Locations
  • FEMS Microbiology Letters (publishedVersion)
  • PubMed (publishedVersion)
Funders
Deutsche Forschungsgemeinschaft
Topics
  • Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Keywords
siderophores, Staphylococcus hyicus, iron regulation, citric acid, D-ornithine, iron acquisition, siderophore biosynthesis
MeSH terms
Chromatography, High Pressure Liquid, Citrates, Iron Chelating Agents, Ornithine, Species Specificity, Staphylococcus, Molecular Structure, Siderophores

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